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Vignesh Raman

House Staff
Surgery
2301 Erwin Road, Durham, NC 27710

Selected Publications


Social Disparities in Lung Cancer Risk and Screening.

Journal Article Thorac Surg Clin · February 2022 Significant disparities exist in lung cancer incidence and screening. Geographic, racial, gender, and socioeconomic disparities affect lung cancer incidence. As the leading cause of lung cancer, smoking varies among different racioethnic groups, genders, a ... Full text Link to item Cite

Commentary: One size fits all, maybe.

Journal Article The Journal of thoracic and cardiovascular surgery · August 2021 Full text Cite

Commentary: Size may matter after all.

Journal Article The Journal of thoracic and cardiovascular surgery · July 2021 Full text Cite

The effect of extent of resection on outcomes in patients with limited stage small cell lung cancer.

Conference J Thorac Cardiovasc Surg · April 2021 BACKGROUND: There is poor understanding of the comparative effectiveness of lobar and sublobar resections for limited-stage small cell lung cancer (SCLC). We analyzed the National Cancer Database to examine the outcomes of patients undergoing wedge resecti ... Full text Link to item Cite

Magnetic Resonance Lymphangiography of the Central Lymphatic System: Technique and Clinical Applications.

Journal Article J Magn Reson Imaging · February 2021 Magnetic resonance lymphangiography (MRL) is a noninvasive imaging technique that can be used in the management of lymphatic disorders to delineate the central lymphatic system for treatment planning. This article reviews the MRL technique, its advantages, ... Full text Link to item Cite

Predictors of nonuse of donation after circulatory death lung allografts.

Journal Article J Thorac Cardiovasc Surg · February 2021 OBJECTIVE: Despite growing evidence of comparable outcomes in recipients of donation after circulatory death and donation after brain death donor lungs, donation after circulatory death allografts continue to be underused nationally. We examined predictors ... Full text Link to item Cite

The Effect of Tumor Size and Histologic Findings on Outcomes After Segmentectomy vs Lobectomy for Clinically Node-Negative Non-Small Cell Lung Cancer.

Journal Article Chest · January 2021 BACKGROUND: The interaction between tumor size and the comparative prognosis of lobar and sublobar resection has been defined poorly. RESEARCH QUESTION: The purpose of this study was to characterize the relationship between tumor size and the receipt of se ... Full text Link to item Cite

Response.

Journal Article Chest · January 2021 Full text Link to item Cite

Adjuvant Therapy is Effective for Melanoma Patients with a Positive Sentinel Lymph Node Biopsy Who Forego Completion Lymphadenectomy.

Journal Article Ann Surg Oncol · December 2020 BACKGROUND: Multiple adjuvant therapies for melanoma have been approved since 2015 based on randomized trials demonstrating improvements in recurrence-free survival (RFS) with adjuvant therapy after surgical resection of high-risk disease. Inclusion criter ... Full text Link to item Cite

Patterns of Care in Neoadjuvant Chemoradiotherapy for Node-Positive Esophageal Adenocarcinoma.

Journal Article Ann Thorac Surg · December 2020 BACKGROUND: The aims of this study were to examine the factors associated with use of neoadjuvant chemoradiotherapy (NCR) for patients with locally advanced esophageal cancer and to evaluate the effect of NCR on survival. METHODS: The 2004 to 2015 National ... Full text Link to item Cite

The Effect of Timing of Adjuvant Therapy on Survival After Esophagectomy.

Journal Article Ann Thorac Surg · September 2020 BACKGROUND: Adjuvant chemotherapy (AC) after esophagectomy improves survival in esophageal cancer when induction therapy is not given; however, the optimal timing for initiation of AC is poorly characterized. We aimed to determine the impact of timing of A ... Full text Link to item Cite

Renal Outcomes in Patients Bridged to Heart Transplant With a Left Ventricular Assist Device.

Journal Article Ann Thorac Surg · August 2020 BACKGROUND: Patients with end-stage heart failure are increasingly being bridged to heart transplant (BTT) with mechanical circulatory support; however the association between a left ventricular assist device (LVAD) BTT strategy and posttransplant renal ou ... Full text Link to item Cite

The effect of age on survival after endoscopic resection versus surgery for T1a esophageal cancer.

