William Christopher Wetsel
Associate Professor in Psychiatry and Behavioral Sciences
RESEARCH INTERESTS
Last Updated: 27 October 2020
My laboratory uses genetically-modified mice to study the roles that certain genes and gene products play in the presentation of abnormal neuroendocrine, neurological, and psychiatric responses. Traditionally, the identification of neuroendocrine dysfunction has involved biochemical analyses of hormonal responses, those for neurological disorders have relied upon behavioral and postmortem analyses, and those for psychiatric conditions have depended upon phenomenology. The use of genetic technologies has allowed specific genes in selected cells and in neural pathways to be related to certain molecular, biochemical, cellular, physiological, and behavioral dysfunctions. As the Director of the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke University (http://sites.duke.edu/mousebehavioralcore/), we have phenotyped many different lines of inbred and mutant mice for my own work as well as for investigators at Duke and at other research institutions. As a consequence, we have helped to develop many different mouse genetic models of neuroendocrine and neuropsychiatric illness. We are working also with academic medicinal chemists and/or certain pharmacological/biotechnological companies to identify novel compounds that will ameliorate abnormal responses in various mutant mouse models. Some of these preclinical studies have formed a basis for clinical trials in humans.
Last Updated: 27 October 2020
My laboratory uses genetically-modified mice to study the roles that certain genes and gene products play in the presentation of abnormal neuroendocrine, neurological, and psychiatric responses. Traditionally, the identification of neuroendocrine dysfunction has involved biochemical analyses of hormonal responses, those for neurological disorders have relied upon behavioral and postmortem analyses, and those for psychiatric conditions have depended upon phenomenology. The use of genetic technologies has allowed specific genes in selected cells and in neural pathways to be related to certain molecular, biochemical, cellular, physiological, and behavioral dysfunctions. As the Director of the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke University (http://sites.duke.edu/mousebehavioralcore/), we have phenotyped many different lines of inbred and mutant mice for my own work as well as for investigators at Duke and at other research institutions. As a consequence, we have helped to develop many different mouse genetic models of neuroendocrine and neuropsychiatric illness. We are working also with academic medicinal chemists and/or certain pharmacological/biotechnological companies to identify novel compounds that will ameliorate abnormal responses in various mutant mouse models. Some of these preclinical studies have formed a basis for clinical trials in humans.
Current Appointments & Affiliations
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2021
- Associate Professor in Neurobiology, Neurobiology, Basic Science Departments 2007
- Assistant Research Professor in Cell Biology, Cell Biology, Basic Science Departments 2009
- Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2020
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2012
Contact Information
- 354 Sands Bldg, Durham, NC 27710
- Box 103203 Med Ctr, Durham, NC 27710
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william.wetsel@duke.edu
(919) 684-4574
- Background
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Education, Training, & Certifications
- Ph.D., Massachusetts Institute of Technology 1983
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Previous Appointments & Affiliations
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2013 - 2021
- Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2010 - 2020
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 2006 - 2013
- Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2008 - 2009
- Assistant Research Professor in Cell Biology, Cell Biology, Basic Science Departments 1999 - 2008
- Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2006 - 2007
- Assistant Research Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 1998 - 2006
- Associate Research Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 1998 - 2006
- Adjunct Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 1996 - 1998
- Expertise
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Subject Headings
- Research
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Selected Grants
- Microglia-Amyloid interactions in delirium superimposed on dementia awarded by National Institutes of Health 2017 - 2027
- Duke Testing Site for Stroke Preclinical Assessment Network awarded by National Institutes of Health 2023 - 2025
- Immunovascular interactions in postoperative delirium superimposed on dementia (DSD). awarded by National Institutes of Health 2022 - 2025
- Behavior and Physiology in Aging awarded by National Institutes of Health 2015 - 2025
- Development of arrestin-biased dopamine D1 receptor (D1R) ligand for the treatment of Parkinson's disease with minimal L-DOPA induced dyskinesia awarded by Michael J. Fox Foundation for Parkinson's Research 2023 - 2024
- The role of pericytes in delirium superimposed on dementia. awarded by National Institutes of Health 2022 - 2024
- Bacteriophage virus-like particle vaccines for fentanyl and heroin overdose awarded by University of New Mexico 2021 - 2024
- Defining the role of peripheral Adrb3 in chronic pain and inflammation awarded by National Institutes of Health 2019 - 2024
- Molecular and circuitry mechanism underlying autism behaviors in Shank3 mouse models awarded by Yale University 2019 - 2023
- Evaluating cell type-specific non-dopaminergics as a Parkinson's treatment paradigm awarded by National Institutes of Health 2021 - 2023
- Exploiting Biased Agonism at the Ghrelin Receptor (GHSR 1a) for Opioid Addiction awarded by National Institutes of Health 2022 - 2023
- Phase 2 - Biased Agonists as Rapidly Acting Neuropsychiatric Drugs awarded by University of North Carolina - Chapel Hill 2020 - 2023
- Interrogating the cholinergic basis of opioid reinforcement with subcellular precision awarded by National Institutes of Health 2020 - 2023
- Heat Shock Factors and Protein Misfolding Disease awarded by National Institutes of Health 2018 - 2023
- DART2.0: comprehensive cell type-specific behavioral neuropharmacology awarded by National Institutes of Health 2018 - 2022
- Phase 1 - Biased Agonists as Rapidly Acting Neuropsychiatric Drugs awarded by University of North Carolina - Chapel Hill 2020 - 2022
- Targeting microbially-derived juvenile protective factors to resolve neuroinflammation and delirium awarded by National Institutes of Health 2019 - 2022
- In Vivo Epigenome Editing with CRISPR-Based Histone Acetyltransferase Transgenic Mice awarded by National Institutes of Health 2016 - 2022
- Bioelectronic rescue of cognitive impairment after surgery awarded by National Institutes of Health 2018 - 2021
- Molecular and cellular control of injury-induced astrogenesis awarded by National Institutes of Health 2017 - 2021
- Novel Adjuvants and Carriers for Opiod Vaccines awarded by National Institutes of Health 2014 - 2020
- Developing a New Therapeutic Agent for Kabuki Syndrome awarded by Rescindo Therapeutics Inc 2019 - 2020
- Akt/GSK-3 Signaling Cascade and the Actions of Dopamine awarded by National Institutes of Health 2005 - 2020
- Simultaneous and Bidirectional Chemogenetic Control of Mesolimbic and Nigrostriatal Circuits awarded by National Institutes of Health 2018 - 2020
- Molecular, Synaptic, and Circuit Basis for Schizophrenia-related Phenotypes awarded by National Institutes of Health 2014 - 2020
- Developing a new therapeutic agent for Kabuki syndrome awarded by Rescindo Therapeutics Inc 2018 - 2019
- Molecular and circuitry mechanism underlying autism behaviors in Shank3 mouse models awarded by National Institutes of Health 2019
- Cortico-striatal neurotransmission and compulsive motor behaviors awarded by National Institutes of Health 2008 - 2019
- Initial SHANK3 Study (Rugen E & F) awarded by Rugen Holdings (Cayman) 2017 - 2019
- Initial SHANK3 Study awarded by Rugen Holdings (Cayman) 2016 - 2019
- Linking Ciliary Biology to the Functional Annotation of Psychiatric Disorders awarded by University of Nevada - Las Vegas 2018
- Quantitative MR Microscopy of Phenotypic Biomarkers in Alzheimer's Disease awarded by National Institutes of Health 2013 - 2018
- Analysis of Shank3 Complete and Temporal and Spatial Specific Knockout Mice awarded by National Institutes of Health 2012 - 2018
- Receptor Regulation of CCK Cell Function awarded by National Institutes of Health 2013 - 2018
- IPA - Jiechun Zhou awarded by National Institutes of Health 2017 - 2018
- IPA - William Wetsel awarded by National Institutes of Health 2017 - 2018
- Fragile X Phenotypes Modulated by Altered Signaling to the Synaptic Cytoskeleton awarded by National Institutes of Health 2014 - 2018
- Linking ciliary biology to the functional annotation of psychiatric disorders awarded by National Institutes of Health 2016 - 2017
- Regulation of Cocaine Reward and Reinforcement by MeCP2 awarded by National Institutes of Health 2013 - 2017
- Functional Selectivity: A Novel Approach for CNS Drug Discovery awarded by University of North Carolina - Chapel Hill 2012 - 2017
- STIM1-dependent calcium signaling in neuronal responses to hypoxia and ischemia awarded by National Institutes of Health 2015 - 2017
- The 5-HT theory of depression tested in a naturalistic model of 5-HT deficiency awarded by National Institutes of Health 2006 - 2017
- Effect of two Rugen compounds on Novel Object Phobia in wild type (WT) and SAPAP3 KO mice awarded by Rugen Holdings (Cayman) 2014 - 2017
- Optimizing Lead 5-HT2C Ligands for Use in the Treatment of Schizoprenia awarded by University of Illinois at Chicago 2013 - 2015
- Novel high-throughput screening for modifiers of TorsinA pathology awarded by National Institutes of Health 2013 - 2015
- Amphetamine-Induced Transcriptional Plasticity in Striatal GABAergic Interneurons awarded by National Institutes of Health 2012 - 2015
- Prevention of Temporal Lobe Epilepsy awarded by National Institutes of Health 2012 - 2014
- Regulation of response to chronic antidepressant treatment by MeCP2 awarded by National Institutes of Health 2012 - 2014
- Imaging NFkB Activity in Relation to Animal Behavior in Peripheral Neuropathy awarded by National Institutes of Health 2013 - 2014
