William Christopher Wetsel
Associate Professor in Psychiatry and Behavioral Sciences
RESEARCH INTERESTS
Last Updated: 31 December 1997
My laboratory uses genetically-modified mice to study the roles that certain genes and gene products play in the expression of abnormal neuroendocrine, neurological, and psychiatric responses. Traditionally, an identification of neuroendocrine dysfunction has involved biochemical analyses of hormonal responses, those for neurological disorders have relied upon behavioral and postmortem analyses, and those for psychiatric conditions have depended upon phenomenology. The advent of gene manipulation in mice has permitted specific genes to be targeted for disruption, mutation, and/or overexpression in the whole organism or in selected regions or cells in the nervous and other systems. In this way, primary and secondary effects of a given gene manipulation can be related to various neuroendoctine, neurological, or psychiatric conditions in humans. As the Director of the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke University (http://sites.duke.edu/mousebehavioralcore/), we have neurobehaviorally phenotyped many different lines of inbred and mutant mice for investigators at Duke and at other research institutions. As a consequence, we have helped to develop many different mouse genetic models of neuroendocrine and neuropsychiatric illness. Following the development of mouse models, we have worked with various investigators to identify the molecular and cellular basis of the neuroendocrine and/or behavioral abnormalities. We are working also with medicinal chemists and certain pharmacological/biotechnological companies to identify novel compounds that will ameliorate abnormal responses in the mutant mice. Some of these preclinical studies are now forming a basis for clinical trials in humans.
Last Updated: 31 December 1997
My laboratory uses genetically-modified mice to study the roles that certain genes and gene products play in the expression of abnormal neuroendocrine, neurological, and psychiatric responses. Traditionally, an identification of neuroendocrine dysfunction has involved biochemical analyses of hormonal responses, those for neurological disorders have relied upon behavioral and postmortem analyses, and those for psychiatric conditions have depended upon phenomenology. The advent of gene manipulation in mice has permitted specific genes to be targeted for disruption, mutation, and/or overexpression in the whole organism or in selected regions or cells in the nervous and other systems. In this way, primary and secondary effects of a given gene manipulation can be related to various neuroendoctine, neurological, or psychiatric conditions in humans. As the Director of the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke University (http://sites.duke.edu/mousebehavioralcore/), we have neurobehaviorally phenotyped many different lines of inbred and mutant mice for investigators at Duke and at other research institutions. As a consequence, we have helped to develop many different mouse genetic models of neuroendocrine and neuropsychiatric illness. Following the development of mouse models, we have worked with various investigators to identify the molecular and cellular basis of the neuroendocrine and/or behavioral abnormalities. We are working also with medicinal chemists and certain pharmacological/biotechnological companies to identify novel compounds that will ameliorate abnormal responses in the mutant mice. Some of these preclinical studies are now forming a basis for clinical trials in humans.
Current Appointments & Affiliations
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Translational Neuroscience, Psychiatry & Behavioral Sciences 2013
- Associate Professor in Neurobiology, Neurobiology, Basic Science Departments 2007
- Assistant Research Professor in Cell Biology, Cell Biology, Basic Science Departments 2009
- Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2010
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2012
Contact Information
- 354 Sands Bldg, Durham, NC 27710
- Box 103203 Med Ctr, Durham, NC 27710
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william.wetsel@duke.edu
(919) 684-4574
- Background
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Education, Training, & Certifications
- Ph.D., Massachusetts Institute of Technology 1983
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Duke Appointment History
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 2006 - 2013
- Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2008 - 2009
- Assistant Research Professor in Cell Biology, Cell Biology, Basic Science Departments 1999 - 2008
- Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2006 - 2007
- Assistant Research Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 1998 - 2006
- Associate Research Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 1998 - 2006
- Adjunct Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 1996 - 1998
- Research
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Selected Grants
- Molecular and circuitry mechanism underlying autism behaviors in Shank3 mouse models awarded by National Institutes of Health 2019 - 2023
- Evaluating cell type-specific non-dopaminergics as a Parkinson's treatment paradigm awarded by National Institutes of Health 2018 - 2023
- Heat Shock Factors and Protein Misfolding Disease awarded by National Institutes of Health 2018 - 2023
- Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health 2017 - 2022
- Exploiting Dopamine Receptor Functional Selectivity as an Approach to Treat Parkinson's Symptoms awarded by National Institutes of Health 2017 - 2022
- Molecular and cellular control of injury-induced astrogenesis awarded by National Institutes of Health 2017 - 2022
- DART2.0: comprehensive cell type-specific behavioral neuropharmacology awarded by National Institutes of Health 2018 - 2021
- Muscle-macrophage constructs for skeletal muscle repair awarded by National Institutes of Health 2016 - 2021
- In Vivo Epigenome Editing with CRISPR-Based Histone Acetyltransferase Transgenic Mice awarded by National Institutes of Health 2016 - 2021
- Akt/GSK-3 Signaling Cascade and the Actions of Dopamine awarded by National Institutes of Health 2005 - 2020
- Behavioral and Physiology in Aging awarded by National Institutes of Health 2015 - 2020
- Bioelectronic rescue of cognitive impairment after surgery awarded by National Institutes of Health 2018 - 2020
- Simultaneous and Bidirectional Chemogenetic Control of Mesolimbic and Nigrostriatal Circuits awarded by National Institutes of Health 2018 - 2020
- Molecular, Synaptic, and Circuit Basis for Schizophrenia-related Phenotypes awarded by National Institutes of Health 2014 - 2020
- Developing a new therapeutic agent for Kabuki syndrome awarded by Rescindo Therapeutics Inc 2018 - 2019
- Cortico-striatal neurotransmission and compulsive motor behaviors awarded by National Institutes of Health 2008 - 2019
- Initial SHANK3 Study (Rugen E & F) awarded by Rugen Holdings (Cayman) 2017 - 2019
- Initial SHANK3 Study awarded by Rugen Holdings (Cayman) 2016 - 2019
