Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Hematology-Oncology, Medicine, Duke University 2000 - 2003
  • Medical Resident, Medicine, Duke University 1997 - 2000
  • M.D., University of Zagreb (Croatia) 1985
• 

  Duke Appointment History

  • Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1997 - 2017
  • Assistant Professor in Surgery, Neurosurgery, Neurosurgery 2012 - 2017
  • Associate Professor of Medicine, Medicine, Medical Oncology, Medicine 2013 - 2017
  • Assistant Professor of Medicine, Medicine, Medical Oncology, Medicine 2012 - 2013
  • Assistant Professor of Medicine, Medicine, Medical Oncology, Medicine 2007 - 2012
  • Medical Instructor in the Department of Medicine, Medicine, Medical Oncology, Medicine 2003 - 2007
• Research
• 

  Selected Grants

  • AVeRT: Anti-PD-1 monoclonal antibody (nivolumab) in combination with DC Vaccines for Grade III/ IV brain tumors awarded by Bristol-Myers Squibb Company 2015 - 2019
  • Brain tumors with regulatory T-cells treated with EGFRvIII-specific T-cells awarded by National Institutes of Health 2013 - 2019
  • Mentored Clinical Research Scholar Program awarded by National Institutes of Health 2002 - 2006
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Khagi, S, and Vlahovic, G. "Immunotherapy Clinical Trials in Neuro-Oncology." In Translational Immunotherapy of Brain Tumors, 181-210. March 2, 2017.  Full Text
    • Fecci, PE, Riccione, K, Dunn, GP, Reap, E, Vlahovic, G, Congdon, K, and Sampson, JH. "Immunotherapy for gliomas." In The Duke Glioma Handbook: Pathology, Diagnosis, and Management, 91-120. March 31, 2016.  Full Text

