Ganesan Vaidyanathan | Scholars@Duke

Ganesan Vaidyanathan
Professor in Radiology

Dr. Vaidyanathan is a professor in the Department of Radiology. He is a member of the Nuclear Medicine track of the Medical Physics Graduate Program. His research involves development of radiopharmaceuticals especially for oncologic applications. Some of the projects he is involved in are given below.

I. New methods of radiohalogenating antibodies and its variants

a) Development of newer residualizing agents for the radiohalogenation of internalizing monoclonal antibodies.

b) Development of fluorine-18 labeled residualizing agents for labeling nanobodies.

c) Pre-targeting approach via bioorthogonal chemistry for in vivo labeling of antibodies and nanobodies with ¹⁸F and ²¹¹At.

d) Methods to label antibodies pre-conjugated with a prosthetic group of the tin precursor of residualizing agents.

e) Multimodal prosthetic groups for labeling antibodies and peptides with multiple radioisotopes.

II. MIBG Analogs for PET imaging

Radioiodinated MIBG is used in the diagnosis of the pathophysiology of the heart as well as neuroendocrine tumors such as neuroblastoma (NB). Design and development of newer fluorine-18 labeled MIBG analogues useful in the PET imaging of NB as well as that of myocardial diseases.

III. Noninvasive Imaging of Alkylguanine-DNA alkyltransferase (AGT)

AGT is a DNA repair protein and is primarily responsible for drug resistance in alkylator chemotherapy. An inverse correlation has been established between the tumor AGT content and the therapeutic outcome. The amount of AGT varies from tumor to tumor and within a group of patients of similar cancer. Thus, it is important to quantify tumor AGT of individual patients before administering alkylator chemotherapy. Our goal is to develop radiolabeled agents with which AGT can be quantified in a noninvasive manner by PET or SPECT imaging.

IV. PSMA targeting for prostate cancer therapy

Development of At-211 labeled urea-based inhibitor of Prostate-specific membrane antigen.

Current Appointments & Affiliations

Professor in Radiology, Radiology, Clinical Science Departments 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1989

Contact Information

161C Bryan Res Bldg, Durham, NC 27710
Box 3808 Med Ctr, Radiology, Durham, NC 27710
vaidy001@mc.duke.edu (919) 684-7811