- Novel Genetic Mouse Model to Study the Consequences of TorsinA Dysfunction awarded by National Institutes of Health 2011 - 2014
- Non-invasive Chemical Genetic Control of Neuronal Activity awarded by National Institutes of Health 2009 - 2014
- Agilent Direct Drive 9.4T MRS/MRI Console awarded by National Institutes of Health 2012 - 2013
- PTSD-like phenotype of mice lacking GIT2 awarded by National Institutes of Health 2010 - 2012
- Hormonal regulation of a Ca2+/AMPK signaling pathway awarded by National Institutes of Health 1984 - 2011
- Epigenetic regulation of transcriptional repression by drugs of abuse awarded by National Institutes of Health 2006 - 2011
- Stress and Behavior in Health and Disease awarded by National Institutes of Health 1989 - 2011
- Pharmacometabolomics Research Network awarded by National Institutes of Health 2010 - 2011
- Roles of SAPAP Proteins in Synaptic Function and Compulsive-like Behavior awarded by National Institutes of Health 2007 - 2010
- Cocaine Withdrawal: A Window of Treatment Opportunity awarded by National Institutes of Health 1999 - 2010
- Collaborative & Physiological Experiments to Breed CPE KO Mice awarded by National Institutes of Health 2006 - 2007
- The Pathophysiology of CMT2A in Cell and Animal Models awarded by National Institutes of Health 2006 - 2007
- Collaborative & Physiological Experiments to Breed CPE KO Mice awarded by National Institutes of Health 2005
- Collaborative & Physiological Experiments awarded by National Institutes of Health 2004 - 2005
- Genetic Rescue Of Pro-Lhrh Processing In Cpefat Mice awarded by National Institutes of Health 1998 - 2004
- Collaborative & Physiological Experiments of CPE K/O Mice awarded by National Institutes of Health 2002 - 2003
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External Relationships
- National Institutes of Health
- Onsero Therapeutics
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Hornburg, Kathryn J., Lauren M. Slosky, Gary Cofer, James Cook, Yi Qi, Fiona Porkka, Nicholas B. Clark, et al. “Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.” Nmr Biomed 36, no. 2 (February 2023): e4842. https://doi.org/10.1002/nbm.4842.Full Text Link to Item
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Yang, Ting, Ravikanth Velagapudi, Cuicui Kong, Unghyeon Ko, Vardhman Kumar, Paris Brown, Nathan O. Franklin, et al. “Protective effects of omega-3 fatty acids in a blood-brain barrier-on-chip model and on postoperative delirium-like behaviour in mice.” Br J Anaesth 130, no. 2 (February 2023): e370–80. https://doi.org/10.1016/j.bja.2022.05.025.Full Text Link to Item
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David-Bercholz, Jennifer, Leah Acker, Ana I. Caceres, Pau Yen Wu, Saanvi Goenka, Nathan O. Franklin, Ramona M. Rodriguiz, et al. “Conserved YKL-40 changes in mice and humans after postoperative delirium.” Brain Behav Immun Health 26 (December 2022): 100555. https://doi.org/10.1016/j.bbih.2022.100555.Full Text Link to Item
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Slosky, Lauren M., Andrea Pires, Yushi Bai, Nicholas B. Clark, Elizabeth R. Hauser, Joshua D. Gross, Fiona Porkka, et al. “Establishment of multi-stage intravenous self-administration paradigms in mice.” Scientific Reports 12, no. 1 (December 2022): 21422. https://doi.org/10.1038/s41598-022-24740-2.Full Text
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Kaplan, Anat Levit, Danielle N. Confair, Kuglae Kim, Ximena Barros-Álvarez, Ramona M. Rodriguiz, Ying Yang, Oh Sang Kweon, et al. “Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity.” Nature 610, no. 7932 (October 2022): 582–91. https://doi.org/10.1038/s41586-022-05258-z.Full Text Link to Item
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Aryal, Dipendra K., Ramona M. Rodriguiz, Ngoc Lien Nguyen, Matthew W. Pease, Daniel J. Morgan, John Pintar, Lloyd D. Fricker, and William C. Wetsel. “Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment.” Genes Brain Behav 21, no. 7 (September 2022): e12827. https://doi.org/10.1111/gbb.12827.Full Text Link to Item
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Fricker, Lloyd D., Mariana Lemos Duarte, Andrei Jeltyi, Lindsay Lueptow, Amanda K. Fakira, Alexandre K. Tashima, Ute Hochgeschwender, William C. Wetsel, and Lakshmi A. Devi. “Mice heterozygous for a null mutation of CPE show reduced expression of carboxypeptidase e mRNA and enzyme activity but normal physiology, behavior, and levels of neuropeptides.” Brain Res 1789 (August 15, 2022): 147951. https://doi.org/10.1016/j.brainres.2022.147951.Full Text Link to Item
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Nilson, Ashley N., Andres Dulcey Garcia, R. B. Free, Noelia Boldizsar, Hannah Pearlstein, Julia A. Rocereta, Ramona M. Rodriguiz, et al. “Characterization and Chemical Optimization of the D2 Dopamine Receptor-Selective Antagonist, ML321, Identifies Lead Compounds for the Clinical Treatment of Neuropsychiatric Disorders.” Faseb J 36 Suppl 1 (May 2022). https://doi.org/10.1096/fasebj.2022.36.S1.R2720.Full Text Link to Item
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Gross, J. D., D. W. Kim, Y. Zhou, D. Jansen, L. M. Slosky, N. B. Clark, C. R. Ray, et al. “Discovery of a functionally selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine.” Proc Natl Acad Sci U S A 119, no. 10 (March 8, 2022): e2112397119. https://doi.org/10.1073/pnas.2112397119.Full Text Link to Item
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Jaaro-Peled, Hanna, Sunil Kumar, Dalton Hughes, Akiko Sumitomo, Sun-Hong Kim, Sandra Zoubovsky, Yuki Hirota-Tsuyada, et al. “Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit.” Mol Psychiatry 27, no. 3 (March 2022): 1805–15. https://doi.org/10.1038/s41380-021-01389-3.Full Text Link to Item
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Chandra, Rashmi, Dipendra K. Aryal, Jonathan D. Douros, Rafiq Shahid, Supriya J. Davis, Jonathan E. Campbell, Olga Ilkayeya, et al. “Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia.” Plos One 17, no. 6 (2022): e0270329. https://doi.org/10.1371/journal.pone.0270329.Full Text Link to Item
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Zhang, Zhiquan, Qing Ma, Ravikanth Velagapudi, William E. Barclay, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Mari L. Shinohara, and Niccolò Terrando. “Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome.” Front Immunol 13 (2022): 856254. https://doi.org/10.3389/fimmu.2022.856254.Full Text Link to Item
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Rodriguiz, Ramona M., Vineet Nadkarni, Christopher R. Means, Vladimir M. Pogorelov, Yi-Ting Chiu, Bryan L. Roth, and William C. Wetsel. “LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1.” Sci Rep 11, no. 1 (September 3, 2021): 17690. https://doi.org/10.1038/s41598-021-96736-3.Full Text Link to Item
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Dong, Chunyang, Calvin Ly, Lee E. Dunlap, Maxemiliano V. Vargas, Junqing Sun, In-Wook Hwang, Arya Azinfar, et al. “Psychedelic-inspired drug discovery using an engineered biosensor.” Cell 184, no. 10 (May 13, 2021): 2779-2792.e18. https://doi.org/10.1016/j.cell.2021.03.043.Full Text Link to Item
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Martini, Michael L., Caroline Ray, Xufen Yu, Jing Liu, Vladimir M. Pogorelov, William C. Wetsel, Xi-Ping Huang, John D. McCorvy, Marc G. Caron, and Jian Jin. “Addition to "Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity".” Acs Chem Neurosci 12, no. 8 (April 21, 2021): 1464. https://doi.org/10.1021/acschemneuro.1c00186.Full Text Link to Item
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Fricker, Lloyd D., Alexandre K. Tashima, Amanda K. Fakira, Ute Hochgeschwender, William C. Wetsel, and Lakshmi A. Devi. “Neuropeptidomic Analysis of a Genetically Defined Cell Type in Mouse Brain and Pituitary.” Cell Chem Biol 28, no. 1 (January 21, 2021): 105-112.e4. https://doi.org/10.1016/j.chembiol.2020.11.003.Full Text Link to Item
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White, Allison N., Joshua D. Gross, Shane W. Kaski, Kristen R. Trexler, Kim A. Wix, William C. Wetsel, Steven G. Kinsey, David P. Siderovski, and Vincent Setola. “Genetic deletion of Rgs12 in mice affects serotonin transporter expression and function in vivo and ex vivo.” J Psychopharmacol 34, no. 12 (December 2020): 1393–1407. https://doi.org/10.1177/0269881120944160.Full Text Link to Item
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Monroe, Tanner O., Melanie E. Garrett, Maria Kousi, Ramona M. Rodriguiz, Sungjin Moon, Yushi Bai, Steven C. Brodar, et al. “PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.” Nat Commun 11, no. 1 (November 19, 2020): 5903. https://doi.org/10.1038/s41467-020-19637-5.Full Text Link to Item
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Yu, Shu, Francesca Galeffi, Ramona M. Rodriguiz, Zhuoran Wang, Yuntian Shen, Jingjun Lyu, Ran Li, et al. “Small ubiquitin-like modifier 2 (SUMO2) is critical for memory processes in mice.” Faseb J 34, no. 11 (November 2020): 14750–67. https://doi.org/10.1096/fj.202000850RR.Full Text Open Access Copy Link to Item
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Slosky, Lauren M., Yushi Bai, Krisztian Toth, Caroline Ray, Lauren K. Rochelle, Alexandra Badea, Rahul Chandrasekhar, et al. “β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.” Cell 181, no. 6 (June 11, 2020): 1364-1379.e14. https://doi.org/10.1016/j.cell.2020.04.053.Full Text Link to Item
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Wang, Ping, Ravikanth Velagapudi, Cuicui Kong, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Miles Berger, Harris A. Gelbard, Carol A. Colton, and Niccolò Terrando. “Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.” Alzheimers Dement 16, no. 5 (May 2020): 734–49. https://doi.org/10.1002/alz.12064.Full Text Link to Item
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Miller-Rhodes, Patrick, Cuicui Kong, Gurpreet S. Baht, Priyanka Saminathan, Ramona M. Rodriguiz, William C. Wetsel, Harris A. Gelbard, and Niccolò Terrando. “The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.” J Neuroinflammation 16, no. 1 (October 28, 2019): 193. https://doi.org/10.1186/s12974-019-1582-5.Full Text Link to Item
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Martini, Michael L., Caroline Ray, Xufen Yu, Jing Liu, Vladimir M. Pogorelov, William C. Wetsel, Xi-Ping Huang, John D. McCorvy, Marc G. Caron, and Jian Jin. “Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity.” Acs Chem Neurosci 10, no. 9 (September 18, 2019): 4160–82. https://doi.org/10.1021/acschemneuro.9b00410.Full Text Link to Item
