Ganesan Vaidyanathan | Scholars@Duke

Ganesan Vaidyanathan
Professor in Radiology

Dr. Vaidyanathan is a professor in the Department of Radiology. He is a member of the Nuclear Medicine track of the Medical Physics Graduate Program. His research involves development of radiopharmaceuticals especially for oncologic applications. Some of the projects he is involved in are given below.

I. New methods of radiohalogenating antibodies and its variants

a) Development of newer residualizing agents for the radiohalogenation of internalizing monoclonal antibodies.

b) Development of fluorine-18 labeled residualizing agents for labeling nanobodies.

c) Pre-targeting approach via bioorthogonal chemistry for in vivo labeling of antibodies and nanobodies with ¹⁸F and ²¹¹At.

d) Methods to label antibodies pre-conjugated with a prosthetic group of the tin precursor of residualizing agents.

e) Multimodal prosthetic groups for labeling antibodies and peptides with multiple radioisotopes.

II. MIBG Analogs for PET imaging

Radioiodinated MIBG is used in the diagnosis of the pathophysiology of the heart as well as neuroendocrine tumors such as neuroblastoma (NB). Design and development of newer fluorine-18 labeled MIBG analogues useful in the PET imaging of NB as well as that of myocardial diseases.

III. Noninvasive Imaging of Alkylguanine-DNA alkyltransferase (AGT)

AGT is a DNA repair protein and is primarily responsible for drug resistance in alkylator chemotherapy. An inverse correlation has been established between the tumor AGT content and the therapeutic outcome. The amount of AGT varies from tumor to tumor and within a group of patients of similar cancer. Thus, it is important to quantify tumor AGT of individual patients before administering alkylator chemotherapy. Our goal is to develop radiolabeled agents with which AGT can be quantified in a noninvasive manner by PET or SPECT imaging.

IV. PSMA targeting for prostate cancer therapy

Development of At-211 labeled urea-based inhibitor of Prostate-specific membrane antigen.

Current Appointments & Affiliations

Professor in Radiology, Radiology, Clinical Science Departments 2022
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1989

Contact Information

161C Bryan Res Bldg, Durham, NC 27710
Box 3808 Med Ctr, Radiology, Durham, NC 27710
vaidy001@mc.duke.edu (919) 684-7811