Background
Education, Training, & Certifications
- Postdoctoral, College Of Pharmacy, University of Kentucky at Lexington 1987 - 1989
- Teaching Assistant, Chemistry Dept, University of Kentucky at Lexington 1983 - 1987
- Ph.D., University of Kentucky at Lexington 1987
Duke Appointment History
- Professor in Radiology, Radiology, Clinical Science Departments 2006 - 2018
- Research Professor in Radiology, Radiology, Clinical Science Departments 2005 - 2006
- Associate Research Professor in Radiology, Radiology, Clinical Science Departments 1998 - 2005
- Assistant Research Professor in Radiology, Radiology, Clinical Science Departments 1994 - 1998
Research
Selected Grants
- Astatine And Iodine Radiolabeled Monoclonal Antibodies awarded by National Institutes of Health 1985 - 2020
- Labeling nanobodies with 18F residualizing labels for HER2 specific PET imaging awarded by National Institutes of Health 2015 - 2020
- Cereius research agreement awarded by Cereius Inc. 2017 - 2019
- Development of Tethered Hsp90 Inhibitors Carrying Radioiodinated Probes to Specifically Discriminate and Kill Malignant awarded by Department of Defense 2015 - 2019
- Small Molecule PSMA-Targeted Alpha Therapy awarded by Johns Hopkins University 2014 - 2019
- Novel Radiohalogenation Strategies for Enhancing Imaging and Targeted Radiotherapy awarded by Memorial Sloan Kettering Cancer Center 2016 - 2018
- Development of a Targeted Radionuclide Therapy for Triple Negative Breast Cancer awarded by OncoTAb, Inc. 2016 - 2017
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Enhancing the efficacy of targeted radiotherapy for neuroblastoma awarded by Children's Hospital of Philadelphia 2013 - 2014
- Cross-disciplinary Training in Medical Physics awarded by National Institutes of Health 2007 - 2013
- Brain Tumors - Immunological and Biological Studies awarded by National Institutes of Health 2001 - 2013
- Small Animal PET / CT Molecular Imaging awarded by National Institutes of Health 2011 - 2012
- Radionuclide-based Molecular Imaging of the DNA Repair Protein AGT awarded by National Institutes of Health 2009 - 2011
- Astatine-211 Radiochemistry: The Development of Methodologies for High Activity Level Radio-Synthesis awarded by Department of Energy 2008 - 2010
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- Imaging of O6-Alkylguianine-DNA Alkyltransferase awarded by National Institutes of Health 2002 - 2007
- Targeted Radiotherapeutics: Chemical and Biological Aspects awarded by Department of Energy 2004 - 2006
- Astatine-211 & Radioiodine Labeled Octreotide Conjugates awarded by National Institutes of Health 2001 - 2006
- Anti-Tenascin Antibody Constructs awarded by Department of Energy 1995 - 2005
- Molecular Imaging Center Planning Grant awarded by National Institutes of Health 2000 - 2004
- Astatine And Iodine Radiolabeled Monoclonal Antibodies awarded by National Institutes of Health 1999 - 2004
- MIBG Analogue Radiopharmaceuticals awarded by National Institutes of Health 1997 - 2003
- Brain Tumors--Immunological and Biological Studies awarded by National Institutes of Health 1976 - 2001
- Brain Tumors - Immunological And Biological Studies awarded by National Institutes of Health 1997 - 1999
- Src On Primary And Matastatic Tumors Of The Cns awarded by National Institutes of Health 1994 - 1999
- Astatine And Iodine Radiolabeled Monoclonal Antibodies awarded by National Institutes of Health 1994 - 1999
- Astatine And Iodine Radiolabeled Monoclonal Antibodies awarded by National Institutes of Health 1993 - 1999
- Astatine And Iodine Radiolabeled Monoclonal Antibodies awarded by National Institutes of Health 1985 - 1999
- Positron Emission Imaging Of Tumors Using Monoclonal Antib awarded by Department of Energy 1995 - 1998
- Migb And Analogs For Diagnosis And Therapy awarded by National Institutes of Health 1994 - 1998
- Mibg And Analogs For Diagnosis And Therapy awarded by National Institutes of Health 1993 - 1998
- Mibg And Analogs For Diagnosis And Therapy awarded by National Institutes of Health 1993 - 1998
- Migb And Analogs For Diagnosis And Therapy awarded by National Institutes of Health 1993 - 1998
- Cancer And Leukemia Group B Statistical Center awarded by National Institutes of Health 1992 - 1993
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Liu, Yang, Austin B. Carpenter, Christopher J. Pirozzi, Hsiangkuo Yuan, Matthew S. Waitkus, Zhengyuan Zhou, Landon Hansen, et al. “Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe..” Nanotechnology 30, no. 27 (March 11, 2019). https://doi.org/10.1088/1361-6528/ab0e9c.
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  - Zhou, Zhengyuan, Darryl McDougald, Nick Devoogdt, Michael R. Zalutsky, and Ganesan Vaidyanathan. “Labeling Single Domain Antibody Fragments with Fluorine-18 Using 2,3,5,6-Tetrafluorophenyl 6-[18F]Fluoronicotinate Resulting in High Tumor-to-Kidney Ratios..” Molecular Pharmaceutics 16, no. 1 (January 2019): 214–26. https://doi.org/10.1021/acs.molpharmaceut.8b00951.
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  - Zhou, Zhengyuan, Nick Devoogdt, Michael R. Zalutsky, and Ganesan Vaidyanathan. “An Efficient Method for Labeling Single Domain Antibody Fragments with 18F Using Tetrazine- Trans-Cyclooctene Ligation and a Renal Brush Border Enzyme-Cleavable Linker..” Bioconjug Chem 29, no. 12 (December 19, 2018): 4090–4103. https://doi.org/10.1021/acs.bioconjchem.8b00699.
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  - Vaidyanathan, Ganesan, Choong Mo Kang, Darryl McDougald, Il Minn, Mary Brummet, Martin G. Pomper, and Michael R. Zalutsky. “Brush border enzyme-cleavable linkers: Evaluation for reducing renal uptake of radiolabeled prostate-specific membrane antigen inhibitors..” Nuclear Medicine and Biology 62–63 (July 2018): 18–30. https://doi.org/10.1016/j.nucmedbio.2018.05.002.
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  - Pruszynski, Marek, Choong Mo Kang, Eftychia Koumarianou, Ganesan Vaidyanathan, and Michael R. Zalutsky. “d-Amino Acid Peptide Residualizing Agents for Protein Radioiodination: Effect of Aspartate for Glutamate Substitution..” Molecules (Basel, Switzerland) 23, no. 5 (May 20, 2018). https://doi.org/10.3390/molecules23051223.
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  - Zhou, Zhengyuan, Satish K. Chitneni, Nick Devoogdt, Michael R. Zalutsky, and Ganesan Vaidyanathan. “Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation..” Bioorganic & Medicinal Chemistry 26, no. 8 (May 2018): 1939–49. https://doi.org/10.1016/j.bmc.2018.02.040.
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  - Choi, Jaeyeon, Ganesan Vaidyanathan, Eftychia Koumarianou, Choong Mo Kang, and Michael R. Zalutsky. “Astatine-211 labeled anti-HER2 5F7 single domain antibody fragment conjugates: radiolabeling and preliminary evaluation..” Nuclear Medicine and Biology 56 (January 2018): 10–20. https://doi.org/10.1016/j.nucmedbio.2017.09.003.
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  - Zhou, Zhengyuan, Ganesan Vaidyanathan, Darryl McDougald, Choong Mo Kang, Irina Balyasnikova, Nick Devoogdt, Angeline N. Ta, Brian R. McNaughton, and Michael R. Zalutsky. “Fluorine-18 Labeling of the HER2-Targeting Single-Domain Antibody 2Rs15d Using a Residualizing Label and Preclinical Evaluation..” Molecular Imaging and Biology : Mib : The Official Publication of the Academy of Molecular Imaging 19, no. 6 (December 2017): 867–77. https://doi.org/10.1007/s11307-017-1082-x.
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  - Chin, Bennett B., Darryl McDougald, Douglas H. Weitzel, Thomas Hawk, Robert E. Reiman, Michael R. Zalutsky, and Ganesan Vaidyanathan. “Synthesis and Preliminary Evaluation of 5-[18F]fluoroleucine..” Current Radiopharmaceuticals 10, no. 1 (January 2017): 41–50. https://doi.org/10.2174/1874471009666161230114954.
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  - Kiess, Ana P., Il Minn, Ganesan Vaidyanathan, Robert F. Hobbs, Anders Josefsson, Colette Shen, Mary Brummet, et al. “(2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl)Ureido)-Pentanedioic Acid for PSMA-Targeted α-Particle Radiopharmaceutical Therapy..” Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 57, no. 10 (October 2016): 1569–75. https://doi.org/10.2967/jnumed.116.174300.
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  - Vaidyanathan, Ganesan, Darryl McDougald, Jaeyeon Choi, Eftychia Koumarianou, Douglas Weitzel, Takuya Osada, H Kim Lyerly, and Michael R. Zalutsky. “Preclinical Evaluation of 18F-Labeled Anti-HER2 Nanobody Conjugates for Imaging HER2 Receptor Expression by Immuno-PET..” Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 57, no. 6 (June 2016): 967–73. https://doi.org/10.2967/jnumed.115.171306.
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  - Chin, Bennett, Darryl McDougald, Douglas Weitzel, Thomas Hawk, Robert Reiman, Michael Zalutsky, and Ganesan Vaidyanathan. “Synthesis and preliminary evaluation of 5-[18F]fluoroleucine: a novel LAT1 substrate.” Journal of Nuclear Medicine 57 (May 1, 2016).
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  - Vaidyanathan, Ganesan, Darryl McDougald, Jaeyeon Choi, Marek Pruszynski, Eftychia Koumarianou, Zhengyuan Zhou, and Michael R. Zalutsky. “N-Succinimidyl 3-((4-(4-[(18)F]fluorobutyl)-1H-1,2,3-triazol-1-yl)methyl)-5-(guanidinomethyl)benzoate ([(18)F]SFBTMGMB): a residualizing label for (18)F-labeling of internalizing biomolecules..” Organic & Biomolecular Chemistry 14, no. 4 (January 2016): 1261–71. https://doi.org/10.1039/c5ob02258d.
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  - Vaidyanathan, Ganesan, Darryl McDougald, Eftychia Koumarianou, Jaeyeon Choi, Marc Hens, and Michael R. Zalutsky. “Synthesis and evaluation of 4-[18F]fluoropropoxy-3-iodobenzylguanidine ([18F]FPOIBG): A novel 18F-labeled analogue of MIBG..” Nuclear Medicine and Biology 42, no. 8 (August 2015): 673–84. https://doi.org/10.1016/j.nucmedbio.2015.04.005.
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  - Liu, Yang, Jeffrey R. Ashton, Everett J. Moding, Hsiangkuo Yuan, Janna K. Register, Andrew M. Fales, Jaeyeon Choi, et al. “A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy..” Theranostics 5, no. 9 (2015): 946–60. https://doi.org/10.7150/thno.11974.