- MECHANISTIC INSIGHTS INTO LSD ACTIONS AT 5-HT2A-SEROTONIN RECEPTORS awarded by University of North Carolina - Chapel Hill 2018 - 2019
- Linking Ciliary Biology to the Functional Annotation of Psychiatric Disorders awarded by University of Nevada - Las Vegas 2018
- Quantitative MR Microscopy of Phenotypic Biomarkers in Alzheimer's Disease awarded by National Institutes of Health 2013 - 2018
- Analysis of Shank3 Complete and Temporal and Spatial Specific Knockout Mice awarded by National Institutes of Health 2012 - 2018
- Neurotrophins and Epileptogenesis awarded by National Institutes of Health 2006 - 2018
- Receptor Regulation of CCK Cell Function awarded by National Institutes of Health 2013 - 2018
- IPA - Jiechun Zhou awarded by National Institutes of Health 2017 - 2018
- IPA - William Wetsel awarded by National Institutes of Health 2017 - 2018
- Fragile X Phenotypes Modulated by Altered Signaling to the Synaptic Cytoskeleton awarded by National Institutes of Health 2014 - 2018
- Linking ciliary biology to the functional annotation of psychiatric disorders awarded by National Institutes of Health 2016 - 2017
- Regulation of Cocaine Reward and Reinforcement by MeCP2 awarded by National Institutes of Health 2013 - 2017
- Functional Selectivity: A Novel Approach for CNS Drug Discovery awarded by University of North Carolina - Chapel Hill 2012 - 2017
- STIM1-dependent calcium signaling in neuronal responses to hypoxia and ischemia awarded by National Institutes of Health 2015 - 2017
- The 5-HT theory of depression tested in a naturalistic model of 5-HT deficiency awarded by National Institutes of Health 2006 - 2017
- Effect of two Rugen compounds on Novel Object Phobia in wild type (WT) and SAPAP3 KO mice awarded by Rugen Holdings (Cayman) 2014 - 2017
- Optimizing Lead 5-HT2C Ligands for Use in the Treatment of Schizoprenia awarded by University of Illinois at Chicago 2013 - 2015
- Novel high-throughput screening for modifiers of TorsinA pathology awarded by National Institutes of Health 2013 - 2015
- Amphetamine-Induced Transcriptional Plasticity in Striatal GABAergic Interneurons awarded by National Institutes of Health 2012 - 2015
- Prevention of Temporal Lobe Epilepsy awarded by National Institutes of Health 2012 - 2014
- Regulation of response to chronic antidepressant treatment by MeCP2 awarded by National Institutes of Health 2012 - 2014
- Imaging NFkB Activity in Relation to Animal Behavior in Peripheral Neuropathy awarded by National Institutes of Health 2013 - 2014
- Novel Genetic Mouse Model to Study the Consequences of TorsinA Dysfunction awarded by National Institutes of Health 2011 - 2014
- Non-invasive Chemical Genetic Control of Neuronal Activity awarded by National Institutes of Health 2009 - 2014
- Fragile X Phenotypes Modulated by Altered Signaling to the Synaptic Cytoskeleton awarded by National Institutes of Health 2007 - 2014
- Agilent Direct Drive 9.4T MRS/MRI Console awarded by National Institutes of Health 2012 - 2013
- PTSD-like phenotype of mice lacking GIT2 awarded by National Institutes of Health 2010 - 2012
- Hormonal regulation of a Ca2+/AMPK signaling pathway awarded by National Institutes of Health 1984 - 2011
- Epigenetic regulation of transcriptional repression by drugs of abuse awarded by National Institutes of Health 2006 - 2011
- Stress and Behavior in Health and Disease awarded by National Institutes of Health 1989 - 2011
- Pharmacometabolomics Research Network awarded by National Institutes of Health 2010 - 2011
- Roles of SAPAP Proteins in Synaptic Function and Compulsive-like Behavior awarded by National Institutes of Health 2007 - 2010
- Cocaine Withdrawal: A Window of Treatment Opportunity awarded by National Institutes of Health 1999 - 2010
- Collaborative & Physiological Experiments to Breed CPE KO Mice awarded by National Institutes of Health 2006 - 2007
- The Pathophysiology of CMT2A in Cell and Animal Models awarded by National Institutes of Health 2006 - 2007
- Collaborative & Physiological Experiments to Breed CPE KO Mice awarded by National Institutes of Health 2005
- Collaborative & Physiological Experiments awarded by National Institutes of Health 2004 - 2005
- Genetic Rescue Of Pro-Lhrh Processing In Cpefat Mice awarded by National Institutes of Health 1998 - 2004
- Collaborative & Physiological Experiments of CPE K/O Mice awarded by National Institutes of Health 2002 - 2003
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Huffman, WJ, Subramaniyan, S, Rodriguiz, RM, Wetsel, WC, Grill, WM, and Terrando, N. "Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice." Brain Stimulation 12, no. 1 (January 2019): 19-29. Full Text
- Helseth, AR, Hunanyan, AS, Adil, S, Linabarger, M, Sachdev, M, Abdelnour, E, Arehart, E, Szabo, M, Richardson, J, Wetsel, WC, Hochgeschwender, U, and Mikati, MA. "Novel E815K knock-in mouse model of alternating hemiplegia of childhood." Neurobiology of Disease 119 (November 2018): 100-112. Full Text
- Bey, AL, Wang, X, Yan, H, Kim, N, Passman, RL, Yang, Y, Cao, X, Towers, AJ, Hulbert, SW, Duffney, LJ, Gaidis, E, Rodriguiz, RM, Wetsel, WC, Yin, HH, and Jiang, Y-H. "Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors." Translational Psychiatry 8, no. 1 (April 27, 2018): 94-null. Full Text
- Wang, X, Gallegos, DA, Pogorelov, VM, O'Hare, JK, Calakos, N, Wetsel, WC, and West, AE. "Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 43, no. 5 (April 2018): 953-963. Full Text
- Martyn, AC, Toth, K, Schmalzigaug, R, Hedrick, NG, Rodriguiz, RM, Yasuda, R, Wetsel, WC, and Premont, RT. "GIT1 regulates synaptic structural plasticity underlying learning." Plos One 13, no. 3 (January 2018): e0194350-null. Full Text
- Berezniuk, I, Rodriguiz, RM, Zee, ML, Marcus, DJ, Pintar, J, Morgan, DJ, Wetsel, WC, and Fricker, LD. "ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine." Journal of Neurochemistry 143, no. 3 (November 2017): 268-281. Full Text
- Butler, RK, Ehling, S, Barbar, M, Thomas, J, Hughes, MA, Smith, CE, Pogorelov, VM, Aryal, DK, Wetsel, WC, and Lascelles, BDX. "Distinct neuronal populations in the basolateral and central amygdala are activated with acute pain, conditioned fear, and fear-conditioned analgesia." Neuroscience Letters 661 (November 2017): 11-17. Full Text
- Pogorelov, VM, Rodriguiz, RM, Cheng, J, Huang, M, Schmerberg, CM, Meltzer, HY, Roth, BL, Kozikowski, AP, and Wetsel, WC. "5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 42, no. 11 (October 2017): 2163-2177. Full Text
- Akkhawattanangkul, Y, Maiti, P, Xue, Y, Aryal, D, Wetsel, WC, Hamilton, D, Fowler, SC, and McDonald, MP. "Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration." Genes, Brain, and Behavior 16, no. 5 (June 2017): 522-536. Full Text
- Cho, K-I, Yoon, D, Qiu, S, Danziger, Z, Grill, WM, Wetsel, WC, and Ferreira, PA. "Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes." Disease Models & Mechanisms 10, no. 5 (May 2017): 559-579. Full Text
- Wang, J, Luo, J, Aryal, DK, Wetsel, WC, Nass, R, and Benovic, JL. "G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans." The Journal of biological chemistry 292, no. 14 (April 2017): 5943-5956. Full Text