Background
Education, Training, & Certifications
- Postdoctoral, College Of Pharmacy, University of Kentucky 1987 - 1989
- Teaching Assistant, Chemistry Dept, University of Kentucky 1983 - 1987
- Ph.D., University of Kentucky 1987
Previous Appointments & Affiliations
- Professor in Radiology, Radiology, Clinical Science Departments 2021 - 2022
- Professor in Radiology, Radiology, Clinical Science Departments 2018 - 2020
- Professor in Radiology, Radiology, Clinical Science Departments 2006 - 2018
- Research Professor in Radiology, Radiology, Clinical Science Departments 2005 - 2006
- Associate Research Professor in Radiology, Radiology, Clinical Science Departments 1998 - 2005
- Assistant Research Professor in Radiology, Radiology, Clinical Science Departments 1994 - 1998
Leadership & Clinical Positions at Duke
- 2005-current Faculty, Medical Physics Graduate Program, Duke University Medical Center, North Carolina.
Research
Selected Grants
- Targeted Radiolabeled PARP inhibitors (PARPi) -Site-specific radiolabeling awarded by Zentera Alpha, Inc 2022 - 2024
- Astatine And Iodine Radiolabeled Monoclonal Antibodies awarded by National Institutes of Health 1985 - 2021
- Labeling nanobodies with 18F residualizing labels for HER2 specific PET imaging awarded by National Institutes of Health 2015 - 2021
- Cereius research agreement awarded by Cereius Inc. 2017 - 2019
- Development of Tethered Hsp90 Inhibitors Carrying Radioiodinated Probes to Specifically Discriminate and Kill Malignant Breast Tumor Cells awarded by Department of Defense 2015 - 2019
- Novel Radiohalogenation Strategies for Enhancing Imaging and Targeted Radiotherapy with Ultrasmall Dual- Modality Silica Nanoparticles (C Dots) awarded by Memorial Sloan-Kettering Cancer Center 2016 - 2018
- Development of a Targeted Radionuclide Therapy for Triple Negative Breast Cancer awarded by OncoTAb, Inc. 2016 - 2017
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Enhancing the efficacy of targeted radiotherapy for neuroblastoma awarded by Children's Hospital of Philadelphia 2013 - 2014
- Cross-disciplinary Training in Medical Physics awarded by National Institutes of Health 2007 - 2013
- Brain Tumors - Immunological and Biological Studies awarded by National Institutes of Health 2001 - 2013
- Small Animal PET / CT Molecular Imaging awarded by National Institutes of Health 2011 - 2012
- Radionuclide-based Molecular Imaging of the DNA Repair Protein AGT awarded by National Institutes of Health 2009 - 2011
- Astatine-211 Radiochemistry: The Development of Methodologies for High Activity Level Radio-Synthesis awarded by Department of Energy 2008 - 2010
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- Imaging of O6-Alkylguianine-DNA Alkyltransferase awarded by National Institutes of Health 2002 - 2007
- Targeted Radiotherapeutics: Chemical and Biological Aspects awarded by Department of Energy 2004 - 2006
- Astatine-211 & Radioiodine Labeled Octreotide Conjugates awarded by National Institutes of Health 2001 - 2006
- Anti-Tenascin Antibody Constructs awarded by Department of Energy 1995 - 2005
- Molecular Imaging Center Planning Grant awarded by National Institutes of Health 2000 - 2004
- Astatine And Iodine Radiolabeled Monoclonal Antibodies awarded by National Institutes of Health 1999 - 2004
- MIBG Analogue Radiopharmaceuticals awarded by National Institutes of Health 1997 - 2003
- Brain Tumors--Immunological and Biological Studies awarded by National Institutes of Health 1976 - 2001
- Brain Tumors - Immunological And Biological Studies awarded by National Institutes of Health 1997 - 1999
- Src On Primary And Matastatic Tumors Of The Cns awarded by National Institutes of Health 1994 - 1999
- Astatine And Iodine Radiolabeled Monoclonal Antibodies awarded by National Institutes of Health 1994 - 1999
- Astatine And Iodine Radiolabeled Monoclonal Antibodies awarded by National Institutes of Health 1993 - 1999
- Astatine And Iodine Radiolabeled Monoclonal Antibodies awarded by National Institutes of Health 1985 - 1999
- Positron Emission Imaging Of Tumors Using Monoclonal Antib awarded by Department of Energy 1995 - 1998
- Migb And Analogs For Diagnosis And Therapy awarded by National Institutes of Health 1994 - 1998
- Mibg And Analogs For Diagnosis And Therapy awarded by National Institutes of Health 1993 - 1998
- Mibg And Analogs For Diagnosis And Therapy awarded by National Institutes of Health 1993 - 1998
- Migb And Analogs For Diagnosis And Therapy awarded by National Institutes of Health 1993 - 1998
- Cancer And Leukemia Group B Statistical Center awarded by National Institutes of Health 1992 - 1993
External Relationships
- Zentera Alpha
- cereius
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Feng, Yutian, Rebecca Meshaw, Xiao-Guang Zhao, Stephen A. Jannetti, Ganesan Vaidyanathan, and Michael R. Zalutsky. “Effective Treatment of Human Breast Carcinoma Xenografts with Single-Dose 211At-Labeled Anti-HER2 Single Domain Antibody Fragment.” J Nucl Med, May 26, 2022. https://doi.org/10.2967/jnumed.122.264071.
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  - Feng, Yutian, Rebecca Meshaw, Darryl McDougald, Zhengyuan Zhou, Xiao-Guang Zhao, Stephen A. Jannetti, Robert E. Reiman, et al. “Evaluation of an 131I-labeled HER2-specific single domain antibody fragment for the radiopharmaceutical therapy of HER2-expressing cancers.” Sci Rep 12, no. 1 (February 22, 2022): 3020. https://doi.org/10.1038/s41598-022-07006-9.
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  - Mease, Ronnie C., Choong Mo Kang, Vivek Kumar, Sangeeta Ray Banerjee, Il Minn, Mary Brummet, Kathleen L. Gabrielson, et al. “An Improved 211At-Labeled Agent for PSMA-Targeted α-Therapy.” J Nucl Med 63, no. 2 (February 2022): 259–67. https://doi.org/10.2967/jnumed.121.262098.
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  - Zhou, Zhengyuan, Rebecca Meshaw, Michael R. Zalutsky, and Ganesan Vaidyanathan. “Site-Specific and Residualizing Linker for 18F Labeling with Enhanced Renal Clearance: Application to an Anti-HER2 Single-Domain Antibody Fragment.” J Nucl Med 62, no. 11 (November 2021): 1624–30. https://doi.org/10.2967/jnumed.120.261446.
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  - Zhou, Zhengyuan, Darryl McDougald, Rebecca Meshaw, Irina Balyasnikova, Michael R. Zalutsky, and Ganesan Vaidyanathan. “Labeling single domain antibody fragments with 18F using a novel residualizing prosthetic agent - N-succinimidyl 3-(1-(2-(2-(2-(2-[18F]fluoroethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-5-(guanidinomethyl)benzoate.” Nucl Med Biol 100–101 (September 2021): 24–35. https://doi.org/10.1016/j.nucmedbio.2021.06.002.
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  - Vaidyanathan, Ganesan, Ronnie C. Mease, Il Minn, Jaeyeon Choi, Ying Chen, Hassan Shallal, Choong Mo Kang, et al. “Synthesis and preliminary evaluation of 211At-labeled inhibitors of prostate-specific membrane antigen for targeted alpha particle therapy of prostate cancer.” Nucl Med Biol 94–95 (March 2021): 67–80. https://doi.org/10.1016/j.nucmedbio.2021.01.002.
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  - Feng, Yutian, Zhengyuan Zhou, Darryl McDougald, Rebecca L. Meshaw, Ganesan Vaidyanathan, and Michael R. Zalutsky. “Site-specific radioiodination of an anti-HER2 single domain antibody fragment with a residualizing prosthetic agent.” Nucl Med Biol 92 (January 2021): 171–83. https://doi.org/10.1016/j.nucmedbio.2020.05.002.
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  - Liu, Yang, Zhengyuan Zhou, Yutian Feng, Xiao-Guang Zhao, Ganesan Vaidyanathan, Michael R. Zalutsky, and Tuan Vo-Dinh. “Gold Nanostars: A Novel Platform for Developing 211At-Labeled Agents for Targeted Alpha-Particle Therapy.” Int J Nanomedicine 16 (2021): 7297–7305. https://doi.org/10.2147/IJN.S327577.
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  - Liu, Yang, Zhengyuan Zhou, Yutian Feng, Xiao-Guang Zhao, Ganesan Vaidyanathan, Michael R. Zalutsky, and Tuan Vo-Dinh. “Gold Nanostars: A Novel Platform for Developing 211At-Labeled Agents for Targeted Alpha-Particle Therapy.” International Journal of Nanomedicine 16 (2021): 7297–7305. https://doi.org/10.2147/IJN.S327577InternationalJournalofNanomedicine2021.
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  - Vaidyanathan, Ganesan, Oscar R. Pozzi, Jaeyeon Choi, Xiao-Guang Zhao, Shawn Murphy, and Michael R. Zalutsky. “Labeling Monoclonal Antibody with α-emitting 211At at High Activity Levels via a Tin Precursor.” Cancer Biother Radiopharm 35, no. 7 (September 2020): 511–19. https://doi.org/10.1089/cbr.2019.3204.
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  - Zhou, Zhengyuan, Michael R. Zalutsky, and Ganesan Vaidyanathan. “Labeling a TCO-functionalized single domain antibody fragment with 18F via inverse electron demand Diels Alder cycloaddition using a fluoronicotinyl moiety-bearing tetrazine derivative.” Bioorg Med Chem 28, no. 17 (September 1, 2020): 115634. https://doi.org/10.1016/j.bmc.2020.115634.
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  - Chitneni, Satish K., Eftychia Koumarianou, Ganesan Vaidyanathan, and Michael R. Zalutsky. “Observations on the Effects of Residualization and Dehalogenation on the Utility of N-Succinimidyl Ester Acylation Agents for Radioiodination of the Internalizing Antibody Trastuzumab.” Molecules 24, no. 21 (October 30, 2019). https://doi.org/10.3390/molecules24213907.
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  - Liu, Yang, Austin B. Carpenter, Christopher J. Pirozzi, Hsiangkuo Yuan, Matthew S. Waitkus, Zhengyuan Zhou, Landon Hansen, et al. “Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe.” Nanotechnology 30, no. 27 (July 5, 2019): 275101. https://doi.org/10.1088/1361-6528/ab0e9c.
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  - Zhou, Zhengyuan, Darryl McDougald, Nick Devoogdt, Michael R. Zalutsky, and Ganesan Vaidyanathan. “Labeling Single Domain Antibody Fragments with Fluorine-18 Using 2,3,5,6-Tetrafluorophenyl 6-[18F]Fluoronicotinate Resulting in High Tumor-to-Kidney Ratios.” Mol Pharm 16, no. 1 (January 7, 2019): 214–26. https://doi.org/10.1021/acs.molpharmaceut.8b00951.
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  - Zhou, Zhengyuan, Nick Devoogdt, Michael R. Zalutsky, and Ganesan Vaidyanathan. “An Efficient Method for Labeling Single Domain Antibody Fragments with 18F Using Tetrazine- Trans-Cyclooctene Ligation and a Renal Brush Border Enzyme-Cleavable Linker.” Bioconjug Chem 29, no. 12 (December 19, 2018): 4090–4103. https://doi.org/10.1021/acs.bioconjchem.8b00699.