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  - Pruszynski, Marek, Eftychia Koumarianou, Ganesan Vaidyanathan, Satish Chitneni, and Michael R. Zalutsky. “D-Amino acid peptide residualizing agents bearing N-hydroxysuccinimido- and maleimido-functional groups and their application for trastuzumab radioiodination..” Nuclear Medicine and Biology 42, no. 1 (January 2015): 19–27. https://doi.org/10.1016/j.nucmedbio.2014.08.007.
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  - Choi, J., G. Vaidyanathan, E. Koumarianou, D. McDougald, M. Pruszynski, T. Osada, T. Lahoutte, H. K. Lyerly, and M. R. Zalutsky. “N-Succinimidyl guanidinomethyl iodobenzoate protein radiohalogenation agents: Influence of isomeric substitution on radiolabeling and target cell residualization.” Nuclear Medicine and Biology 41, no. 10 (November 1, 2014): 802–12. https://doi.org/10.1016/j.nucmedbio.2014.07.005.
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  - Choi, Jaeyeon, Ganesan Vaidyanathan, Eftychia Koumarianou, Darryl McDougald, Marek Pruszynski, Takuya Osada, Tony Lahoutte, H Kim Lyerly, and Michael R. Zalutsky. “N-Succinimidyl guanidinomethyl iodobenzoate protein radiohalogenation agents: influence of isomeric substitution on radiolabeling and target cell residualization..” Nuclear Medicine and Biology 41, no. 10 (November 2014): 802–12. https://doi.org/10.1016/j.nucmedbio.2014.07.005.
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  - Koumarianou, Eftychia, Tatiana A. Slastnikova, Marek Pruszynski, Andrey A. Rosenkranz, Ganesan Vaidyanathan, Alexander S. Sobolev, and Michael R. Zalutsky. “Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter--a potential Auger electron emitting EGFR-targeted radiotherapeutic..” Nuclear Medicine and Biology 41, no. 6 (July 2014): 441–49. https://doi.org/10.1016/j.nucmedbio.2014.03.026.
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  - Pruszynski, Marek, Eftychia Koumarianou, Ganesan Vaidyanathan, Hilde Revets, Nick Devoogdt, Tony Lahoutte, H Kim Lyerly, and Michael R. Zalutsky. “Improved tumor targeting of anti-HER2 nanobody through N-succinimidyl 4-guanidinomethyl-3-iodobenzoate radiolabeling..” Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 55, no. 4 (April 2014): 650–56. https://doi.org/10.2967/jnumed.113.127100.
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  - Zhang, Hanwen, Ruimin Huang, NagaVaraKishore Pillarsetty, Daniel L. J. Thorek, Ganesan Vaidyanathan, Inna Serganova, Ronald G. Blasberg, and Jason S. Lewis. “Synthesis and evaluation of 18F-labeled benzylguanidine analogs for targeting the human norepinephrine transporter..” European Journal of Nuclear Medicine and Molecular Imaging 41, no. 2 (February 2014): 322–32. https://doi.org/10.1007/s00259-013-2558-9.
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  - Koumarianou, E., T. A. Slastnikova, M. Pruszynski, A. A. Rosenkranz, G. Vaidyanathan, A. S. Sobolev, and M. R. Zalutsky. “Radiolabeling and in vitro evaluation of ⁶⁷Ga-NOTA-modular nanotransporter - A potential Auger electron emitting EGFR-targeted radiotherapeutic.” Nuclear Medicine and Biology 41, no. 6 (January 1, 2014): 441–49. https://doi.org/10.1016/j.nucmedbio.2014.03.026.
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  - Zhang, H., R. Huang, N. V. K. Pillarsetty, D. L. J. Thorek, G. Vaidyanathan, I. Serganova, R. G. Blasberg, and J. S. Lewis. “Synthesis and evaluation of ¹⁸F-labeled benzylguanidine analogs for targeting the human norepinephrine transporter.” European Journal of Nuclear Medicine and Molecular Imaging 41, no. 2 (January 1, 2014): 322–32. https://doi.org/10.1007/s00259-013-2558-9.
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  - Barrott, Jared J., Philip F. Hughes, Takuya Osada, Xiao-Yi Yang, Zachary C. Hartman, David R. Loiselle, Neil L. Spector, et al. “Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells..” Chemistry & Biology 20, no. 9 (September 12, 2013): 1187–97. https://doi.org/10.1016/j.chembiol.2013.08.004.
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  - Choi, Jaeyeon, Ganesan Vaidyanathan, Eftychia Koumarianou, Marek Pruszynski, Tony Lahoutte, and Michael Rod Zalutsky. “Isomeric N-succinimidyl 3-guanidinomethyl-5-[I-131]iodobenzoate (iso-[I-131]SGMIB): A guanidine-containing residualizing agent for radiohalogenation of internalizing biomolecules.” Journal of Labelled Compounds & Radiopharmaceuticals 56 (May 1, 2013): S39–S39.
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  - Vaidyanathan, Ganesan, Darryl McDougald, Marek Pruszynski, Eftychia Koumarianou, Marc Anton Hens, Tony Lahoutte, and Michael Rod Zalutsky. “SFBTMGMB (N-succinimidyl 3-((4-(4-fluorobutyl)-1H-1,2,3-triazol-1-yl)methyl)-5-(guanidinomethyl)benzoate): An SGMIB analogue for labeling internalizing biomolecules with F-18.” Journal of Labelled Compounds & Radiopharmaceuticals 56 (May 1, 2013): S127–S127.
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  - Pruszynski, M., E. Koumarianou, G. Vaidyanathan, H. Revets, N. Devoogdt, T. Lahoutte, and M. R. Zalutsky. “Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody.” Nuclear Medicine and Biology 40, no. 1 (2013): 52–59. https://doi.org/10.1016/j.nucmedbio.2012.08.008.
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  - Pruszynski, Marek, Eftychia Koumarianou, Ganesan Vaidyanathan, Hilde Revets, Nick Devoogdt, Tony Lahoutte, and Michael R. Zalutsky. “Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody..” Nuclear Medicine and Biology 40, no. 1 (January 2013): 52–59. https://doi.org/10.1016/j.nucmedbio.2012.08.008.
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  - Weisenberger, A. G., G. Bonito, S. Lee, J. E. McKisson, A. Gryganskyi, C. D. Reid, M. F. Smith, G. Vaidyanathan, and B. Welch. “A radioisotope based methodology for plant-fungal interactions in the rhizosphere.” Ieee Nuclear Science Symposium Conference Record, January 1, 2013. https://doi.org/10.1109/NSSMIC.2013.6829457.
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  - Vaidyanathan, G., B. J. White, D. J. Affleck, X. G. Zhao, P. C. Welsh, D. McDougald, J. Choi, and M. R. Zalutsky. “SIB-DOTA: a trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies..” Bioorganic & Medicinal Chemistry 20, no. 24 (December 2012): 6929–39. https://doi.org/10.1016/j.bmc.2012.10.025.
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  - Chin, Bennett B., Anita Hjelemand, Jeremy Rich, Haijing Song, Christopher Lascola, Robert Storms, Roger McLendon, et al. “Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression..” Current Radiopharmaceuticals 5, no. 1 (January 2012): 47–58.
  - Slastnikova, Tatiana A., Eftychia Koumarianou, Andrey A. Rosenkranz, Ganesan Vaidyanathan, Tatiana N. Lupanova, Alexander S. Sobolev, and Michael R. Zalutsky. “Modular nanotransporters: a versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I..” Ejnmmi Research 2, no. 1 (January 2012). https://doi.org/10.1186/2191-219X-2-59.
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  - Vaidyanathan, Gayathri. “Virus hunters: catching bugs in the field..” Cell 147, no. 6 (December 2011): 1209–11. https://doi.org/10.1016/j.cell.2011.11.037.
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  - Vaidyanathan, Gayathri. “Dam controversy: Remaking the Mekong..” Nature 478, no. 7369 (October 19, 2011): 305–7. https://doi.org/10.1038/478305a.
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  - Vaidyanathan, Ganesan, Darryl McDougald, Linda Grasfeder, Michael R. Zalutsky, and Bennett Chin. “An alternative and expedient synthesis of radioiodinated 4-iodophenylalanine..” Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine 69, no. 10 (October 2011): 1401–6. https://doi.org/10.1016/j.apradiso.2011.05.004.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “Applications of 211At and 223Ra in targeted alpha-particle radiotherapy..” Curr Radiopharm 4, no. 4 (October 2011): 283–94.
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  - Vaidyanathan, Gayathri. “Apes in Africa: The cultured chimpanzees..” Nature 476, no. 7360 (August 17, 2011): 266–69. https://doi.org/10.1038/476266a.
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  - Vaidyanathan, Gayatri, Nuttapong Ngamphaiboon, and Francisco J. Hernandez-Ilizaliturri. “Clinical spectrum and prognosis of follicular lymphoma with blastoid transformation: case series and a review of the literature..” Annals of Hematology 90, no. 8 (August 2011): 955–62. https://doi.org/10.1007/s00277-011-1162-y.
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  - Irikefe, Vivienne, Gayathri Vaidyanathan, Linda Nordling, Aimable Twahirwa, Esther Nakkazi, and Richard Monastersky. “Science in Africa: The view from the front line..” Nature 474, no. 7353 (June 29, 2011): 556–59. https://doi.org/10.1038/474556a.
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  - Vaidyanathan, Gayathri. “Science in Africa: The wheat stalker..” Nature 474, no. 7353 (June 29, 2011): 563–65. https://doi.org/10.1038/474563a.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Applications of ²¹¹AT and ²²³RA in targeted alpha-particle radiotherapy.” Current Radiopharmaceuticals 4, no. 4 (2011): 283–94.
  - Vaidyanathan, Ganesan, Benjamin White, Donna J. Affleck, Darryl McDougald, and Michael R. Zalutsky. “Radioiodinated O(6)-Benzylguanine derivatives containing an azido function..” Nuclear Medicine and Biology 38, no. 1 (January 2011): 77–92. https://doi.org/10.1016/j.nucmedbio.2010.07.006.
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  - Vaidyanathan, Ganesan, Darryl McDougald, Donna J. Affleck, and Michael R. Zalutsky. “A tin precursor of SGMIB potentially useful in the direct modification of peptides and proteins before radiohalogenation.” Journal of Labelled Compounds & Radiopharmaceuticals 54 (January 1, 2011): S64–S64.
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  - Hens, Marc, Ganesan Vaidyanathan, Xiao-Guang Zhao, Darell D. Bigner, and Michael R. Zalutsky. “Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands..” Nuclear Medicine and Biology 37, no. 7 (October 2010): 741–50. https://doi.org/10.1016/j.nucmedbio.2010.04.020.
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  - Kato, Yukinari, Ganesan Vaidyanathan, Mika Kato Kaneko, Kazuhiko Mishima, Nidhi Srivastava, Vidyalakshmi Chandramohan, Charles Pegram, et al. “Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas..” Nuclear Medicine and Biology 37, no. 7 (October 2010): 785–94. https://doi.org/10.1016/j.nucmedbio.2010.03.010.