Conference J Thorac Cardiovasc Surg · July 2020 BACKGROUND: Endoscopic resection has emerged as a treatment option for T1a esophageal cancer, but the impact of age on patient selection for surgery versus endoscopic resection has not been well studied. We hypothesized that endoscopic resection would be a ... Full text Link to item Cite

Reassessing Recipient Mortality Under the New Heart Allocation System: An Updated UNOS Registry Analysis.

Journal Article JACC Heart Fail · July 2020 BACKGROUND: An early report of recipient heart transplantation outcomes under the new U.S. heart allocation system introduced in late 2018 found a lower post-transplant survival rate compared with that of the prior system. OBJECTIVES: The aim of this study ... Full text Link to item Cite

Aortic valve repair with a newly approved geometric annuloplasty ring in patients undergoing proximal aortic repair: early results from a single-centre experience.

Journal Article Eur J Cardiothorac Surg · June 1, 2020 OBJECTIVES: Aortic insufficiency (AI) is common in patients with proximal aortic disease, but limited options exist to facilitate aortic valve repair (AVr) in this population. This study reports 'real-world' early results of AVr using newly FDA-approved tr ... Full text Link to item Cite

Increasing the United States heart transplant donor pool with donation after circulatory death.

Journal Article J Thorac Cardiovasc Surg · May 2020 DCD heart donation has the potential to significantly increase the pool of available donor allografts in the US, by as much as 30%, and will lead to a substantial decrease in waiting list mortality. ... Full text Link to item Cite

The influence of adjuvant therapy on survival in patients with indeterminate margins following surgery for non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · May 2020 BACKGROUND: The significance of indeterminate margins following surgery for non-small cell lung cancer (NSCLC) is unknown. We evaluated the influence of adjuvant therapy on survival in patients whose cancer showed indeterminate margins. METHODS: Patients w ... Full text Link to item Cite

A Minimally Invasive Approach to Lobectomy After Induction Therapy Does Not Compromise Survival.

Journal Article Ann Thorac Surg · May 2020 BACKGROUND: The objective of this study was to evaluate the impact of a video-assisted thoracoscopic (VATS) approach on outcomes in patients who underwent lobectomy after induction therapy. METHODS: Outcomes of patients with T2-T4, N0, M0 and T1-T4, N1-N2, ... Full text Link to item Cite

The Role of Adjuvant Therapy in Patients With Margin-Positive (R1) Esophagectomy: A National Analysis.

Journal Article J Surg Res · May 2020 BACKGROUND: We performed a nationwide analysis to assess the impact of adjuvant therapy on survival after a microscopically margin-positive (R1) resection for esophageal cancer. METHODS: The National Cancer Database was used to identify patients with R1 re ... Full text Link to item Cite

Influence of donor brain death duration on outcomes following heart transplantation: A United Network for Organ Sharing Registry analysis.

Journal Article J Thorac Cardiovasc Surg · April 2020 OBJECTIVES: We hypothesized that an increased duration of donor brain death may worsen survival following orthotopic heart transplantation. METHODS: The United Network for Organ Sharing Registry was queried for first-time, adult recipients of heart transpl ... Full text Link to item Cite

Social Disparities in Lung Cancer Risk and Screening.

Journal Article Thorac Surg Clin · February 2022 Significant disparities exist in lung cancer incidence and screening. Geographic, racial, gender, and socioeconomic disparities affect lung cancer incidence. As the leading cause of lung cancer, smoking varies among different racioethnic groups, genders, a ... Full text Link to item Cite

Commentary: One size fits all, maybe.

Journal Article The Journal of thoracic and cardiovascular surgery · August 2021 Full text Cite

Commentary: Size may matter after all.

Journal Article The Journal of thoracic and cardiovascular surgery · July 2021 Full text Cite

The effect of extent of resection on outcomes in patients with limited stage small cell lung cancer.

Conference J Thorac Cardiovasc Surg · April 2021 BACKGROUND: There is poor understanding of the comparative effectiveness of lobar and sublobar resections for limited-stage small cell lung cancer (SCLC). We analyzed the National Cancer Database to examine the outcomes of patients undergoing wedge resecti ... Full text Link to item Cite

Magnetic Resonance Lymphangiography of the Central Lymphatic System: Technique and Clinical Applications.