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  - Vaidyanathan, Ganesan, Choong Mo Kang, Darryl McDougald, Il Minn, Mary Brummet, Martin G. Pomper, and Michael R. Zalutsky. “Brush border enzyme-cleavable linkers: Evaluation for reducing renal uptake of radiolabeled prostate-specific membrane antigen inhibitors.” Nucl Med Biol 62–63 (July 2018): 18–30. https://doi.org/10.1016/j.nucmedbio.2018.05.002.
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  - Pruszynski, Marek, Choong Mo Kang, Eftychia Koumarianou, Ganesan Vaidyanathan, and Michael R. Zalutsky. “d-Amino Acid Peptide Residualizing Agents for Protein Radioiodination: Effect of Aspartate for Glutamate Substitution.” Molecules 23, no. 5 (May 20, 2018). https://doi.org/10.3390/molecules23051223.
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  - Zhou, Zhengyuan, Satish K. Chitneni, Nick Devoogdt, Michael R. Zalutsky, and Ganesan Vaidyanathan. “Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation.” Bioorg Med Chem 26, no. 8 (May 1, 2018): 1939–49. https://doi.org/10.1016/j.bmc.2018.02.040.
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  - Choi, Jaeyeon, Ganesan Vaidyanathan, Eftychia Koumarianou, Choong Mo Kang, and Michael R. Zalutsky. “Astatine-211 labeled anti-HER2 5F7 single domain antibody fragment conjugates: radiolabeling and preliminary evaluation.” Nucl Med Biol 56 (January 2018): 10–20. https://doi.org/10.1016/j.nucmedbio.2017.09.003.
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  - Zhou, Zhengyuan, Ganesan Vaidyanathan, Darryl McDougald, Choong Mo Kang, Irina Balyasnikova, Nick Devoogdt, Angeline N. Ta, Brian R. McNaughton, and Michael R. Zalutsky. “Fluorine-18 Labeling of the HER2-Targeting Single-Domain Antibody 2Rs15d Using a Residualizing Label and Preclinical Evaluation.” Mol Imaging Biol 19, no. 6 (December 2017): 867–77. https://doi.org/10.1007/s11307-017-1082-x.
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  - Chin, Bennett B., Darryl McDougald, Douglas H. Weitzel, Thomas Hawk, Robert E. Reiman, Michael R. Zalutsky, and Ganesan Vaidyanathan. “Synthesis and Preliminary Evaluation of 5-[18F]fluoroleucine.” Curr Radiopharm 10, no. 1 (2017): 41–50. https://doi.org/10.2174/1874471009666161230114954.
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  - Kiess, Ana P., Il Minn, Ganesan Vaidyanathan, Robert F. Hobbs, Anders Josefsson, Colette Shen, Mary Brummet, et al. “(2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl)Ureido)-Pentanedioic Acid for PSMA-Targeted α-Particle Radiopharmaceutical Therapy.” J Nucl Med 57, no. 10 (October 2016): 1569–75. https://doi.org/10.2967/jnumed.116.174300.
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  - Vaidyanathan, Ganesan, Darryl McDougald, Jaeyeon Choi, Eftychia Koumarianou, Douglas Weitzel, Takuya Osada, H Kim Lyerly, and Michael R. Zalutsky. “Preclinical Evaluation of 18F-Labeled Anti-HER2 Nanobody Conjugates for Imaging HER2 Receptor Expression by Immuno-PET.” J Nucl Med 57, no. 6 (June 2016): 967–73. https://doi.org/10.2967/jnumed.115.171306.
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  - Vaidyanathan, Ganesan, Darryl McDougald, Jaeyeon Choi, Marek Pruszynski, Eftychia Koumarianou, Zhengyuan Zhou, and Michael R. Zalutsky. “N-Succinimidyl 3-((4-(4-[(18)F]fluorobutyl)-1H-1,2,3-triazol-1-yl)methyl)-5-(guanidinomethyl)benzoate ([(18)F]SFBTMGMB): a residualizing label for (18)F-labeling of internalizing biomolecules.” Org Biomol Chem 14, no. 4 (January 28, 2016): 1261–71. https://doi.org/10.1039/c5ob02258d.
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  - Chin, B. B., D. McDougald, D. Weitzel, T. Hawk, R. E. Reiman, M. R. Zalutsky, and G. Vaidyanathan. “Synthesis and preliminary evaluation of 5-[18F]fluoroleucine: a novel LAT1 substrate (In preparation).” Current Radiopharmaceuticals, 2016.
  - Vaidyanathan, Ganesan, Darryl McDougald, Eftychia Koumarianou, Jaeyeon Choi, Marc Hens, and Michael R. Zalutsky. “Synthesis and evaluation of 4-[18F]fluoropropoxy-3-iodobenzylguanidine ([18F]FPOIBG): A novel 18F-labeled analogue of MIBG.” Nucl Med Biol 42, no. 8 (August 2015): 673–84. https://doi.org/10.1016/j.nucmedbio.2015.04.005.
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  - Pruszynski, Marek, Eftychia Koumarianou, Ganesan Vaidyanathan, Satish Chitneni, and Michael R. Zalutsky. “D-Amino acid peptide residualizing agents bearing N-hydroxysuccinimido- and maleimido-functional groups and their application for trastuzumab radioiodination.” Nucl Med Biol 42, no. 1 (January 2015): 19–27. https://doi.org/10.1016/j.nucmedbio.2014.08.007.
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  - Liu, Yang, Jeffrey R. Ashton, Everett J. Moding, Hsiangkuo Yuan, Janna K. Register, Andrew M. Fales, Jaeyeon Choi, et al. “A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy.” Theranostics 5, no. 9 (2015): 946–60. https://doi.org/10.7150/thno.11974.
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  - Choi, Jaeyeon, Ganesan Vaidyanathan, Eftychia Koumarianou, Darryl McDougald, Marek Pruszynski, Takuya Osada, Tony Lahoutte, H Kim Lyerly, and Michael R. Zalutsky. “N-Succinimidyl guanidinomethyl iodobenzoate protein radiohalogenation agents: influence of isomeric substitution on radiolabeling and target cell residualization.” Nucl Med Biol 41, no. 10 (November 2014): 802–12. https://doi.org/10.1016/j.nucmedbio.2014.07.005.
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  - Koumarianou, Eftychia, Tatiana A. Slastnikova, Marek Pruszynski, Andrey A. Rosenkranz, Ganesan Vaidyanathan, Alexander S. Sobolev, and Michael R. Zalutsky. “Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter--a potential Auger electron emitting EGFR-targeted radiotherapeutic.” Nucl Med Biol 41, no. 6 (July 2014): 441–49. https://doi.org/10.1016/j.nucmedbio.2014.03.026.
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  - Pruszynski, Marek, Eftychia Koumarianou, Ganesan Vaidyanathan, Hilde Revets, Nick Devoogdt, Tony Lahoutte, H Kim Lyerly, and Michael R. Zalutsky. “Improved tumor targeting of anti-HER2 nanobody through N-succinimidyl 4-guanidinomethyl-3-iodobenzoate radiolabeling.” J Nucl Med 55, no. 4 (April 2014): 650–56. https://doi.org/10.2967/jnumed.113.127100.
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  - Zhang, Hanwen, Ruimin Huang, NagaVaraKishore Pillarsetty, Daniel L. J. Thorek, Ganesan Vaidyanathan, Inna Serganova, Ronald G. Blasberg, and Jason S. Lewis. “Synthesis and evaluation of 18F-labeled benzylguanidine analogs for targeting the human norepinephrine transporter.” Eur J Nucl Med Mol Imaging 41, no. 2 (February 2014): 322–32. https://doi.org/10.1007/s00259-013-2558-9.
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  - Barrott, Jared J., Philip F. Hughes, Takuya Osada, Xiao-Yi Yang, Zachary C. Hartman, David R. Loiselle, Neil L. Spector, et al. “Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.” Chem Biol 20, no. 9 (September 19, 2013): 1187–97. https://doi.org/10.1016/j.chembiol.2013.08.004.
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  - Choi, Jaeyeon, Ganesan Vaidyanathan, Eftychia Koumarianou, Marek Pruszynski, Tony Lahoutte, and Michael Rod Zalutsky. “Isomeric N-succinimidyl 3-guanidinomethyl-5-[I-131]iodobenzoate (iso-[I-131]SGMIB): A guanidine-containing residualizing agent for radiohalogenation of internalizing biomolecules.” Journal of Labelled Compounds & Radiopharmaceuticals 56 (May 1, 2013): S39–S39.
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  - Vaidyanathan, Ganesan, Darryl McDougald, Marek Pruszynski, Eftychia Koumarianou, Marc Anton Hens, Tony Lahoutte, and Michael Rod Zalutsky. “SFBTMGMB (N-succinimidyl 3-((4-(4-fluorobutyl)-1H-1,2,3-triazol-1-yl)methyl)-5-(guanidinomethyl)benzoate): An SGMIB analogue for labeling internalizing biomolecules with F-18.” Journal of Labelled Compounds & Radiopharmaceuticals 56 (May 1, 2013): S127–S127.
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  - Weisenberger, A. G., G. Bonito, S. Lee, J. E. McKisson, A. Gryganskyi, C. D. Reid, M. F. Smith, G. Vaidyanathan, and B. Welch. “A radioisotope based methodology for plant-fungal interactions in the rhizosphere.” Ieee Nuclear Science Symposium Conference Record, January 1, 2013. https://doi.org/10.1109/NSSMIC.2013.6829457.
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  - Pruszynski, Marek, Eftychia Koumarianou, Ganesan Vaidyanathan, Hilde Revets, Nick Devoogdt, Tony Lahoutte, and Michael R. Zalutsky. “Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody.” Nucl Med Biol 40, no. 1 (January 2013): 52–59. https://doi.org/10.1016/j.nucmedbio.2012.08.008.
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  - Vaidyanathan, G., B. J. White, D. J. Affleck, X. G. Zhao, P. C. Welsh, D. McDougald, J. Choi, and M. R. Zalutsky. “SIB-DOTA: a trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies.” Bioorg Med Chem 20, no. 24 (December 15, 2012): 6929–39. https://doi.org/10.1016/j.bmc.2012.10.025.
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  - Slastnikova, Tatiana A., Eftychia Koumarianou, Andrey A. Rosenkranz, Ganesan Vaidyanathan, Tatiana N. Lupanova, Alexander S. Sobolev, and Michael R. Zalutsky. “Modular nanotransporters: a versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I.” Ejnmmi Res 2, no. 1 (October 29, 2012): 59. https://doi.org/10.1186/2191-219X-2-59.
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  - Chin, Bennett B., Anita Hjelemand, Jeremy Rich, Haijing Song, Christopher Lascola, Robert Storms, Roger McLendon, et al. “Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression.” Curr Radiopharm 5, no. 1 (January 2012): 47–58. https://doi.org/10.2174/1874471011205010047.
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  - Vaidyanathan, Gayathri. “Virus hunters: catching bugs in the field.” Cell 147, no. 6 (December 9, 2011): 1209–11. https://doi.org/10.1016/j.cell.2011.11.037.
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  - Vaidyanathan, Gayathri. “Dam controversy: Remaking the Mekong.” Nature 478, no. 7369 (October 19, 2011): 305–7. https://doi.org/10.1038/478305a.
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  - Vaidyanathan, Ganesan, Darryl McDougald, Linda Grasfeder, Michael R. Zalutsky, and Bennett Chin. “An alternative and expedient synthesis of radioiodinated 4-iodophenylalanine.” Appl Radiat Isot 69, no. 10 (October 2011): 1401–6. https://doi.org/10.1016/j.apradiso.2011.05.004.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “Applications of 211At and 223Ra in targeted alpha-particle radiotherapy.” Curr Radiopharm 4, no. 4 (October 2011): 283–94. https://doi.org/10.2174/1874471011104040283.
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  - Vaidyanathan, Gayathri. “Apes in Africa: The cultured chimpanzees.” Nature 476, no. 7360 (August 17, 2011): 266–69. https://doi.org/10.1038/476266a.