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  - Vaidyanathan, G., D. J. Affleck, X. G. Zhao, S. T. Keir, and M. R. Zalutsky. “[¹⁷⁷Lu]-DOTA⁰-Tyr³-octreotate: A potential targeted radiotherapeutic for the treatment of Medulloblastoma.” Current Radiopharmaceuticals 3, no. 1 (July 12, 2010): 29–36. https://doi.org/10.2174/1874471011003010029.
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  - Vaidyanathan, G., and M. G. Fakih. “A case of curative-intent hepatectomy for colon cancer metastatic to the scapula and liver..” Anticancer Research 30, no. 2 (February 2010): 677–79.
  - Vaidyanathan, Ganesan, Donna J. Affleck, Xiao-Guang Zhao, Stephen T. Keir, and Michael R. Zalutsky. “[Lu]-DOTA-Tyr-octreotate: A Potential Targeted Radiotherapeutic for the Treatment of Medulloblastoma..” Current Radiopharmaceuticals 3, no. 1 (January 2010): 29–36. https://doi.org/10.2174/1874471011003010029.
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  - Vaidyanathan, Gayatri, Adrienne Groman, Gregory Wilding, and Marwan G. Fakih. “Stop and go FOLFOX plus bevacizumab chemotherapy in the first-line treatment of metastatic colorectal cancer..” Oncology 79, no. 1–2 (January 2010): 67–71. https://doi.org/10.1159/000319549.
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  - Vaidyanathan, Ganesan, Haijing Song, Donna Affleck, Darryl L. McDougald, Robert W. Storms, Michael R. Zalutsky, and Bennett B. Chin. “Targeting aldehyde dehydrogenase: a potential approach for cell labeling..” Nuclear Medicine and Biology 36, no. 8 (November 2009): 919–29. https://doi.org/10.1016/j.nucmedbio.2009.08.001.
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  - Vaidyanathan, Ganesan, Emmanuelle Jestin, Tove Olafsen, Anna M. Wu, and Michael R. Zalutsky. “Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK..” Nuclear Medicine and Biology 36, no. 6 (August 2009): 671–80. https://doi.org/10.1016/j.nucmedbio.2009.04.002.
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  - Hens, Marc, Ganesan Vaidyanathan, Phil Welsh, and Michael R. Zalutsky. “Labeling internalizing anti-epidermal growth factor receptor variant III monoclonal antibody with (177)Lu: in vitro comparison of acyclic and macrocyclic ligands..” Nuclear Medicine and Biology 36, no. 2 (February 2009): 117–28. https://doi.org/10.1016/j.nucmedbio.2008.11.001.
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  - Vaidyanathan, G., B. White, D. Affleck, X. Zhao, P. Welsh, and M. Zalutsky. “DOTA-SIB, A TRIFUNCTIONAL PROSTHETIC GROUP FOR MULTI-MODAL LABELING.” Journal of Labelled Compounds & Radiopharmaceuticals 52 (January 1, 2009): S70–S70.
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  - Vaidyanathan, Ganesan, Benjamin J. White, and Michael R. Zalutsky. “Propargyl 4-[F]fluorobenzoate: A Putatively More Stable Prosthetic group for the Fluorine-18 Labeling of Biomolecules via Click Chemistry..” Current Radiopharmaceuticals 2, no. 1 (January 2009): 63–74. https://doi.org/10.2174/1874471010902010063.
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  - Vaidyanathan, G. “Meta-iodobenzylguanidine and analogues: chemistry and biology..” The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (Aimn) [And] the International Association of Radiopharmacology (Iar), [And] Section of the Society Of.. 52, no. 4 (December 2008): 351–68.
  - Simmons, Kirk, John Kinney, Aaron Owens, Daniel A. Kleier, Karen Bloch, Dave Argentar, Alicia Walsh, and Ganesh Vaidyanathan. “Practical outcomes of applying ensemble machine learning classifiers to High-Throughput Screening (HTS) data analysis and screening..” Journal of Chemical Information and Modeling 48, no. 11 (November 2008): 2196–2206. https://doi.org/10.1021/ci800164u.
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  - Rosenkranz, Andrey A., Ganesan Vaidyanathan, Oscar R. Pozzi, Vladimir G. Lunin, Michael R. Zalutsky, and Alexander S. Sobolev. “Engineered modular recombinant transporters: application of new platform for targeted radiotherapeutic agents to alpha-particle emitting 211 At..” International Journal of Radiation Oncology, Biology, Physics 72, no. 1 (September 2008): 193–200. https://doi.org/10.1016/j.ijrobp.2008.05.055.
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  - Sun, C., A. Dobi, A. Mohamed, H. Li, R. L. Thangapazham, B. Furusato, S. Shaheduzzaman, et al. “TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation..” Oncogene 27, no. 40 (September 2008): 5348–53. https://doi.org/10.1038/onc.2008.183.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “Astatine Radiopharmaceuticals: Prospects and Problems..” Current Radiopharmaceuticals 1, no. 3 (September 2008). https://doi.org/10.2174/1874471010801030177.
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  - Simmons, Kirk, John Kinney, Aaron Owens, Dan Kleier, Karen Bloch, Dave Argentar, Alicia Walsh, and Ganesh Vaidyanathan. “Comparative study of machine-learning and chemometric tools for analysis of in-vivo high-throughput screening data..” Journal of Chemical Information and Modeling 48, no. 8 (August 6, 2008): 1663–68. https://doi.org/10.1021/ci800142d.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Joseph Norman, Susan O’Dorisio, and Michael R. Zalutsky. “A radioiodinated MIBG-octreotate conjugate exhibiting enhanced uptake and retention in SSTR2-expressing tumor cells..” Bioconjugate Chemistry 18, no. 6 (November 3, 2007): 2122–30. https://doi.org/10.1021/bc700240r.
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  - Zalutsky, Michael R., David A. Reardon, Oscar R. Pozzi, Ganesan Vaidyanathan, and Darell D. Bigner. “Targeted alpha-particle radiotherapy with 211At-labeled monoclonal antibodies..” Nuclear Medicine and Biology 34, no. 7 (October 2007): 779–85. https://doi.org/10.1016/j.nucmedbio.2007.03.007.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Kevin L. Alston, Xiao-Guang Zhao, Marc Hens, Duncan H. Hunter, John Babich, and Michael R. Zalutsky. “A kit method for the high level synthesis of [211At]MABG..” Bioorganic & Medicinal Chemistry 15, no. 10 (May 2007): 3430–36. https://doi.org/10.1016/j.bmc.2007.03.016.
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  - Park, Jae, Gayathri Vaidyanathan, Bhag Singh, and Radhey S. Gupta. “Identification and biochemical studies on novel non-nucleoside inhibitors of the enzyme adenosine kinase..” The Protein Journal 26, no. 3 (April 2007): 203–12. https://doi.org/10.1007/s10930-006-9062-z.
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  - Vaidyanathan, G., D. J. Affleck, K. L. Alston, and M. R. Zalutsky. “A tin precursor for the synthesis of no-carrier-added [*I]MIBG and [²¹¹At]MABG.” Journal of Labelled Compounds and Radiopharmaceuticals 50, no. 3 (March 1, 2007): 177–82. https://doi.org/10.1002/jlcr.1243.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “Synthesis of N-succinimidyl 4-guanidinomethyl-3-[*I]iodobenzoate: a radio-iodination agent for labeling internalizing proteins and peptides..” Nature Protocols 2, no. 2 (January 2007): 282–86. https://doi.org/10.1038/nprot.2007.20.
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  - Vaidyanathan, G., K. L. Alston, D. D. Bigner, and M. R. Zalutsky. “N^ε-(3[*I]iodobenzoyl)-Lys⁵-N ^α-maleimido-Gly¹-GEEEK([*I]IB-Mal-D-GEEEK): A radioiodinated prosthetic group containing negatively charged D-glutamates for labeling internalizing monoclonal antibodies.” Bioconjugate Chemistry 17, no. 4 (July 1, 2006): 1085–92. https://doi.org/10.1021/bc0600766.
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  - Vaidyanathan, Ganesan, Kevin L. Alston, Darrel D. Bigner, and Michael R. Zalutsky. “Nepsilon-(3-[*I]Iodobenzoyl)-Lys5-Nalpha-maleimido-Gly1-GEEEK ([*I]IB-Mal-D-GEEEK): a radioiodinated prosthetic group containing negatively charged D-glutamates for labeling internalizing monoclonal antibodies..” Bioconjugate Chemistry 17, no. 4 (July 2006): 1085–92. https://doi.org/10.1021/bc0600766.
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  - Shankar, Sriram, Michael R. Zalutsky, Henry Friedman, and Ganesan Vaidyanathan. “Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine..” Nuclear Medicine and Biology 33, no. 3 (April 2006): 399–407. https://doi.org/10.1016/j.nucmedbio.2005.12.015.
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  - Shankar, Sriram, Ganesan Vaidyanathan, Chien-Tsun Kuan, Darell D. Bigner, and Michael R. Zalutsky. “Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance..” Nuclear Medicine and Biology 33, no. 1 (January 2006): 101–10. https://doi.org/10.1016/j.nucmedbio.2005.08.004.
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  - Vaidyanathan, G., D. J. Affleck, M. Schottelius, H. Wester, H. S. Friedman, and M. R. Zalutsky. “Synthesis and evaluation of glycosylated octreotate analogues labeled with radioiodine and 211At via a tin precursor..” Bioconjugate Chemistry 17, no. 1 (January 2006): 195–203. https://doi.org/10.1021/bc0502560.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “Preparation of N-succinimidyl 3-[*I]iodobenzoate: an agent for the indirect radioiodination of proteins..” Nature Protocols 1, no. 2 (January 2006): 707–13. https://doi.org/10.1038/nprot.2006.99.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “Synthesis of N-succinimidyl 4-[18F]fluorobenzoate, an agent for labeling proteins and peptides with 18F..” Nature Protocols 1, no. 4 (January 2006): 1655–61. https://doi.org/10.1038/nprot.2006.264.
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  - Shankar, Sriram, Michael R. Zalutsky, and Ganesan Vaidyanathan. “O6-3-[125I]iodobenzyl-2'-deoxyguanosine ([125I]IBdG): synthesis and evaluation of its usefulness as an agent for quantification of alkylguanine-DNA alkyltransferase (AGT)..” Bioorganic & Medicinal Chemistry 13, no. 12 (June 2005): 3889–98. https://doi.org/10.1016/j.bmc.2005.04.014.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “No-carrier-added synthesis of a 4-methyl-substituted meta-iodobenzylguanidine analogue..” Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine 62, no. 3 (March 2005): 435–40. https://doi.org/10.1016/j.apradiso.2004.07.001.
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  - Vaidyanathan, G. “Astatine-211 Labeled Radiopharmaceuticals, invited.” Transactions of the American Nuclear Society 91 (December 1, 2004).
  - Vaidyanathan, Ganesan, Abraham Boskovitz, Sriram Shankar, and Michael R. Zalutsky. “Radioiodine and 211At-labeled guanidinomethyl halobenzoyl octreotate conjugates: potential peptide radiotherapeutics for somatostatin receptor-positive cancers..” Peptides 25, no. 12 (December 2004): 2087–97. https://doi.org/10.1016/j.peptides.2004.08.018.