Journal Article J Magn Reson Imaging · February 2021 Magnetic resonance lymphangiography (MRL) is a noninvasive imaging technique that can be used in the management of lymphatic disorders to delineate the central lymphatic system for treatment planning. This article reviews the MRL technique, its advantages, ... Full text Link to item Cite

Predictors of nonuse of donation after circulatory death lung allografts.

Journal Article J Thorac Cardiovasc Surg · February 2021 OBJECTIVE: Despite growing evidence of comparable outcomes in recipients of donation after circulatory death and donation after brain death donor lungs, donation after circulatory death allografts continue to be underused nationally. We examined predictors ... Full text Link to item Cite

The Effect of Tumor Size and Histologic Findings on Outcomes After Segmentectomy vs Lobectomy for Clinically Node-Negative Non-Small Cell Lung Cancer.

Journal Article Chest · January 2021 BACKGROUND: The interaction between tumor size and the comparative prognosis of lobar and sublobar resection has been defined poorly. RESEARCH QUESTION: The purpose of this study was to characterize the relationship between tumor size and the receipt of se ... Full text Link to item Cite

Response.

Journal Article Chest · January 2021 Full text Link to item Cite

Adjuvant Therapy is Effective for Melanoma Patients with a Positive Sentinel Lymph Node Biopsy Who Forego Completion Lymphadenectomy.

Journal Article Ann Surg Oncol · December 2020 BACKGROUND: Multiple adjuvant therapies for melanoma have been approved since 2015 based on randomized trials demonstrating improvements in recurrence-free survival (RFS) with adjuvant therapy after surgical resection of high-risk disease. Inclusion criter ... Full text Link to item Cite

Patterns of Care in Neoadjuvant Chemoradiotherapy for Node-Positive Esophageal Adenocarcinoma.

Journal Article Ann Thorac Surg · December 2020 BACKGROUND: The aims of this study were to examine the factors associated with use of neoadjuvant chemoradiotherapy (NCR) for patients with locally advanced esophageal cancer and to evaluate the effect of NCR on survival. METHODS: The 2004 to 2015 National ... Full text Link to item Cite

The Effect of Timing of Adjuvant Therapy on Survival After Esophagectomy.

Journal Article Ann Thorac Surg · September 2020 BACKGROUND: Adjuvant chemotherapy (AC) after esophagectomy improves survival in esophageal cancer when induction therapy is not given; however, the optimal timing for initiation of AC is poorly characterized. We aimed to determine the impact of timing of A ... Full text Link to item Cite

Renal Outcomes in Patients Bridged to Heart Transplant With a Left Ventricular Assist Device.

Journal Article Ann Thorac Surg · August 2020 BACKGROUND: Patients with end-stage heart failure are increasingly being bridged to heart transplant (BTT) with mechanical circulatory support; however the association between a left ventricular assist device (LVAD) BTT strategy and posttransplant renal ou ... Full text Link to item Cite

The effect of age on survival after endoscopic resection versus surgery for T1a esophageal cancer.

Conference J Thorac Cardiovasc Surg · July 2020 BACKGROUND: Endoscopic resection has emerged as a treatment option for T1a esophageal cancer, but the impact of age on patient selection for surgery versus endoscopic resection has not been well studied. We hypothesized that endoscopic resection would be a ... Full text Link to item Cite

Reassessing Recipient Mortality Under the New Heart Allocation System: An Updated UNOS Registry Analysis.

Journal Article JACC Heart Fail · July 2020 BACKGROUND: An early report of recipient heart transplantation outcomes under the new U.S. heart allocation system introduced in late 2018 found a lower post-transplant survival rate compared with that of the prior system. OBJECTIVES: The aim of this study ... Full text Link to item Cite

Aortic valve repair with a newly approved geometric annuloplasty ring in patients undergoing proximal aortic repair: early results from a single-centre experience.

Journal Article Eur J Cardiothorac Surg · June 1, 2020 OBJECTIVES: Aortic insufficiency (AI) is common in patients with proximal aortic disease, but limited options exist to facilitate aortic valve repair (AVr) in this population. This study reports 'real-world' early results of AVr using newly FDA-approved tr ... Full text Link to item Cite

Increasing the United States heart transplant donor pool with donation after circulatory death.