- Urs, NM, Gee, SM, Pack, TF, McCorvy, JD, Evron, T, Snyder, JC, Yang, X, Rodriguiz, RM, Borrelli, E, Wetsel, WC, Jin, J, Roth, BL, O'Donnell, P, and Caron, MG. "Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties." Proceedings of the National Academy of Sciences of the United States of America 113, no. 50 (December 2016): E8178-E8186. Full Text
- Badea, A, Kane, L, Anderson, RJ, Qi, Y, Foster, M, Cofer, GP, Medvitz, N, Buckley, AF, Badea, AK, Wetsel, WC, and Colton, CA. "The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease." Neuroimage 142 (November 2016): 498-511. Full Text
- Ade, KK, Wan, Y, Hamann, HC, O'Hare, JK, Guo, W, Quian, A, Kumar, S, Bhagat, S, Rodriguiz, RM, Wetsel, WC, Conn, PJ, Dzirasa, K, Huber, KM, and Calakos, N. "Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice." Biological Psychiatry 80, no. 7 (October 2016): 522-533. Full Text
- Bhagat, SL, Qiu, S, Caffall, ZF, Wan, Y, Pan, Y, Rodriguiz, RM, Wetsel, WC, Badea, A, Hochgeschwender, U, and Calakos, N. "Mouse model of rare TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models." Neurobiology of disease 93 (September 2016): 137-145. Full Text
- Barak, LS, Bai, Y, Peterson, S, Evron, T, Urs, NM, Peddibhotla, S, Hedrick, MP, Hershberger, P, Maloney, PR, Chung, TDY, Rodriguiz, RM, Wetsel, WC, Thomas, JB, Hanson, GR, Pinkerton, AB, and Caron, MG. "ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse." Acs Chemical Biology 11, no. 7 (July 2016): 1880-1890. Full Text
- Klein, RC, Acheson, SK, Qadri, LH, Dawson, AA, Rodriguiz, RM, Wetsel, WC, Moore, SD, Laskowitz, DT, and Dawson, HN. "Opposing effects of traumatic brain injury on excitatory synaptic function in the lateral amygdala in the absence and presence of preinjury stress." Journal of neuroscience research 94, no. 6 (June 2016): 579-589. Full Text
- Weitzel, DH, Tovmasyan, A, Ashcraft, KA, Boico, A, Birer, SR, Roy Choudhury, K, Herndon, J, Rodriguiz, RM, Wetsel, WC, Peters, KB, Spasojevic, I, Batinic-Haberle, I, and Dewhirst, MW. "Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier." Environmental and Molecular Mutagenesis 57, no. 5 (June 2016): 372-381. Full Text
- Wang, X, Bey, AL, Katz, BM, Badea, A, Kim, N, David, LK, Duffney, LJ, Kumar, S, Mague, SD, Hulbert, SW, Dutta, N, Hayrapetyan, V, Yu, C, Gaidis, E, Zhao, S, Ding, J-D, Xu, Q, Chung, L, Rodriguiz, RM, Wang, F, Weinberg, RJ, Wetsel, WC, Dzirasa, K, Yin, H, and Jiang, Y-H. "Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism." Nature Communications 7 (May 10, 2016): 11459-null. Full Text Open Access Copy
- Bao, X, Chandramohan, V, Reynolds, RP, Norton, JN, Wetsel, WC, Rodriguiz, RM, Aryal, DK, McLendon, RE, Levin, ED, Petry, NA, Zalutsky, MR, Burnett, BK, Kuan, C-T, Pastan, IH, and Bigner, DD. "Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats." Investigational new drugs 34, no. 2 (April 2016): 149-158. Full Text
- Urban, DJ, Zhu, H, Marcinkiewcz, CA, Michaelides, M, Oshibuchi, H, Rhea, D, Aryal, DK, Farrell, MS, Lowery-Gionta, E, Olsen, RHJ, Wetsel, WC, Kash, TL, Hurd, YL, Tecott, LH, and Roth, BL. "Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 41, no. 5 (April 2016): 1404-1415. Full Text
- Matak, P, Matak, A, Moustafa, S, Aryal, DK, Benner, EJ, Wetsel, W, and Andrews, NC. "Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice." Proceedings of the National Academy of Sciences of the United States of America 113, no. 13 (March 2016): 3428-3435. Full Text
- Park, SM, Chen, M, Schmerberg, CM, Dulman, RS, Rodriguiz, RM, Caron, MG, Jin, J, and Wetsel, WC. "Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 41, no. 3 (February 2016): 704-715. Full Text
- Cheng, J, Giguere, PM, Schmerberg, CM, Pogorelov, VM, Rodriguiz, RM, Huang, X-P, Zhu, H, McCorvy, JD, Wetsel, WC, Roth, BL, and Kozikowski, AP. "Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models." Journal of Medicinal Chemistry 59, no. 2 (January 13, 2016): 578-591. Full Text
- Farrell, MS, McCorvy, JD, Huang, X-P, Urban, DJ, White, KL, Giguere, PM, Doak, AK, Bernstein, AI, Stout, KA, Park, SM, Rodriguiz, RM, Gray, BW, Hyatt, WS, Norwood, AP, Webster, KA, Gannon, BM, Miller, GW, Porter, JH, Shoichet, BK, Fantegrossi, WE, Wetsel, WC, and Roth, BL. "In Vitro and In Vivo Characterization of the Alkaloid Nuciferine." Plos One 11, no. 3 (January 2016): e0150602-null. Full Text
- Nagy, E, Rodriguiz, RM, Wetsel, WC, MacIver, NJ, and Hale, LP. "Reproduction and Growth in a Murine Model of Early Life-Onset Inflammatory Bowel Disease." PloS one 11, no. 4 (January 2016): e0152764-. Full Text Open Access Copy
- Wu, C-L, Jain, D, McNeill, JN, Little, D, Anderson, JA, Huebner, JL, Kraus, VB, Rodriguiz, RM, Wetsel, WC, and Guilak, F. "Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury." Annals of the Rheumatic Diseases 74, no. 11 (November 2015): 2076-2083. Full Text
- Scott, JW, Park, E, Rodriguiz, RM, Oakhill, JS, Issa, SMA, O'Brien, MT, Dite, TA, Langendorf, CG, Wetsel, WC, Means, AR, and Kemp, BE. "Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder." Scientific Reports 5 (September 23, 2015): 14436-null. Full Text
- Cheng, Y, Rodriguiz, RM, Murthy, SRK, Senatorov, V, Thouennon, E, Cawley, NX, Aryal, DK, Ahn, S, Lecka-Czernik, B, Wetsel, WC, and Loh, YP. "Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone." Molecular Psychiatry 20, no. 6 (June 2015): 744-754. Full Text
- Kim, IH, Rossi, MA, Aryal, DK, Racz, B, Kim, N, Uezu, A, Wang, F, Wetsel, WC, Weinberg, RJ, Yin, H, and Soderling, SH. "Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine." Nature Neuroscience 18, no. 6 (June 2015): 883-891. Full Text
- Sachs, BD, Rodriguiz, RM, Tran, HL, Iyer, A, Wetsel, WC, and Caron, MG. "Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience." Psychoneuroendocrinology 53 (March 2015): 69-81. Full Text
- Cheng, J, Giguère, PM, Onajole, OK, Lv, W, Gaisin, A, Gunosewoyo, H, Schmerberg, CM, Pogorelov, VM, Rodriguiz, RM, Vistoli, G, Wetsel, WC, Roth, BL, and Kozikowski, AP. "Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents." Journal of medicinal chemistry 58, no. 4 (February 10, 2015): 1992-2002. Full Text
- Hunanyan, AS, Fainberg, NA, Linabarger, M, Arehart, E, Leonard, AS, Adil, SM, Helseth, AR, Swearingen, AK, Forbes, SL, Rodriguiz, RM, Rhodes, T, Yao, X, Kibbi, N, Hochman, DW, Wetsel, WC, Hochgeschwender, U, and Mikati, MA. "Knock-in mouse model of alternating hemiplegia of childhood: behavioral and electrophysiologic characterization." Epilepsia 56, no. 1 (January 2015): 82-93. Full Text
- Hunanyan, AS, Fainberg, NA, Linabarger, M, Arehart, E, Leonard, AS, Adil, SM, Helseth, AR, Swearingen, AK, Forbes, SL, Rodriguiz, RM, Rhodes, T, Yao, X, Kibbi, N, Hochman, DW, Wetsel, WC, Hochgeschwender, U, and Mikati, MA. "Knock-in mouse model of alternating hemiplegia of childhood: Behavioral and electrophysiologic characterization." Epilepsia 56, no. 1 (January 1, 2015): 82-93. Full Text
- Weitzel, DH, Tovmasyan, A, Ashcraft, KA, Rajic, Z, Weitner, T, Liu, C, Li, W, Buckley, AF, Prasad, MR, Young, KH, Rodriguiz, RM, Wetsel, WC, Peters, KB, Spasojevic, I, Herndon, JE, Batinic-Haberle, I, and Dewhirst, MW. "Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+." Molecular Cancer Therapeutics 14, no. 1 (January 2015): 70-79. Full Text