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  - Vaidyanathan, Gayatri, Nuttapong Ngamphaiboon, and Francisco J. Hernandez-Ilizaliturri. “Clinical spectrum and prognosis of follicular lymphoma with blastoid transformation: case series and a review of the literature.” Ann Hematol 90, no. 8 (August 2011): 955–62. https://doi.org/10.1007/s00277-011-1162-y.
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  - Irikefe, Vivienne, Gayathri Vaidyanathan, Linda Nordling, Aimable Twahirwa, Esther Nakkazi, and Richard Monastersky. “Science in Africa: The view from the front line.” Nature 474, no. 7353 (June 29, 2011): 556–59. https://doi.org/10.1038/474556a.
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  - Vaidyanathan, Gayathri. “Science in Africa: The wheat stalker.” Nature 474, no. 7353 (June 29, 2011): 563–65. https://doi.org/10.1038/474563a.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Applications of ²¹¹AT and ²²³RA in targeted alpha-particle radiotherapy.” Current Radiopharmaceuticals 4, no. 4 (2011): 283–94.
  - Vaidyanathan, Ganesan, Darryl McDougald, Donna J. Affleck, and Michael R. Zalutsky. “A tin precursor of SGMIB potentially useful in the direct modification of peptides and proteins before radiohalogenation.” Journal of Labelled Compounds & Radiopharmaceuticals 54 (January 1, 2011): S64–S64.
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  - Vaidyanathan, Ganesan, Benjamin White, Donna J. Affleck, Darryl McDougald, and Michael R. Zalutsky. “Radioiodinated O(6)-Benzylguanine derivatives containing an azido function.” Nucl Med Biol 38, no. 1 (January 2011): 77–92. https://doi.org/10.1016/j.nucmedbio.2010.07.006.
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  - Hens, Marc, Ganesan Vaidyanathan, Xiao-Guang Zhao, Darell D. Bigner, and Michael R. Zalutsky. “Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands.” Nucl Med Biol 37, no. 7 (October 2010): 741–50. https://doi.org/10.1016/j.nucmedbio.2010.04.020.
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  - Kato, Yukinari, Ganesan Vaidyanathan, Mika Kato Kaneko, Kazuhiko Mishima, Nidhi Srivastava, Vidyalakshmi Chandramohan, Charles Pegram, et al. “Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas.” Nucl Med Biol 37, no. 7 (October 2010): 785–94. https://doi.org/10.1016/j.nucmedbio.2010.03.010.
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  - Vaidyanathan, G., and M. G. Fakih. “A case of curative-intent hepatectomy for colon cancer metastatic to the scapula and liver.” Anticancer Res 30, no. 2 (February 2010): 677–79.
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  - Vaidyanathan, Gayatri, Adrienne Groman, Gregory Wilding, and Marwan G. Fakih. “Stop and go FOLFOX plus bevacizumab chemotherapy in the first-line treatment of metastatic colorectal cancer.” Oncology 79, no. 1–2 (2010): 67–71. https://doi.org/10.1159/000319549.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Xiao-Guang Zhao, Stephen T. Keir, and Michael R. Zalutsky. “[Lu]-DOTA-Tyr-octreotate: A Potential Targeted Radiotherapeutic for the Treatment of Medulloblastoma.” Curr Radiopharm 3, no. 1 (2010): 29–36. https://doi.org/10.2174/1874471011003010029.
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  - Vaidyanathan, Ganesan, Haijing Song, Donna Affleck, Darryl L. McDougald, Robert W. Storms, Michael R. Zalutsky, and Bennett B. Chin. “Targeting aldehyde dehydrogenase: a potential approach for cell labeling.” Nucl Med Biol 36, no. 8 (November 2009): 919–29. https://doi.org/10.1016/j.nucmedbio.2009.08.001.
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  - Vaidyanathan, Ganesan, Emmanuelle Jestin, Tove Olafsen, Anna M. Wu, and Michael R. Zalutsky. “Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK.” Nucl Med Biol 36, no. 6 (August 2009): 671–80. https://doi.org/10.1016/j.nucmedbio.2009.04.002.
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  - Hens, Marc, Ganesan Vaidyanathan, Phil Welsh, and Michael R. Zalutsky. “Labeling internalizing anti-epidermal growth factor receptor variant III monoclonal antibody with (177)Lu: in vitro comparison of acyclic and macrocyclic ligands.” Nucl Med Biol 36, no. 2 (February 2009): 117–28. https://doi.org/10.1016/j.nucmedbio.2008.11.001.
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  - Vaidyanathan, G., B. White, D. Affleck, X. Zhao, P. Welsh, and M. Zalutsky. “DOTA-SIB, A TRIFUNCTIONAL PROSTHETIC GROUP FOR MULTI-MODAL LABELING.” Journal of Labelled Compounds & Radiopharmaceuticals 52 (January 1, 2009): S70–S70.
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  - Vaidyanathan, Ganesan, Benjamin J. White, and Michael R. Zalutsky. “Propargyl 4-[F]fluorobenzoate: A Putatively More Stable Prosthetic group for the Fluorine-18 Labeling of Biomolecules via Click Chemistry.” Curr Radiopharm 2, no. 1 (January 1, 2009): 63–74. https://doi.org/10.2174/1874471010902010063.
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  - Vaidyanathan, G. “Meta-iodobenzylguanidine and analogues: chemistry and biology.” Q J Nucl Med Mol Imaging 52, no. 4 (December 2008): 351–68.
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  - Simmons, Kirk, John Kinney, Aaron Owens, Daniel A. Kleier, Karen Bloch, Dave Argentar, Alicia Walsh, and Ganesh Vaidyanathan. “Practical outcomes of applying ensemble machine learning classifiers to High-Throughput Screening (HTS) data analysis and screening.” J Chem Inf Model 48, no. 11 (November 2008): 2196–2206. https://doi.org/10.1021/ci800164u.
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  - Sun, C., A. Dobi, A. Mohamed, H. Li, R. L. Thangapazham, B. Furusato, S. Shaheduzzaman, et al. “TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation.” Oncogene 27, no. 40 (September 11, 2008): 5348–53. https://doi.org/10.1038/onc.2008.183.
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  - Rosenkranz, Andrey A., Ganesan Vaidyanathan, Oscar R. Pozzi, Vladimir G. Lunin, Michael R. Zalutsky, and Alexander S. Sobolev. “Engineered modular recombinant transporters: application of new platform for targeted radiotherapeutic agents to alpha-particle emitting 211 At.” Int J Radiat Oncol Biol Phys 72, no. 1 (September 1, 2008): 193–200. https://doi.org/10.1016/j.ijrobp.2008.05.055.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “Astatine Radiopharmaceuticals: Prospects and Problems.” Curr Radiopharm 1, no. 3 (September 1, 2008): 177. https://doi.org/10.2174/1874471010801030177.
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  - Simmons, Kirk, John Kinney, Aaron Owens, Dan Kleier, Karen Bloch, Dave Argentar, Alicia Walsh, and Ganesh Vaidyanathan. “Comparative study of machine-learning and chemometric tools for analysis of in-vivo high-throughput screening data.” J Chem Inf Model 48, no. 8 (August 2008): 1663–68. https://doi.org/10.1021/ci800142d.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Joseph Norman, Susan O’Dorisio, and Michael R. Zalutsky. “A radioiodinated MIBG-octreotate conjugate exhibiting enhanced uptake and retention in SSTR2-expressing tumor cells.” Bioconjug Chem 18, no. 6 (November 2007): 2122–30. https://doi.org/10.1021/bc700240r.
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  - Zalutsky, Michael R., David A. Reardon, Oscar R. Pozzi, Ganesan Vaidyanathan, and Darell D. Bigner. “Targeted alpha-particle radiotherapy with 211At-labeled monoclonal antibodies.” Nucl Med Biol 34, no. 7 (October 2007): 779–85. https://doi.org/10.1016/j.nucmedbio.2007.03.007.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Kevin L. Alston, Xiao-Guang Zhao, Marc Hens, Duncan H. Hunter, John Babich, and Michael R. Zalutsky. “A kit method for the high level synthesis of [211At]MABG.” Bioorg Med Chem 15, no. 10 (May 15, 2007): 3430–36. https://doi.org/10.1016/j.bmc.2007.03.016.
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  - Park, Jae, Gayathri Vaidyanathan, Bhag Singh, and Radhey S. Gupta. “Identification and biochemical studies on novel non-nucleoside inhibitors of the enzyme adenosine kinase.” Protein J 26, no. 3 (April 2007): 203–12. https://doi.org/10.1007/s10930-006-9062-z.
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  - Vaidyanathan, G., D. J. Affleck, K. L. Alston, and M. R. Zalutsky. “A tin precursor for the synthesis of no-carrier-added [*I]MIBG and [²¹¹At]MABG.” Journal of Labelled Compounds and Radiopharmaceuticals 50, no. 3 (March 1, 2007): 177–82. https://doi.org/10.1002/jlcr.1243.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “Synthesis of N-succinimidyl 4-guanidinomethyl-3-[*I]iodobenzoate: a radio-iodination agent for labeling internalizing proteins and peptides.” Nat Protoc 2, no. 2 (2007): 282–86. https://doi.org/10.1038/nprot.2007.20.
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  - Vaidyanathan, Ganesan, Kevin L. Alston, Darrel D. Bigner, and Michael R. Zalutsky. “Nepsilon-(3-[*I]Iodobenzoyl)-Lys5-Nalpha-maleimido-Gly1-GEEEK ([*I]IB-Mal-D-GEEEK): a radioiodinated prosthetic group containing negatively charged D-glutamates for labeling internalizing monoclonal antibodies.” Bioconjug Chem 17, no. 4 (July 2006): 1085–92. https://doi.org/10.1021/bc0600766.
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  - Shankar, Sriram, Michael R. Zalutsky, Henry Friedman, and Ganesan Vaidyanathan. “Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine.” Nucl Med Biol 33, no. 3 (April 2006): 399–407. https://doi.org/10.1016/j.nucmedbio.2005.12.015.
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  - Shankar, Sriram, Ganesan Vaidyanathan, Chien-Tsun Kuan, Darell D. Bigner, and Michael R. Zalutsky. “Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance.” Nucl Med Biol 33, no. 1 (January 2006): 101–10. https://doi.org/10.1016/j.nucmedbio.2005.08.004.
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  - Vaidyanathan, G., D. J. Affleck, M. Schottelius, H. Wester, H. S. Friedman, and M. R. Zalutsky. “Synthesis and evaluation of glycosylated octreotate analogues labeled with radioiodine and 211At via a tin precursor.” Bioconjug Chem 17, no. 1 (January 2006): 195–203. https://doi.org/10.1021/bc0502560.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “Preparation of N-succinimidyl 3-[*I]iodobenzoate: an agent for the indirect radioiodination of proteins.” Nat Protoc 1, no. 2 (2006): 707–13. https://doi.org/10.1038/nprot.2006.99.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “Synthesis of N-succinimidyl 4-[18F]fluorobenzoate, an agent for labeling proteins and peptides with 18F.” Nat Protoc 1, no. 4 (2006): 1655–61. https://doi.org/10.1038/nprot.2006.264.