Journal Article J Thorac Cardiovasc Surg · May 2020 DCD heart donation has the potential to significantly increase the pool of available donor allografts in the US, by as much as 30%, and will lead to a substantial decrease in waiting list mortality. ... Full text Link to item Cite

The influence of adjuvant therapy on survival in patients with indeterminate margins following surgery for non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · May 2020 BACKGROUND: The significance of indeterminate margins following surgery for non-small cell lung cancer (NSCLC) is unknown. We evaluated the influence of adjuvant therapy on survival in patients whose cancer showed indeterminate margins. METHODS: Patients w ... Full text Link to item Cite

A Minimally Invasive Approach to Lobectomy After Induction Therapy Does Not Compromise Survival.

Journal Article Ann Thorac Surg · May 2020 BACKGROUND: The objective of this study was to evaluate the impact of a video-assisted thoracoscopic (VATS) approach on outcomes in patients who underwent lobectomy after induction therapy. METHODS: Outcomes of patients with T2-T4, N0, M0 and T1-T4, N1-N2, ... Full text Link to item Cite

The Role of Adjuvant Therapy in Patients With Margin-Positive (R1) Esophagectomy: A National Analysis.

Journal Article J Surg Res · May 2020 BACKGROUND: We performed a nationwide analysis to assess the impact of adjuvant therapy on survival after a microscopically margin-positive (R1) resection for esophageal cancer. METHODS: The National Cancer Database was used to identify patients with R1 re ... Full text Link to item Cite

Influence of donor brain death duration on outcomes following heart transplantation: A United Network for Organ Sharing Registry analysis.

Journal Article J Thorac Cardiovasc Surg · April 2020 OBJECTIVES: We hypothesized that an increased duration of donor brain death may worsen survival following orthotopic heart transplantation. METHODS: The United Network for Organ Sharing Registry was queried for first-time, adult recipients of heart transpl ... Full text Link to item Cite

Impact of Positive Margins and Radiation After Tracheal Adenoid Cystic Carcinoma Resection on Survival.

Journal Article Ann Thorac Surg · April 2020 BACKGROUND: Achieving negative margins for adenoid cystic carcinoma (ACC) of the trachea can be technically difficult. This study evaluated the impact of positive margins on prognosis and tested the hypothesis that radiation improves survival in the settin ... Full text Link to item Cite

Effect of time to surgery on outcomes in stage I esophageal adenocarcinoma.

Journal Article J Thorac Cardiovasc Surg · April 2020 BACKGROUND: There are limited data on the safe interval from diagnosis to surgery in patients with stage I esophageal adenocarcinoma. We hypothesized that increased time to surgery would be associated with worse survival and increased nodal upstaging. METH ... Full text Link to item Cite

Five Year Follow-Up of Staged Bilateral Lung Transplantation for High-Risk Patients with Interstitial Lung Disease: A Matched Case-Control Study

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: The choice of single (SOLT) or bilateral orthotopic lung transplant (BOLT) for interstitial lung disease (ILD) remains controversial. Our center adopted a staged BOLT approach for higher surgical risk ILD patients, in which they undergo a single l ... Full text Cite

Commentary: Absence of evidence is not evidence of absence.

Journal Article The Journal of thoracic and cardiovascular surgery · March 2020 Full text Cite

Surgery Is Associated With Survival Benefit in T4a Esophageal Adenocarcinoma: A National Analysis.

Journal Article Ann Thorac Surg · December 2019 BACKGROUND: The National Comprehensive Cancer Network guidelines recommend consideration of surgery for clinical T4a esophageal adenocarcinoma. There are limited data on the outcomes of patients with T4a adenocarcinoma treated with surgery vs definitive ch ... Full text Link to item Cite

Outcomes for Surgery in Large Cell Lung Neuroendocrine Cancer.