- Wang, L, Rodriguiz, RM, Wetsel, WC, Sheng, H, Zhao, S, Liu, X, Paschen, W, and Yang, W. "Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories." Journal of Psychiatry & Neuroscience : Jpn 39, no. 4 (July 2014): 259-266. Full Text
- Gaier, ED, Rodriguiz, RM, Zhou, J, Ralle, M, Wetsel, WC, Eipper, BA, and Mains, RE. "In vivo and in vitro analyses of amygdalar function reveal a role for copper." Journal of Neurophysiology 111, no. 10 (May 2014): 1927-1939. Full Text
- Deng, JV, Wan, Y, Wang, X, Cohen, S, Wetsel, WC, Greenberg, ME, Kenny, PJ, Calakos, N, and West, AE. "MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 34, no. 13 (March 2014): 4519-4527. Full Text
- Gaier, ED, Miller, MB, Ralle, M, Aryal, D, Wetsel, WC, Mains, RE, and Eipper, BA. "Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity." J Neurochem 127, no. 5 (December 2013): 605-619. Full Text Link to Item
- Sassano, MF, Allen, JA, Jin, J, Setola, V, Wetsel, WC, Caron, MG, and Roth, BL. "D2 Functionally Selective Ligands: Novel Therapeutics?." (December 1, 2013): 105-null. (Chapter) Full Text
- Wetsel, WC, Rodriguiz, RM, Guillemot, J, Rousselet, E, Essalmani, R, Kim, IH, Bryant, JC, Marcinkiewicz, J, Desjardins, R, Day, R, Constam, DB, Prat, A, and Seidah, NG. "Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice." Proceedings of the National Academy of Sciences of the United States of America 110, no. 43 (October 7, 2013): 17362-17367. Full Text
- Gomes, I, Aryal, DK, Wardman, JH, Gupta, A, Gagnidze, K, Rodriguiz, RM, Kumar, S, Wetsel, WC, Pintar, JE, Fricker, LD, and Devi, LA. "GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding." Proc Natl Acad Sci U S A 110, no. 40 (October 1, 2013): 16211-16216. Full Text Link to Item
- Ruzzo, EK, Capo-Chichi, J-M, Ben-Zeev, B, Chitayat, D, Mao, H, Pappas, AL, Hitomi, Y, Lu, Y-F, Yao, X, Hamdan, FF, Pelak, K, Reznik-Wolf, H, Bar-Joseph, I, Oz-Levi, D, Lev, D, Lerman-Sagie, T, Leshinsky-Silver, E, Anikster, Y, Ben-Asher, E, Olender, T, Colleaux, L, Décarie, J-C, Blaser, S, Banwell, B, Joshi, RB, He, X-P, Patry, L, Silver, RJ, Dobrzeniecka, S, Islam, MS, Hasnat, A, Samuels, ME, Aryal, DK, Rodriguiz, RM, Jiang, Y-H, Wetsel, WC, McNamara, JO, Rouleau, GA, Silver, DL, Lancet, D, Pras, E, Mitchell, GA, Michaud, JL, and Goldstein, DB. "Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy." Neuron 80, no. 2 (October 2013): 429-441. Full Text
- Sachs, BD, Rodriguiz, RM, Siesser, WB, Kenan, A, Royer, EL, Jacobsen, JPR, Wetsel, WC, and Caron, MG. "The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress." The International Journal of Neuropsychopharmacology 16, no. 9 (October 2013): 2081-2094. Full Text
- Rodriguiz, RM, Wilkins, JJ, Creson, TK, Biswas, R, Berezniuk, I, Fricker, AD, Fricker, LD, and Wetsel, WC. "Emergence of anxiety-like behaviours in depressive-like Cpe(fat/fat) mice." The International Journal of Neuropsychopharmacology 16, no. 7 (August 2013): 1623-1634. Full Text
- Liu, G, Gu, B, He, X-P, Joshi, RB, Wackerle, HD, Rodriguiz, RM, Wetsel, WC, and McNamara, JO. "Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy." Neuron 79, no. 1 (July 10, 2013): 31-38. Full Text Open Access Copy Link to Item
- Kim, IH, Racz, B, Wang, H, Burianek, L, Weinberg, R, Yasuda, R, Wetsel, WC, and Soderling, SH. "Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 33, no. 14 (April 2013): 6081-6092. Full Text
- Gaier, ED, Miller, MB, Ralle, M, Aryal, D, Wetsel, WC, Mains, RE, and Eipper, BA. "Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity." Journal of Neurochemistry (2013).
- Liu, G, Gu, B, He, X-P, Joshi, R, Wackerle, H, Rodriguiz, R, Wetsel, W, and McNamara, J. "Transient Inhibition of TrkB Kinase after Status Epilepticus Prevents Development of Temporal Lobe Epilepsy." Neuron 79, no. 1 (2013): 31-38. Full Text
- Wetsel, WC, Moy, SS, and Jiang, Y-H. "Mouse Behavioral Models for Autism Spectrum Disorders." (2013): 363-378. Full Text
- Besnard, J, Ruda, GF, Setola, V, Abecassis, K, Rodriguiz, RM, Huang, X-P, Norval, S, Sassano, MF, Shin, AI, Webster, LA, Simeons, FRC, Stojanovski, L, Prat, A, Seidah, NG, Constam, DB, Bickerton, GR, Read, KD, Wetsel, WC, Gilbert, IH, Roth, BL, and Hopkins, AL. "Automated design of ligands to polypharmacological profiles." Nature 492, no. 7428 (December 2012): 215-220. Full Text
- Por, ED, Bierbower, SM, Berg, KA, Gomez, R, Akopian, AN, Wetsel, WC, and Jeske, NA. "β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel." The Journal of Biological Chemistry 287, no. 44 (October 2012): 37552-37563. Full Text
- Chen, X, Sassano, MF, Zheng, L, Setola, V, Chen, M, Bai, X, Frye, SV, Wetsel, WC, Roth, BL, and Jin, J. "Structure-functional selectivity relationship studies of β-arrestin-biased dopamine Dâ‚‚ receptor agonists." Journal of Medicinal Chemistry 55, no. 16 (August 13, 2012): 7141-7153. Full Text
- Lee, TH, Szabo, ST, Fowler, JC, Mannelli, P, Mangum, OB, Beyer, WF, Patkar, A, and Wetsel, WC. "Pharmacologically-mediated reactivation and reconsolidation blockade of the psychostimulant-abuse circuit: a novel treatment strategy." Drug Alcohol Depend 124, no. 1-2 (July 1, 2012): 11-18. (Review) Full Text Link to Item
- Cawley, NX, Wetsel, WC, Murthy, SRK, Park, JJ, Pacak, K, and Loh, YP. "New roles of carboxypeptidase E in endocrine and neural function and cancer." Endocrine Reviews 33, no. 2 (April 2012): 216-253. (Review) Full Text
- Fukada, M, Hanai, A, Nakayama, A, Suzuki, T, Miyata, N, Rodriguiz, RM, Wetsel, WC, Yao, T-P, and Kawaguchi, Y. "Loss of deacetylation activity of Hdac6 affects emotional behavior in mice." PLoS One 7, no. 2 (2012): e30924-. Full Text Link to Item
- Hutchinson, AN, Deng, JV, Aryal, DK, Wetsel, WC, and West, AE. "Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 37, no. 2 (January 2012): 321-337. Full Text
- Wong, P, Chang, CCR, Marx, CE, Caron, MG, Wetsel, WC, and Zhang, X. "Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice." PLoS One 7, no. 12 (2012): e51455-. Full Text Link to Item
- Miller, LK, Hou, X, Rodriguiz, RM, Gagnidze, K, Sweedler, JV, Wetsel, WC, and Devi, LA. "Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord." J Neurochem 119, no. 5 (December 2011): 1074-1085. Full Text Link to Item
- Allen, JA, Yost, JM, Setola, V, Chen, X, Sassano, MF, Chen, M, Peterson, S, Yadav, PN, Huang, X-P, Feng, B, Jensen, NH, Che, X, Bai, X, Frye, SV, Wetsel, WC, Caron, MG, Javitch, JA, Roth, BL, and Jin, J. "Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy." Proceedings of the National Academy of Sciences of the United States of America 108, no. 45 (November 2011): 18488-18493. Full Text
- Daigle, TL, Wetsel, WC, and Caron, MG. "Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling." Eur J Neurosci 34, no. 9 (November 2011): 1378-1389. Full Text Link to Item
- Cohen, S, Gabel, HW, Hemberg, M, Hutchinson, AN, Sadacca, LA, Ebert, DH, Harmin, DA, Greenberg, RS, Verdine, VK, Zhou, Z, Wetsel, WC, West, AE, and Greenberg, ME. "Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function." Neuron 72, no. 1 (October 2011): 72-85. Full Text