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  - Shankar, Sriram, Michael R. Zalutsky, and Ganesan Vaidyanathan. “O6-3-[125I]iodobenzyl-2'-deoxyguanosine ([125I]IBdG): synthesis and evaluation of its usefulness as an agent for quantification of alkylguanine-DNA alkyltransferase (AGT).” Bioorg Med Chem 13, no. 12 (June 2, 2005): 3889–98. https://doi.org/10.1016/j.bmc.2005.04.014.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “No-carrier-added synthesis of a 4-methyl-substituted meta-iodobenzylguanidine analogue.” Appl Radiat Isot 62, no. 3 (March 2005): 435–40. https://doi.org/10.1016/j.apradiso.2004.07.001.
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  - Vaidyanathan, G. “Astatine-211 Labeled Radiopharmaceuticals, invited.” Transactions of the American Nuclear Society 91 (December 1, 2004): 856.
  - Vaidyanathan, Ganesan, Abraham Boskovitz, Sriram Shankar, and Michael R. Zalutsky. “Radioiodine and 211At-labeled guanidinomethyl halobenzoyl octreotate conjugates: potential peptide radiotherapeutics for somatostatin receptor-positive cancers.” Peptides 25, no. 12 (December 2004): 2087–97. https://doi.org/10.1016/j.peptides.2004.08.018.
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  - Shankar, Sriram, Ganesan Vaidyanathan, Donna J. Affleck, Katia Peixoto, Darell D. Bigner, and Michael R. Zalutsky. “Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent.” Nucl Med Biol 31, no. 7 (October 2004): 909–19. https://doi.org/10.1016/j.nucmedbio.2004.04.007.
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  - Vaidyanathan, Ganesan, Philip C. Welsh, Katia C. Vitorello, Stacey Snyder, Henry S. Friedman, and Michael R. Zalutsky. “A 4-methyl-substituted meta-iodobenzylguanidine analogue with prolonged retention in human neuroblastoma cells.” Eur J Nucl Med Mol Imaging 31, no. 10 (October 2004): 1362–70. https://doi.org/10.1007/s00259-004-1596-8.
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  - Kumar, Y Ravindra, G. Ramulu, V. V. Vevakanand, Gopal Vaidyanathan, Keesari Srinivas, M Kishore Kumar, K. Mukkanti, M Satyanarayana Reddy, S. Venkatraman, and M. V. Suryanarayana. “A validated chiral HPLC method for the enantiomeric separation of tolterodine tartarate.” J Pharm Biomed Anal 35, no. 5 (September 3, 2004): 1279–85. https://doi.org/10.1016/j.jpba.2004.03.026.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Kevin L. Alston, Philip Welsh, and Michael R. Zalutsky. “Catabolism of 4-fluoro-3-iodobenzylguanidine and meta-iodobenzylguanidine by SK-N-SH neuroblastoma cells.” Nucl Med Commun 25, no. 9 (September 2004): 947–55. https://doi.org/10.1097/00006231-200409000-00013.
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  - Boyd, Marie, Robert J. Mairs, W Nicol Keith, Susan C. Ross, Philip Welsh, Gamal Akabani, Jonathan Owens, et al. “An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects.” J Gene Med 6, no. 8 (August 2004): 937–47. https://doi.org/10.1002/jgm.578.
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  - Vaidyanathan, Govindan, Mary J. Cismowski, Guoshun Wang, Timothy S. Vincent, Kevin D. Brown, and Stephen M. Lanier. “The Ras-related protein AGS1/RASD1 suppresses cell growth.” Oncogene 23, no. 34 (July 29, 2004): 5858–63. https://doi.org/10.1038/sj.onc.1207774.
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  - Vaidyanathan, Ganesh. “InfoEvolve: moving from data to knowledge using information theory and genetic algorithms.” Ann N Y Acad Sci 1020 (May 2004): 227–38. https://doi.org/10.1196/annals.1310.019.
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  - Vaidyanathan, Ganesan, Sriram Shankar, Donna J. Affleck, Kevin Alston, Joseph Norman, Philip Welsh, Holly LeGrand, and Michael R. Zalutsky. “Meta-iodobenzylguanidine derivatives containing a second guanidine moiety.” Bioorg Med Chem 12, no. 7 (April 1, 2004): 1649–56. https://doi.org/10.1016/j.bmc.2004.01.026.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Joseph Norman, Phil Welsh, Wenge Liu, Stewart P. Johnson, Henry S. Friedman, and Michael R. Zalutsky. “O6-3-[131I]iodobenzylguanine: improved synthesis and further evaluation of a potential agent for imaging of alkylguanine-DNA alkyltransferase.” Bioconjug Chem 15, no. 2 (March 2004): 402–8. https://doi.org/10.1021/bc0341977.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Imaging drug resistance with radiolabeled molecules.” Curr Pharm Des 10, no. 24 (2004): 2965–79. https://doi.org/10.2174/1381612043383449.
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  - Vivekanand, V. V., D. Sreenivas Rao, G. Vaidyanathan, N. M. Sekhar, S. Avijit Kelkar, and P. Ramachandra Puranik. “A validated LC method for imatinib mesylate.” J Pharm Biomed Anal 33, no. 5 (December 4, 2003): 879–89. https://doi.org/10.1016/s0731-7085(03)00419-9.
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  - Vaidyanathan, Ganesan, Henry S. Friedman, Donna J. Affleck, Margaret Schottelius, Hans-Jürgen Wester, and Michael R. Zalutsky. “Specific and high-level targeting of radiolabeled octreotide analogues to human medulloblastoma xenografts.” Clin Cancer Res 9, no. 5 (May 2003): 1868–76.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Darell D. Bigner, and Michael R. Zalutsky. “N-succinimidyl 3-[211At]astato-4-guanidinomethylbenzoate: an acylation agent for labeling internalizing antibodies with alpha-particle emitting 211At.” Nucl Med Biol 30, no. 4 (May 2003): 351–59. https://doi.org/10.1016/s0969-8051(03)00005-2.
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  - Shankar, Sriram, Ganesan Vaidyanathan, Donna Affleck, Phillip C. Welsh, and Michael R. Zalutsky. “N-succinimidyl 3-[(131)I]iodo-4-phosphonomethylbenzoate ([(131)I]SIPMB), a negatively charged substituent-bearing acylation agent for the radioiodination of peptides and mAbs.” Bioconjug Chem 14, no. 2 (March 2003): 331–41. https://doi.org/10.1021/bc025636p.
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  - Shankar, S., G. Vaidyanathan, D. J. Affleck, P. Welsh, H. LeGrand, and M. R. Zalutsky. “Negatively charged substituent-bearing acylation agent for the radiohalogenation of mAbs.” Journal of Nuclear Medicine 43, no. 5 (May 1, 2002): 366P-366P.
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  - Vaidyanathan, G., D. J. Affleck, P. Welsh, M. Schottelius, H. Wester, J. A. Norman, K. L. Alston, and M. R. Zalutsky. “Synthesis and in vitro evaluation of glycated octreotate conjugates labeled with radioiodine and At-211 via a tin precursor.” Journal of Nuclear Medicine 43, no. 5 (May 1, 2002): 92P-92P.
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  - Dingus, Jane, Bronwyn S. Tatum, Govindan Vaidyanathan, and John D. Hilderbrandt. “Purification of G protein beta gamma from bovine brain.” Methods Enzymol 344 (2002): 194–208. https://doi.org/10.1016/s0076-6879(02)44716-7.
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  - Vaidyanathan, Ganesan, Donna J. Affleck, Darell D. Bigner, and Michael R. Zalutsky. “Improved xenograft targeting of tumor-specific anti-epidermal growth factor receptor variant III antibody labeled using N-succinimidyl 4-guanidinomethyl-3-iodobenzoate.” Nucl Med Biol 29, no. 1 (January 2002): 1–11. https://doi.org/10.1016/s0969-8051(01)00277-3.
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  - Vaidyanathan, G., S. Shankar, D. J. Affleck, P. C. Welsh, S. K. Slade, and M. R. Zalutsky. “Biological evaluation of ring- and side-chain-substituted m-iodobenzylguanidine analogues.” Bioconjug Chem 12, no. 5 (September 2001): 798–806. https://doi.org/10.1021/bc010032r.
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  - Vaidyanathan, G., S. Shankar, and M. R. Zalutsky. “Synthesis of ring- and side-chain-substituted m-iodobenzylguanidine analogues.” Bioconjug Chem 12, no. 5 (September 2001): 786–97. https://doi.org/10.1021/bc010031z.
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  - Vaidyanathan, G., D. J. Affleck, J. Li, P. Welsh, and M. R. Zalutsky. “A polar substituent-containing acylation agent for the radioiodination of internalizing monoclonal antibodies: N-succinimidyl 4-guanidinomethyl-3-[131I]iodobenzoate ([131I]SGMIB).” Bioconjug Chem 12, no. 3 (May 2001): 428–38. https://doi.org/10.1021/bc0001490.
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  - Vaidyanathan, G., D. J. Affleck, C. M. Cavazos, S. P. Johnson, S. Shankar, H. S. Friedman, M. O. Colvin, and M. R. Zalutsky. “Radiolabeled guanine derivatives for the in vivo mapping of O(6)-alkylguanine-DNA alkyltransferase: 6-(4-[(18)F]Fluoro-benzyloxy)-9H-purin-2-ylamine and 6-(3-[(131)I]Iodo-benzyloxy)-9H-purin-2-ylamine.” Bioconjug Chem 11, no. 6 (November 2000): 868–75. https://doi.org/10.1021/bc0000435.
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  - Bardiès, M., and P. Pihet. “Dosimetry and microdosimetry of targeted radiotherapy.” Curr Pharm Des 6, no. 14 (September 2000): 1469–1502. https://doi.org/10.2174/1381612003399176.
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  - Zalutsky, M. R., and G. Vaidyanathan. “Astatine-211-labeled radiotherapeutics: an emerging approach to targeted alpha-particle radiotherapy.” Curr Pharm Des 6, no. 14 (September 2000): 1433–55. https://doi.org/10.2174/1381612003399275.
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  - Vaidyanathan, G., D. Affleck, P. Welsh, A. Srinivasan, M. Schmidt, and M. R. Zalutsky. “Radioiodination and astatination of octreotide by conjugation labeling.” Nucl Med Biol 27, no. 4 (May 2000): 329–37. https://doi.org/10.1016/s0969-8051(00)00098-6.
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  - Vaidyanathan, G., D. Affleck, P. Welsh, A. Srinivasan, M. Schmidt, and M. R. Zalutsky. “Radioiodination and astatination of octreotide by conjugation labeling.” Journal of Inorganic Biochemistry 78, no. 3 (February 29, 2000): 329–37.
  - Vaidyanathan, G., and M. R. Zalutsky. “Low molecular weight radiopharmaceuticals: Radiohalogenated MIBG and IUdR analogues.” Abstracts of Papers of the American Chemical Society 217 (March 21, 1999): U41–U41.
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  - Vaidyanathan, G., A. Srinivasan, D. J. Affleck, P. C. Welsh, S. K. Slade, M. A. Schmidt, and M. R. Zalutsky. “Octreotide analogues labeled with radioiodine and astatine-211.” Journal of Labelled Compounds and Radiopharmaceuticals 42, no. SUPPL. 1 (January 1, 1999).
  - Wang, L., J. Kristensen, and D. E. Ruffner. “Delivery of antisense oligonucleotides using HPMA polymer: synthesis of A thiol polymer and its conjugation to water-soluble molecules.” Bioconjug Chem 9, no. 6 (November 1998): 749–57. https://doi.org/10.1021/bc980034k.
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  - Vaidyanathan, G., M. R. Zalutsky, and T. R. DeGrado. “Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine.” Bioconjug Chem 9, no. 6 (November 1998): 758–64. https://doi.org/10.1021/bc980037x.