  • Journal Articles

    • Desjardins, A, Gromeier, M, Herndon, JE, Beaubier, N, Bolognesi, DP, Friedman, AH, Friedman, HS, McSherry, F, Muscat, AM, Nair, S, Peters, KB, Randazzo, D, Sampson, JH, Vlahovic, G, Harrison, WT, McLendon, RE, Ashley, D, and Bigner, DD. "Recurrent Glioblastoma Treated with Recombinant Poliovirus." The New England Journal of Medicine 379, no. 2 (July 2018): 150-161.  Full Text
    • Vlahovic, G, Meadows, KL, Hatch, AJ, Jia, J, Nixon, AB, Uronis, HE, Morse, MA, Selim, MA, Crawford, J, Riedel, RF, Zafar, SY, Howard, LA, O'Neill, M, Meadows, JJ, Haley, ST, Arrowood, CC, Rushing, C, Pang, H, and Hurwitz, HI. "A Phase I Trial of the IGF-1R Antibody Ganitumab (AMG 479) in Combination with Everolimus (RAD001) and Panitumumab in Patients with Advanced Cancer." The Oncologist 23, no. 7 (July 2018): 782-790.  Full Text
    • Omuro, A, Vlahovic, G, Lim, M, Sahebjam, S, Baehring, J, Cloughesy, T, Voloschin, A, Ramkissoon, SH, Ligon, KL, Latek, R, Zwirtes, R, Strauss, L, Paliwal, P, Harbison, CT, Reardon, DA, and Sampson, JH. "Nivolumab with or without ipilimumab in patients with recurrent glioblastoma: results from exploratory phase I cohorts of CheckMate 143." Neuro Oncology 20, no. 5 (April 2018): 674-686.  Full Text
    • Reap, EA, Suryadevara, CM, Batich, KA, Sanchez-Perez, L, Archer, GE, Schmittling, RJ, Norberg, PK, Herndon, JE, Healy, P, Congdon, KL, Gedeon, PC, Campbell, OC, Swartz, AM, Riccione, KA, Yi, JS, Hossain-Ibrahim, MK, Saraswathula, A, Nair, SK, Dunn-Pirio, AM, Broome, TM, Weinhold, KJ, Desjardins, A, Vlahovic, G, McLendon, RE, Friedman, AH, Friedman, HS, Bigner, DD, Fecci, PE, Mitchell, DA, and Sampson, JH. "Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma." Cancer research 78, no. 1 (January 2018): 256-264.  Full Text
    • Randazzo, DM, McSherry, F, Herndon, JE, Affronti, ML, Lipp, ES, Flahiff, C, Miller, E, Woodring, S, Freeman, M, Healy, P, Minchew, J, Boulton, S, Desjardins, A, Vlahovic, G, Friedman, HS, Keir, S, and Peters, KB. "A cross sectional analysis from a single institution's experience of psychosocial distress and health-related quality of life in the primary brain tumor population." Journal of Neuro Oncology 134, no. 2 (September 2017): 363-369.  Full Text
    • Batich, KA, Reap, EA, Archer, GE, Sanchez-Perez, L, Nair, SK, Schmittling, RJ, Norberg, P, Xie, W, Herndon, JE, Healy, P, McLendon, RE, Friedman, AH, Friedman, HS, Bigner, D, Vlahovic, G, Mitchell, DA, and Sampson, JH. "Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 23, no. 8 (April 2017): 1898-1909.  Full Text
    • Dunn-Pirio, AM, and Vlahovic, G. "Immunotherapy approaches in the treatment of malignant brain tumors." Cancer 123, no. 5 (March 2017): 734-750. (Review)  Full Text
    • Dowlati, A, Vlahovic, G, Natale, RB, Rasmussen, E, Singh, I, Hwang, YC, Rossi, J, Bass, MB, Friberg, G, and Pickett, CA. "A Phase I, First-in-Human Study of AMG 780, an Angiopoietin-1 and -2 Inhibitor, in Patients with Advanced Solid Tumors." Clinical cancer research : an official journal of the American Association for Cancer Research 22, no. 18 (September 2016): 4574-4584.  Full Text
    • Farber, SH, Tsvankin, V, Narloch, JL, Kim, GJ, Salama, AKS, Vlahovic, G, Blackwell, KL, Kirkpatrick, JP, and Fecci, PE. "Embracing rejection: Immunologic trends in brain metastasis." Oncoimmunology 5, no. 7 (July 2016): e1172153-null. (Review)  Full Text
    • Desjardins, A, Vlahovic, G, and Friedman, HS. "Vaccine Therapy, Oncolytic Viruses, and Gliomas." Oncology (Williston Park, N.Y.) 30, no. 3 (March 2016): 211-218. (Review)
    • Gurzadyan, VG, Yan, H, Vlahovic, G, Kashin, A, Killela, P, Reitman, Z, Sargsyan, S, Yegorian, G, Milledge, G, and Vlahovic, B. "Detecting somatic mutations in genomic sequences by means of Kolmogorov-Arnold analysis." Royal Society open science 2, no. 8 (August 26, 2015): 150143-.  Full Text