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Kritzer, M., W. Rosario, J. Tharayil, C. Lai, P. Botros, A. Lowell, D. Cruz, et al. “Erratum to ‘Electroconvulsive stimulation increases astrocyte marker GFAP in mouse hippocampus regardless of chronic social defeat stress’ (Brain Stimulation (2019) 12(2) (543), (S1935861X18312105), (10.1016/j.brs.2018.12.791)).” Brain Stimulation 12, no. 5 (September 1, 2019): e167. https://doi.org/10.1016/j.brs.2019.06.008.Full Text
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Yang, Rui, Kathryn K. Walder-Christensen, Namsoo Kim, Danwei Wu, Damaris N. Lorenzo, Alexandra Badea, Yong-Hui Jiang, Henry H. Yin, William C. Wetsel, and Vann Bennett. “ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity.” Proc Natl Acad Sci U S A 116, no. 30 (July 23, 2019): 15262–71. https://doi.org/10.1073/pnas.1904348116.Full Text Link to Item
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Badea, Alexandra, Natalie A. Delpratt, R. J. Anderson, Russell Dibb, Yi Qi, Hongjiang Wei, Chunlei Liu, William C. Wetsel, Brian B. Avants, and Carol Colton. “Multivariate MR biomarkers better predict cognitive dysfunction in mouse models of Alzheimer's disease.” Magn Reson Imaging 60 (July 2019): 52–67. https://doi.org/10.1016/j.mri.2019.03.022.Full Text Link to Item
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Pogorelov, Vladimir M., Hung-Teh Kao, George J. Augustine, and William C. Wetsel. “Postsynaptic Mechanisms Render Syn I/II/III Mice Highly Responsive to Psychostimulants.” Int J Neuropsychopharmacol 22, no. 7 (July 1, 2019): 453–65. https://doi.org/10.1093/ijnp/pyz019.Full Text Link to Item
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Shen, Yudao, John D. McCorvy, Michael L. Martini, Ramona M. Rodriguiz, Vladimir M. Pogorelov, Karen M. Ward, William C. Wetsel, Jing Liu, Bryan L. Roth, and Jian Jin. “D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine.” J Med Chem 62, no. 9 (May 9, 2019): 4755–71. https://doi.org/10.1021/acs.jmedchem.9b00508.Full Text Link to Item
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Arbogast, Thomas, Parisa Razaz, Jacob Ellegood, Spencer U. McKinstry, Serkan Erdin, Benjamin Currall, Tanya Aneichyk, et al. “Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions.” Hum Mol Genet 28, no. 9 (May 1, 2019): 1474–86. https://doi.org/10.1093/hmg/ddy436.Full Text Link to Item
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McGaughey, Kara D., Tulay Yilmaz-Swenson, Nourhan M. Elsayed, Dianne A. Cruz, Ramona M. Rodriguiz, Michael D. Kritzer, Angel V. Peterchev, Jeffrey Roach, William C. Wetsel, and Douglas E. Williamson. “Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice.” Sci Rep 9, no. 1 (March 1, 2019): 3281. https://doi.org/10.1038/s41598-019-40140-5.Full Text Link to Item
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McGaughey, Kara D., Tulay Yilmaz-Swenson, Nourhan M. Elsayed, Dianne A. Cruz, Ramona M. Rodriguez, Michael D. Kritzer, Angel V. Peterchev, et al. “Correction: Comparative evaluation of a new magnetic bead-based DNA extraction method from fecal samples for downstream next-generation 16S rRNA gene sequencing.” Plos One 14, no. 2 (2019): e0212712. https://doi.org/10.1371/journal.pone.0212712.Full Text Link to Item
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Huffman, William J., Saraswathi Subramaniyan, Ramona M. Rodriguiz, William C. Wetsel, Warren M. Grill, and Niccolò Terrando. “Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice.” Brain Stimul 12, no. 1 (2019): 19–29. https://doi.org/10.1016/j.brs.2018.10.005.Full Text Link to Item
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Velagapudi, Ravikanth, Saraswathi Subramaniyan, Chao Xiong, Fiona Porkka, Ramona M. Rodriguiz, William C. Wetsel, and Niccolò Terrando. “Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model.” Front Immunol 10 (2019): 2675. https://doi.org/10.3389/fimmu.2019.02675.Full Text Link to Item
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Helseth, Ashley R., Arsen S. Hunanyan, Syed Adil, Molly Linabarger, Monisha Sachdev, Elie Abdelnour, Eric Arehart, et al. “Novel E815K knock-in mouse model of alternating hemiplegia of childhood.” Neurobiol Dis 119 (November 2018): 100–112. https://doi.org/10.1016/j.nbd.2018.07.028.Full Text Link to Item
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Bey, Alexandra L., Xiaoming Wang, Haidun Yan, Namsoo Kim, Rebecca L. Passman, Yilin Yang, Xinyu Cao, et al. “Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors.” Transl Psychiatry 8, no. 1 (April 27, 2018): 94. https://doi.org/10.1038/s41398-018-0142-6.Full Text Link to Item
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Wang, Xiaoting, David A. Gallegos, Vladimir M. Pogorelov, Justin K. O’Hare, Nicole Calakos, William C. Wetsel, and Anne E. West. “Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference.” Neuropsychopharmacology 43, no. 5 (April 2018): 953–63. https://doi.org/10.1038/npp.2017.178.Full Text Link to Item
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Martyn, Amanda C., Krisztian Toth, Robert Schmalzigaug, Nathan G. Hedrick, Ramona M. Rodriguiz, Ryohei Yasuda, William C. Wetsel, and Richard T. Premont. “GIT1 regulates synaptic structural plasticity underlying learning.” Plos One 13, no. 3 (2018): e0194350. https://doi.org/10.1371/journal.pone.0194350.Full Text Link to Item
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McGaughey, Kara D., Tulay Yilmaz-Swenson, Nourhan M. Elsayed, Dianne A. Cruz, Ramona R. Rodriguez, Michael D. Kritzer, Angel V. Peterchev, et al. “Comparative evaluation of a new magnetic bead-based DNA extraction method from fecal samples for downstream next-generation 16S rRNA gene sequencing.” Plos One 13, no. 8 (2018): e0202858. https://doi.org/10.1371/journal.pone.0202858.Full Text Link to Item
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Butler, Ryan K., Sarah Ehling, Megan Barbar, Jess Thomas, Mary A. Hughes, Charles E. Smith, Vladimir M. Pogorelov, Dipendra K. Aryal, William C. Wetsel, and B Duncan X. Lascelles. “Distinct neuronal populations in the basolateral and central amygdala are activated with acute pain, conditioned fear, and fear-conditioned analgesia.” Neurosci Lett 661 (November 20, 2017): 11–17. https://doi.org/10.1016/j.neulet.2017.09.025.Full Text Link to Item
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Berezniuk, Iryna, Ramona M. Rodriguiz, Michael L. Zee, David J. Marcus, John Pintar, Daniel J. Morgan, William C. Wetsel, and Lloyd D. Fricker. “ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine.” Journal of Neurochemistry 143, no. 3 (November 2017): 268–81. https://doi.org/10.1111/jnc.14209.Full Text
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Pogorelov, Vladimir M., Ramona M. Rodriguiz, Jianjun Cheng, Mei Huang, Claire M. Schmerberg, Herbert Y. Meltzer, Bryan L. Roth, Alan P. Kozikowski, and William C. Wetsel. “5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice.” Neuropsychopharmacology 42, no. 11 (October 2017): 2163–77. https://doi.org/10.1038/npp.2017.52.Full Text Link to Item
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Pappas, Andrea L., Alexandra L. Bey, Xiaoming Wang, Mark Rossi, Yong Ho Kim, Haidun Yan, Fiona Porkka, et al. “Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.” Jci Insight 2, no. 20 (October 2017): 92052. https://doi.org/10.1172/jci.insight.92052.Full Text
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Akkhawattanangkul, Y., P. Maiti, Y. Xue, D. Aryal, W. C. Wetsel, D. Hamilton, S. C. Fowler, and M. P. McDonald. “Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration.” Genes Brain Behav 16, no. 5 (June 2017): 522–36. https://doi.org/10.1111/gbb.12377.Full Text Link to Item
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Cho, Kyoung-In, Dosuk Yoon, Sunny Qiu, Zachary Danziger, Warren M. Grill, William C. Wetsel, and Paulo A. Ferreira. “Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.” Dis Model Mech 10, no. 5 (May 1, 2017): 559–79. https://doi.org/10.1242/dmm.027730.Full Text Link to Item
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Wang, Jianjun, Jiansong Luo, Dipendra K. Aryal, William C. Wetsel, Richard Nass, and Jeffrey L. Benovic. “G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans.” J Biol Chem 292, no. 14 (April 7, 2017): 5943–56. https://doi.org/10.1074/jbc.M116.760850.Full Text Link to Item
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Urs, Nikhil M., Steven M. Gee, Thomas F. Pack, John D. McCorvy, Tama Evron, Joshua C. Snyder, Xiaobao Yang, et al. “Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.” Proc Natl Acad Sci U S A 113, no. 50 (December 13, 2016): E8178–86. https://doi.org/10.1073/pnas.1614347113.Full Text Link to Item
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Badea, Alexandra, Lauren Kane, Robert J. Anderson, Yi Qi, Mark Foster, Gary P. Cofer, Neil Medvitz, et al. “The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease.” Neuroimage 142 (November 15, 2016): 498–511. https://doi.org/10.1016/j.neuroimage.2016.08.014.Full Text Link to Item
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Ade, Kristen K., Yehong Wan, Harold C. Hamann, Justin K. O’Hare, Weirui Guo, Anna Quian, Sunil Kumar, et al. “Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice.” Biol Psychiatry 80, no. 7 (October 1, 2016): 522–33. https://doi.org/10.1016/j.biopsych.2016.04.023.Full Text Link to Item
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Bhagat, Srishti L., Sunny Qiu, Zachary F. Caffall, Yehong Wan, Yuanji Pan, Ramona M. Rodriguiz, William C. Wetsel, Alexandra Badea, Ute Hochgeschwender, and Nicole Calakos. “Mouse model of rare TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models.” Neurobiol Dis 93 (September 2016): 137–45. https://doi.org/10.1016/j.nbd.2016.05.003.Full Text Link to Item
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Barak, Larry S., Yushi Bai, Sean Peterson, Tama Evron, Nikhil M. Urs, Satyamaheshwar Peddibhotla, Michael P. Hedrick, et al. “ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.” Acs Chem Biol 11, no. 7 (July 15, 2016): 1880–90. https://doi.org/10.1021/acschembio.6b00291.Full Text Link to Item
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Weitzel, Douglas H., Artak Tovmasyan, Kathleen A. Ashcraft, Alina Boico, Samuel R. Birer, Kingshuk Roy Choudhury, James Herndon, et al. “Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.” Environ Mol Mutagen 57, no. 5 (June 2016): 372–81. https://doi.org/10.1002/em.22021.Full Text Link to Item