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  - Walicka, M. A., G. Vaidyanathan, M. R. Zalutsky, S. J. Adelstein, and A. I. Kassis. “Survival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211.” Radiation Research 150, no. 3 (September 1998): 263–68. https://doi.org/10.2307/3579974.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Preparation of 5-[131I]iodo- and 5-[211At]astato-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil by a halodestannylation reaction.” Nucl Med Biol 25, no. 5 (July 1998): 487–96. https://doi.org/10.1016/s0969-8051(98)00004-3.
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  - Cunningham, S. H., R. J. Mairs, T. E. Wheldon, P. C. Welsh, G. Vaidyanathan, and M. R. Zalutsky. “Toxicity to neuroblastoma cells and spheroids of benzylguanidine conjugated to radionuclides with short-range emissions.” Br J Cancer 77, no. 12 (June 1998): 2061–68. https://doi.org/10.1038/bjc.1998.348.
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  - Berry, C. R., G. Vaidyanathan, P. E. Fisher, M. R. Zalutsky, R. E. Coleman, and T. R. DeGrado. “Myocardial kinetics of meta-[I-131]iodobenzylguanidine in an adriamycin cardiomyopathy rat model.” Journal of Nuclear Medicine 39, no. 5 (May 1, 1998): 47P-47P.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Targeted therapy using astatinated radiopharmaceuticals.” Abstracts of Papers of the American Chemical Society 215 (April 2, 1998): U946–U946.
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  - DeGrado, T. R., M. R. Zalutsky, R. E. Coleman, and G. Vaidyanathan. “Effects of specific activity on meta-[(131)I]iodobenzylguanidine kinetics in isolated rat heart.” Nucl Med Biol 25, no. 1 (January 1998): 59–64. https://doi.org/10.1016/s0969-8051(97)00158-3.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “Method for radioiodination of proteins using N-succinimidyl 3-hydroxy-4-iodobenzoate.” Bioconjug Chem 8, no. 5 (September 1997): 724–29. https://doi.org/10.1021/bc9700502.
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  - Vaidyanathan, G., X. -. G. Zhao, R. H. Larsen, and M. R. Zalutsky. “3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells.” British Journal of Cancer 76, no. 2 (July 1997): 226–33. https://doi.org/10.1038/bjc.1997.366.
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  - Vaidyanathan, Ganesan, and Michael R. Zalutsky. “A New Route to Guanidines from Bromoalkanes.” The Journal of Organic Chemistry 62, no. 14 (July 1, 1997): 4867–69. https://doi.org/10.1021/jo9704164.
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  - Larsen, R. H., G. Vaidyanathan, and M. R. Zalutsky. “Cytotoxicity of alpha-particle-emitting 5-[211At]astato-2'-deoxyuridine in human cancer cells.” Int J Radiat Biol 72, no. 1 (July 1997): 79–90. https://doi.org/10.1080/095530097143563.
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  - DeGrado, T. R., M. R. Zalutsky, and G. Vaidyanathan. “Mechanisms of uptake in isolated rat heart of potential radiotherapeutic agent [At-211]meta-astatobenzylguanidine (MABG).” Journal of Nuclear Medicine 38, no. 5 (May 1, 1997): 106–106.
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  - Kassis, A. I., M. A. Walicka, G. Vaidyanathan, M. R. Zalutsky, and S. J. Adelstein. “Survival and DNA damage in V79 cells exposed to the alpha emitters 5-[At-211]astato-2'-deoxy-uridine and [At-211]astatide.” Journal of Nuclear Medicine 38, no. 5 (May 1, 1997): 964–964.
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  - Vaidyanathan, G., X. G. Zhao, D. K. Strickland, and M. R. Zalutsky. “No-carrier-added iodine-131-FIBG: evaluation of an MIBG analog.” J Nucl Med 38, no. 2 (February 1997): 330–34.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Fluorine-18-labeled [Nle4,D-Phe7]-alpha-MSH, an alpha-melanocyte stimulating hormone analogue.” Nucl Med Biol 24, no. 2 (February 1997): 171–78. https://doi.org/10.1016/s0969-8051(96)00211-9.
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  - Vaidyanathan, G., X. G. Zhao, R. H. Larsen, and M. R. Zalutsky. “3-[²¹¹At]astato-4-fluorobenzylguanidine: A potential therapeutic agent with prolonged retention by neuroblastoma cells.” British Journal of Cancer 76, no. 2 (1997): 226–33.
  - Vaidyanathan, G., X. G. Zhao, R. H. Larsen, and M. R. Zalutsky. “3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells.” Br J Cancer 76, no. 2 (1997): 226–33. https://doi.org/10.1038/bjc.1997.366.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Targeted therapy using alpha emitters.” Phys Med Biol 41, no. 10 (October 1996): 1915–31. https://doi.org/10.1088/0031-9155/41/10/005.
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  - Vaidyanathan, G., H. S. Friedman, S. T. Keir, and M. R. Zalutsky. “Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model.” Nucl Med Biol 23, no. 6 (August 1996): 851–56. https://doi.org/10.1016/0969-8051(96)00115-1.
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  - DeGrado, T. R., M. R. Zalutsky, R. E. Coleman, and G. Vaidyanathan. “Effects of specific activity on uptake and retention of metaiodobenzylguanidine (MIBG) in the heart: Revisited.” Journal of Nuclear Medicine 37, no. 5 (May 1, 1996): 701–701.
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  - Vaidyanathan, G., D. J. Affleck, P. C. Welsh, S. A. Slade, K. L. Alston, and M. R. Zalutsky. “Fluorine-18 labeling of [Nle(4),D-Phe(7)]-alpha-MSH, an alpha-melanocyte stimulating hormone (alpha-MSH) analogue.” Journal of Nuclear Medicine 37, no. 5 (May 1, 1996): 875–875.
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  - Vaidyanathan, G., H. S. Friedman, S. T. Keir, and M. R. Zalutsky. “Meta-[At-211]astatobenzylguanidine (MABG): In vivo evaluation in an athymic mouse human neuroblastoma xenograft model.” Journal of Nuclear Medicine 37, no. 5 (May 1, 1996): 236–236.
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  - Zweit, J., M. Flower, A. Brown, P. Carnochan, S. Luthra, F. Brady, V. Pike, et al. “Iodine-120-mIBG: Production and NCA labelling of a new PET radiotracer.” Journal of Nuclear Medicine 37, no. 5 (May 1, 1996): 874–874.
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  - Vaidyanathan, G., H. S. Friedman, S. T. Keir, and M. R. Zalutsky. “Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity.” Br J Cancer 73, no. 10 (May 1996): 1171–77. https://doi.org/10.1038/bjc.1996.226.
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  - Vaidyanathan, G., R. H. Larsen, and M. R. Zalutsky. “Particle-emitting endoradiotherapeutic agent undergoing DNA incorporation.” Cancer Research 56, no. 6 (March 15, 1996): 1204–9.
  - Vaidyanathan, G., R. H. Larsen, and M. R. Zalutsky. “5-[At-211]astato-2'-deoxyuridine, an alpha-particle-emitting endoradiotherapeutic agent undergoing DNA incorporation.” Cancer Research 56, no. 6 (March 15, 1996): 1204–9.
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  - Vaidyanathan, G., R. H. Larsen, and M. R. Zalutsky. “5-[211 At]astato-2'-deoxyuridine, an alpha particle-emitting endoradiotherapeutic agent undergoing DNA incorporation.” Cancer Res 56, no. 6 (March 15, 1996): 1204–9.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “No-carrier-added (4-fluoro-3-[131I]iodobenzyl)guanidine and (3-[211At]astato-4-fluorobenzyl)guanidine.” Bioconjug Chem 7, no. 1 (January 1996): 102–7. https://doi.org/10.1021/bc950078i.
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  - Reist, C. J., G. E. Archer, S. N. Kurpad, C. J. Wikstrand, G. Vaidyanathan, M. C. Willingham, D. K. Moscatello, A. J. Wong, D. D. Bigner, and M. R. Zalutsky. “Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts.” Cancer Res 55, no. 19 (October 1, 1995): 4375–82.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection.” Nucl Med Biol 22, no. 6 (August 1995): 759–64. https://doi.org/10.1016/0969-8051(95)00028-v.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “Validation of 4-[fluorine-18]fluoro-3-iodobenzylguanidine as a positron-emitting analog of MIBG.” J Nucl Med 36, no. 4 (April 1995): 644–50.
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  - Degrado, T. R., M. R. Zalutsky, and G. Vaidyanathan. “Uptake mechanisms of meta-[123I]iodobenzylguanidine in isolated rat heart.” Nucl Med Biol 22, no. 1 (January 1995): 1–12. https://doi.org/10.1016/0969-8051(94)00084-w.
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  - Johnson, E. L., T. G. Turkington, R. J. Jaszczak, D. R. Gilland, G. Vaidyanathan, K. L. Greer, R. E. Coleman, and M. R. Zalutsky. “Quantitation of 211At in small volumes for evaluation of targeted radiotherapy in animal models.” Nucl Med Biol 22, no. 1 (January 1995): 45–54. https://doi.org/10.1016/0969-8051(94)00077-w.
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  - Mairs, R. J., J. Russell, S. Cunningham, J. A. O’Donoghue, M. N. Gaze, J. Owens, G. Vaidyanathan, and M. R. Zalutsky. “Enhanced tumour uptake and in vitro radiotoxicity of no-carrier-added [131I]meta-iodobenzylguanidine: implications for the targeted radiotherapy of neuroblastoma.” Eur J Cancer 31A, no. 4 (1995): 576–81. https://doi.org/10.1016/0959-8049(95)00052-k.
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  - Strickland, D. K., G. Vaidyanathan, H. S. Friedman, and M. R. Zalutsky. “Meta-[131I]iodobenzylguanidine uptake and meta-[211At]astatobenzylguanidine treatment in human medulloblastoma cell lines.” J Neurooncol 25, no. 1 (1995): 9–17. https://doi.org/10.1007/BF01054718.
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  - Vaidyanathan, G., and M. R. Zalutsky. “No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation.” Nucl Med Biol 22, no. 1 (January 1995): 61–64. https://doi.org/10.1016/0969-8051(94)00078-x.
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  - Strickland, D. K., G. Vaidyanathan, and M. R. Zalutsky. “Cytotoxicity of alpha-particle-emitting m-[211At]astatobenzylguanidine on human neuroblastoma cells.” Cancer Res 54, no. 20 (October 15, 1994): 5414–19.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “(4-[18F]fluoro-3-iodobenzyl)guanidine, a potential MIBG analogue for positron emission tomography.” J Med Chem 37, no. 21 (October 14, 1994): 3655–62. https://doi.org/10.1021/jm00047a022.
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  - Page, R. L., P. K. Garg, G. Vaidyanathan, and M. R. Zalutsky. “Preclinical evaluation and PET imaging of 18F-labeled Mel-14 F(ab')2 fragment in normal dogs.” Nucl Med Biol 21, no. 7 (October 1994): 911–19. https://doi.org/10.1016/0969-8051(94)90079-5.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Improved synthesis of N-succinimidyl 4-[18F]fluorobenzoate and its application to the labeling of a monoclonal antibody fragment.” Bioconjug Chem 5, no. 4 (July 1994): 352–56. https://doi.org/10.1021/bc00028a012.