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  - Shankar, Sriram, Ganesan Vaidyanathan, Donna J. Affleck, Katia Peixoto, Darell D. Bigner, and Michael R. Zalutsky. “Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent..” Nuclear Medicine and Biology 31, no. 7 (October 2004): 909–19. https://doi.org/10.1016/j.nucmedbio.2004.04.007.
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  - Vaidyanathan, Ganesan, Philip C. Welsh, Katia C. Vitorello, Stacey Snyder, Henry S. Friedman, and Michael R. Zalutsky. “A 4-methyl-substituted meta-iodobenzylguanidine analogue with prolonged retention in human neuroblastoma cells..” European Journal of Nuclear Medicine and Molecular Imaging 31, no. 10 (October 2004): 1362–70. https://doi.org/10.1007/s00259-004-1596-8.
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  - Kumar, Y Ravindra, G. Ramulu, V. V. Vevakanand, Gopal Vaidyanathan, Keesari Srinivas, M Kishore Kumar, K. Mukkanti, M Satyanarayana Reddy, S. Venkatraman, and M. V. Suryanarayana. “A validated chiral HPLC method for the enantiomeric separation of tolterodine tartarate..” Journal of Pharmaceutical and Biomedical Analysis 35, no. 5 (September 2004): 1279–85. https://doi.org/10.1016/j.jpba.2004.03.026.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Kevin L. Alston, Philip Welsh, and Michael R. Zalutsky. “Catabolism of 4-fluoro-3-iodobenzylguanidine and meta-iodobenzylguanidine by SK-N-SH neuroblastoma cells..” Nuclear Medicine Communications 25, no. 9 (September 2004): 947–55. https://doi.org/10.1097/00006231-200409000-00013.
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  - Boyd, Marie, Robert J. Mairs, W Nicol Keith, Susan C. Ross, Philip Welsh, Gamal Akabani, Jonathan Owens, et al. “An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects..” The Journal of Gene Medicine 6, no. 8 (August 2004): 937–47. https://doi.org/10.1002/jgm.578.
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  - Vaidyanathan, Govindan, Mary J. Cismowski, Guoshun Wang, Timothy S. Vincent, Kevin D. Brown, and Stephen M. Lanier. “The Ras-related protein AGS1/RASD1 suppresses cell growth..” Oncogene 23, no. 34 (July 2004): 5858–63. https://doi.org/10.1038/sj.onc.1207774.
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  - Vaidyanathan, Ganesh. “InfoEvolve: moving from data to knowledge using information theory and genetic algorithms..” Annals of the New York Academy of Sciences 1020 (May 2004): 227–38. https://doi.org/10.1196/annals.1310.019.
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  - Vaidyanathan, Ganesan, Sriram Shankar, Donna J. Affleck, Kevin Alston, Joseph Norman, Philip Welsh, Holly LeGrand, and Michael R. Zalutsky. “Meta-iodobenzylguanidine derivatives containing a second guanidine moiety..” Bioorganic & Medicinal Chemistry 12, no. 7 (April 2004): 1649–56. https://doi.org/10.1016/j.bmc.2004.01.026.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Joseph Norman, Phil Welsh, Wenge Liu, Stewart P. Johnson, Henry S. Friedman, and Michael R. Zalutsky. “O6-3-[131I]iodobenzylguanine: improved synthesis and further evaluation of a potential agent for imaging of alkylguanine-DNA alkyltransferase..” Bioconjugate Chemistry 15, no. 2 (March 2004): 402–8. https://doi.org/10.1021/bc0341977.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Imaging drug resistance with radiolabeled molecules..” Current Pharmaceutical Design 10, no. 24 (January 2004): 2965–79. https://doi.org/10.2174/1381612043383449.
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  - Vivekanand, V. V., D. Sreenivas Rao, G. Vaidyanathan, N. M. Sekhar, S. Avijit Kelkar, and P. Ramachandra Puranik. “A validated LC method for imatinib mesylate..” Journal of Pharmaceutical and Biomedical Analysis 33, no. 5 (December 2003): 879–89. https://doi.org/10.1016/s0731-7085(03)00419-9.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Darell D. Bigner, and Michael R. Zalutsky. “N-succinimidyl 3-[211At]astato-4-guanidinomethylbenzoate: an acylation agent for labeling internalizing antibodies with alpha-particle emitting 211At..” Nuclear Medicine and Biology 30, no. 4 (May 2003): 351–59. https://doi.org/10.1016/s0969-8051(03)00005-2.
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  - Vaidyanathan, Ganesan, Henry S. Friedman, Donna J. Affleck, Margaret Schottelius, Hans-Jürgen Wester, and Michael R. Zalutsky. “Specific and high-level targeting of radiolabeled octreotide analogues to human medulloblastoma xenografts..” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 9, no. 5 (May 2003): 1868–76.
  - Shankar, Sriram, Ganesan Vaidyanathan, Donna Affleck, Phillip C. Welsh, and Michael R. Zalutsky. “N-succinimidyl 3-[(131)I]iodo-4-phosphonomethylbenzoate ([(131)I]SIPMB), a negatively charged substituent-bearing acylation agent for the radioiodination of peptides and mAbs..” Bioconjugate Chemistry 14, no. 2 (March 2003): 331–41. https://doi.org/10.1021/bc025636p.
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  - Shankar, S., G. Vaidyanathan, D. J. Affleck, P. Welsh, H. LeGrand, and M. R. Zalutsky. “Negatively charged substituent-bearing acylation agent for the radiohalogenation of mAbs..” Journal of Nuclear Medicine 43, no. 5 (May 1, 2002): 366P-366P.
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  - Vaidyanathan, G., D. J. Affleck, P. Welsh, M. Schottelius, H. Wester, J. A. Norman, K. L. Alston, and M. R. Zalutsky. “Synthesis and in vitro evaluation of glycated octreotate conjugates labeled with radioiodine and At-211 via a tin precursor..” Journal of Nuclear Medicine 43, no. 5 (May 1, 2002): 92P-92P.
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  - Dingus, Jane, Bronwyn S. Tatum, Govindan Vaidyanathan, and John D. Hilderbrandt. “Purification of G protein beta gamma from bovine brain..” Methods in Enzymology 344 (January 2002): 194–208. https://doi.org/10.1016/s0076-6879(02)44716-7.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Darell D. Bigner, and Michael R. Zalutsky. “Improved xenograft targeting of tumor-specific anti-epidermal growth factor receptor variant III antibody labeled using N-succinimidyl 4-guanidinomethyl-3-iodobenzoate..” Nuclear Medicine and Biology 29, no. 1 (January 2002): 1–11. https://doi.org/10.1016/s0969-8051(01)00277-3.
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  - Vaidyanathan, G., S. Shankar, D. J. Affleck, P. C. Welsh, S. K. Slade, and M. R. Zalutsky. “Biological evaluation of ring- and side-chain-substituted m-iodobenzylguanidine analogues..” Bioconjugate Chemistry 12, no. 5 (September 2001): 798–806. https://doi.org/10.1021/bc010032r.
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  - Vaidyanathan, G., S. Shankar, and M. R. Zalutsky. “Synthesis of ring- and side-chain-substituted m-iodobenzylguanidine analogues..” Bioconjugate Chemistry 12, no. 5 (September 2001): 786–97. https://doi.org/10.1021/bc010031z.
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  - Vaidyanathan, G., D. J. Affleck, J. Li, P. Welsh, and M. R. Zalutsky. “A polar substituent-containing acylation agent for the radioiodination of internalizing monoclonal antibodies: N-succinimidyl 4-guanidinomethyl-3-[131I]iodobenzoate ([131I]SGMIB)..” Bioconjugate Chemistry 12, no. 3 (May 2001): 428–38. https://doi.org/10.1021/bc0001490.
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  - Vaidyanathan, G., D. J. Affleck, C. M. Cavazos, S. P. Johnson, S. Shankar, H. S. Friedman, M. O. Colvin, and M. R. Zalutsky. “Radiolabeled guanine derivatives for the in vivo mapping of O(6)-alkylguanine-DNA alkyltransferase: 6-(4-[(18)F]Fluoro-benzyloxy)-9H-purin-2-ylamine and 6-(3-[(131)I]Iodo-benzyloxy)-9H-purin-2-ylamine..” Bioconjugate Chemistry 11, no. 6 (November 2000): 868–75. https://doi.org/10.1021/bc0000435.
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  - Bardiès, M., and P. Pihet. “Dosimetry and microdosimetry of targeted radiotherapy..” Current Pharmaceutical Design 6, no. 14 (September 2000): 1469–1502. https://doi.org/10.2174/1381612003399176.
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  - Zalutsky, M. R., and G. Vaidyanathan. “Astatine-211-labeled radiotherapeutics: an emerging approach to targeted alpha-particle radiotherapy..” Current Pharmaceutical Design 6, no. 14 (September 2000): 1433–55. https://doi.org/10.2174/1381612003399275.
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  - Vaidyanathan, G., D. Affleck, P. Welsh, A. Srinivasan, M. Schmidt, and M. R. Zalutsky. “Radioiodination and astatination of octreotide by conjugation labeling..” Nuclear Medicine and Biology 27, no. 4 (May 2000): 329–37. https://doi.org/10.1016/s0969-8051(00)00098-6.
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  - Vaidyanathan, G., D. Affleck, P. Welsh, A. Srinivasan, M. Schmidt, and M. R. Zalutsky. “Radioiodination and astatination of octreotide by conjugation labeling.” Journal of Inorganic Biochemistry 78, no. 3 (February 29, 2000): 329–37.
  - Vaidyanathan, G., and M. R. Zalutsky. “Low molecular weight radiopharmaceuticals: Radiohalogenated MIBG and IUdR analogues..” Abstracts of Papers of the American Chemical Society 217 (March 21, 1999): U41–U41.
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  - Vaidyanathan, G., A. Srinivasan, D. J. Affleck, P. C. Welsh, S. K. Slade, M. A. Schmidt, and M. R. Zalutsky. “Octreotide analogues labeled with radioiodine and astatine-211.” Journal of Labelled Compounds and Radiopharmaceuticals 42, no. SUPPL. 1 (January 1, 1999).
  - Vaidyanathan, G., M. R. Zalutsky, and T. R. DeGrado. “Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine..” Bioconjugate Chemistry 9, no. 6 (November 1998): 758–64. https://doi.org/10.1021/bc980037x.
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  - Wang, L., J. Kristensen, and D. E. Ruffner. “Delivery of antisense oligonucleotides using HPMA polymer: synthesis of A thiol polymer and its conjugation to water-soluble molecules..” Bioconjugate Chemistry 9, no. 6 (November 1998): 749–57. https://doi.org/10.1021/bc980034k.
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  - Walicka, M. A., G. Vaidyanathan, M. R. Zalutsky, S. J. Adelstein, and A. I. Kassis. “Survival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211..” Radiation Research 150, no. 3 (September 1998): 263–68. https://doi.org/10.2307/3579974.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Preparation of 5-[131I]iodo- and 5-[211At]astato-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil by a halodestannylation reaction..” Nuclear Medicine and Biology 25, no. 5 (July 1998): 487–96. https://doi.org/10.1016/s0969-8051(98)00004-3.
