Overview
The research work in my laboratory focuses on identifying novel immunotherapeutic targets for the treatment of brain tumors, specifically glioblastoma (GBM). My previous work includes the development of the dual-specific immunotoxin (IT) D2C7-IT, which is currently in Phase I clinical trials in recurrent GBM (rGBM) patients. My current research seeks to identify novel strategies to enhance the efficacy of D2C7-IT and other GBM-targeted cytotoxic therapies. In conjunction with this, my research includes the investigation of immune-related biomarkers to predict the clinical outcome of D2C7-IT therapy in patients with GBM.
Current Appointments & Affiliations
Associate Professor in Neurosurgery
·
2021 - Present
Neurosurgery, Neuro-Oncology,
Neurosurgery
Associate Professor in Pathology
·
2020 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
2015 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Publisher Correction: Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor‑like population.
Journal Article Acta Neuropathol Commun · June 27, 2024 Full text Link to item CiteGene expression analysis suggests immunosuppressive roles of endolysosomes in glioblastoma.
Journal Article PLoS One · 2024 Targeting endolysosomes is a strategy extensively pursued for treating cancers, including glioblastomas (GBMs), on the basis that the intact function of these subcellular organelles is key to tumor cell autophagy and survival. Through gene expression analy ... Full text Link to item CiteAltered ontogeny and transcriptomic signatures of tissue-resident pulmonary interstitial macrophages ameliorate allergic airway hyperresponsiveness.
Journal Article Front Immunol · 2024 INTRODUCTION: Environmental exposures and experimental manipulations can alter the ontogenetic composition of tissue-resident macrophages. However, the impact of these alterations on subsequent immune responses, particularly in allergic airway diseases, re ... Full text Link to item CiteRecent Grants
PRECLINICAL THERAPEUTIC SCREENING FOR NEW THERAPIES FOR GLIOBLASTOMA MULTIFORME
ResearchInvestigator · Awarded by Jewish Communal Fund · 2007 - 2026Synergestic microglial activation and tumor cell killing for improved GBM response
ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2021 - 2025PVSRIPO in melanoma
ResearchCollaborator · Awarded by National Cancer Institute · 2020 - 2025View All Grants
Education, Training & Certifications
North Carolina State University ·
2020
M.B.A.
Boston University ·
2006
Ph.D.