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  - Vaidyanathan, G., D. K. Strickland, and M. R. Zalutsky. “Meta-[211At]astatobenzylguanidine: further evaluation of a potential therapeutic agent.” Int J Cancer 57, no. 6 (June 15, 1994): 908–13. https://doi.org/10.1002/ijc.2910570622.
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  - DEGRADO, T. R., M. R. ZALUTSKY, D. J. AFFLECK, and G. VAIDYANATHAN. “MECHANISTIC STUDIES OF METAIODOBENZYLGUANIDINE (METAIODOBENZYLGUANIDINE) UPTAKE AND RETENTION IN ISOLATED RAT-HEART.” Journal of Nuclear Medicine 35, no. 5 (May 1, 1994): P57–P57.
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  - JOHNSON, E. L., T. G. TURKINGTON, R. J. JASZCZAK, M. R. ZALUTSKY, D. R. GILLAND, G. VAIDYANATHAN, K. L. GREER, and R. E. COLEMAN. “QUANTITATIVE IMAGING OF AT-211 RADIOTHERAPEUTIC AGENTS IN SMALL VOLUMES.” Journal of Nuclear Medicine 35, no. 5 (May 1, 1994): P180–P180.
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  - VAIDYANATHAN, G., D. J. AFFLECK, S. A. SLADE, P. C. WELSH, and M. R. ZALUTSKY. “SYNTHESIS AND PRELIMINARY EVALUATION OF 4-[F-18]FLUORO-3-IODOBENZYLGUANIDINE (FIBG) - A METAIODOBENZYLGUANIDINE ANALOG FOR PET.” Journal of Nuclear Medicine 35, no. 5 (May 1, 1994): P248–P248.
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  - Mairs, R. J., M. N. Gaze, D. G. Watson, G. G. Skellern, P. Constable, K. McKellar, J. Owens, G. Vaidyanathan, and M. R. Zalutsky. “Carrier-free 131I-meta-iodobenzylguanidine: comparison of production from meta-diazobenzylguanidine and from meta-trimethylsilylbenzylguanidine.” Nucl Med Commun 15, no. 4 (April 1994): 268–74. https://doi.org/10.1097/00006231-199404000-00157.
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  - Shepherd, N. S., B. D. Pfrogner, J. N. Coulby, S. L. Ackerman, G. Vaidyanathan, R. H. Sauer, T. C. Balkenhol, and N. Sternberg. “Preparation and screening of an arrayed human genomic library generated with the P1 cloning system.” Proc Natl Acad Sci U S A 91, no. 7 (March 29, 1994): 2629–33. https://doi.org/10.1073/pnas.91.7.2629.
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  - Vaidyanathan, G., D. A. Affleck, P. Welsh, and M. R. Zalutsky. “Fluorine-18 labeled chemotactic peptide: A potential agent for the PET imaging of focal infection.” Journal of Labelled Compounds and Radiopharmaceuticals 35 (January 1, 1994): 365–67.
  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “(4-[¹⁸F]fluoro-3-iodobenzyl)guanidine, a potential mibg analogue for positron emission tomography.” Journal of Medicinal Chemistry 37, no. 21 (1994): 3655–62.
  - Vaidyanathan, G., D. K. Strickland, D. A. Affleck, P. Welsh, and M. R. Zalutsky. “Meta-[²¹¹At]astatobenzylguanidine: Further validation of in vitro and in vivo uptake mechanisms.” Journal of Labelled Compounds and Radiopharmaceuticals 35 (1994): 589–91.
  - Gaze, M. N., R. J. Mairs, G. Vaidyanathan, and M. R. Zalutsky. “Synthesis of carrier-free 131I-meta-iodobenzyl-guanidine by novel routes to enhance therapeutic efficiency in neuroblastoma.” Prog Clin Biol Res 385 (1994): 347–53.
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  - Vaidyanathan, G., D. Affleck, and M. R. Zalutsky. “Monoclonal antibody F(ab')2 fragment labeled with N-succinimidyl 2,4-dimethoxy-3-halobenzoates: in vivo comparison of iodinated and astatinated fragments.” Nucl Med Biol 21, no. 1 (January 1994): 105–10. https://doi.org/10.1016/0969-8051(94)90136-8.
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  - DEGRADO, T. R., M. R. ZALUTSKY, D. J. AFFLECK, and G. VAIDYANATHAN. “UPTAKE MECHANISMS OF I-123 METAIODOBENZYLGUANIDINE (METAIODOBENZYLGUANIDINE) IN ISOLATED RAT-HEART.” Circulation 88, no. 4 (October 1, 1993): 355–355.
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  - Turkington, T. G., M. R. Zalutsky, R. J. Jaszczak, P. K. Garg, G. Vaidyanathan, and R. E. Coleman. “Measuring astatine-211 distributions with SPECT.” Phys Med Biol 38, no. 8 (August 1993): 1121–30. https://doi.org/10.1088/0031-9155/38/8/010.
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  - TURKINGTON, T. G., M. R. ZALUTSKY, R. J. JASZCZAK, P. GARG, G. VAIDYANATHAN, and R. E. COLEMAN. “MEASURING ASTATINE-211 DISTRIBUTIONS WITH SPECT.” Journal of Nuclear Medicine 34, no. 5 (May 1, 1993): P191–P191.
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  - VAIDYANATHAN, G., C. HARRISON, P. WELSH, D. AFFLECK, and M. R. ZALUTSKY. “INVITRO CYTOTOXICITY OF M-[AT-211]ASTATOBENZYLGUANIDINE (MABG).” Journal of Nuclear Medicine 34, no. 5 (May 1, 1993): P218–P218.
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  - Vaidyanathan, G., and M. R. Zalutsky. “No-carrier-added synthesis of meta-[131I]iodobenzylguanidine.” Appl Radiat Isot 44, no. 3 (March 1993): 621–28. https://doi.org/10.1016/0969-8043(93)90179-e.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “Radioiodination of proteins using N-succinimidyl 4-hydroxy-3-iodobenzoate.” Bioconjug Chem 4, no. 1 (January 1993): 78–84. https://doi.org/10.1021/bc00019a011.
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  - Vaidyanathan, G., and M. R. Zalutsky. “1-(m-[211At]astatobenzyl)guanidine: synthesis via astato demetalation and preliminary in vitro and in vivo evaluation.” Bioconjug Chem 3, no. 6 (November 1992): 499–503. https://doi.org/10.1021/bc00018a006.
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  - Vaidyanathan, G., D. D. Bigner, and M. R. Zalutsky. “Fluorine-18-labeled monoclonal antibody fragments: a potential approach for combining radioimmunoscintigraphy and positron emission tomography.” J Nucl Med 33, no. 8 (August 1992): 1535–41.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Labeling proteins with fluorine-18 using N-succinimidyl 4-[18F]fluorobenzoate.” Int J Rad Appl Instrum B 19, no. 3 (April 1992): 275–81. https://doi.org/10.1016/0883-2897(92)90111-b.
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  - Vaidyanathan, G., and M. R. Zalutsky. “1-(m-[²¹¹At]astatobenzyl)guanidine: Synthesis via astato demetalation and preliminary in vitro and in vivo evaluation.” Bioconjugate Chemistry 3, no. 6 (1992): 499–503.
  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “Aromatic acylation reagents for use in the radioiodination of proteins.” Journal of Labelled Compounds and Radiopharmaceuticals 30 (April 5, 1991).
  - Vaidyanathan, G., M. Jay, R. K. Bera, P. R. Mayer, and R. K. Brazzell. “Scintigraphic evaluation of the ocular disposition of 18F-imirestat in rabbits.” Pharm Res 7, no. 11 (November 1990): 1198–1200. https://doi.org/10.1023/a:1015952930541.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Radioiodination of antibodies via N-succinimidyl 2,4-dimethoxy-3-(trialkylstannyl)benzoates.” Bioconjug Chem 1, no. 6 (November 1990): 387–93. https://doi.org/10.1021/bc00006a004.
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  - Vaidyanathan, G., and M. R. Zalutsky. “Protein radiohalogenation: observations on the design of N-succinimidyl ester acylation agents.” Bioconjug Chem 1, no. 4 (July 1990): 269–73. https://doi.org/10.1021/bc00004a007.
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  - GARG, P. K., G. VAIDYANATHAN, S. GARG, and M. R. ZALUTSKY. “RADIOIODINATION AND ASTATINATION OF MONOCLONAL-ANTIBODIES.” Abstracts of Papers of the American Chemical Society 199 (April 22, 1990): 16-NUCL.
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  - Vaidyanathan, G., and J. W. Wilson. “Reaction of Cyclopropanamines with Hypochlorite.” Journal of Organic Chemistry 54, no. 8 (April 1, 1989): 1815–20. https://doi.org/10.1021/jo00269a014.
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  - Vaidyanathan, G., and J. W. Wilson. “Decarboxylation of 1-Aminocyclopropanecarboxylic Acid and Its Derivatives.” Journal of Organic Chemistry 54, no. 8 (April 1, 1989): 1810–15. https://doi.org/10.1021/jo00269a013.
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- Conference Papers
  - Feng, Yutian, Samantha Sarrett, Rebecca Meshaw, Ganesan Vaidyanathan, Brian Zeglis, and Michael Zalutsky. “Site-specific radiolabeling of an anti-HER2 single domain antibody fragment with an At-211-labeled prosthetic agent: preliminary evaluation of a potential targeted alpha-particle therapeutic.” In Nuclear Medicine and Biology, 108:S32–S32, 2022.
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  - Feng, Yutian, Stephen Jannetti, Rebecca Meshaw, Ganesan Vaidyanathan, and Michael Zalutsky. “Therapeutic efficacy of single-dose iso-[211At]SAGMB-anti-HER2 sdAb in mice with subcutaneous HER2-expressing breast carcinoma xenografts.” In Journal of Nuclear Medicine, Vol. 62, 2021.
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  - Feng, Yutian, Zhengyuan Zhou, Darryl McDougald, Ganesan Vaidyanathan, and Michael Zalutsky. “N-(Maleimidoethyl)-3-(guanidinomethyl)-5-[I-131]iodobenzmide ([I-131]MEGMIB): A Residualizing Prosthetic Agent for Site-Specific Radioiodination of Internalizing Single Domain Antibody Fragments.” In Journal of Nuclear Medicine, Vol. 61, 2020.
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  - Minn, Il, Ronnie Mease, Choong Mo Kang, Vivek Kumar, Sangeeta Ray, Mary Brummet, Ana Kiess, Ganesan Vaidyanathan, Michael Zalutsky, and Martin Pomper. “PSMA-targeted alpha therapeutic agent with fast kidney clearance.” In Journal of Nuclear Medicine, Vol. 60. SOC NUCLEAR MEDICINE INC, 2019.
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  - Zhou, Zhengyuan, Darryl McDougald, Nick Devoogdt, Michael Zalutsky, and Ganesan Vaidyanathan. “Fluorine-18 labeling of a single domain antibody fragment with 2,5-dioxopyrrolidin-1-yl 3-(1-(2-(2-(2-(2-[F-18]fluoroethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-5-(guanidinomethyl)benzoate, an alternative residualizing prosthetic agent.” In Journal of Labelled Compounds & Radiopharmaceuticals, 62:S484–86. WILEY, 2019.
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  - Zhou, Zhengyuan, Michael Zalutsky, and Ganesan Vaidyanathan. “Fluorine-18 labeling of an anti-HER2 sdAb with 6-fluoronicotinyl moiety via the inverse electron-demand Diels-Alder reaction (IEDDAR) including a renal brush border enzyme-cleavable linker.” In Journal of Labelled Compounds & Radiopharmaceuticals, 62:S480–82. WILEY, 2019.
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  - Kang, Choong Mo, Ganesan Vaidyanathan, Darryl McDougald, and Michael Zalutsky. “Simplified At-211-labeling of internalizing proteins by preconjugation with the tin precursor of a residualizing prosthetic agent: Application to an anti-HER2 single domain antibody fragment.” In Journal of Nuclear Medicine, Vol. 59. SOC NUCLEAR MEDICINE INC, 2018.