    • Vlahovic, G, Fecci, PE, Reardon, D, and Sampson, JH. "Programmed death ligand 1 (PD-L1) as an immunotherapy target in patients with glioblastoma." Neuro-oncology 17, no. 8 (August 2015): 1043-1045.  Full Text
    • Smith, DC, Kalebic, T, Infante, JR, Siu, LL, Sullivan, D, Vlahovic, G, Kauh, JS, Gao, F, Berger, AJ, Tirrell, S, Gupta, N, Di Bacco, A, Berg, D, Liu, G, Lin, J, Hui, A-M, and Thompson, JA. "Phase 1 study of ixazomib, an investigational proteasome inhibitor, in advanced non-hematologic malignancies." Investigational new drugs 33, no. 3 (June 2015): 652-663.  Full Text
    • Desjardins, A, Herndon, J, McSherry, F, Ravelo, A, Lipp, E, Healy, P, Boulton, S, Peters, K, Vlahovic, G, Sampson, J, Friedman, A, and Friedman, H. "AT-19 * SINGLE INSTITUTION RETROSPECTIVE COMPARISON OF GLIOBLASTOMA (GBM) PATIENTS (PTS) INITIATED ON BEVACIZUMAB (BEV) BEFORE VERSUS AFTER RECURRENCE IN CLINICAL PRACTICE." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v12-v12.  Full Text
    • Desjardins, A, Herndon, J, McSherry, F, Ravelo, A, Lipp, E, Healy, P, Peters, K, Vlahovic, G, Sampson, J, Friedman, A, and Friedman, H. "AT-20 * SINGLE INSTITUTION RETROSPECTIVE REVIEW OF PERFORMANCE STATUS AND CORTICOSTEROID USE IN NEWLY DIAGNOSED GLIOBLASTOMA (GBM) PATIENTS (PTS) TREATED ON BEVACIZUMAB (BEV)." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v12-v13.  Full Text
    • Desjardins, A, Sampson, J, Peters, K, Vlahovic, G, Threatt, S, Herndon, J, Boulton, S, Lally-Goss, D, McSherry, F, Lipp, E, Friedman, A, Friedman, H, Bigner, D, and Gromeier, M. "AT-21 * FINAL RESULTS OF A PHASE 1 TRIAL OF AN ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) AGAINST RECURRENT GLIOBLASTOMA (GBM)." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v13-v13.  Full Text
    • Ghiaseddin, A, Dunn-Pirio, A, Peters, K, Vlahovic, G, Herndon, J, Threatt, S, Sampson, J, Friedman, A, Friedman, H, and Desjardins, A. "AT-22 * PHASE II TRIAL OF BEVACIZUMAB, RADIATION THERAPY (RT) AND TEMOZOLOMIDE FOLLOWED BY BEVACIZUMAB AND TEMOZOLOMIDE WITH CONTINUATION OF BEVACIZUMAB BEYOND PROGRESSION." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v13-v13.  Full Text
    • Kang, J, Desjardins, A, Healy, P, Herndon, J, Lipp, E, Peters, K, Vlahovic, G, Sampson, J, Friedman, H, Friedman, A, and Adamson, C. "SM-02 * LEVETIRACETAM USAGE IN POST-OPERATIVE SEIZURE MANAGEMENT IN MALIGNANT GLIOMA." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v206-v206.  Full Text
    • Mowery, Y, Wright, A, Desjardins, A, Peters, K, Ranjan, T, Vlahovic, G, Friedman, H, Zomorodi, A, Kaylie, D, Adogwa, O, Nimjee, S, Sperduto, W, Chagoya, G, Fatemi, P, McLendon, R, Cummings, T, Friedman, A, Sampson, J, and Kirkpatrick, J. "MS-19 * LONG-TERM OUTCOMES FOR PATIENTS WITH INTRACRANIAL MENINGIOMAS: A SINGLE-INSTITUTION RETROSPECTIVE ANALYSIS." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v130-v131.  Full Text
    • Peters, K, Randazzo, D, Affronti, M, Lipp, E, McSherry, F, Herndon, J, Flahiff, C, Miller, E, Woodring, S, Freeman, M, Healy, P, Minchew, J, Boulton, S, Desjardins, A, Ranjan, T, Vlahovic, G, Jones, L, and Friedman, H. "QL-20 * PROGNOSTIC IMPORTANCE OF HEALTH-RELATED QUALITY OF LIFE AND FATIGUE IN NEWLY DIAGNOSED GLIOBLASTOMA." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v182-v182.  Full Text
    • Peters, K, Reardon, D, Randazzo, D, Dutton, S, Edwards, A, Lipp, E, Herndon, J, McSherry, F, Desjardins, A, Ranjan, T, Vlahovic, G, and Friedman, H. "AT-46 * VORINOSTAT AND BEVACIZUMAB FOR RECURRENT HIGH-GRADE GLIOMA: INTERIM ANALYSIS OF A PHASE II CLINICAL TRIAL." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v18-v18.  Full Text