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  - Cunningham, S. H., R. J. Mairs, T. E. Wheldon, P. C. Welsh, G. Vaidyanathan, and M. R. Zalutsky. “Toxicity to neuroblastoma cells and spheroids of benzylguanidine conjugated to radionuclides with short-range emissions..” British Journal of Cancer 77, no. 12 (June 1998): 2061–68. https://doi.org/10.1038/bjc.1998.348.
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  - Berry, C. R., G. Vaidyanathan, P. E. Fisher, M. R. Zalutsky, R. E. Coleman, and T. R. DeGrado. “Myocardial kinetics of meta-[I-131]iodobenzylguanidine in an adriamycin cardiomyopathy rat model..” Journal of Nuclear Medicine 39, no. 5 (May 1, 1998): 47P-47P.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Targeted therapy using astatinated radiopharmaceuticals..” Abstracts of Papers of the American Chemical Society 215 (April 2, 1998): U946–U946.
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  - DeGrado, T. R., M. R. Zalutsky, R. E. Coleman, and G. Vaidyanathan. “Effects of specific activity on meta-[(131)I]iodobenzylguanidine kinetics in isolated rat heart..” Nuclear Medicine and Biology 25, no. 1 (January 1998): 59–64. https://doi.org/10.1016/s0969-8051(97)00158-3.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “Method for radioiodination of proteins using N-succinimidyl 3-hydroxy-4-iodobenzoate..” Bioconjugate Chemistry 8, no. 5 (September 1997): 724–29. https://doi.org/10.1021/bc9700502.
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  - Larsen, R. H., G. Vaidyanathan, and M. R. Zalutsky. “Cytotoxicity of alpha-particle-emitting 5-[211At]astato-2'-deoxyuridine in human cancer cells..” International Journal of Radiation Biology 72, no. 1 (July 1997): 79–90. https://doi.org/10.1080/095530097143563.
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  - Vaidyanathan, G., X. -. G. Zhao, R. H. Larsen, and M. R. Zalutsky. “3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells.” British Journal of Cancer 76, no. 2 (July 1997): 226–33. https://doi.org/10.1038/bjc.1997.366.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “A New Route to Guanidines from Bromoalkanes.” The Journal of Organic Chemistry 62, no. 14 (July 1997): 4867–69. https://doi.org/10.1021/jo9704164.
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  - DeGrado, T. R., M. R. Zalutsky, and G. Vaidyanathan. “Mechanisms of uptake in isolated rat heart of potential radiotherapeutic agent [At-211]meta-astatobenzylguanidine (MABG)..” Journal of Nuclear Medicine 38, no. 5 (May 1, 1997): 106–106.
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  - Kassis, A. I., M. A. Walicka, G. Vaidyanathan, M. R. Zalutsky, and S. J. Adelstein. “Survival and DNA damage in V79 cells exposed to the alpha emitters 5-[At-211]astato-2'-deoxy-uridine and [At-211]astatide..” Journal of Nuclear Medicine 38, no. 5 (May 1, 1997): 964–964.
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  - Vaidyanathan, G., X. G. Zhao, D. K. Strickland, and M. R. Zalutsky. “No-carrier-added iodine-131-FIBG: evaluation of an MIBG analog..” Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 38, no. 2 (February 1997): 330–34.
  - Vaidyanathan, G., and M. R. Zalutsky. “Fluorine-18-labeled [Nle4,D-Phe7]-alpha-MSH, an alpha-melanocyte stimulating hormone analogue..” Nuclear Medicine and Biology 24, no. 2 (February 1997): 171–78. https://doi.org/10.1016/s0969-8051(96)00211-9.
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  - Vaidyanathan, G., X. G. Zhao, R. H. Larsen, and M. R. Zalutsky. “3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells..” British Journal of Cancer 76, no. 2 (January 1997): 226–33. https://doi.org/10.1038/bjc.1997.366.
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  - Vaidyanathan, G., X. G. Zhao, R. H. Larsen, and M. R. Zalutsky. “3-[²¹¹At]astato-4-fluorobenzylguanidine: A potential therapeutic agent with prolonged retention by neuroblastoma cells.” British Journal of Cancer 76, no. 2 (1997): 226–33.
  - Vaidyanathan, G., and M. R. Zalutsky. “Fluorine-18-labeled [Nle⁴,D-Phe⁷]-α-MSH, an α-melanocyte stimulating hormone analogue.” Nuclear Medicine and Biology 24, no. 2 (1997): 171–78. https://doi.org/10.1016/S0969-8051(96)00211-9.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Targeted therapy using alpha emitters..” Physics in Medicine and Biology 41, no. 10 (October 1996): 1915–31. https://doi.org/10.1088/0031-9155/41/10/005.
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  - Vaidyanathan, G., H. S. Friedman, S. T. Keir, and M. R. Zalutsky. “Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model..” Nuclear Medicine and Biology 23, no. 6 (August 1996): 851–56. https://doi.org/10.1016/0969-8051(96)00115-1.
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  - DeGrado, T. R., M. R. Zalutsky, R. E. Coleman, and G. Vaidyanathan. “Effects of specific activity on uptake and retention of metaiodobenzylguanidine (MIBG) in the heart: Revisited.” Journal of Nuclear Medicine 37, no. 5 (May 1, 1996): 701–701.
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  - Vaidyanathan, G., D. J. Affleck, P. C. Welsh, S. A. Slade, K. L. Alston, and M. R. Zalutsky. “Fluorine-18 labeling of [Nle(4),D-Phe(7)]-alpha-MSH, an alpha-melanocyte stimulating hormone (alpha-MSH) analogue..” Journal of Nuclear Medicine 37, no. 5 (May 1, 1996): 875–875.
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  - Vaidyanathan, G., H. S. Friedman, S. T. Keir, and M. R. Zalutsky. “Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity..” British Journal of Cancer 73, no. 10 (May 1996): 1171–77. https://doi.org/10.1038/bjc.1996.226.
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  - Vaidyanathan, G., H. S. Friedman, S. T. Keir, and M. R. Zalutsky. “Meta-[At-211]astatobenzylguanidine (MABG): In vivo evaluation in an athymic mouse human neuroblastoma xenograft model..” Journal of Nuclear Medicine 37, no. 5 (May 1, 1996): 236–236.
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  - Zweit, J., M. Flower, A. Brown, P. Carnochan, S. Luthra, F. Brady, V. Pike, et al. “Iodine-120-mIBG: Production and NCA labelling of a new PET radiotracer..” Journal of Nuclear Medicine 37, no. 5 (May 1, 1996): 874–874.
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  - Vaidyanathan, G., R. H. Larsen, and M. R. Zalutsky. “Particle-emitting endoradiotherapeutic agent undergoing DNA incorporation.” Cancer Research 56, no. 6 (March 15, 1996): 1204–9.
  - Vaidyanathan, G., R. H. Larsen, and M. R. Zalutsky. “5-[At-211]astato-2'-deoxyuridine, an alpha-particle-emitting endoradiotherapeutic agent undergoing DNA incorporation.” Cancer Research 56, no. 6 (March 15, 1996): 1204–9.
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  - Vaidyanathan, G., R. H. Larsen, and M. R. Zalutsky. “5-[211 At]astato-2'-deoxyuridine, an alpha particle-emitting endoradiotherapeutic agent undergoing DNA incorporation..” Cancer Research 56, no. 6 (March 1996): 1204–9.
  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “No-carrier-added (4-fluoro-3-[131I]iodobenzyl)guanidine and (3-[211At]astato-4-fluorobenzyl)guanidine..” Bioconjugate Chemistry 7, no. 1 (January 1996): 102–7. https://doi.org/10.1021/bc950078i.
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  - Reist, C. J., G. E. Archer, S. N. Kurpad, C. J. Wikstrand, G. Vaidyanathan, M. C. Willingham, D. K. Moscatello, A. J. Wong, D. D. Bigner, and M. R. Zalutsky. “Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts..” Cancer Research 55, no. 19 (October 1995): 4375–82.
  - Vaidyanathan, G., and M. R. Zalutsky. “Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection..” Nuclear Medicine and Biology 22, no. 6 (August 1995): 759–64. https://doi.org/10.1016/0969-8051(95)00028-v.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “Validation of 4-[fluorine-18]fluoro-3-iodobenzylguanidine as a positron-emitting analog of MIBG..” Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 36, no. 4 (April 1995): 644–50.
  - Degrado, T. R., M. R. Zalutsky, and G. Vaidyanathan. “Uptake mechanisms of meta-[123I]iodobenzylguanidine in isolated rat heart..” Nuclear Medicine and Biology 22, no. 1 (January 1995): 1–12. https://doi.org/10.1016/0969-8051(94)00084-w.
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  - Johnson, E. L., T. G. Turkington, R. J. Jaszczak, D. R. Gilland, G. Vaidyanathan, K. L. Greer, R. E. Coleman, and M. R. Zalutsky. “Quantitation of 211At in small volumes for evaluation of targeted radiotherapy in animal models..” Nuclear Medicine and Biology 22, no. 1 (January 1995): 45–54. https://doi.org/10.1016/0969-8051(94)00077-w.
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  - Mairs, R. J., J. Russell, S. Cunningham, J. A. O’Donoghue, M. N. Gaze, J. Owens, G. Vaidyanathan, and M. R. Zalutsky. “Enhanced tumour uptake and in vitro radiotoxicity of no-carrier-added [131I]meta-iodobenzylguanidine: implications for the targeted radiotherapy of neuroblastoma..” European Journal of Cancer (Oxford, England : 1990) 31A, no. 4 (January 1995): 576–81. https://doi.org/10.1016/0959-8049(95)00052-k.
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  - Mairs, R. J., J. Russell, S. Cunningham, J. A. O’Donoghue, M. N. Gaze, J. Owens, G. Vaidyanathan, and M. R. Zalutsky. “Enhanced tumour uptake and in vitro radiotoxicity of no-carrier-added [¹³¹i] metaiodobenzylguanidine: Implications for the targeted radiotherapy of neuroblastoma.” European Journal of Cancer 31, no. 4 (January 1, 1995): 576–81. https://doi.org/10.1016/0959-8049(95)00052-K.
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  - Strickland, D. K., G. Vaidyanathan, H. S. Friedman, and M. R. Zalutsky. “Meta-[131I]iodobenzylguanidine uptake and meta-[211At]astatobenzylguanidine treatment in human medulloblastoma cell lines..” J Neurooncol 25, no. 1 (1995): 9–17.
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  - Strickland, D. K., G. Vaidyanathan, H. S. Friedman, and M. R. Zalutsky. “Meta-[¹³¹I]iodobenzylguanidine uptake and meta-[²¹¹At]astatobenzylguanidine treatment in human medulloblastoma cell lines.” Journal of Neuro Oncology 25, no. 1 (1995): 9–17. https://doi.org/10.1007/BF01054718.