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Klein, Rebecca C., Shawn K. Acheson, Laura H. Qadri, Alina A. Dawson, Ramona M. Rodriguiz, William C. Wetsel, Scott D. Moore, Daniel T. Laskowitz, and Hana N. Dawson. “Opposing effects of traumatic brain injury on excitatory synaptic function in the lateral amygdala in the absence and presence of preinjury stress.” J Neurosci Res 94, no. 6 (June 2016): 579–89. https://doi.org/10.1002/jnr.23702.Full Text Link to Item
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Wang, Xiaoming, Alexandra L. Bey, Brittany M. Katz, Alexandra Badea, Namsoo Kim, Lisa K. David, Lara J. Duffney, et al. “Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.” Nat Commun 7 (May 10, 2016): 11459. https://doi.org/10.1038/ncomms11459.Full Text Open Access Copy Link to Item
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Bao, Xuhui, Vidyalakshmi Chandramohan, Randall P. Reynolds, John N. Norton, William C. Wetsel, Ramona M. Rodriguiz, Dipendra K. Aryal, et al. “Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats.” Invest New Drugs 34, no. 2 (April 2016): 149–58. https://doi.org/10.1007/s10637-015-0318-3.Full Text Link to Item
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Urban, Daniel J., Hu Zhu, Catherine A. Marcinkiewcz, Michael Michaelides, Hidehiro Oshibuchi, Darren Rhea, Dipendra K. Aryal, et al. “Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons.” Neuropsychopharmacology 41, no. 5 (April 2016): 1404–15. https://doi.org/10.1038/npp.2015.293.Full Text Link to Item
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Matak, Pavle, Andrija Matak, Sarah Moustafa, Dipendra K. Aryal, Eric J. Benner, William Wetsel, and Nancy C. Andrews. “Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice.” Proc Natl Acad Sci U S A 113, no. 13 (March 29, 2016): 3428–35. https://doi.org/10.1073/pnas.1519473113.Full Text Link to Item
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Park, Su M., Meng Chen, Claire M. Schmerberg, Russell S. Dulman, Ramona M. Rodriguiz, Marc G. Caron, Jian Jin, and William C. Wetsel. “Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice.” Neuropsychopharmacology 41, no. 3 (February 2016): 704–15. https://doi.org/10.1038/npp.2015.196.Full Text Link to Item
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Cheng, Jianjun, Patrick M. Giguere, Claire M. Schmerberg, Vladimir M. Pogorelov, Ramona M. Rodriguiz, Xi-Ping Huang, Hu Zhu, et al. “Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.” J Med Chem 59, no. 2 (January 28, 2016): 578–91. https://doi.org/10.1021/acs.jmedchem.5b01153.Full Text Link to Item
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Farrell, Martilias S., John D. McCorvy, Xi-Ping Huang, Daniel J. Urban, Kate L. White, Patrick M. Giguere, Allison K. Doak, et al. “In Vitro and In Vivo Characterization of the Alkaloid Nuciferine.” Plos One 11, no. 3 (2016): e0150602. https://doi.org/10.1371/journal.pone.0150602.Full Text Link to Item
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Nagy, Eniko, Ramona M. Rodriguiz, William C. Wetsel, Nancie J. MacIver, and Laura P. Hale. “Reproduction and Growth in a Murine Model of Early Life-Onset Inflammatory Bowel Disease.” Plos One 11, no. 4 (2016): e0152764. https://doi.org/10.1371/journal.pone.0152764.Full Text Open Access Copy Link to Item
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Wu, Chia-Lung, Deeptee Jain, Jenna N. McNeill, Dianne Little, John A. Anderson, Janet L. Huebner, Virginia B. Kraus, Ramona M. Rodriguiz, William C. Wetsel, and Farshid Guilak. “Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury.” Ann Rheum Dis 74, no. 11 (November 2015): 2076–83. https://doi.org/10.1136/annrheumdis-2014-205601.Full Text Link to Item
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Scott, John W., Elizabeth Park, Ramona M. Rodriguiz, Jonathan S. Oakhill, Samah M. A. Issa, Matthew T. O’Brien, Toby A. Dite, et al. “Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder.” Sci Rep 5 (September 23, 2015): 14436. https://doi.org/10.1038/srep14436.Full Text Link to Item
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Cheng, Y., R. M. Rodriguiz, S. R. K. Murthy, V. Senatorov, E. Thouennon, N. X. Cawley, D. K. Aryal, et al. “Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone.” Mol Psychiatry 20, no. 6 (June 2015): 744–54. https://doi.org/10.1038/mp.2014.136.Full Text Link to Item
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Kim, Il Hwan, Mark A. Rossi, Dipendra K. Aryal, Bence Racz, Namsoo Kim, Akiyoshi Uezu, Fan Wang, et al. “Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.” Nat Neurosci 18, no. 6 (June 2015): 883–91. https://doi.org/10.1038/nn.4015.Full Text Link to Item
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Sachs, Benjamin D., Ramona M. Rodriguiz, Ha L. Tran, Akshita Iyer, William C. Wetsel, and Marc G. Caron. “Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience.” Psychoneuroendocrinology 53 (March 2015): 69–81. https://doi.org/10.1016/j.psyneuen.2014.12.019.Full Text Link to Item
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Cheng, Jianjun, Patrick M. Giguère, Oluseye K. Onajole, Wei Lv, Arsen Gaisin, Hendra Gunosewoyo, Claire M. Schmerberg, et al. “Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.” J Med Chem 58, no. 4 (February 26, 2015): 1992–2002. https://doi.org/10.1021/jm5019274.Full Text Link to Item
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Hunanyan, Arsen S., Nina A. Fainberg, Molly Linabarger, Eric Arehart, A Soren Leonard, Syed M. Adil, Ashley R. Helseth, et al. “Knock-in mouse model of alternating hemiplegia of childhood: behavioral and electrophysiologic characterization.” Epilepsia 56, no. 1 (January 2015): 82–93. https://doi.org/10.1111/epi.12878.Full Text Link to Item
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Weitzel, Douglas H., Artak Tovmasyan, Kathleen A. Ashcraft, Zrinka Rajic, Tin Weitner, Chunlei Liu, Wei Li, et al. “Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.” Mol Cancer Ther 14, no. 1 (January 2015): 70–79. https://doi.org/10.1158/1535-7163.MCT-14-0343.Full Text Link to Item
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Wang, Liangli, Ramona M. Rodriguiz, William C. Wetsel, Huaxin Sheng, Shengli Zhao, Xiaozhi Liu, Wulf Paschen, and Wei Yang. “Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.” J Psychiatry Neurosci 39, no. 4 (July 2014): 259–66. https://doi.org/10.1503/jpn.130148.Full Text Open Access Copy Link to Item
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Gaier, E. D., R. M. Rodriguiz, J. Zhou, M. Ralle, W. C. Wetsel, B. A. Eipper, and R. E. Mains. “In vivo and in vitro analyses of amygdalar function reveal a role for copper.” J Neurophysiol 111, no. 10 (May 2014): 1927–39. https://doi.org/10.1152/jn.00631.2013.Full Text Link to Item
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Deng, Jie V., Yehong Wan, Xiaoting Wang, Sonia Cohen, William C. Wetsel, Michael E. Greenberg, Paul J. Kenny, Nicole Calakos, and Anne E. West. “MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity.” J Neurosci 34, no. 13 (March 26, 2014): 4519–27. https://doi.org/10.1523/JNEUROSCI.2821-13.2014.Full Text Link to Item
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Gaier, Eric D., Megan B. Miller, Martina Ralle, Dipendra Aryal, William C. Wetsel, Richard E. Mains, and Betty A. Eipper. “Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity.” J Neurochem 127, no. 5 (December 2013): 605–19. https://doi.org/10.1111/jnc.12438.Full Text Link to Item
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Wetsel, William C., Ramona M. Rodriguiz, Johann Guillemot, Estelle Rousselet, Rachid Essalmani, Il Hwan Kim, Jesse C. Bryant, et al. “Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.” Proc Natl Acad Sci U S A 110, no. 43 (October 22, 2013): 17362–67. https://doi.org/10.1073/pnas.1314698110.Full Text Link to Item
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Ruzzo, Elizabeth K., José-Mario Capo-Chichi, Bruria Ben-Zeev, David Chitayat, Hanqian Mao, Andrea L. Pappas, Yuki Hitomi, et al. “Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy.” Neuron 80, no. 2 (October 16, 2013): 429–41. https://doi.org/10.1016/j.neuron.2013.08.013.Full Text Link to Item
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Gomes, Ivone, Dipendra K. Aryal, Jonathan H. Wardman, Achla Gupta, Khatuna Gagnidze, Ramona M. Rodriguiz, Sanjai Kumar, et al. “GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.” Proc Natl Acad Sci U S A 110, no. 40 (October 1, 2013): 16211–16. https://doi.org/10.1073/pnas.1312938110.Full Text Link to Item
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Sachs, Benjamin D., Ramona M. Rodriguiz, William B. Siesser, Alexander Kenan, Elizabeth L. Royer, Jacob P. R. Jacobsen, William C. Wetsel, and Marc G. Caron. “The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress.” Int J Neuropsychopharmacol 16, no. 9 (October 2013): 2081–94. https://doi.org/10.1017/S1461145713000321.Full Text Link to Item
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Wetsel, W. C., S. S. Moy, and Y. H. Jiang. “Mouse Behavioral Models for Autism Spectrum Disorders,” August 27, 2013, 363–78. https://doi.org/10.1016/B978-0-12-391924-3.00026-0.Full Text
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Rodriguiz, Ramona M., John J. Wilkins, Thomas K. Creson, Reeta Biswas, Iryna Berezniuk, Arun D. Fricker, Lloyd D. Fricker, and William C. Wetsel. “Emergence of anxiety-like behaviours in depressive-like Cpe(fat/fat) mice.” Int J Neuropsychopharmacol 16, no. 7 (August 2013): 1623–34. https://doi.org/10.1017/S1461145713000059.Full Text Link to Item
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Liu, Gumei, Bin Gu, Xiao-Ping He, Rasesh B. Joshi, Harold D. Wackerle, Ramona Marie Rodriguiz, William C. Wetsel, and James O. McNamara. “Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy.” Neuron 79, no. 1 (July 10, 2013): 31–38. https://doi.org/10.1016/j.neuron.2013.04.027.Full Text Open Access Copy Link to Item
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Kim, Il Hwan, Bence Racz, Hong Wang, Lauren Burianek, Richard Weinberg, Ryohei Yasuda, William C. Wetsel, and Scott H. Soderling. “Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities.” J Neurosci 33, no. 14 (April 3, 2013): 6081–92. https://doi.org/10.1523/JNEUROSCI.0035-13.2013.Full Text Link to Item
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Gaier, E. D., M. B. Miller, M. Ralle, D. Aryal, W. C. Wetsel, R. E. Mains, and B. A. Eipper. “Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity.” Journal of Neurochemistry, 2013.