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  - Mease, Ronnie, Choong Kang, Vivek Kumar, Sangeeta Ray, I. L. Minn, Mary Brummet, Andrew Park, et al. “Small Molecule Radiohalogenated (I-125/At-211), DOTA Containing PSMA Inhibitors: Metal Complexation and Competing Inhibitor Improve Biodistribution in Mice.” In Journal of Nuclear Medicine, Vol. 59. SOC NUCLEAR MEDICINE INC, 2018.
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  - Zhou, Zhengyuan, Nick Devoogdt, Michael Zalutsky, and Ganesan Vaidyanathan. “F-18-labeling of an anti-HER2 sdAb with a renal brush border enzyme-cleavable linker-containing prosthetic agent via a trans-cyclooctene (TCO)-terazine (Tz) inverse electron-demand Diels-Alder reaction (IEDDAR) for reduced renal uptake.” In Journal of Nuclear Medicine, Vol. 59. SOC NUCLEAR MEDICINE INC, 2018.
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  - Zhou, Zhengyuan, Nick Devoogdt, Michael Zalutsky, and Ganesan Vaidyanathan. “Labeling an anti-HER2 VHH with F-18 using a residualizing prosthetic group via strain-promoted click reaction: preliminary evaluation.” In Journal of Nuclear Medicine, Vol. 58. SOC NUCLEAR MEDICINE INC, 2017.
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  - Chin, Bennett, Thomas Hawk, Douglas Weitzel, Darryl McDougald, Robert Reiman, Gregory Palmer, Michael Zalutsky, and Ganesan Vaidyanathan. “Feasibility of 124I anti-PD-L1 PET/CT imaging in a syngeneic tumor model of breast cancer.” In Journal of Nuclear Medicine, Vol. 58. SOC NUCLEAR MEDICINE INC, 2017.
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  - Vaidyanathan, G. V., Z. Zhou, D. McDougald, T. Lahoutte, and M. R. Zalutsky. “Anti-HER2 Single Domain Antibody 2Rs15d Labeled with F-18 Using a Residualizing Label: Preliminary Evaluation.” In European Journal of Nuclear Medicine and Molecular Imaging, 43:S179–S179. SPRINGER, 2016.
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  - Kiess, Ana, Il Minn, Ganesan Vaidyanathan, Robert Hobbs, Anders Josefsson, Colette Shen, Mary Brummet, et al. “[211At]YC-I-27 for PSMA-Targeted Alpha-Particle Radiopharmaceutical Therapy.” In Journal of Nuclear Medicine, Vol. 57. SOC NUCLEAR MEDICINE INC, 2016.
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  - Mease, Ronnie, Ganesan Vaidyanathan, Darryl McGougald, Jaeyeon Choi, Ying Chen, Hassan Shallal, Mary Brummet, et al. “211At-Labeled Small-Molecule PSMA Inhibitors: Effect of Structure on Biodistribution in Mice.” In Journal of Nuclear Medicine, Vol. 57. SOC NUCLEAR MEDICINE INC, 2016.
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  - Vaidyanathan, G., D. McDougald, J. Choi, E. Koumarianou, M. Pruszynski, T. Osada, H. Lyerly, T. Lahoutte, and M. R. Zalutsky. “An Anti-HER2 Nanobody Labeled with 18F Using a Residualizing Label for Assessing HER2 Status.” In European Journal of Nuclear Medicine and Molecular Imaging, 42:S102–S102. SPRINGER, 2015.
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  - Batra, Vandana, Pietro Ranieri, Mehran Makvandi, Matthew Tsang, Catherine Hou, Yimei Li, Ganesan Vaidyanathan, Daniel A. Pryma, and John M. Maris. “Abstract 1610: Development of meta-[211At]astatobenzylguanidine ([211At]MABG) as an alpha particle emitting systemic targeted radiotherapeutic for neuroblastoma.” In Clinical Research (Excluding Clinical Trials). American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-1610.
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  - Batra, Vandana, Mehran Makvandi, Pietro Ranieri, Matthew Tsang, Catherine Hou, Yimei Li, Ganesan Vaidyanathan, John Maris, and Daniel Pryma. “Preclinical development of Meta-[At-211]astatobenzylguanidine ([At-211]MABG) as an alpha particle emitting systemic targeted radiotherapeutic for neuroblastoma (NB).” In Journal of Nuclear Medicine, Vol. 56. SOC NUCLEAR MEDICINE INC, 2015.
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  - Choi, Jaeyeon, Ganesan Vaidyanathan, Eftychia Koumarianou, Tony Lahoutte, and Michael Zalutsky. “A At-211-labeled nanobody for alpha-particle therapy of HER2-expressing cancers.” In Journal of Nuclear Medicine, Vol. 56. SOC NUCLEAR MEDICINE INC, 2015.
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  - Vaidyanathan, Ganesan, Sri Gururangan, Darell Bigner, and Michael Zalutsky. “PRE-CLINICAL EFFICACY STUDY OF INTRA-THECAL (IT) (LU)-L-177-DOTA-TATE (SOMATOSTATIN ANALOGUE) IN ATHYMIC RATS WITH LEPTOMENINGEAL DISEASE (LMD) FROM MEDULLOBLASTOMA (MBL).” In Neuro Oncology, 16:71–71. OXFORD UNIV PRESS INC, 2014.
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  - Slastnikova, T., E. Koumarianou, A. Rosenkranz, G. Vaidyanathan, M. Zalutsky, and A. Sobolev. “Modular nanotransporters efficiently deliver Auger electron emitters into nuclei of cancer cells.” In Febs Journal, 280:315–16. WILEY-BLACKWELL, 2013.
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  - Chin, Bennett, Linda Grasfeder, Darryl McDougald, and Ganesan Vaidyanathan. “Iodoquine as a potential PET radiolabel for in vivo cell trafficking of leukocyte tumor cell lines.” In Journal of Nuclear Medicine, Vol. 53. SOC NUCLEAR MEDICINE INC, 2012.
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  - Koumarianou, Eftychia, Tatiana Slastnikova, Marek Pruszynski, Xiao-Guang Zhao, Andrey Rosenkranz, Ganesan Vaidyanathan, Alexander Sobolev, and Michael Zalutsky. “Modular nanotransporters: A flexible platform forward for targeted Auger electron therapy.” In Journal of Nuclear Medicine, Vol. 53. SOC NUCLEAR MEDICINE INC, 2012.
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  - Zalutsky, M. R., and G. Vaidyanathan. “TARGETED ALPHA THERAPY.” In Radiotherapy and Oncology, 102:S195–S195. ELSEVIER IRELAND LTD, 2012.
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  - Vaidyanathan, Ganesan, Darryl MacDougald, Linda Grasfeder, Michael Zalutsky, and Bennett Chin. “An alternative and expedient synthesis of radioiodinated 4-iodophenylalanine.” In Journal of Nuclear Medicine, Vol. 52. SOC NUCLEAR MEDICINE INC, 2011.
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  - Vaidyanathan, Ganesan, Jianjun Li, Darell D. Bigner, and Michael R. Zalutsky. “TARGETED RADIOTHERAPY OF MEDULLOBLASTOMA USING SOMATOSTATIN RECEPTOR AVID RADIOLABELED PEPTIDES.” In Neuro Oncology, 13:I27–I27. OXFORD UNIV PRESS INC, 2011.
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  - Vaidyanathan, G., B. White, D. J. Affleck, D. McDougald, and M. R. Zalutsky. “Radioiodinated O6-Benzylguanine Analogues Containing an Azido Function.” In European Journal of Nuclear Medicine and Molecular Imaging, 37:S265–S265. SPRINGER, 2010.
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  - Vaidyanathan, Ganesan, Ronnie Mease, Donna Affleck, Ying Chen, Philip Welsh, Marc Hens, Martin Pomper, and Michael Zalutsky. “An astatine-211 labeled PSMA inhibitor for targeted alpha-particle radiotherapy of prostate carcinoma.” In Journal of Nuclear Medicine, Vol. 50. SOC NUCLEAR MEDICINE INC, 2009.
  - Chin, B. B., R. E. Reiman, H. Song, and G. Vaidyanathan. “Radiation dose estimates of [125I] and [131I] – iodoquine, a putative radiotracer targeting cells with high ALDH expression.” In Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, Vol. 50. Society of Nuclear Medicine, 2009.
  - Barrett, J. A., R. Coleman, M. Morse, N. Borys, J. Kronauge, J. B. Stubbs, H. Mok, et al. “Phase 1 study of radiation dosimetry and clearance of no carrier added 131I-MIBG (ultratrace iobenguane) in 7 carcinoid and 4 pheochromocytoma patients.” In European Journal of Nuclear Medicine and Molecular Imaging, 34:S241–S241. SPRINGER, 2007.
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  - Chin, B. B., R. W. Storms, K. Base, C. Lascola, T. Haystead, M. R. Zalutsky, and G. Vaidyanathan. “[I-125] iodoquine uptake in tumor cell lines with high ALDH expression.” In European Journal of Nuclear Medicine and Molecular Imaging, 34:S222–S222. SPRINGER, 2007.
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  - Gamcsik, Michael P., James B. Springer, Timothy A. Driscoll, Ganesan Vaidyanathan, O Michael Colvin, and Susan M. Ludeman. “Targeted drug delivery for neuroblastoma using MIBG.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.
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  - Vaidyanathan, G., K. L. Alston, P. C. Welsh, and M. R. Zalutsky. “Enhanced cellular retention of an internalizing anti-EGFRvIII monoclonal antibody radioiodinated using LYS5-[*I]iodobenzoyl Gly(1)-maleimido GEEEK ([*I]IB-Mal-D-GEEEK), a prosthetic group containing negatively charged D-glutamates.” In Neuro Oncology, 7:386–386. DUKE UNIV PRESS, 2005.
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  - Vaidyanathan, G., K. Base, and M. R. Zalutsky. “0(6)-{4-(3-[F-18]fluoropropyl)-benzyl}-2 '-deoxyguanosine ([F-18]FPBdG) - Synthesis and evaluation of a potential DNA repair protein 0(6)-alkyguanine-DNA alkyltransferase (AGT) imaging agent.” In Abstracts of Papers of the American Chemical Society, 229:U182–U182. AMER CHEMICAL SOC, 2005.
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  - Boskovitz, A., G. Vaidyanathan, G. E. Archer, H. Ochiai, T. Okamura, J. H. Sampson, D. D. Bigner, and M. R. Zalutsky. “Medulloblastoma neoplastic meningitis targeted radiotherapy with intrathecal alpha-emitter At-211-labeled thymidine analogue.” In Neuro Oncology, 6:403–403. DUKE UNIV PRESS, 2004.
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  - Vaidyanathan, G., A. Boskovitz, H. S. Friedman, D. J. Affleck, and M. R. Zalutsky. “Somatostatin targeted radiotherapeuiccs for medulloblastoma.” In Neuro Oncology, 6:416–416. DUKE UNIV PRESS, 2004.
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  - Vaidyanathan, G., D. J. Affleck, and M. R. Zalutsky. “N-succinimidyl 3-[211AT]astato-4-guanidinomethylbenzoate: An acylation agent for labeling internalizing antibodies with alpha-particle emitting (211)AT.” In Abstracts of Papers of the American Chemical Society, 225:U265–U265. AMER CHEMICAL SOC, 2003.
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  - VAIDYANATHAN, G., D. J. AFFLECK, S. A. SLADE, P. WELSH, and M. R. ZALUTSKY. “NO-CARRIER-ADDED 4-FLUORO-3-IODOBENZYLGUANIDINE LABELED WITH I-131 ([I-131]FIBG) AND F-18 ([F-18]FIBG - POTENTIAL MIBG ANALOGS FOR PET IMAGING AND THERAPY OF NEUROENDOCRINE TUMORS.” In Proceedings of the Xvi International Cancer Congress Free Papers and Posters, Tomes 1 4, edited by R. S. Rao, M. G. Deo, L. D. Sanghvi, and I. Mittra, 3013–17. MONDUZZI EDITORE, 1994.
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  - Vaidyanathan, G., D. K. Strickland, D. A. Affleck, P. Welsh, and M. R. Zalutsky. “Meta-[²¹¹At]astatobenzylguanidine: Further validation of in vitro and in vivo uptake mechanisms.” In Journal of Labelled Compounds and Radiopharmaceuticals, 35:589–91, 1994.

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