Journal Article J Thorac Oncol · December 2019 INTRODUCTION: There are limited small, single-institution observational studies examining the role of surgery in large cell neuroendocrine cancer (LCNEC). We investigated the outcomes of surgery for stage I to IIIA LCNEC by using the National Cancer Databa ... Full text Link to item Cite

Outcomes of surgery versus chemoradiotherapy in patients with clinical or pathologic stage N3 non-small cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · December 2019 BACKGROUND: Because surgery is rarely recommended, there is minimal literature comparing the outcomes of surgery and chemoradiation in stage N3 non-small cell lung cancer (NSCLC). We examined the outcomes of definitive chemoradiation versus multimodality t ... Full text Link to item Cite

Disparity of Colon Cancer Outcomes in Rural America: Making the Case to Travel the Extra Mile.

Journal Article J Gastrointest Surg · November 2019 OBJECTIVES: Rural patients experience disparities in cancer care compared to urban patients. We hypothesized that rural patients with colon cancer who traveled to high-volume centers for treatment have similar survival compared to urban patients who also t ... Full text Link to item Cite

Impact of Donor Brain Death Duration on Outcomes After Lung Transplantation.

Journal Article Ann Thorac Surg · November 2019 BACKGROUND: Donor brain death duration (BDD) may impact posttransplant graft function and survival in lung transplant. METHODS: We queried the 2007 to 2018 United Network for Organ Sharing Registry for adult recipients undergoing first-time isolated lung t ... Full text Link to item Cite

Donor and recipient age matching in heart transplantation: analysis of the UNOS Registry.

Journal Article Transpl Int · November 2019 The association of donor and recipient age with survival following adult heart transplantation has not been well characterized. The purpose of this study was to examine the impact of the relationship between donor and recipient age on post-transplant survi ... Full text Link to item Cite

Adjuvant Therapy for Patients With Early Large Cell Lung Neuroendocrine Cancer: A National Analysis.

Journal Article Ann Thorac Surg · August 2019 BACKGROUND: Current guidelines do not routinely recommend adjuvant therapy for resected stage I large cell lung neuroendocrine cancer (LCNEC). However, data regarding the role of adjuvant therapy in early LCNEC are limited. This National Cancer Database (N ... Full text Link to item Cite

Surgical treatment for early stage non-small cell lung cancer.

Journal Article J Thorac Dis · April 2018 Surgery is the standard of care for early stage non-small cell lung cancer. There is significant debate about the type of operation most effective for lung cancer. Minimally invasive techniques like video-assisted (VATS) and robot-assisted thoracoscopic su ... Full text Link to item Cite

Silver-Impregnated Dressing Does Not Decrease Incidence of Surgical Site Infection After Adult Cardiac Surgery.

Journal Article Innovations (Phila) · 2018 OBJECTIVE: Sternal wound infections complicate 1% to 8% of cardiac surgeries and carry significant morbidity. We investigated the utility of silver-impregnated dressing in decreasing sternal wound infections after sternotomy cases. METHODS: A single-instit ... Full text Link to item Cite

Endoscopy after esophagectomy: Safety demonstrated in a porcine model.

Journal Article The Journal of thoracic and cardiovascular surgery · September 2017 BackgroundEndoscopy is useful in assessing conduit ischemia and anastomotic leaks after esophagectomy but poses a theoretical threat of anastomotic disruption. We used a porcine model to evaluate the safety of endoscopy after esophagectomy.Met ... Full text Cite

Response

Journal Article Chest · February 2016 Full text Cite

Warming barium sulfate improves esophageal leak detection in pig model

Journal Article Journal of Surgical Research · December 2015 Full text Cite

Response

Journal Article Chest · March 2015 Full text Cite

Laparoscopic Repair of Hiatal Hernia After Esophagectomy

Journal Article Journal of Gastrointestinal Surgery · August 2013 Full text Cite

Intrinsically disordered proteins aggregate at fungal cell-to-cell channels and regulate intercellular connectivity

Journal Article Proceedings of the National Academy of Sciences · September 25, 2012 Like animals and plants, multicellular fungi possess cell-to-cell channels (septal pores) that allow intercellular communication and transport. Here, using a combination of MS of Woronin body-associated proteins and a bioinformatics approach that i ... Full text Cite

Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions

Journal Article Journal of Cell Biology · August 9, 2010 Reversible phosphoinositide phosphorylation provides a dynamic membrane code that balances opposing cell functions. However, in vivo regulatory relationships between specific kinases, phosphatases, and phosphoinositide subpools are not clear. We id ... Full text Cite