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Sassano, M. F., J. A. Allen, J. Jin, V. Setola, W. C. Wetsel, M. G. Caron, and B. L. Roth. “D2 Functionally Selective Ligands: Novel Therapeutics?,” January 1, 2013, 105. https://doi.org/10.1016/B978-0-12-800044-1.00091-X.Full Text
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Besnard, Jérémy, Gian Filippo Ruda, Vincent Setola, Keren Abecassis, Ramona M. Rodriguiz, Xi-Ping Huang, Suzanne Norval, et al. “Automated design of ligands to polypharmacological profiles.” Nature 492, no. 7428 (December 13, 2012): 215–20. https://doi.org/10.1038/nature11691.Full Text Link to Item
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Por, Elaine D., Sonya M. Bierbower, Kelly A. Berg, Ruben Gomez, Armen N. Akopian, William C. Wetsel, and Nathaniel A. Jeske. “β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.” J Biol Chem 287, no. 44 (October 26, 2012): 37552–63. https://doi.org/10.1074/jbc.M112.391847.Full Text Link to Item
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Chen, Xin, Maria F. Sassano, Lianyou Zheng, Vincent Setola, Meng Chen, Xu Bai, Stephen V. Frye, William C. Wetsel, Bryan L. Roth, and Jian Jin. “Structure-functional selectivity relationship studies of β-arrestin-biased dopamine Dâ‚‚ receptor agonists.” J Med Chem 55, no. 16 (August 23, 2012): 7141–53. https://doi.org/10.1021/jm300603y.Full Text Link to Item
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Lee, Tong H., Steven T. Szabo, J Corey Fowler, Paolo Mannelli, O Barry Mangum, Wayne F. Beyer, Ashwin Patkar, and William C. Wetsel. “Pharmacologically-mediated reactivation and reconsolidation blockade of the psychostimulant-abuse circuit: a novel treatment strategy.” Drug Alcohol Depend 124, no. 1–2 (July 1, 2012): 11–18. https://doi.org/10.1016/j.drugalcdep.2012.01.021.Full Text Link to Item
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Cawley, Niamh X., William C. Wetsel, Saravana R. K. Murthy, Joshua J. Park, Karel Pacak, and Y Peng Loh. “New roles of carboxypeptidase E in endocrine and neural function and cancer.” Endocr Rev 33, no. 2 (April 2012): 216–53. https://doi.org/10.1210/er.2011-1039.Full Text Link to Item
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Fukada, Masahide, Atsuko Hanai, Atsuo Nakayama, Takayoshi Suzuki, Naoki Miyata, Ramona M. Rodriguiz, William C. Wetsel, Tso-Pang Yao, and Yoshiharu Kawaguchi. “Loss of deacetylation activity of Hdac6 affects emotional behavior in mice.” Plos One 7, no. 2 (2012): e30924. https://doi.org/10.1371/journal.pone.0030924.Full Text Link to Item
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Hutchinson, Ashley N., Jie V. Deng, Dipendra K. Aryal, William C. Wetsel, and Anne E. West. “Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.” Neuropsychopharmacology 37, no. 2 (January 2012): 321–37. https://doi.org/10.1038/npp.2011.190.Full Text Link to Item
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Wong, Peiyan, Cecilia Chin Roei Chang, Christine E. Marx, Marc G. Caron, William C. Wetsel, and Xiaodong Zhang. “Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice.” Plos One 7, no. 12 (2012): e51455. https://doi.org/10.1371/journal.pone.0051455.Full Text Link to Item
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Miller, Lydia K., Xiaowen Hou, Ramona M. Rodriguiz, Khatuna Gagnidze, Jonathan V. Sweedler, William C. Wetsel, and Lakshmi A. Devi. “Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord.” J Neurochem 119, no. 5 (December 2011): 1074–85. https://doi.org/10.1111/j.1471-4159.2011.07513.x.Full Text Link to Item
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Allen, John A., Julianne M. Yost, Vincent Setola, Xin Chen, Maria F. Sassano, Meng Chen, Sean Peterson, et al. “Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.” Proc Natl Acad Sci U S A 108, no. 45 (November 8, 2011): 18488–93. https://doi.org/10.1073/pnas.1104807108.Full Text Link to Item
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Daigle, Tanya L., William C. Wetsel, and Marc G. Caron. “Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.” Eur J Neurosci 34, no. 9 (November 2011): 1378–89. https://doi.org/10.1111/j.1460-9568.2011.07874.x.Full Text Link to Item
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Cohen, Sonia, Harrison W. Gabel, Martin Hemberg, Ashley N. Hutchinson, L Amanda Sadacca, Daniel H. Ebert, David A. Harmin, et al. “Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function.” Neuron 72, no. 1 (October 6, 2011): 72–85. https://doi.org/10.1016/j.neuron.2011.08.022.Full Text Link to Item
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Bhatia, Kamal S., Steven T. Szabo, J Corey Fowler, William C. Wetsel, and Tong H. Lee. “Reversal of long-term methamphetamine sensitization by combination of pergolide with ondansetron or ketanserin, but not mirtazapine.” Behav Brain Res 223, no. 1 (September 30, 2011): 227–32. https://doi.org/10.1016/j.bbr.2011.04.045.Full Text Link to Item
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Wang, Xiaoming, Portia A. McCoy, Ramona M. Rodriguiz, Yanzhen Pan, H Shawn Je, Adam C. Roberts, Caroline J. Kim, et al. “Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3.” Hum Mol Genet 20, no. 15 (August 1, 2011): 3093–3108. https://doi.org/10.1093/hmg/ddr212.Full Text Link to Item
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Porton, Barbara, William C. Wetsel, and Hung-Teh Kao. “Synapsin III: role in neuronal plasticity and disease.” Semin Cell Dev Biol 22, no. 4 (June 2011): 416–24. https://doi.org/10.1016/j.semcdb.2011.07.007.Full Text Link to Item
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Carlson, Benjamin R., Krissey E. Lloyd, Allison Kruszewski, Il-Hwan Kim, Ramona M. Rodriguiz, Clifford Heindel, Marika Faytell, Serena M. Dudek, William C. Wetsel, and Scott H. Soderling. “WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory.” J Neurosci 31, no. 7 (February 16, 2011): 2447–60. https://doi.org/10.1523/JNEUROSCI.4433-10.2011.Full Text Link to Item
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Wetsel, William C. “Sensing hot and cold with TRP channels.” Int J Hyperthermia 27, no. 4 (2011): 388–98. https://doi.org/10.3109/02656736.2011.554337.Full Text Link to Item
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Wetsel, William C. “Hyperthermic effects on behavior.” Int J Hyperthermia 27, no. 4 (2011): 353–73. https://doi.org/10.3109/02656736.2010.550905.Full Text Link to Item
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Rodriguiz, Ramona M., Jennifer S. Colvin, and William C. Wetsel. “Neurophenotyping genetically modified mice for social behavior.” Methods Mol Biol 768 (2011): 343–63. https://doi.org/10.1007/978-1-61779-204-5_19.Full Text Link to Item
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Gaier, Eric D., Ramona M. Rodriguiz, Xin-Ming M. Ma, Shobhana Sivaramakrishnan, Danielle Bousquet-Moore, William C. Wetsel, Betty A. Eipper, and Richard E. Mains. “Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses.” J Neurosci 30, no. 41 (October 13, 2010): 13656–69. https://doi.org/10.1523/JNEUROSCI.2200-10.2010.Full Text Link to Item
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Deng, Jie V., Ramona M. Rodriguiz, Ashley N. Hutchinson, Il-Hwan Kim, William C. Wetsel, and Anne E. West. “MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.” Nat Neurosci 13, no. 9 (September 2010): 1128–36. https://doi.org/10.1038/nn.2614.Full Text Link to Item
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Kile, Brian M., Thomas S. Guillot, B Jill Venton, William C. Wetsel, George J. Augustine, and R Mark Wightman. “Synapsins differentially control dopamine and serotonin release.” J Neurosci 30, no. 29 (July 21, 2010): 9762–70. https://doi.org/10.1523/JNEUROSCI.2071-09.2010.Full Text Link to Item
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McDowell, Kelli A., Ashley N. Hutchinson, Sarah J. E. Wong-Goodrich, Matthew M. Presby, Dan Su, Ramona M. Rodriguiz, Krystal C. Law, Christina L. Williams, William C. Wetsel, and Anne E. West. “Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice.” J Neurosci 30, no. 22 (June 2, 2010): 7453–65. https://doi.org/10.1523/JNEUROSCI.3997-09.2010.Full Text Link to Item
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Crooks, Kristy R., Daniel T. Kleven, Ramona M. Rodriguiz, William C. Wetsel, and James O. McNamara. “TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine.” Neuropharmacology 58, no. 7 (June 2010): 1067–77. https://doi.org/10.1016/j.neuropharm.2010.01.014.Full Text Link to Item
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Porton, B., R. M. Rodriguiz, L. E. Phillips, J. W. Gilbert, J. Feng, P. Greengard, H. -. T. Kao, and W. C. Wetsel. “Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear.” Genes Brain Behav 9, no. 3 (April 2010): 257–68. https://doi.org/10.1111/j.1601-183X.2009.00555.x.Full Text Link to Item
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Chen, Qiang, Xiongzhao Zhu, Yu Zhang, William C. Wetsel, Tong H. Lee, and Xiuwu Zhang. “Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation.” J Mol Neurosci 40, no. 3 (March 2010): 284–94. https://doi.org/10.1007/s12031-009-9218-3.Full Text Link to Item
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Bousquet-Moore, Danielle, Joseph R. Prohaska, Eduardo A. Nillni, Traci Czyzyk, William C. Wetsel, Richard E. Mains, and Betty A. Eipper. “Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction.” Neurobiol Dis 37, no. 1 (January 2010): 130–40. https://doi.org/10.1016/j.nbd.2009.09.016.Full Text Link to Item
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Griffin, Timothy M., Beverley Fermor, Janet L. Huebner, Virginia B. Kraus, Ramona M. Rodriguiz, William C. Wetsel, Li Cao, Lori A. Setton, and Farshid Guilak. “Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.” Arthritis Res Ther 12, no. 4 (2010): R130. https://doi.org/10.1186/ar3068.Full Text Open Access Copy Link to Item
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Yuan, Langtian, Jin-Soo Seo, Nam Sook Kang, Shahar Keinan, Sarah E. Steele, Gregory A. Michelotti, William C. Wetsel, et al. “Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse.” Mol Biosyst 5, no. 9 (September 2009): 927–30. https://doi.org/10.1039/b903036k.Full Text Link to Item
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Allen, Kyle D., Timothy M. Griffin, Ramona M. Rodriguiz, William C. Wetsel, Virginia B. Kraus, Janet L. Huebner, Lawrence M. Boyd, and Lori A. Setton. “Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen.” Arthritis Rheum 60, no. 9 (September 2009): 2684–93. https://doi.org/10.1002/art.24783.Full Text Link to Item
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Roberts, Adam C., Javier Díez-García, Ramona M. Rodriguiz, Iciar Paula López, Rafael Luján, Rebeca Martínez-Turrillas, Esther Picó, et al. “Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation.” Neuron 63, no. 3 (August 13, 2009): 342–56. https://doi.org/10.1016/j.neuron.2009.06.016.Full Text Link to Item
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Yan, Feng, Ruslan V. Bikbulatov, Viorel Mocanu, Nedyalka Dicheva, Carol E. Parker, William C. Wetsel, Philip D. Mosier, et al. “Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor.” Biochemistry 48, no. 29 (July 28, 2009): 6898–6908. https://doi.org/10.1021/bi900605n.Full Text Link to Item
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Nehrenberg, Derrick L., Ramona M. Rodriguiz, Michel Cyr, Xiaodong Zhang, Jean M. Lauder, Jean-Louis Gariépy, and William C. Wetsel. “An anxiety-like phenotype in mice selectively bred for aggression.” Behav Brain Res 201, no. 1 (July 19, 2009): 179–91. https://doi.org/10.1016/j.bbr.2009.02.010.Full Text Link to Item
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Schmalzigaug, Robert, Ramona M. Rodriguiz, Pamela E. Bonner, Collin E. Davidson, William C. Wetsel, and Richard T. Premont. “Impaired fear response in mice lacking GIT1.” Neurosci Lett 458, no. 2 (July 17, 2009): 79–83. https://doi.org/10.1016/j.neulet.2009.04.037.Full Text Link to Item
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Schmalzigaug, Robert, Ramona M. Rodriguiz, Lindsey E. Phillips, Collin E. Davidson, William C. Wetsel, and Richard T. Premont. “Anxiety-like behaviors in mice lacking GIT2.” Neurosci Lett 451, no. 2 (February 20, 2009): 156–61. https://doi.org/10.1016/j.neulet.2008.12.034.Full Text Link to Item
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Liu, Yingmiao, Qi-An Sun, Qiang Chen, Tong H. Lee, Yangzhong Huang, William C. Wetsel, Gregory A. Michelotti, Bruce A. Sullenger, and Xiuwu Zhang. “Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking.” J Neurochem 108, no. 1 (January 2009): 147–57. https://doi.org/10.1111/j.1471-4159.2008.05748.x.Full Text Link to Item
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Chen, Qiang, Xueying Xiong, Tong H. Lee, Yingmiao Liu, William C. Wetsel, and Xiuwu Zhang. “Neural plasticity and addiction: integrin-linked kinase and cocaine behavioral sensitization.” J Neurochem 107, no. 3 (November 2008): 679–89. https://doi.org/10.1111/j.1471-4159.2008.05619.x.Full Text Link to Item
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Taylor, Gregory A., Ramona M. Rodriguiz, Robert I. Greene, Xiaoju Daniell, Stanley C. Henry, Kristy R. Crooks, Robert Kotloski, Lino Tessarollo, Lindsey E. Phillips, and William C. Wetsel. “Behavioral characterization of P311 knockout mice.” Genes Brain Behav 7, no. 7 (October 2008): 786–95. https://doi.org/10.1111/j.1601-183X.2008.00420.x.Full Text Link to Item
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Jensen, Niels H., Ramona M. Rodriguiz, Marc G. Caron, William C. Wetsel, Richard B. Rothman, and Bryan L. Roth. “N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity.” Neuropsychopharmacology 33, no. 10 (September 2008): 2303–12. https://doi.org/10.1038/sj.npp.1301646.Full Text Link to Item
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Ream, Margie A., Rashmi Chandra, Mary Peavey, Alisa M. Ray, Suzanne Roffler-Tarlov, Hyung-Gun Kim, William C. Wetsel, Howard A. Rockman, and Dona M. Chikaraishi. “High oxygen prevents fetal lethality due to lack of catecholamines.” Am J Physiol Regul Integr Comp Physiol 295, no. 3 (September 2008): R942–53. https://doi.org/10.1152/ajpregu.00860.2007.Full Text Link to Item
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Chen, Qiang, Xueying Xiong, Tong H. Lee, Yingmiao Liu, Qi-An Sun, William Wetsel, and Xiuwu Zhang. “Adeno-associated virus-mediated ILK gene silencing in the rat NAc core.” J Neurosci Methods 173, no. 2 (August 30, 2008): 208–14. https://doi.org/10.1016/j.jneumeth.2008.06.004.Full Text Link to Item
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Rodriguiz, R. M., K. Gadnidze, A. Ragnauth, N. Dorr, M. Yanagisawa, W. C. Wetsel, and L. A. Devi. “Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory.” Genes Brain Behav 7, no. 4 (June 2008): 418–26. https://doi.org/10.1111/j.1601-183X.2007.00365.x.Full Text Link to Item
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Beaulieu, J. M., X. Zhang, R. M. Rodriguiz, T. D. Sotnikova, W. C. Wetsel, R. R. Gainetdinov, and M. G. Caron. “Reply to Belmaker et al.: GSK3β haploinsufficiency results in lithium-like effects in the forced-swim test.” Proceedings of the National Academy of Sciences of the United States of America 105, no. 20 (May 20, 2008). https://doi.org/10.1073/pnas.0803026105.Full Text
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Beaulieu, Jean-Martin, Xiaodong Zhang, Ramona M. Rodriguiz, Tatyana D. Sotnikova, Michael J. Cools, William C. Wetsel, Raul R. Gainetdinov, and Marc G. Caron. “Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency.” Proc Natl Acad Sci U S A 105, no. 4 (January 29, 2008): 1333–38. https://doi.org/10.1073/pnas.0711496105.Full Text Link to Item
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Beaulieu, Jean-Martin, Sébastien Marion, Ramona M. Rodriguiz, Ivan O. Medvedev, Tatyana D. Sotnikova, Valentina Ghisi, William C. Wetsel, Robert J. Lefkowitz, Raul R. Gainetdinov, and Marc G. Caron. “A beta-arrestin 2 signaling complex mediates lithium action on behavior.” Cell 132, no. 1 (January 11, 2008): 125–36. https://doi.org/10.1016/j.cell.2007.11.041.Full Text Link to Item
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Woronowicz, Alicja, Hisatsugu Koshimizu, Su-Youne Chang, Niamh X. Cawley, Joanna M. Hill, Ramona M. Rodriguiz, Daniel Abebe, et al. “Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits.” Hippocampus 18, no. 10 (2008): 1051–63. https://doi.org/10.1002/hipo.20462.Full Text Link to Item
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Fukui, Masato, Ramona M. Rodriguiz, Jiechun Zhou, Sara X. Jiang, Lindsey E. Phillips, Marc G. Caron, and William C. Wetsel. “Vmat2 heterozygous mutant mice display a depressive-like phenotype.” J Neurosci 27, no. 39 (September 26, 2007): 10520–29. https://doi.org/10.1523/JNEUROSCI.4388-06.2007.Full Text Link to Item
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Welch, Jeffrey M., Jing Lu, Ramona M. Rodriguiz, Nicholas C. Trotta, Joao Peca, Jin-Dong Ding, Catia Feliciano, et al. “Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice.” Nature 448, no. 7156 (August 23, 2007): 894–900. https://doi.org/10.1038/nature06104.Full Text Link to Item
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Porton, Barbara, and William C. Wetsel. “Reduction of synapsin III in the prefrontal cortex of individuals with schizophrenia.” Schizophr Res 94, no. 1–3 (August 2007): 366–70. https://doi.org/10.1016/j.schres.2007.04.016.Full Text Link to Item
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Chen, Qiang, Tong H. Lee, William C. Wetsel, Qi-An Sun, Yingmiao Liu, Colin Davidson, Xueying Xiong, Everett H. Ellinwood, and Xiuwu Zhang. “Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABAA receptor alpha2 subunit expression, and PKC zeta activity.” Biochem Biophys Res Commun 356, no. 3 (May 11, 2007): 733–38. https://doi.org/10.1016/j.bbrc.2007.03.041.Full Text Link to Item
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Badea, Alexandra, Peter J. Nicholls, G Allan Johnson, and William C. Wetsel. “Neuroanatomical phenotypes in the reeler mouse.” Neuroimage 34, no. 4 (February 15, 2007): 1363–74. https://doi.org/10.1016/j.neuroimage.2006.09.053.Full Text Link to Item
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Zhang, Xiuwu, Tong H. Lee, Colin Davidson, Cindy Lazarus, William C. Wetsel, and Everett H. Ellinwood. “Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors.” Neuropsychopharmacology 32, no. 2 (February 2007): 377–87. https://doi.org/10.1038/sj.npp.1301101.Full Text Link to Item
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Zhang, Xiuwu, Tong H. Lee, Xueying Xiong, Qiang Chen, Colin Davidson, William C. Wetsel, and Everett H. Ellinwood. “Methamphetamine induces long-term changes in GABAA receptor alpha2 subunit and GAD67 expression.” Biochem Biophys Res Commun 351, no. 1 (December 8, 2006): 300–305. https://doi.org/10.1016/j.bbrc.2006.10.046.Full Text Link to Item
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Prado, Vania F., Cristina Martins-Silva, Braulio M. de Castro, Ricardo F. Lima, Daniela M. Barros, Ernani Amaral, Amy J. Ramsey, et al. “Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition.” Neuron 51, no. 5 (September 7, 2006): 601–12. https://doi.org/10.1016/j.neuron.2006.08.005.Full Text Link to Item
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Venton, B Jill, Andrew T. Seipel, Paul E. M. Phillips, William C. Wetsel, Daniel Gitler, Paul Greengard, George J. Augustine, and R Mark Wightman. “Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool.” J Neurosci 26, no. 12 (March 22, 2006): 3206–9. https://doi.org/10.1523/JNEUROSCI.4901-04.2006.Full Text Link to Item
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Zhang, Xiuwu, Jing Mi, William C. Wetsel, Colin Davidson, Xieying Xiong, Qiang Chen, Everett H. Ellinwood, and Tong H. Lee. “PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity.” Biochem Biophys Res Commun 340, no. 4 (February 24, 2006): 1144–50. https://doi.org/10.1016/j.bbrc.2005.12.114.Full Text Link to Item
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Pogorelov, Vladimir M., Ramona M. Rodriguiz, Megan L. Insco, Marc G. Caron, and William C. Wetsel. “Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene.” Neuropsychopharmacology 30, no. 10 (October 2005): 1818–31. https://doi.org/10.1038/sj.npp.1300724.Full Text Link to Item
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Gammon, C Michael, G Mark Freeman, Weihua Xie, Sandra L. Petersen, and William C. Wetsel. “Regulation of gonadotropin-releasing hormone secretion by cannabinoids.” Endocrinology 146, no. 10 (October 2005): 4491–99. https://doi.org/10.1210/en.2004-1672.Full Text Link to Item
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Pogorelov, V. M., R. M. Rodriguiz, M. L. Insco, M. G. Caron, and W. C. Wetsel. “Erratum: Novelty seeking and stereotypic activation of behavior in mice with disruption of the DatI gene (Neuropsychopharmacology (April 27, 2005), DOI:10.1038/sj.npp.1300724).” Neuropsychopharmacology 30, no. 9 (September 1, 2005): 1772. https://doi.org/10.1038/sj.npp.1300797.Full Text
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Sotnikova, Tatyana D., Jean-Martin Beaulieu, Larry S. Barak, William C. Wetsel, Marc G. Caron, and Raul R. Gainetdinov. “Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease.” Plos Biol 3, no. 8 (August 2005): e271. https://doi.org/10.1371/journal.pbio.0030271.Full Text Link to Item
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Pillai-Nair, Neeta, Anitha K. Panicker, Ramona M. Rodriguiz, Kelly L. Gilmore, Galina P. Demyanenko, Josh Z. Huang, William C. Wetsel, and Patricia F. Maness. “Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior.” J Neurosci 25, no. 18 (May 4, 2005): 4659–71. https://doi.org/10.1523/JNEUROSCI.0565-05.2005.Full Text Link to Item
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Jacobsen, J. P. R., R. M. Rodriguiz, A. Mørk, and W. C. Wetsel. “Monoaminergic dysregulation in glutathione-deficient mice: possible relevance to schizophrenia?” Neuroscience 132, no. 4 (2005): 1055–72. https://doi.org/10.1016/j.neuroscience.2005.01.059.Full Text Link to Item
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Gitler, Daniel, Yoshiko Takagishi, Jian Feng, Yong Ren, Ramona M. Rodriguiz, William C. Wetsel, Paul Greengard, and George J. Augustine. “Different presynaptic roles of synapsins at excitatory and inhibitory synapses.” J Neurosci 24, no. 50 (December 15, 2004): 11368–80. https://doi.org/10.1523/JNEUROSCI.3795-04.2004.Full Text Link to Item
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Cawley, Niamh X., Jiechun Zhou, Joanna M. Hill, Daniel Abebe, Sylvie Romboz, Tulin Yanik, Ramona M. Rodriguiz, William C. Wetsel, and Y Peng Loh. “The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits.” Endocrinology 145, no. 12 (December 2004): 5807–19. https://doi.org/10.1210/en.2004-0847.Full Text Link to Item
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Grove, Matthew, Galina Demyanenko, Asier Echarri, Patricia A. Zipfel, Marisol E. Quiroz, Ramona M. Rodriguiz, Martin Playford, et al. “ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.” Mol Cell Biol 24, no. 24 (December 2004): 10905–22. https://doi.org/10.1128/MCB.24.24.10905-10922.2004.Full Text Link to Item