- Bhatia, KS, Szabo, ST, Fowler, JC, Wetsel, WC, and Lee, TH. "Reversal of long-term methamphetamine sensitization by combination of pergolide with ondansetron or ketanserin, but not mirtazapine." Behavioural Brain Research 223, no. 1 (September 2011): 227-232. Full Text
- Wang, X, McCoy, PA, Rodriguiz, RM, Pan, Y, Je, HS, Roberts, AC, Kim, CJ, Berrios, J, Colvin, JS, Bousquet-Moore, D, Lorenzo, I, Wu, G, Weinberg, RJ, Ehlers, MD, Philpot, BD, Beaudet, AL, Wetsel, WC, and Jiang, Y-H. "Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3." Human Molecular Genetics 20, no. 15 (August 2011): 3093-3108. Full Text
- Porton, B, Wetsel, WC, and Kao, H-T. "Synapsin III: role in neuronal plasticity and disease." Seminars in Cell & Developmental Biology 22, no. 4 (June 2011): 416-424. (Review) Full Text
- Carlson, BR, Lloyd, KE, Kruszewski, A, Kim, I-H, Rodriguiz, RM, Heindel, C, Faytell, M, Dudek, SM, Wetsel, WC, and Soderling, SH. "WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 31, no. 7 (February 2011): 2447-2460. Full Text
- Rodriguiz, RM, Colvin, JS, and Wetsel, WC. "Neurophenotyping genetically modified mice for social behavior." Methods Mol Biol 768 (2011): 343-363. Full Text Link to Item
- Wetsel, WC. "Sensing hot and cold with TRP channels." Int J Hyperthermia 27, no. 4 (2011): 388-398. (Review) Full Text Link to Item
- Wetsel, WC. "Hyperthermic effects on behavior." International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 27, no. 4 (January 2011): 353-373. (Review) Full Text
- Gaier, ED, Rodriguiz, RM, Ma, X-MM, Sivaramakrishnan, S, Bousquet-Moore, D, Wetsel, WC, Eipper, BA, and Mains, RE. "Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 30, no. 41 (October 2010): 13656-13669. Full Text
- Deng, JV, Rodriguiz, RM, Hutchinson, AN, Kim, I-H, Wetsel, WC, and West, AE. "MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants." Nature Neuroscience 13, no. 9 (September 2010): 1128-1136. Full Text
- Kile, BM, Guillot, TS, Venton, BJ, Wetsel, WC, Augustine, GJ, and Wightman, RM. "Synapsins differentially control dopamine and serotonin release." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 30, no. 29 (July 2010): 9762-9770. Full Text
- Crooks, KR, Kleven, DT, Rodriguiz, RM, Wetsel, WC, and McNamara, JO. "TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine." Neuropharmacology 58, no. 7 (June 2010): 1067-1077. Full Text Link to Item
- McDowell, KA, Hutchinson, AN, Wong-Goodrich, SJE, Presby, MM, Su, D, Rodriguiz, RM, Law, KC, Williams, CL, Wetsel, WC, and West, AE. "Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 30, no. 22 (June 2010): 7453-7465. Full Text
- Porton, B, Rodriguiz, RM, Phillips, LE, Gilbert, JW, Feng, J, Greengard, P, Kao, H-T, and Wetsel, WC. "Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear." Genes, Brain, and Behavior 9, no. 3 (April 2010): 257-268. Full Text
- Chen, Q, Zhu, X, Zhang, Y, Wetsel, WC, Lee, TH, and Zhang, X. "Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation." Journal of Molecular Neuroscience : Mn 40, no. 3 (March 2010): 284-294. Full Text
- Bousquet-Moore, D, Prohaska, JR, Nillni, EA, Czyzyk, T, Wetsel, WC, Mains, RE, and Eipper, BA. "Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction." Neurobiology of Disease 37, no. 1 (January 2010): 130-140. Full Text
- Griffin, TM, Fermor, B, Huebner, JL, Kraus, VB, Rodriguiz, RM, Wetsel, WC, Cao, L, Setton, LA, and Guilak, F. "Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice." Arthritis Res Ther 12, no. 4 (2010): R130-. Full Text Open Access Copy Link to Item
- Allen, KD, Griffin, TM, Rodriguiz, RM, Wetsel, WC, Kraus, VB, Huebner, JL, Boyd, LM, and Setton, LA. "Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen." Arthritis Rheum 60, no. 9 (September 2009): 2684-2693. Full Text Link to Item
- Yuan, L, Seo, J-S, Kang, NS, Keinan, S, Steele, SE, Michelotti, GA, Wetsel, WC, Beratan, DN, Gong, Y-D, Lee, TH, and Hong, J. "Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse." Molecular Biosystems 5, no. 9 (September 2009): 927-930. Full Text
- Roberts, AC, Díez-García, J, Rodriguiz, RM, López, IP, Luján, R, Martínez-Turrillas, R, Picó, E, Henson, MA, Bernardo, DR, Jarrett, TM, Clendeninn, DJ, López-Mascaraque, L, Feng, G, Lo, DC, Wesseling, JF, Wetsel, WC, Philpot, BD, and Pérez-Otaño, I. "Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation." Neuron 63, no. 3 (August 2009): 342-356. Full Text
- Nehrenberg, DL, Rodriguiz, RM, Cyr, M, Zhang, X, Lauder, JM, Gariépy, J-L, and Wetsel, WC. "An anxiety-like phenotype in mice selectively bred for aggression." Behav Brain Res 201, no. 1 (July 19, 2009): 179-191. Full Text Link to Item
- Schmalzigaug, R, Rodriguiz, RM, Bonner, PE, Davidson, CE, Wetsel, WC, and Premont, RT. "Impaired fear response in mice lacking GIT1." Neurosci Lett 458, no. 2 (July 17, 2009): 79-83. Full Text Link to Item
- Yan, F, Bikbulatov, RV, Mocanu, V, Dicheva, N, Parker, CE, Wetsel, WC, Mosier, PD, Westkaemper, RB, Allen, JA, Zjawiony, JK, and Roth, BL. "Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor." Biochemistry 48, no. 29 (July 2009): 6898-6908. Full Text
- Schmalzigaug, R, Rodriguiz, RM, Phillips, LE, Davidson, CE, Wetsel, WC, and Premont, RT. "Anxiety-like behaviors in mice lacking GIT2." Neurosci Lett 451, no. 2 (February 20, 2009): 156-161. Full Text Link to Item
- Liu, Y, Sun, Q-A, Chen, Q, Lee, TH, Huang, Y, Wetsel, WC, Michelotti, GA, Sullenger, BA, and Zhang, X. "Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking." J Neurochem 108, no. 1 (January 2009): 147-157. Full Text Link to Item
- Chen, Q, Xiong, X, Lee, TH, Liu, Y, Wetsel, WC, and Zhang, X. "Neural plasticity and addiction: integrin-linked kinase and cocaine behavioral sensitization." Journal of Neurochemistry 107, no. 3 (November 2008): 679-689. Full Text
- Taylor, GA, Rodriguiz, RM, Greene, RI, Daniell, X, Henry, SC, Crooks, KR, Kotloski, R, Tessarollo, L, Phillips, LE, and Wetsel, WC. "Behavioral characterization of P311 knockout mice." Genes, Brain, and Behavior 7, no. 7 (October 2008): 786-795. Full Text
- Jensen, NH, Rodriguiz, RM, Caron, MG, Wetsel, WC, Rothman, RB, and Roth, BL. "N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 33, no. 10 (September 2008): 2303-2312. Full Text
- Ream, MA, Chandra, R, Peavey, M, Ray, AM, Roffler-Tarlov, S, Kim, H-G, Wetsel, WC, Rockman, HA, and Chikaraishi, DM. "High oxygen prevents fetal lethality due to lack of catecholamines." American Journal of Physiology Regulatory, Integrative and Comparative Physiology 295, no. 3 (September 2008): R942-R953. Full Text
- Chen, Q, Xiong, X, Lee, TH, Liu, Y, Sun, Q-A, Wetsel, W, and Zhang, X. "Adeno-associated virus-mediated ILK gene silencing in the rat NAc core." J Neurosci Methods 173, no. 2 (August 30, 2008): 208-214. Full Text Link to Item
- Rodriguiz, RM, Gadnidze, K, Ragnauth, A, Dorr, N, Yanagisawa, M, Wetsel, WC, and Devi, LA. "Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory." Genes, Brain, and Behavior 7, no. 4 (June 2008): 418-426. Full Text
- Beaulieu, JM, Zhang, X, Rodriguiz, RM, Sotnikova, TD, Wetsel, WC, Gainetdinov, RR, and Caron, MG. "Reply to Belmaker et al.: GSK3β haploinsufficiency results in lithium-like effects in the forced-swim test." Proceedings of the National Academy of Sciences of the United States of America 105, no. 20 (May 20, 2008). (Letter) Full Text
- Beaulieu, J-M, Zhang, X, Rodriguiz, RM, Sotnikova, TD, Cools, MJ, Wetsel, WC, Gainetdinov, RR, and Caron, MG. "Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency." Proceedings of the National Academy of Sciences of the United States of America 105, no. 4 (January 22, 2008): 1333-1338. Full Text
- Beaulieu, J-M, Marion, S, Rodriguiz, RM, Medvedev, IO, Sotnikova, TD, Ghisi, V, Wetsel, WC, Lefkowitz, RJ, Gainetdinov, RR, and Caron, MG. "A beta-arrestin 2 signaling complex mediates lithium action on behavior." Cell 132, no. 1 (January 2008): 125-136. Full Text
- Woronowicz, A, Koshimizu, H, Chang, S-Y, Cawley, NX, Hill, JM, Rodriguiz, RM, Abebe, D, Dorfman, C, Senatorov, V, Zhou, A, Xiong, Z-G, Wetsel, WC, and Loh, YP. "Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits." Hippocampus 18, no. 10 (January 2008): 1051-1063. Full Text
- Fukui, M, Rodriguiz, RM, Zhou, J, Jiang, SX, Phillips, LE, Caron, MG, and Wetsel, WC. "Vmat2 heterozygous mutant mice display a depressive-like phenotype." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 27, no. 39 (September 2007): 10520-10529. Full Text
- Porton, B, and Wetsel, WC. "Reduction of synapsin III in the prefrontal cortex of individuals with schizophrenia." Schizophr Res 94, no. 1-3 (August 2007): 366-370. Full Text Link to Item
- Welch, JM, Lu, J, Rodriguiz, RM, Trotta, NC, Peca, J, Ding, J-D, Feliciano, C, Chen, M, Adams, JP, Luo, J, Dudek, SM, Weinberg, RJ, Calakos, N, Wetsel, WC, and Feng, G. "Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice." Nature 448, no. 7156 (August 2007): 894-900. Full Text
- Chen, Q, Lee, TH, Wetsel, WC, Sun, Q-A, Liu, Y, Davidson, C, Xiong, X, Ellinwood, EH, and Zhang, X. "Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABAA receptor alpha2 subunit expression, and PKC zeta activity." Biochemical and Biophysical Research Communications 356, no. 3 (May 2007): 733-738. Full Text
- Badea, A, Nicholls, PJ, Johnson, GA, and Wetsel, WC. "Neuroanatomical phenotypes in the reeler mouse." Neuroimage 34, no. 4 (February 2007): 1363-1374. Full Text
- Zhang, X, Lee, TH, Davidson, C, Lazarus, C, Wetsel, WC, and Ellinwood, EH. "Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 32, no. 2 (February 2007): 377-387. Full Text
- Zhang, X, Lee, TH, Xiong, X, Chen, Q, Davidson, C, Wetsel, WC, and Ellinwood, EH. "Methamphetamine induces long-term changes in GABAA receptor alpha2 subunit and GAD67 expression." Biochemical and Biophysical Research Communications 351, no. 1 (December 2006): 300-305. Full Text
- Prado, VF, Martins-Silva, C, de Castro, BM, Lima, RF, Barros, DM, Amaral, E, Ramsey, AJ, Sotnikova, TD, Ramirez, MR, Kim, H-G, Rossato, JI, Koenen, J, Quan, H, Cota, VR, Moraes, MFD, Gomez, MV, Guatimosim, C, Wetsel, WC, Kushmerick, C, Pereira, GS, Gainetdinov, RR, Izquierdo, I, Caron, MG, and Prado, MAM. "Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition." Neuron 51, no. 5 (September 7, 2006): 601-612. Full Text Link to Item
- Venton, BJ, Seipel, AT, Phillips, PEM, Wetsel, WC, Gitler, D, Greengard, P, Augustine, GJ, and Wightman, RM. "Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 26, no. 12 (March 2006): 3206-3209. Full Text
- Zhang, X, Mi, J, Wetsel, WC, Davidson, C, Xiong, X, Chen, Q, Ellinwood, EH, and Lee, TH. "PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity." Biochemical and Biophysical Research Communications 340, no. 4 (February 2006): 1144-1150. Full Text
- Gammon, CM, Freeman, GM, Xie, W, Petersen, SL, and Wetsel, WC. "Regulation of gonadotropin-releasing hormone secretion by cannabinoids." Endocrinology 146, no. 10 (October 2005): 4491-4499. Full Text
- Pogorelov, VM, Rodriguiz, RM, Insco, ML, Caron, MG, and Wetsel, WC. "Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 30, no. 10 (October 2005): 1818-1831. Full Text
- Pogorelov, VM, Rodriguiz, RM, Insco, ML, Caron, MG, and Wetsel, WC. "Erratum: Novelty seeking and stereotypic activation of behavior in mice with disruption of the DatI gene (Neuropsychopharmacology (April 27, 2005), DOI:10.1038/sj.npp.1300724)." Neuropsychopharmacology 30, no. 9 (September 1, 2005): 1772-null. Full Text
- Sotnikova, TD, Beaulieu, J-M, Barak, LS, Wetsel, WC, Caron, MG, and Gainetdinov, RR. "Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease." Plos Biology 3, no. 8 (August 2, 2005): e271-null. Full Text
- Pillai-Nair, N, Panicker, AK, Rodriguiz, RM, Gilmore, KL, Demyanenko, GP, Huang, JZ, Wetsel, WC, and Maness, PF. "Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior." J Neurosci 25, no. 18 (May 4, 2005): 4659-4671. Full Text Link to Item
- Jacobsen, JPR, Rodriguiz, RM, Mørk, A, and Wetsel, WC. "Monoaminergic dysregulation in glutathione-deficient mice: possible relevance to schizophrenia?." Neuroscience 132, no. 4 (2005): 1055-1072. Full Text Link to Item
- Cawley, NX, Zhou, J, Hill, JM, Abebe, D, Romboz, S, Yanik, T, Rodriguiz, RM, Wetsel, WC, and Loh, YP. "The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits." Endocrinology 145, no. 12 (December 2004): 5807-5819. Full Text Link to Item
- Gitler, D, Takagishi, Y, Feng, J, Ren, Y, Rodriguiz, RM, Wetsel, WC, Greengard, P, and Augustine, GJ. "Different presynaptic roles of synapsins at excitatory and inhibitory synapses." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 24, no. 50 (December 2004): 11368-11380. Full Text
- Grove, M, Demyanenko, G, Echarri, A, Zipfel, PA, Quiroz, ME, Rodriguiz, RM, Playford, M, Martensen, SA, Robinson, MR, Wetsel, WC, Maness, PF, and Pendergast, AM. "ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory." Molecular and Cellular Biology 24, no. 24 (December 2004): 10905-10922. Full Text
- Quan, H, Athirakul, K, Wetsel, WC, Torres, GE, Stevens, R, Chen, YT, Coffman, TM, and Caron, MG. "Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2." Molecular and Cellular Biology 24, no. 10 (May 2004): 4166-4173. Full Text
- Srinivasan, S, Bunch, DO, Feng, Y, Rodriguiz, RM, Li, M, Ravenell, RL, Luo, GX, Arimura, A, Fricker, LD, Eddy, EM, and Wetsel, WC. "Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice." Endocrinology 145, no. 4 (April 2004): 2023-2034. Full Text Link to Item
- Longo, M, Brama, M, Marino, M, Bernardini, S, Korach, KS, Wetsel, WC, Scandurra, R, Faraggiana, T, Spera, G, Baron, R, Teti, A, and Migliaccio, S. "Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation." Bone 34, no. 1 (January 2004): 100-111. Full Text
- Rodriguiz, RM, Chu, R, Caron, MG, and Wetsel, WC. "Aberrant responses in social interaction of dopamine transporter knockout mice." Behavioural Brain Research 148, no. 1-2 (January 2004): 185-198. Full Text
- Trinh, JV, Nehrenberg, DL, Jacobsen, JPR, Caron, MG, and Wetsel, WC. "Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice." Neuroscience 118, no. 2 (2003): 297-310. Link to Item
- Nillni, EA, Xie, W, Mulcahy, L, Sanchez, VC, and Wetsel, WC. "Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice." J Biol Chem 277, no. 50 (December 13, 2002): 48587-48595. Full Text Link to Item