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  - Vaidyanathan, G., and M. R. Zalutsky. “No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation..” Nuclear Medicine and Biology 22, no. 1 (January 1995): 61–64. https://doi.org/10.1016/0969-8051(94)00078-x.
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  - VAIDYANATHAN, G., D. J. AFFLECK, and M. R. ZALUTSKY. “(4-[F-18]FLUORO-3-IODOBENZYL) GUANIDINE, A POTENTIAL MIBG ANALOG FOR POSITRON EMISSION TOMOGRAPHY.” Journal of Medicinal Chemistry 37, no. 21 (October 14, 1994): 3655–62. https://doi.org/10.1021/jm00047a022.
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  - Page, R. L., P. K. Garg, G. Vaidyanathan, and M. R. Zalutsky. “Preclinical evaluation and PET imaging of 18F-labeled Mel-14 F(ab')2 fragment in normal dogs..” Nuclear Medicine and Biology 21, no. 7 (October 1994): 911–19. https://doi.org/10.1016/0969-8051(94)90079-5.
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  - Strickland, D. K., G. Vaidyanathan, and M. R. Zalutsky. “Cytotoxicity of alpha-particle-emitting m-[211At]astatobenzylguanidine on human neuroblastoma cells..” Cancer Research 54, no. 20 (October 1994): 5414–19.
  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “(4-[18F]fluoro-3-iodobenzyl)guanidine, a potential MIBG analogue for positron emission tomography..” Journal of Medicinal Chemistry 37, no. 21 (October 1994): 3655–62. https://doi.org/10.1021/jm00047a022.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Improved synthesis of N-succinimidyl 4-[18F]fluorobenzoate and its application to the labeling of a monoclonal antibody fragment..” Bioconjugate Chemistry 5, no. 4 (July 1994): 352–56. https://doi.org/10.1021/bc00028a012.
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  - Vaidyanathan, G., D. K. Strickland, and M. R. Zalutsky. “Meta-[211At]astatobenzylguanidine: further evaluation of a potential therapeutic agent..” International Journal of Cancer 57, no. 6 (June 1994): 908–13. https://doi.org/10.1002/ijc.2910570622.
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  - DEGRADO, T. R., M. R. ZALUTSKY, D. J. AFFLECK, and G. VAIDYANATHAN. “MECHANISTIC STUDIES OF METAIODOBENZYLGUANIDINE (METAIODOBENZYLGUANIDINE) UPTAKE AND RETENTION IN ISOLATED RAT-HEART.” Journal of Nuclear Medicine 35, no. 5 (May 1, 1994): P57–P57.
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  - JOHNSON, E. L., T. G. TURKINGTON, R. J. JASZCZAK, M. R. ZALUTSKY, D. R. GILLAND, G. VAIDYANATHAN, K. L. GREER, and R. E. COLEMAN. “QUANTITATIVE IMAGING OF AT-211 RADIOTHERAPEUTIC AGENTS IN SMALL VOLUMES.” Journal of Nuclear Medicine 35, no. 5 (May 1, 1994): P180–P180.
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  - VAIDYANATHAN, G., D. J. AFFLECK, S. A. SLADE, P. C. WELSH, and M. R. ZALUTSKY. “SYNTHESIS AND PRELIMINARY EVALUATION OF 4-[F-18]FLUORO-3-IODOBENZYLGUANIDINE (FIBG) - A METAIODOBENZYLGUANIDINE ANALOG FOR PET.” Journal of Nuclear Medicine 35, no. 5 (May 1, 1994): P248–P248.
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  - Mairs, R. J., M. N. Gaze, D. G. Watson, G. G. Skellern, P. Constable, K. McKellar, J. Owens, G. Vaidyanathan, and M. R. Zalutsky. “Carrier-free 131I-meta-iodobenzylguanidine: comparison of production from meta-diazobenzylguanidine and from meta-trimethylsilylbenzylguanidine..” Nuclear Medicine Communications 15, no. 4 (April 1994): 268–74.
  - Shepherd, N. S., B. D. Pfrogner, J. N. Coulby, S. L. Ackerman, G. Vaidyanathan, R. H. Sauer, T. C. Balkenhol, and N. Sternberg. “Preparation and screening of an arrayed human genomic library generated with the P1 cloning system..” Proceedings of the National Academy of Sciences of the United States of America 91, no. 7 (March 1994): 2629–33. https://doi.org/10.1073/pnas.91.7.2629.
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  - Gaze, M. N., R. J. Mairs, G. Vaidyanathan, and M. R. Zalutsky. “Synthesis of carrier-free 131I-meta-iodobenzyl-guanidine by novel routes to enhance therapeutic efficiency in neuroblastoma..” Progress in Clinical and Biological Research 385 (January 1994): 347–53.
  - Vaidyanathan, G., D. A. Affleck, P. Welsh, and M. R. Zalutsky. “Fluorine-18 labeled chemotactic peptide: A potential agent for the PET imaging of focal infection.” Journal of Labelled Compounds and Radiopharmaceuticals 35 (January 1, 1994): 365–67.
  - Vaidyanathan, G., D. Affleck, and M. R. Zalutsky. “Monoclonal antibody F(ab')2 fragment labeled with N-succinimidyl 2,4-dimethoxy-3-halobenzoates: in vivo comparison of iodinated and astatinated fragments..” Nuclear Medicine and Biology 21, no. 1 (January 1994): 105–10. https://doi.org/10.1016/0969-8051(94)90136-8.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “(4-[¹⁸F]fluoro-3-iodobenzyl)guanidine, a potential mibg analogue for positron emission tomography.” Journal of Medicinal Chemistry 37, no. 21 (1994): 3655–62.
  - Vaidyanathan, G., D. K. Strickland, D. A. Affleck, P. Welsh, and M. R. Zalutsky. “Meta-[²¹¹At]astatobenzylguanidine: Further validation of in vitro and in vivo uptake mechanisms.” Journal of Labelled Compounds and Radiopharmaceuticals 35 (1994): 589–91.
  - Vaidyanathan, G., D. K. Strickland, and M. R. Zalutsky. “Meta-[²¹¹At]astatobenzylguanidine: Further evaluation of a potential therapeutic agent.” International Journal of Cancer 57, no. 6 (1994): 908–13. https://doi.org/10.1002/ijc.2910570622.
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  - DEGRADO, T. R., M. R. ZALUTSKY, D. J. AFFLECK, and G. VAIDYANATHAN. “UPTAKE MECHANISMS OF I-123 METAIODOBENZYLGUANIDINE (METAIODOBENZYLGUANIDINE) IN ISOLATED RAT-HEART.” Circulation 88, no. 4 (October 1, 1993): 355–355.
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  - Turkington, T. G., M. R. Zalutsky, R. J. Jaszczak, P. K. Garg, G. Vaidyanathan, and R. E. Coleman. “Measuring astatine-211 distributions with SPECT..” Physics in Medicine and Biology 38, no. 8 (August 1993): 1121–30. https://doi.org/10.1088/0031-9155/38/8/010.
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  - TURKINGTON, T. G., M. R. ZALUTSKY, R. J. JASZCZAK, P. GARG, G. VAIDYANATHAN, and R. E. COLEMAN. “MEASURING ASTATINE-211 DISTRIBUTIONS WITH SPECT.” Journal of Nuclear Medicine 34, no. 5 (May 1, 1993): P191–P191.
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  - VAIDYANATHAN, G., C. HARRISON, P. WELSH, D. AFFLECK, and M. R. ZALUTSKY. “INVITRO CYTOTOXICITY OF M-[AT-211]ASTATOBENZYLGUANIDINE (MABG).” Journal of Nuclear Medicine 34, no. 5 (May 1, 1993): P218–P218.
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  - Vaidyanathan, G., and M. R. Zalutsky. “No-carrier-added synthesis of meta-[131I]iodobenzylguanidine..” Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine 44, no. 3 (March 1993): 621–28. https://doi.org/10.1016/0969-8043(93)90179-e.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “Radioiodination of proteins using N-succinimidyl 4-hydroxy-3-iodobenzoate..” Bioconjugate Chemistry 4, no. 1 (January 1993): 78–84. https://doi.org/10.1021/bc00019a011.
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  - Vaidyanathan, G., and M. R. Zalutsky. “1-(m-[211At]astatobenzyl)guanidine: synthesis via astato demetalation and preliminary in vitro and in vivo evaluation..” Bioconjugate Chemistry 3, no. 6 (November 1992): 499–503. https://doi.org/10.1021/bc00018a006.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “1-(meta-[211At]Astatobenzyl)guanidine: synthesis via astato demetalation and preliminary in vitro and in vivo evaluation.” Bioconjugate Chemistry 3, no. 6 (November 1992): 499–503. https://doi.org/10.1021/bc00018a006.
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  - Vaidyanathan, G., D. D. Bigner, and M. R. Zalutsky. “Fluorine-18-labeled monoclonal antibody fragments: a potential approach for combining radioimmunoscintigraphy and positron emission tomography..” Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 33, no. 8 (August 1992): 1535–41.
  - Vaidyanathan, G., and M. R. Zalutsky. “Labeling proteins with fluorine-18 using N-succinimidyl 4-[18F]fluorobenzoate..” International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology 19, no. 3 (April 1992): 275–81. https://doi.org/10.1016/0883-2897(92)90111-b.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Labeling proteins with fluorine-18 using N-succinimidyl 4-[18F]fluorobenzoate.” Nuclear Medicine and Biology 19, no. 3 (March 27, 1992): 275–81. https://doi.org/10.1016/0883-2897(92)90111-B.
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  - Vaidyanathan, G., and M. R. Zalutsky. “1-(m-[²¹¹At]astatobenzyl)guanidine: Synthesis via astato demetalation and preliminary in vitro and in vivo evaluation.” Bioconjugate Chemistry 3, no. 6 (1992): 499–503.
  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “Aromatic acylation reagents for use in the radioiodination of proteins.” Journal of Labelled Compounds and Radiopharmaceuticals 30 (April 5, 1991).
  - Vaidyanathan, G., M. Jay, R. K. Bera, P. R. Mayer, and R. K. Brazzell. “Scintigraphic evaluation of the ocular disposition of 18F-imirestat in rabbits..” Pharmaceutical Research 7, no. 11 (November 1990): 1198–1200. https://doi.org/10.1023/a:1015952930541.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Radioiodination of antibodies via N-succinimidyl 2,4-dimethoxy-3-(trialkylstannyl)benzoates..” Bioconjugate Chemistry 1, no. 6 (November 1990): 387–93. https://doi.org/10.1021/bc00006a004.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Protein radiohalogenation: observations on the design of N-succinimidyl ester acylation agents..” Bioconjugate Chemistry 1, no. 4 (July 1990): 269–73. https://doi.org/10.1021/bc00004a007.
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  - GARG, P. K., G. VAIDYANATHAN, S. GARG, and M. R. ZALUTSKY. “RADIOIODINATION AND ASTATINATION OF MONOCLONAL-ANTIBODIES.” Abstracts of Papers of the American Chemical Society 199 (April 22, 1990): 16-NUCL.
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  - Vaidyanathan, G., and J. W. Wilson. “Reaction of Cyclopropanamines with Hypochlorite.” Journal of Organic Chemistry 54, no. 8 (April 1, 1989): 1815–20. https://doi.org/10.1021/jo00269a014.
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  - Vaidyanathan, G., and J. W. Wilson. “Decarboxylation of 1-Aminocyclopropanecarboxylic Acid and Its Derivatives.” Journal of Organic Chemistry 54, no. 8 (April 1, 1989): 1810–15. https://doi.org/10.1021/jo00269a013.
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- Conference Papers