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Quan, Hui, Krairerk Athirakul, William C. Wetsel, Gonzalo E. Torres, Robert Stevens, Y. T. Chen, Thomas M. Coffman, and Marc G. Caron. “Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2.” Mol Cell Biol 24, no. 10 (May 2004): 4166–73. https://doi.org/10.1128/MCB.24.10.4166-4173.2004.Full Text Link to Item
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Srinivasan, Sudha, Donna O. Bunch, Yun Feng, Ramona M. Rodriguiz, Min Li, Roneka L. Ravenell, Guo X. Luo, et al. “Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice.” Endocrinology 145, no. 4 (April 2004): 2023–34. https://doi.org/10.1210/en.2003-1442.Full Text Link to Item
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Rodriguiz, Ramona M., Richard Chu, Marc G. Caron, and William C. Wetsel. “Aberrant responses in social interaction of dopamine transporter knockout mice.” Behav Brain Res 148, no. 1–2 (January 5, 2004): 185–98. https://doi.org/10.1016/s0166-4328(03)00187-6.Full Text Link to Item
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Longo, Maurizio, Marina Brama, Maria Marino, Silvia Bernardini, Kenneth S. Korach, William C. Wetsel, Roberto Scandurra, et al. “Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation.” Bone 34, no. 1 (January 2004): 100–111. https://doi.org/10.1016/j.bone.2003.09.007.Full Text Link to Item
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Trinh, J. V., D. L. Nehrenberg, J. P. R. Jacobsen, M. G. Caron, and W. C. Wetsel. “Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice.” Neuroscience 118, no. 2 (2003): 297–310. https://doi.org/10.1016/s0306-4522(03)00165-9.Full Text Link to Item
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Nillni, Eduardo A., Weihua Xie, Lawrence Mulcahy, Vanesa C. Sanchez, and William C. Wetsel. “Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.” J Biol Chem 277, no. 50 (December 13, 2002): 48587–95. https://doi.org/10.1074/jbc.M206702200.Full Text Link to Item
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Haller, József, Nikoletta Bakos, Ramona M. Rodriguiz, Marc G. Caron, William C. Wetsel, and Zsolt Liposits. “Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depression.” Brain Res Bull 58, no. 3 (July 2002): 279–84. https://doi.org/10.1016/s0361-9230(02)00789-x.Full Text Link to Item
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Wetsel, William C., and Sudha Srinivasan. “Pro-GnRH processing.” Prog Brain Res 141 (2002): 221–41. https://doi.org/10.1016/S0079-6123(02)41096-5.Full Text Link to Item
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Kreda, S. M., M. Sumner, S. Fillo, C. M. Ribeiro, G. X. Luo, W. Xie, K. W. Daniel, S. Shears, S. Collins, and W. C. Wetsel. “alpha(1)-adrenergic receptors mediate LH-releasing hormone secretion through phospholipases C and A(2) in immortalized hypothalamic neurons.” Endocrinology 142, no. 11 (November 2001): 4839–51. https://doi.org/10.1210/endo.142.11.8506.Full Text Link to Item
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Ribar, T. J., R. M. Rodriguiz, L. Khiroug, W. C. Wetsel, G. J. Augustine, and A. R. Means. “Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice.” J Neurosci 20, no. 22 (November 15, 2000): RC107. https://doi.org/10.1523/JNEUROSCI.20-22-j0004.2000.Full Text Link to Item
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Jeohn, G. H., B. Wilson, W. C. Wetsel, and J. S. Hong. “The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures.” Brain Res Mol Brain Res 79, no. 1–2 (June 23, 2000): 32–44. https://doi.org/10.1016/s0169-328x(00)00082-6.Full Text Link to Item
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Jeohn, G. H., R. C. Chang, W. G. Kim, B. Wilson, R. P. Mohney, W. C. Wetsel, and J. S. Hong. “Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by Gö6976 in murine microglia.” Brain Res Mol Brain Res 79, no. 1–2 (June 23, 2000): 18–31. https://doi.org/10.1016/s0169-328x(00)00081-4.Full Text Link to Item
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Xu, F., R. R. Gainetdinov, W. C. Wetsel, S. R. Jones, L. M. Bohn, G. W. Miller, Y. M. Wang, and M. G. Caron. “Mice lacking the norepinephrine transporter are supersensitive to psychostimulants.” Nat Neurosci 3, no. 5 (May 2000): 465–71. https://doi.org/10.1038/74839.Full Text Link to Item
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Sarkis, E. H. “"Model" behavior.” Science 287, no. 5461 (March 24, 2000): 2160–62. https://doi.org/10.1126/science.287.5461.2159e.Full Text Link to Item
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Davis, B. J., D. E. Lennard, C. A. Lee, H. F. Tiano, S. G. Morham, W. C. Wetsel, and R. Langenbach. “Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta.” Endocrinology 140, no. 6 (June 1999): 2685–95. https://doi.org/10.1210/endo.140.6.6715.Full Text Link to Item
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Isaac, R. E., A. Michaud, J. N. Keen, T. A. Williams, D. Coates, W. C. Wetsel, and P. Corvol. “Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin.” Eur J Biochem 262, no. 2 (June 1999): 569–74. https://doi.org/10.1046/j.1432-1327.1999.00419.x.Full Text Link to Item
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Gainetdinov, R. R., W. C. Wetsel, S. R. Jones, E. D. Levin, M. Jaber, and M. G. Caron. “Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.” Science 283, no. 5400 (January 15, 1999): 397–401. https://doi.org/10.1126/science.283.5400.397.Full Text Link to Item
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Migliaccio, S., T. F. Washburn, S. Fillo, H. Rivera, A. Teti, K. S. Korach, and W. C. Wetsel. “Modulation of estrogen receptor levels in mouse uterus by protein kinase C isoenzymes.” Endocrinology 139, no. 11 (November 1998): 4598–4606. https://doi.org/10.1210/endo.139.11.6300.Full Text Link to Item
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Lindzey, J., W. C. Wetsel, J. F. Couse, T. Stoker, R. Cooper, and K. S. Korach. “Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-alpha knockout mice.” Endocrinology 139, no. 10 (October 1998): 4092–4101. https://doi.org/10.1210/endo.139.10.6253.Full Text Link to Item
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Migliaccio, S., S. Bernardini, W. C. Wetsel, K. S. Korach, T. Faraggiana, and A. Teti. “Protein kinase C modulates estrogen receptors in differentiated osteoblastic cells in vitro.” Steroids 63, no. 5–6 (1998): 352–54. https://doi.org/10.1016/s0039-128x(98)00040-3.Full Text Link to Item
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Colombo, P. J., W. C. Wetsel, and M. Gallagher. “Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats.” Proc Natl Acad Sci U S A 94, no. 25 (December 9, 1997): 14195–99. https://doi.org/10.1073/pnas.94.25.14195.Full Text Link to Item
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Caron, K. M., S. C. Soo, W. C. Wetsel, D. M. Stocco, B. J. Clark, and K. L. Parker. “Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia.” Proc Natl Acad Sci U S A 94, no. 21 (October 14, 1997): 11540–45. https://doi.org/10.1073/pnas.94.21.11540.Full Text Link to Item
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Bossé, R., F. Fumagalli, M. Jaber, B. Giros, R. R. Gainetdinov, W. C. Wetsel, C. Missale, and M. G. Caron. “Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter.” Neuron 19, no. 1 (July 1997): 127–38. https://doi.org/10.1016/s0896-6273(00)80353-0.Full Text Link to Item
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Ma, Y. J., K. Berg-von der Emde, F. Rage, W. C. Wetsel, and S. R. Ojeda. “Hypothalamic astrocytes respond to transforming growth factor-alpha with the secretion of neuroactive substances that stimulate the release of luteinizing hormone-releasing hormone.” Endocrinology 138, no. 1 (January 1997): 19–25. https://doi.org/10.1210/endo.138.1.4863.Full Text Link to Item
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Pascale, A., I. Fortino, S. Govoni, M. Trabucchi, W. C. Wetsel, and F. Battaini. “Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex.” J Neurochem 67, no. 6 (December 1996): 2471–77. https://doi.org/10.1046/j.1471-4159.1996.67062471.x.Full Text Link to Item
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Zappelli, F., D. Willems, S. Osada, S. Ohno, W. C. Wetsel, M. Molinaro, G. Cossu, and M. Bouché. “The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.” Dev Biol 180, no. 1 (November 25, 1996): 156–64. https://doi.org/10.1006/dbio.1996.0292.Full Text Link to Item
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Pascale, A., I. Fortino, S. Govoni, M. Trabucchi, W. C. Wetsel, and F. Battaini. “Differential isoform-specific regulation of calcium-independent protein kinase C in rat cerebral cortex.” Neurosci Lett 214, no. 2–3 (August 23, 1996): 99–102. https://doi.org/10.1016/0304-3940(96)12901-3.Full Text Link to Item
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Voigt, P., Y. J. Ma, D. Gonzalez, W. H. Fahrenbach, W. C. Wetsel, K. Berg-von der Emde, D. F. Hill, et al. “Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons.” Endocrinology 137, no. 6 (June 1996): 2593–2605. https://doi.org/10.1210/endo.137.6.8641214.Full Text Link to Item
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Wetsel, W. C., D. F. Hill, and S. R. Ojeda. “Basic fibroblast growth factor regulates the conversion of pro-luteinizing hormone-releasing hormone (Pro-LHRH) to LHRH in immortalized hypothalamic neurons.” Endocrinology 137, no. 6 (June 1996): 2606–16. https://doi.org/10.1210/endo.137.6.8641215.Full Text Link to Item
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Chen, W., W. Wetsel, C. Steenbergen, and E. Murphy. “Effect of ischemic preconditioning and PKC activation on acidification during ischemia in rat heart.” J Mol Cell Cardiol 28, no. 5 (May 1996): 871–80. https://doi.org/10.1006/jmcc.1996.0082.Full Text Link to Item
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Belsham, D. D., W. C. Wetsel, and P. L. Mellon. “NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression.” Embo J 15, no. 3 (February 1, 1996): 538–47.Link to Item
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Bergamaschi, S., G. Binetti, S. Govoni, W. C. Wetsel, F. Battaini, M. Trabucchi, A. Bianchetti, and M. Racchi. “Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts.” Neurosci Lett 201, no. 1 (December 1, 1995): 1–5. https://doi.org/10.1016/0304-3940(95)12168-4.Full Text Link to Item
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Wetsel, W. C., Z. Liposits, N. G. Seidah, and S. Collins. “Expression of candidate pro-GnRH processing enzymes in rat hypothalamus and an immortalized hypothalamic neuronal cell line.” Neuroendocrinology 62, no. 2 (August 1995): 166–77. https://doi.org/10.1159/000127001.Full Text Link to Item
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Olson, B. R., D. C. Scott, W. C. Wetsel, S. J. Elliot, M. Tomic, S. Stojilkovic, L. K. Nieman, and S. Wray. “Effects of insulin-like growth factors I and II and insulin on the immortalized hypothalamic GTI-7 cell line.” Neuroendocrinology 62, no. 2 (August 1995): 155–65. https://doi.org/10.1159/000127000.Full Text Link to Item
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Bouché, M., F. Zappelli, M. Polimeni, S. Adamo, W. C. Wetsel, M. I. Senni, and M. Molinaro. “Rapid activation and down-regulation of protein kinase C alpha in 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells.” Cell Growth Differ 6, no. 7 (July 1995): 845–52.Link to Item
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Wetsel, W. C. “Immortalized hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons: a new tool for dissecting the molecular and cellular basis of LHRH physiology.” Cell Mol Neurobiol 15, no. 1 (February 1995): 43–78. https://doi.org/10.1007/BF02069558.Full Text Link to Item
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Battaini, F., S. Elkabes, S. Bergamaschi, V. Ladisa, L. Lucchi, P. N. De Graan, T. Schuurman, W. C. Wetsel, M. Trabucchi, and S. Govoni. “Protein kinase C activity, translocation, and conventional isoforms in aging rat brain.” Neurobiol Aging 16, no. 2 (1995): 137–48. https://doi.org/10.1016/0197-4580(94)00154-5.Full Text Link to Item
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Racchi, M., S. Bergamaschi, S. Govoni, W. C. Wetsel, A. Bianchetti, G. Binetti, F. Battaini, and M. Trabucchi. “Characterization and distribution of protein kinase C isoforms in human skin fibroblasts.” Arch Biochem Biophys 314, no. 1 (October 1994): 107–11. https://doi.org/10.1006/abbi.1994.1417.Full Text Link to Item
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Battaini, F., A. Pascale, L. Lucchi, M. Racchi, S. Bergamaschi, M. Parenti, W. C. Wetsel, S. Govoni, and M. Trabucchi. “Expression and regulation of calcium-independent protein kinase C in NG 108-15 cell differentiation.” Biochem Biophys Res Commun 203, no. 3 (September 30, 1994): 1423–31. https://doi.org/10.1006/bbrc.1994.2344.Full Text Link to Item
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Battaini, F., G. Garbillo, S. Bergamaschi, M. Parenti, W. C. Wetsel, S. Govoni, and M. Trabucchi. “Regulation of protein kinase C in NG108-15 cell differentiation.” Biochem Biophys Res Commun 201, no. 1 (May 30, 1994): 135–42. https://doi.org/10.1006/bbrc.1994.1679.Full Text Link to Item
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Ghalayini, A. J., C. A. Koutz, W. C. Wetsel, Y. A. Hannun, and R. E. Anderson. “Immunolocalization of PKC zeta in rat photoreceptor inner segments.” Curr Eye Res 13, no. 2 (February 1994): 145–50. https://doi.org/10.3109/02713689409042409.Full Text Link to Item
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Favit, A., W. C. Wetsel, and A. Negro-Vilar. “Differential expression of gamma-aminobutyric acid receptors in immortalized luteinizing hormone-releasing hormone neurons.” Endocrinology 133, no. 5 (November 1993): 1983–89. https://doi.org/10.1210/endo.133.5.8404645.Full Text Link to Item
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Merchenthaler, I., Z. Liposits, J. J. Reid, and W. C. Wetsel. “Light and electron microscopic immunocytochemical localization of PKC delta immunoreactivity in the rat central nervous system.” J Comp Neurol 336, no. 3 (October 15, 1993): 378–99. https://doi.org/10.1002/cne.903360306.Full Text Link to Item
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Migliaccio, S., W. C. Wetsel, W. M. Fox, T. F. Washburn, and K. S. Korach. “Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels.” Mol Endocrinol 7, no. 9 (September 1993): 1133–43. https://doi.org/10.1210/mend.7.9.8247015.Full Text Link to Item
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Wetsel, W. C., S. A. Eraly, D. B. Whyte, and P. L. Mellon. “Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons.” Endocrinology 132, no. 6 (June 1993): 2360–70. https://doi.org/10.1210/endo.132.6.8504741.Full Text Link to Item
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Khan, W. A., G. Blobe, A. Halpern, W. Taylor, W. C. Wetsel, D. Burns, C. Loomis, and Y. A. Hannun. “Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets.” J Biol Chem 268, no. 7 (March 5, 1993): 5063–68.Link to Item
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Blobe, G. C., C. W. Sachs, W. A. Khan, D. Fabbro, S. Stabel, W. C. Wetsel, L. M. Obeid, R. L. Fine, and Y. A. Hannun. “Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.” J Biol Chem 268, no. 1 (January 5, 1993): 658–64.Link to Item
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Wetsel, W. C., M. M. Valença, I. Merchenthaler, Z. Liposits, F. J. López, R. I. Weiner, P. L. Mellon, and A. Negro-Vilar. “Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons.” Proc Natl Acad Sci U S A 89, no. 9 (May 1, 1992): 4149–53. https://doi.org/10.1073/pnas.89.9.4149.Full Text Link to Item
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Weiner, R. I., W. Wetsel, P. Goldsmith, G. Martinez de la Escalera, J. Windle, C. Padula, A. Choi, A. Negro-Vilar, and P. Mellon. “Gonadotropin-releasing hormone neuronal cell lines.” Front Neuroendocrinol 13, no. 2 (April 1992): 95–119.Link to Item
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Wetsel, W. C., W. A. Khan, I. Merchenthaler, H. Rivera, A. E. Halpern, H. M. Phung, A. Negro-Vilar, and Y. A. Hannun. “Tissue and cellular distribution of the extended family of protein kinase C isoenzymes.” J Cell Biol 117, no. 1 (April 1992): 121–33. https://doi.org/10.1083/jcb.117.1.121.Full Text Link to Item
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Alessenko, A., W. A. Khan, W. C. Wetsel, and Y. A. Hannun. “Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration.” Biochem Biophys Res Commun 182, no. 3 (February 14, 1992): 1333–39. https://doi.org/10.1016/0006-291x(92)91879-u.Full Text Link to Item
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Mellon, P. L., W. C. Wetsel, J. J. Windle, M. M. Valença, P. C. Goldsmith, D. B. Whyte, S. A. Eraly, A. Negro-Vilar, and R. I. Weiner. “Immortalized hypothalamic gonadotropin-releasing hormone neurons.” Ciba Found Symp 168 (1992): 104–17. https://doi.org/10.1002/9780470514283.ch8.Full Text Link to Item
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Liposits, Z., I. Merchenthaler, W. C. Wetsel, J. J. Reid, P. L. Mellon, R. I. Weiner, and A. Negro-Vilar. “Morphological characterization of immortalized hypothalamic neurons synthesizing luteinizing hormone-releasing hormone.” Endocrinology 129, no. 3 (September 1991): 1575–83. https://doi.org/10.1210/endo-129-3-1575.Full Text Link to Item
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Wetsel, W. C., P. L. Mellon, R. I. Weiner, and A. Negro-Vilar. “Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons.” Endocrinology 129, no. 3 (September 1991): 1584–95. https://doi.org/10.1210/endo-129-3-1584.Full Text Link to Item
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Cubeddu, L. X., C. M. Lindley, W. Wetsel, P. L. Carl, and A. Negro-Vilar. “Role of angiotensin II and vasopressin in cisplatin-induced emesis.” Life Sci 46, no. 10 (1990): 699–705. https://doi.org/10.1016/0024-3205(90)90075-3.Full Text Link to Item
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Wetsel, W. C., and A. Negro-Vilar. “Testosterone selectively influences protein kinase-C-coupled secretion of proluteinizing hormone-releasing hormone-derived peptides.” Endocrinology 125, no. 1 (July 1989): 538–47. https://doi.org/10.1210/endo-125-1-538.Full Text Link to Item
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Wetsel, W., and A. Negro-Vilar. “Combined antibody-high-performance liquid chromatography approach to assess prohormone processing.” Methods Enzymol 168 (1989): 517–45. https://doi.org/10.1016/0076-6879(89)68040-8.Full Text Link to Item
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Wetsel, W. C., M. D. Culler, C. A. Johnston, and A. Negro-Vilar. “Processing of the luteinizing hormone-releasing hormone precursor in the preoptic area and hypothalamus of the rat.” Mol Endocrinol 2, no. 1 (January 1988): 22–31. https://doi.org/10.1210/mend-2-1-22.Full Text Link to Item
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Valenca, M. M., W. C. Wetsel, M. D. Culler, and A. Negro-Vilar. “Differential secretion of proLHRH fragments in response to [K+], prostaglandin E2 and C kinase activation.” Mol Cell Endocrinol 55, no. 1 (January 1988): 95–100. https://doi.org/10.1016/0303-7207(88)90095-0.Full Text Link to Item
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Wetsel, W. C., and J. D. Fernstrom. “In vivo biosynthesis of arginine vasopressin and oxytocin in hypothalami from intact and hypophysectomized rats.” Endocrinology 120, no. 6 (June 1987): 2562–68. https://doi.org/10.1210/endo-120-6-2562.Full Text Link to Item
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Culler, M. C., W. C. Wetsel, M. M. Valenca, C. A. Johnston, C. Masotto, M. Sar, and A. Negro-Vilar. “Orchidectomy induces temporal and regional changes in the synthesis and processing of the LHRH prohormone in the rat brain.” Adv Exp Med Biol 219 (1987): 623–28. https://doi.org/10.1007/978-1-4684-5395-9_32.Full Text Link to Item
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Wetsel, W. C., and J. D. Fernstrom. “Effect of hypophysectomy on somatostatin-14 and somatostatin-28 biosynthesis in the rat hypothalamus.” Brain Res 370, no. 2 (April 9, 1986): 315–20. https://doi.org/10.1016/0006-8993(86)90486-5.Full Text Link to Item
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Wetsel, W. C., and A. E. Rogers. “Hepatic prolactin binding in female Sprague-Dawley rats fed a diet high in corn oil.” J Natl Cancer Inst 73, no. 2 (August 1984): 531–36. https://doi.org/10.1093/jnci/73.2.531.Full Text Link to Item
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Wetsel, W. C., A. E. Rogers, A. Rutledge, and W. W. Leavitt. “Absence of an effect of dietary corn oil content on plasma prolactin, progesterone, and 17 beta-estradiol in female Sprague-Dawley rats.” Cancer Res 44, no. 4 (April 1984): 1420–25.Link to Item
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Wetsel, W. C., and A. E. Rogers. “Hepatic prolactin binding in female rats fed control or high corn oil diets.” Federation Proceedings 43, no. 3 (January 1, 1984).
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Rogers, A. E., and W. C. Wetsel. “Mammary carcinogenesis in rats fed different amounts and types of fat.” Cancer Res 41, no. 9 Pt 2 (September 1981): 3735–37.Link to Item
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Rogers, A. E., and W. C. Wetsel. “Mammary Carcinogenesis In Rats Fed Different Amounts And Types Of Fat.” Cancer Research 41 (September 1, 1981): 3735–37.
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Wetsel, W. C., A. E. Rogers, and P. M. Newberne. “Dietary fat and DMBA mammary carcinogenesis in rats.” Cancer Detect Prev 4, no. 1–4 (1981): 535–43.Link to Item
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Wetsel, W. C., and A. E. Rogers. “Effect of dietary fat on mammary carcinogenesis and serum prolactin in rats.” Federation Proceedings 39, no. 3 II (January 1, 1980): 3248.
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Treichler, F. R., and W. C. Wetsel. “Pressure influences on air-licking behavior of rats.” Physiological Psychology 6, no. 3 (January 1, 1978): 399–402. https://doi.org/10.3758/BF03326747.Full Text
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Treichler, F. R., W. C. Wetsel, and S. A. Lesner. “Some characteristics of concurrent discrimination and retention by monkeys.” Learning and Motivation 8, no. 2 (January 1, 1977): 213–28. https://doi.org/10.1016/0023-9690(77)90006-6.Full Text
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Wetsel, W. C., D. C. Riccio, and C. F. Hinderliter. “Effects of artificial rewarming upon hypothermia-induced retrograde amnesia.” Physiological Psychology 4, no. 2 (January 1, 1976): 201–6. https://doi.org/10.3758/BF03326580.Full Text
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Book Sections
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Rodriguiz, R. M., and W. C. Wetsel. “Assessments of cognitive deficits in mutant mice.” In Animal Models of Cognitive Impairment, 223–82, 2006.
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Conference Papers
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Free, R Benjamin, Ashley N. Nilson, Noelia M. Boldizsar, Trevor B. Doyle, Ramona M. Rodriguiz, Vladimir M. Pogorelov, Mayako Machino, et al. “Identification and Characterization of ML321: A Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity.” In Acs Pharmacol Transl Sci, 6:151–70, 2023. https://doi.org/10.1021/acsptsci.2c00202.Full Text Link to Item
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Recent Courses
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