    • Randazzo, D, Affronti, M, Lipp, E, McSherry, F, Herndon, J, Flahiff, C, Miller, E, Woodring, S, Freeman, M, Healy, P, Minchew, J, Boulton, S, Desjardins, A, Ranjan, T, Vlahovic, G, Friedman, H, and Peters, K. "QL-21 * SPIRITUAL WELL-BEING AND ITS ASSOCIATION WITH HEALTH-RELATED QUALITY OF LIFE IN PRIMARY BRAIN TUMOR PATIENTS." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v182-v183.  Full Text
    • Ranjan, T, Peters, KB, Vlahovic, G, Watts, J, Dutton, S, Boulton, S, Lipp, E, Herndon, J, Healy, P, Miller, E, Friedman, H, Karmali, R, and Desjardins, A. "AT-48 * A PHASE 1 TRIAL OF CARBOXYAMIDOTRIAZOLE OROTATE (CTO) IN COMBINATION WITH BEVACIZUMAB FOR ADULT PATIENTS WITH RECURRENT MALIGNANT GLIOMA POST-BEVACIZUMAB FAILURE." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v19-v19.  Full Text
    • Razis, E, Vlahovic, G, Recht, L, Wheeler, H, Reardon, D, Fisher, PG, Owen, S, Nicholas, K, Paradise, E, Yellin, M, Davis, T, Weller, M, Stupp, R, and Hottinger, AF. "IT-28 * VACCINATION AGAINST EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III IN GLIOBLASTOMA: THE RINDOPEPIMUT COMPASSIONATE USE EXPERIENCE." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v115-v116.  Full Text
    • Vlahovic, G, Archer, G, Lally-Goss, D, Reap, E, Batich, K, Desjardins, A, Peters, K, Ranjan, T, Healy, P, Herndon, J, Friedman, A, Friedman, H, Bigner, D, and Sampson, J. "IT-34 * PILOT STUDY OF COMBINATION OF ANTITUMOR IMMUNOTHERAPY TARGETED AGAINST CYTOMEGALOVIRUS (CMV) PLUS REGULATORY T-CELL INHIBITION IN PATIENTS WITH NEWLY-DIAGNOSED GLIOBLASTOMA MULTIFORME (GBM)." Neuro-Oncology 16, no. suppl 5 (November 1, 2014): v117-v117.  Full Text
    • Vlahovic, G, Karantza, V, Wang, D, Cosgrove, D, Rudersdorf, N, Yang, J, Xiong, H, Busman, T, and Mabry, M. "A phase I safety and pharmacokinetic study of ABT-263 in combination with carboplatin/paclitaxel in the treatment of patients with solid tumors." Investigational new drugs 32, no. 5 (October 2014): 976-984.  Full Text
    • Sampson, JH, and Vlahovic, G. "Editorial on "heat shock protein peptide complex-96 (HSPPC-96) vaccination for recurrent glioblastoma: a phase II, single arm trial"." Neuro-oncology 16, no. 2 (January 2014): 169-170.  Full Text
    • Vlahovic, G, Karantza, V, Wang, D, Cosgrove, D, Rudersdorf, N, Yang, J, Xiong, H, Busman, T, and Mabry, M. "A phase I safety and pharmacokinetic study of ABT-263 in combination with carboplatin/paclitaxel in the treatment of patients with solid tumors." Investigational New Drugs 32, no. 5 (January 1, 2014): 976-984.  Full Text
    • Zhang, T, Das, SK, Fels, DR, Hansen, KS, Wong, TZ, Dewhirst, MW, and Vlahovic, G. "PET with 62Cu-ATSM and 62Cu-PTSM is a useful imaging tool for hypoxia and perfusion in pulmonary lesions." Ajr. American Journal of Roentgenology 201, no. 5 (November 2013): W698-W706.  Full Text
    • Vlahovic, G, Meadows, KL, Uronis, HE, Morse, MA, Blobe, GC, Riedel, RF, Zafar, SY, Alvarez-Secord, A, Gockerman, J, Starodub, AN, Ready, NE, Anderson, EL, Bendell, JC, and Hurwitz, HI. "A phase I study of bevacizumab, everolimus and panitumumab in advanced solid tumors." Cancer Chemother Pharmacol 70, no. 1 (July 2012): 95-102.  Full Text  Link to Item
    • Rodgers, GM, Becker, PS, Blinder, M, Cella, D, Chanan-Khan, A, Cleeland, C, Coccia, PF, Djulbegovic, B, Gilreath, JA, Kraut, EH, Matulonis, UA, Millenson, MM, Reinke, D, Rosenthal, J, Schwartz, RN, Soff, G, Stein, RS, Vlahovic, G, and Weir, AB. "Cancer- and chemotherapy-induced anemia." Journal of the National Comprehensive Cancer Network : Jnccn 10, no. 5 (May 2012): 628-653.  Full Text
    • Herbst, RS, Ansari, R, Bustin, F, Flynn, P, Hart, L, Otterson, GA, Vlahovic, G, Soh, C-H, O'Connor, P, and Hainsworth, J. "Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, phase 3 trial." Lancet (London, England) 377, no. 9780 (May 2011): 1846-1854.  Full Text