  - Chin, Bennett, Thomas Hawk, Douglas Weitzel, Darryl McDougald, Robert Reiman, Gregory Palmer, Michael Zalutsky, and Ganesan Vaidyanathan. “Feasibility of 124I anti-PD-L1 PET/CT imaging in a syngeneic tumor model of breast cancer..” In Journal of Nuclear Medicine, Vol. 58. SOC NUCLEAR MEDICINE INC, 2017.
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  - Zhou, Zhengyuan, Nick Devoogdt, Michael Zalutsky, and Ganesan Vaidyanathan. “Labeling an anti-HER2 VHH with F-18 using a residualizing prosthetic group via strain-promoted click reaction: preliminary evaluation.” In Journal of Nuclear Medicine, Vol. 58. SOC NUCLEAR MEDICINE INC, 2017.
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  - Vaidyanathan, G. V., Z. Zhou, D. McDougald, T. Lahoutte, and M. R. Zalutsky. “Anti-HER2 Single Domain Antibody 2Rs15d Labeled with F-18 Using a Residualizing Label: Preliminary Evaluation.” In European Journal of Nuclear Medicine and Molecular Imaging, 43:S179–S179. SPRINGER, 2016.
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  - Kiess, Ana, Il Minn, Ganesan Vaidyanathan, Robert Hobbs, Anders Josefsson, Colette Shen, Mary Brummet, et al. “[211At]YC-I-27 for PSMA-Targeted Alpha-Particle Radiopharmaceutical Therapy.” In Journal of Nuclear Medicine, Vol. 57. SOC NUCLEAR MEDICINE INC, 2016.
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  - Mease, Ronnie, Ganesan Vaidyanathan, Darryl McGougald, Jaeyeon Choi, Ying Chen, Hassan Shallal, Mary Brummet, et al. “211At-Labeled Small-Molecule PSMA Inhibitors: Effect of Structure on Biodistribution in Mice.” In Journal of Nuclear Medicine, Vol. 57. SOC NUCLEAR MEDICINE INC, 2016.
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  - Vaidyanathan, G., D. McDougald, J. Choi, E. Koumarianou, M. Pruszynski, T. Osada, H. Lyerly, T. Lahoutte, and M. R. Zalutsky. “An Anti-HER2 Nanobody Labeled with 18F Using a Residualizing Label for Assessing HER2 Status.” In European Journal of Nuclear Medicine and Molecular Imaging, 42:S102–S102. SPRINGER, 2015.
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  - Batra, Vandana, Pietro Ranieri, Mehran Makvandi, Matthew Tsang, Catherine Hou, Yimei Li, Ganesan Vaidyanathan, Daniel A. Pryma, and John M. Maris. “Abstract 1610: Development of meta-[211At]astatobenzylguanidine ([211At]MABG) as an alpha particle emitting systemic targeted radiotherapeutic for neuroblastoma.” In Cancer Research, 75:1610–1610. American Association for Cancer Research (AACR), 2015. https://doi.org/10.1158/1538-7445.am2015-1610.
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  - Batra, Vandana, Mehran Makvandi, Pietro Ranieri, Matthew Tsang, Catherine Hou, Yimei Li, Ganesan Vaidyanathan, John Maris, and Daniel Pryma. “Preclinical development of Meta-[At-211]astatobenzylguanidine ([At-211]MABG) as an alpha particle emitting systemic targeted radiotherapeutic for neuroblastoma (NB)..” In Journal of Nuclear Medicine, Vol. 56. SOC NUCLEAR MEDICINE INC, 2015.
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  - Choi, Jaeyeon, Ganesan Vaidyanathan, Eftychia Koumarianou, Tony Lahoutte, and Michael Zalutsky. “A At-211-labeled nanobody for alpha-particle therapy of HER2-expressing cancers.” In Journal of Nuclear Medicine, Vol. 56. SOC NUCLEAR MEDICINE INC, 2015.
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  - Vaidyanathan, Ganesan, Sri Gururangan, Darell Bigner, and Michael Zalutsky. “PRE-CLINICAL EFFICACY STUDY OF INTRA-THECAL (IT) (LU)-L-177-DOTA-TATE (SOMATOSTATIN ANALOGUE) IN ATHYMIC RATS WITH LEPTOMENINGEAL DISEASE (LMD) FROM MEDULLOBLASTOMA (MBL).” In Neuro Oncology, 16:71–71. OXFORD UNIV PRESS INC, 2014.
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  - Slastnikova, T., E. Koumarianou, A. Rosenkranz, G. Vaidyanathan, M. Zalutsky, and A. Sobolev. “Modular nanotransporters efficiently deliver Auger electron emitters into nuclei of cancer cells.” In Febs Journal, 280:315–16. WILEY-BLACKWELL, 2013.
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  - Chin, Bennett, Linda Grasfeder, Darryl McDougald, and Ganesan Vaidyanathan. “Iodoquine as a potential PET radiolabel for in vivo cell trafficking of leukocyte tumor cell lines.” In Journal of Nuclear Medicine, Vol. 53. SOC NUCLEAR MEDICINE INC, 2012.
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  - Koumarianou, Eftychia, Tatiana Slastnikova, Marek Pruszynski, Xiao-Guang Zhao, Andrey Rosenkranz, Ganesan Vaidyanathan, Alexander Sobolev, and Michael Zalutsky. “Modular nanotransporters: A flexible platform forward for targeted Auger electron therapy.” In Journal of Nuclear Medicine, Vol. 53. SOC NUCLEAR MEDICINE INC, 2012.
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  - Zalutsky, M. R., and G. Vaidyanathan. “TARGETED ALPHA THERAPY.” In Radiotherapy and Oncology, 102:S195–S195. ELSEVIER IRELAND LTD, 2012.
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  - Vaidyanathan, Ganesan, Darryl MacDougald, Linda Grasfeder, Michael Zalutsky, and Bennett Chin. “An alternative and expedient synthesis of radioiodinated 4-iodophenylalanine.” In Journal of Nuclear Medicine, Vol. 52. SOC NUCLEAR MEDICINE INC, 2011.
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  - Vaidyanathan, Ganesan, Jianjun Li, Darell D. Bigner, and Michael R. Zalutsky. “TARGETED RADIOTHERAPY OF MEDULLOBLASTOMA USING SOMATOSTATIN RECEPTOR AVID RADIOLABELED PEPTIDES.” In Neuro Oncology, 13:I27–I27. OXFORD UNIV PRESS INC, 2011.
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  - Vaidyanathan, G., B. White, D. J. Affleck, D. McDougald, and M. R. Zalutsky. “Radioiodinated O6-Benzylguanine Analogues Containing an Azido Function.” In European Journal of Nuclear Medicine and Molecular Imaging, 37:S265–S265. SPRINGER, 2010.
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  - Chin, Bennett, Robert Reiman, Haijing Song, and Ganesan Vaidyanathan. “Radiation dose estimates of [123I] and [131I] iodoquine, putative radiotracers targeting cells with high ALDH expression.” In Journal of Nuclear Medicine, Vol. 50. SOC NUCLEAR MEDICINE INC, 2009.
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  - Vaidyanathan, Ganesan, Ronnie Mease, Donna Affleck, Ying Chen, Philip Welsh, Marc Hens, Martin Pomper, and Michael Zalutsky. “An astatine-211 labeled PSMA inhibitor for targeted alpha-particle radiotherapy of prostate carcinoma.” In Journal of Nuclear Medicine, Vol. 50. SOC NUCLEAR MEDICINE INC, 2009.
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  - Barrett, J. A., R. Coleman, M. Morse, N. Borys, J. Kronauge, J. B. Stubbs, H. Mok, et al. “Phase 1 study of radiation dosimetry and clearance of no carrier added 131I-MIBG (ultratrace iobenguane) in 7 carcinoid and 4 pheochromocytoma patients.” In European Journal of Nuclear Medicine and Molecular Imaging, 34:S241–S241. SPRINGER, 2007.
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  - Chin, B. B., R. W. Storms, K. Base, C. Lascola, T. Haystead, M. R. Zalutsky, and G. Vaidyanathan. “[I-125] iodoquine uptake in tumor cell lines with high ALDH expression.” In European Journal of Nuclear Medicine and Molecular Imaging, 34:S222–S222. SPRINGER, 2007.
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  - Zalutsky, Michael R., David A. Reardon, Oscar R. Pozzi, Ganesan Vaidyanathan, and Darell D. Bigner. “Targeted α-particle radiotherapy with 211At-labeled monoclonal antibodies.” In Nuclear Medicine and Biology, 34:779–85. Elsevier BV, 2007. https://doi.org/10.1016/j.nucmedbio.2007.03.007.
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  - Gamcsik, Michael P., James B. Springer, Timothy A. Driscoll, Ganesan Vaidyanathan, O Michael Colvin, and Susan M. Ludeman. “Targeted drug delivery for neuroblastoma using MIBG..” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.
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  - Vaidyanathan, G., K. L. Alston, P. C. Welsh, and M. R. Zalutsky. “Enhanced cellular retention of an internalizing anti-EGFRvIII monoclonal antibody radioiodinated using LYS5-[*I]iodobenzoyl Gly(1)-maleimido GEEEK ([*I]IB-Mal-D-GEEEK), a prosthetic group containing negatively charged D-glutamates.” In Neuro Oncology, 7:386–386. DUKE UNIV PRESS, 2005.
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  - Vaidyanathan, G., K. Base, and M. R. Zalutsky. “0(6)-{4-(3-[F-18]fluoropropyl)-benzyl}-2 '-deoxyguanosine ([F-18]FPBdG) - Synthesis and evaluation of a potential DNA repair protein 0(6)-alkyguanine-DNA alkyltransferase (AGT) imaging agent..” In Abstracts of Papers of the American Chemical Society, 229:U182–U182. AMER CHEMICAL SOC, 2005.
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  - Boskovitz, A., G. Vaidyanathan, G. E. Archer, H. Ochiai, T. Okamura, J. H. Sampson, D. D. Bigner, and M. R. Zalutsky. “Medulloblastoma neoplastic meningitis targeted radiotherapy with intrathecal alpha-emitter At-211-labeled thymidine analogue.” In Neuro Oncology, 6:403–403. DUKE UNIV PRESS, 2004.
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  - Vaidyanathan, G., A. Boskovitz, H. S. Friedman, D. J. Affleck, and M. R. Zalutsky. “Somatostatin targeted radiotherapeuiccs for medulloblastoma.” In Neuro Oncology, 6:416–416. DUKE UNIV PRESS, 2004.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “N-succinimidyl 3-[211AT]astato-4-guanidinomethylbenzoate: An acylation agent for labeling internalizing antibodies with alpha-particle emitting (211)AT..” In Abstracts of Papers of the American Chemical Society, 225:U265–U265. AMER CHEMICAL SOC, 2003.
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  - VAIDYANATHAN, G., D. J. AFFLECK, S. A. SLADE, P. WELSH, and M. R. ZALUTSKY. “NO-CARRIER-ADDED 4-FLUORO-3-IODOBENZYLGUANIDINE LABELED WITH I-131 ([I-131]FIBG) AND F-18 ([F-18]FIBG - POTENTIAL MIBG ANALOGS FOR PET IMAGING AND THERAPY OF NEUROENDOCRINE TUMORS.” In Proceedings of the Xvi International Cancer Congress Free Papers and Posters, Tomes 1 4, edited by R. S. Rao, M. G. Deo, L. D. Sanghvi, and I. Mittra, 3013–17. MONDUZZI EDITORE, 1994.
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  - Vaidyanathan, G., D. K. Strickland, D. A. Affleck, P. Welsh, and M. R. Zalutsky. “Meta-[²¹¹At]astatobenzylguanidine: Further validation of in vitro and in vivo uptake mechanisms.” In Journal of Labelled Compounds and Radiopharmaceuticals, 35:589–91, 1994.
Teaching & Mentoring
Recent Courses
- MEDPHY 746: Radiopharmaceutical Chemistry 2017

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses