Overview
I am Director of the Duke University NMR Center and a faculty member in the Duke Radiology Department (https://radiology.duke.edu/faculty/divisions/research-admin/). I have over 35 years of experience in the structure determination and dynamics of large biological macromolecules and in NMR methods development. I am actively involved with training investigators in these areas and in assisting them with their projects.
Current Appointments & Affiliations
Adjunct Assistant Professor in the Department of Radiology
·
2025 - Present
Radiology,
Clinical Science Departments
Recent Publications
Structure-guided design and synthesis of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi.
Journal Article Proc Natl Acad Sci U S A · January 7, 2025 Invasive fungal infections are a leading cause of death worldwide. Translating molecular insights into clinical benefits is challenging because fungal pathogens and their hosts share similar eukaryotic physiology. Consequently, current antifungal treatment ... Full text Link to item CiteBackbone and sidechain 1H, 15N and 13C resonance assignments of the free and RNA-bound tandem zinc finger domain of the tristetraprolin family member from Selaginella moellendorffii.
Journal Article Biomol NMR Assign · April 2022 Members of the tristetraprolin (TTP) family of RNA binding proteins (RBPs) regulate the metabolism of a variety of mRNA targets. In mammals, these proteins modulate many physiological processes, including immune cell activation, hematopoiesis, and embryoni ... Full text Link to item CiteLeveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs.
Journal Article mBio · December 21, 2021 Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically accessible calcineurin inhibitors, such as FK506, are immunosuppressive to humans, so exploiting calci ... Full text Open Access Link to item CiteRecent Grants
Structural Biological Development of Fungal-Specific Calcineurin Inhibitors
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2014 - 2022Structural Biological Development of Fungal-Specific Calcineurin Inhibitors
ResearchSenior Research Scientist · Awarded by National Institutes of Health · 2014 - 2019New Console and Cold Probe for the Duke 600 MHz NMR Spectrometer System
EquipmentPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2014View All Grants
Education, Training & Certifications
Northwestern University ·
1985
Ph.D.