- Haller, J, Bakos, N, Rodriguiz, RM, Caron, MG, Wetsel, WC, and Liposits, Z. "Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depression." Brain Research Bulletin 58, no. 3 (July 2002): 279-284. Full Text
- Wetsel, WC, and Srinivasan, S. "Pro-GnRH processing." Prog Brain Res 141 (2002): 221-241. (Review) Full Text Link to Item
- Kreda, SM, Sumner, M, Fillo, S, Ribeiro, CM, Luo, GX, Xie, W, Daniel, KW, Shears, S, Collins, S, and Wetsel, WC. "alpha(1)-adrenergic receptors mediate LH-releasing hormone secretion through phospholipases C and A(2) in immortalized hypothalamic neurons." Endocrinology 142, no. 11 (November 2001): 4839-4851. Full Text Link to Item
- Kreda, SM, Sumner, M, Fillo, S, Ribeiro, CM, Luo, GX, Xie, W, Daniel, KW, Shears, S, Collins, S, and Wetsel, WC. "α1-Adrenergic receptors mediate LH-releasing hormone secretion through phospholipases C and A2 in immortalized hypothalamic neurons." Endocrinology 142, no. 11 (2001): 4839-4851. Full Text
- Kreda, SM, Sumner, M, Fillo, S, Ribeiro, CM, Luo, GX, Xie, W, Daniel, KW, Shears, S, Collins, S, and Wetsel, WC. "α1-Adrenergic receptors mediate LH-releasing hormone secretion through phospholipases C and A2 in immortalized hypothalamic neurons." Endocrinology 142, no. 11 (January 1, 2001): 4839-4851. Full Text
- Ribar, TJ, Rodriguiz, RM, Khiroug, L, Wetsel, WC, Augustine, GJ, and Means, AR. "Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 20, no. 22 (November 2000): RC107-null. Full Text
- Jeohn, GH, Chang, RC, Kim, WG, Wilson, B, Mohney, RP, Wetsel, WC, and Hong, JS. "Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by Gö6976 in murine microglia." Brain Res Mol Brain Res 79, no. 1-2 (June 23, 2000): 18-31. Link to Item
- Jeohn, GH, Wilson, B, Wetsel, WC, and Hong, JS. "The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures." Brain Res Mol Brain Res 79, no. 1-2 (June 23, 2000): 32-44. Link to Item
- Xu, F, Gainetdinov, RR, Wetsel, WC, Jones, SR, Bohn, LM, Miller, GW, Wang, YM, and Caron, MG. "Mice lacking the norepinephrine transporter are supersensitive to psychostimulants." Nature Neuroscience 3, no. 5 (May 2000): 465-471. Full Text
- Sarkis, EH, Gainetdinov, RR, Wetsel, WC, and Caron, MG. "'Model' behavior [4] (multiple letters)." Science 287, no. 5461 (2000): 2160-2162.
- Davis, BJ, Lennard, DE, Lee, CA, Tiano, HF, Morham, SG, Wetsel, WC, and Langenbach, R. "Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta." Endocrinology 140, no. 6 (June 1999): 2685-2695. Full Text Link to Item
- Isaac, RE, Michaud, A, Keen, JN, Williams, TA, Coates, D, Wetsel, WC, and Corvol, P. "Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin." Eur J Biochem 262, no. 2 (June 1999): 569-574. Link to Item
- Gainetdinov, RR, Wetsel, WC, Jones, SR, Levin, ED, Jaber, M, and Caron, MG. "Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity." Science (New York, N.Y.) 283, no. 5400 (January 1999): 397-401. Full Text
- Migliaccio, S, Washburn, TF, Fillo, S, Rivera, H, Teti, A, Korach, KS, and Wetsel, WC. "Modulation of estrogen receptor levels in mouse uterus by protein kinase C isoenzymes." Endocrinology 139, no. 11 (November 1998): 4598-4606. Full Text
- Lindzey, J, Wetsel, WC, Couse, JF, Stoker, T, Cooper, R, and Korach, KS. "Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-alpha knockout mice." Endocrinology 139, no. 10 (October 1998): 4092-4101. Full Text
- Migliaccio, S, Bernardini, S, Wetsel, WC, Korach, KS, Faraggiana, T, and Teti, A. "Protein kinase C modulates estrogen receptors in differentiated osteoblastic cells in vitro." Steroids 63, no. 5-6 (May 1998): 352-354. (Review) Link to Item
- Colombo, PJ, Wetsel, WC, and Gallagher, M. "Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats." Proceedings of the National Academy of Sciences of the United States of America 94, no. 25 (December 1997): 14195-14199. Full Text
- Caron, KM, Soo, SC, Wetsel, WC, Stocco, DM, Clark, BJ, and Parker, KL. "Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia." Proceedings of the National Academy of Sciences of the United States of America 94, no. 21 (October 1997): 11540-11545. Full Text
- Bossé, R, Fumagalli, F, Jaber, M, Giros, B, Gainetdinov, RR, Wetsel, WC, Missale, C, and Caron, MG. "Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter." Neuron 19, no. 1 (July 1997): 127-138. Link to Item
- Ma, YJ, Berg-von der Emde, K, Rage, F, Wetsel, WC, and Ojeda, SR. "Hypothalamic astrocytes respond to transforming growth factor-alpha with the secretion of neuroactive substances that stimulate the release of luteinizing hormone-releasing hormone." Endocrinology 138, no. 1 (January 1997): 19-25. Full Text
- Pascale, A, Fortino, I, Govoni, S, Trabucchi, M, Wetsel, WC, and Battaini, F. "Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex." Journal of Neurochemistry 67, no. 6 (December 1996): 2471-2477.
- Zappelli, F, Willems, D, Osada, S, Ohno, S, Wetsel, WC, Molinaro, M, Cossu, G, and Bouché, M. "The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis." Dev Biol 180, no. 1 (November 25, 1996): 156-164. Link to Item
- Pascale, A, Fortino, I, Govoni, S, Trabucchi, M, Wetsel, WC, and Battaini, F. "Differential isoform-specific regulation of calcium-independent protein kinase C in rat cerebral cortex." Neurosci Lett 214, no. 2-3 (August 23, 1996): 99-102. Link to Item
- Voigt, P, Ma, YJ, Gonzalez, D, Fahrenbach, WH, Wetsel, WC, Berg-von der Emde, K, Hill, DF, Taylor, KG, Costa, ME, Seidah, NG, and Ojeda, SR. "Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons." Endocrinology 137, no. 6 (June 1996): 2593-2605. Full Text
- Wetsel, WC, Hill, DF, and Ojeda, SR. "Basic fibroblast growth factor regulates the conversion of pro-luteinizing hormone-releasing hormone (Pro-LHRH) to LHRH in immortalized hypothalamic neurons." Endocrinology 137, no. 6 (June 1996): 2606-2616. Full Text
- Belsham, DD, Wetsel, WC, and Mellon, PL. "NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression." The Embo Journal 15, no. 3 (February 1996): 538-547. Full Text
- Chen, W, Wetsel, W, Steenbergen, C, and Murphy, E. "Effect of ischemic preconditioning and PKC activation on acidification during ischemia in rat heart." Journal of Molecular and Cellular Cardiology 28, no. 5 (1996): 871-880. Full Text
- Bergamaschi, S, Binetti, G, Govoni, S, Wetsel, WC, Battaini, F, Trabucchi, M, Bianchetti, A, and Racchi, M. "Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts." Neurosci Lett 201, no. 1 (December 1, 1995): 1-5. Link to Item
- Olson, BR, Scott, DC, Wetsel, WC, Elliot, SJ, Tomic, M, Stojilkovic, S, Nieman, LK, and Wray, S. "Effects of insulin-like growth factors I and II and insulin on the immortalized hypothalamic GTI-7 cell line." Neuroendocrinology 62, no. 2 (August 1995): 155-165. Full Text Link to Item
- Wetsel, WC, Liposits, Z, Seidah, NG, and Collins, S. "Expression of candidate pro-GnRH processing enzymes in rat hypothalamus and an immortalized hypothalamic neuronal cell line." Neuroendocrinology 62, no. 2 (August 1995): 166-177. Full Text
- Bouché, M, Zappelli, F, Polimeni, M, Adamo, S, Wetsel, WC, Senni, MI, and Molinaro, M. "Rapid activation and down-regulation of protein kinase C alpha in 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells." Cell Growth Differ 6, no. 7 (July 1995): 845-852. Link to Item