    • Shetty, V, Sinnathamby, G, Nickens, Z, Shah, P, Hafner, J, Mariello, L, Kamal, S, Vlahović, G, Lyerly, HK, Morse, MA, and Philip, R. "MHC class I-presented lung cancer-associated tumor antigens identified by immunoproteomics analysis are targets for cancer-specific T cell response." Journal of Proteomics 74, no. 5 (May 2011): 728-743.  Full Text
    • Michael, M, Vlahovic, G, Khamly, K, Pierce, KJ, Guo, F, and Olszanski, AJ. "Phase Ib study of CP-868,596, a PDGFR inhibitor, combined with docetaxel with or without axitinib, a VEGFR inhibitor." British Journal of Cancer 103, no. 10 (November 2010): 1554-1561.  Full Text
    • Stevenson, M, Mostertz, W, Acharya, C, Kim, W, Walters, K, Barry, W, Higgins, K, Tuchman, SA, Crawford, J, Vlahovic, G, Ready, N, Onaitis, M, and Potti, A. "Characterizing the clinical relevance of an embryonic stem cell phenotype in lung adenocarcinoma." Clin Cancer Res 15, no. 24 (December 15, 2009): 7553-7561.  Full Text  Link to Item
    • Goudar, RK, and Vlahovic, G. "Hypoxia, angiogenesis, and lung cancer." Curr Oncol Rep 10, no. 4 (July 2008): 277-282. (Review)  Link to Item
    • Wong, TZ, Lacy, JL, Petry, NA, Hawk, TC, Sporn, TA, Dewhirst, MW, and Vlahovic, G. "PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator." Ajr. American Journal of Roentgenology 190, no. 2 (February 2008): 427-432.  Full Text
    • Vlahovic, G, Ponce, AM, Rabbani, Z, Salahuddin, FK, Zgonjanin, L, Spasojevic, I, Vujaskovic, Z, and Dewhirst, MW. "Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts." British Journal of Cancer 97, no. 6 (September 2007): 735-740.  Full Text
    • Willett, CG, Duda, DG, di Tomaso, E, Boucher, Y, Czito, BG, Vujaskovic, Z, Vlahovic, G, Bendell, J, Cohen, KS, Hurwitz, HI, Bentley, R, Lauwers, GY, Poleski, M, Wong, TZ, Paulson, E, Ludwig, KA, and Jain, RK. "Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer." Nat Clin Pract Oncol 4, no. 5 (May 2007): 316-321.  Full Text  Link to Item
    • Vlahovic, G, Rabbani, ZN, Herndon, JE, Dewhirst, MW, and Vujaskovic, Z. "Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation." British Journal of Cancer 95, no. 8 (October 2006): 1013-1019.  Full Text  Open Access Copy
    • Marjanović, B, Durić, M, Zamurović, D, Kravljanac, R, Vlahović, G, and Komazec, D. "[Aetiological aspects of West Syndrome]." Srp Arh Celok Lek 134 Suppl 1 (May 2006): 45-49.  Link to Item
    • Vlahovic, G, and Crawford, J. "Activation of tyrosine kinases in cancer." Oncologist 8, no. 6 (2003): 531-538. (Review)  Link to Item
    • Stajić, N, Rajić, V, Zdravković, D, Marjanović, B, Zamurović, D, Gujanica, Z, Vlahović, G, and Bogdanović, R. "[Schimke immuno-osseous dysplasia]." Srp Arh Celok Lek 129 Suppl 1 (May 2001): 63-67.  Link to Item
    • Vlahovic, G, Russell, ML, Mercer, RR, and Crapo, JD. "Cellular and connective tissue changes in alveolar septal walls in emphysema." American Journal of Respiratory and Critical Care Medicine 160, no. 6 (December 1999): 2086-2092.  Full Text
    • Miskovic, M, Lalic, T, Radivojevic, D, Cirkovic, S, Vlahovic, G, Zamurovic, D, and Guc-Scekic, M. "Lower incidence of deletions in the survival of motor neuron gene and the neuronal apoptosis inhibitory protein gene in children with spinal muscular atrophy from Serbia." Tohoku J Exp Med 225, no. 3: 153-159.  Link to Item

  • Other Articles

    • Stevenson, M, Mostertz, W, Acharya, CR, Kim, W, Walters, K, Barry, W, Higgins, K, Tuchman, SA, Crawford, J, Vlahovic, G, Ready, N, Onaitis, M, and Potti, A. "Retraction: characterizing the clinical relevance of an embryonic stem cell phenotype in lung adenocarcinoma." Clin Cancer Res 18, no. 6 (March 15, 2012): 1818-.  Full Text  Link to Item

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