- Battaini, F, Elkabes, S, Bergamaschi, S, Ladisa, V, Lucchi, L, De Graan, PN, Schuurman, T, Wetsel, WC, Trabucchi, M, and Govoni, S. "Protein kinase C activity, translocation, and conventional isoforms in aging rat brain." Neurobiol Aging 16, no. 2 (March 1995): 137-148. Link to Item
- Wetsel, WC. "Immortalized hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons: a new tool for dissecting the molecular and cellular basis of LHRH physiology." Cell Mol Neurobiol 15, no. 1 (February 1995): 43-78. (Review) Link to Item
- Racchi, M, Bergamaschi, S, Govoni, S, Wetsel, WC, Bianchetti, A, Binetti, G, Battaini, F, and Trabucchi, M. "Characterization and distribution of protein kinase C isoforms in human skin fibroblasts." Arch Biochem Biophys 314, no. 1 (October 1994): 107-111. Full Text Link to Item
- Battaini, F, Pascale, A, Lucchi, L, Racchi, M, Bergamaschi, S, Parenti, M, Wetsel, WC, Govoni, S, and Trabucchi, M. "Expression and regulation of calcium-independent protein kinase C in NG 108-15 cell differentiation." Biochem Biophys Res Commun 203, no. 3 (September 30, 1994): 1423-1431. Full Text Link to Item
- Battaini, F, Garbillo, G, Bergamaschi, S, Parenti, M, Wetsel, WC, Govoni, S, and Trabucchi, M. "Regulation of protein kinase C in NG108-15 cell differentiation." Biochem Biophys Res Commun 201, no. 1 (May 30, 1994): 135-142. Full Text Link to Item
- Ghalayini, AJ, Koutz, CA, Wetsel, WC, Hannun, YA, and Anderson, RE. "Immunolocalization of PKC zeta in rat photoreceptor inner segments." Current Eye Research 13, no. 2 (February 1994): 145-150. Full Text
- Favit, A, Wetsel, WC, and Negro-Vilar, A. "Differential expression of gamma-aminobutyric acid receptors in immortalized luteinizing hormone-releasing hormone neurons." Endocrinology 133, no. 5 (November 1993): 1983-1989. Full Text Link to Item
- Merchenthaler, I, Liposits, Z, Reid, JJ, and Wetsel, WC. "Light and electron microscopic immunocytochemical localization of PKC delta immunoreactivity in the rat central nervous system." J Comp Neurol 336, no. 3 (October 15, 1993): 378-399. Full Text Link to Item
- Migliaccio, S, Wetsel, WC, Fox, WM, Washburn, TF, and Korach, KS. "Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels." Molecular Endocrinology (Baltimore, Md.) 7, no. 9 (September 1993): 1133-1143. Full Text
- Wetsel, WC, Eraly, SA, Whyte, DB, and Mellon, PL. "Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons." Endocrinology 132, no. 6 (June 1993): 2360-2370. Full Text
- Khan, WA, Blobe, G, Halpern, A, Taylor, W, Wetsel, WC, Burns, D, Loomis, C, and Hannun, YA. "Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets." The Journal of Biological Chemistry 268, no. 7 (March 1993): 5063-5068.
- Blobe, GC, Sachs, CW, Khan, WA, Fabbro, D, Stabel, S, Wetsel, WC, Obeid, LM, Fine, RL, and Hannun, YA. "Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha." The Journal of Biological Chemistry 268, no. 1 (January 1993): 658-664.
- Wetsel, WC, Valença, MM, Merchenthaler, I, Liposits, Z, López, FJ, Weiner, RI, Mellon, PL, and Negro-Vilar, A. "Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons." Proceedings of the National Academy of Sciences of the United States of America 89, no. 9 (May 1992): 4149-4153. Full Text
- Wetsel, WC, Khan, WA, Merchenthaler, I, Rivera, H, Halpern, AE, Phung, HM, Negro-Vilar, A, and Hannun, YA. "Tissue and cellular distribution of the extended family of protein kinase C isoenzymes." J Cell Biol 117, no. 1 (April 1992): 121-133. Link to Item
- Alessenko, A, Khan, WA, Wetsel, WC, and Hannun, YA. "Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration." Biochemical and Biophysical Research Communications 182, no. 3 (February 1992): 1333-1339. Full Text
- Mellon, PL, Wetsel, WC, Windle, JJ, Valença, MM, Goldsmith, PC, Whyte, DB, Eraly, SA, Negro-Vilar, A, and Weiner, RI. "Immortalized hypothalamic gonadotropin-releasing hormone neurons." Ciba Foundation Symposium 168 (January 1992): 104-117. (Review)
- Weiner, RI, Wetsel, W, Goldsmith, P, Escalera, GMDL, Windle, J, Padula, C, Choi, A, Negro-Vilar, A, and Mellon, P. "Gonadotropin-releasing hormone neuronal cell lines." Frontiers in Neuroendocrinology 13, no. 2 (1992): 95-119.
- Liposits, Z, Merchenthaler, I, Wetsel, WC, Reid, JJ, Mellon, PL, Weiner, RI, and Negro-Vilar, A. "Morphological characterization of immortalized hypothalamic neurons synthesizing luteinizing hormone-releasing hormone." Endocrinology 129, no. 3 (September 1991): 1575-1583. Full Text Link to Item
- Wetsel, WC, Mellon, PL, Weiner, RI, and Negro-Vilar, A. "Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons." Endocrinology 129, no. 3 (September 1991): 1584-1595. Full Text
- Cubeddu, LX, Lindley, CM, Wetsel, W, Carl, PL, and Negro-Vilar, A. "Role of angiotensin II and vasopressin in cisplatin-induced emesis." Life Sciences 46, no. 10 (1990): 699-705. Full Text
- Wetsel, WC, and Negro-Vilar, A. "Testosterone selectively influences protein kinase-C-coupled secretion of proluteinizing hormone-releasing hormone-derived peptides." Endocrinology 125, no. 1 (July 1989): 538-547. Full Text
- Wetsel, W, and Negro-Vilar, A. "Combined antibody-high performance liquid chromatography approach to assess prohormone processing." Methods in Enzymology 168 (1989): 517-545.
- Valenca, MM, Wetsel, WC, Culler, MD, and Negro-Vilar, A. "Differential secretion of proLHRH fragments in response to [K+], prostaglandin E2 and C kinase activation." Mol Cell Endocrinol 55, no. 1 (January 1988): 95-100. Link to Item
- Wetsel, WC, Culler, MD, Johnston, CA, and Negro-Vilar, A. "Processing of the luteinizing hormone-releasing hormone precursor in the preoptic area and hypothalamus of the rat." Mol Endocrinol 2, no. 1 (January 1988): 22-31. Full Text Link to Item
- Wetsel, WC, and Fernstrom, JD. "In vivo biosynthesis of arginine vasopressin and oxytocin in hypothalami from intact and hypophysectomized rats." Endocrinology 120, no. 6 (June 1987): 2562-2568. Full Text Link to Item
- Culler, MC, Wetsel, WC, Valenca, MM, Johnston, CA, Masotto, C, Sar, M, and Negro-Vilar, A. "Orchidectomy induces temporal and regional changes in the synthesis and processing of the LHRH prohormone in the rat brain." Adv Exp Med Biol 219 (1987): 623-628. Link to Item
- Wetsel, WC, and Fernstrom, JD. "Effect of hypophysectomy on somatostatin-14 and somatostatin-28 biosynthesis in the rat hypothalamus." Brain Res 370, no. 2 (April 9, 1986): 315-320. Link to Item
- Wetsel, WC, and Rogers, AE. "Hepatic prolactin binding in female Sprague-Dawley rats fed a diet high in corn oil." J Natl Cancer Inst 73, no. 2 (August 1984): 531-536. Link to Item
- Wetsel, WC, Rogers, AE, Rutledge, A, and Leavitt, WW. "Absence of an effect of dietary corn oil content on plasma prolactin, progesterone, and 17 beta-estradiol in female Sprague-Dawley rats." Cancer Res 44, no. 4 (April 1984): 1420-1425. Link to Item
- Wetsel, WC, and Rogers, AE. "Hepatic prolactin binding in female rats fed control or high corn oil diets." Federation Proceedings 43, no. 3 (January 1, 1984).
- Rogers, AE, and Wetsel, WC. "Mammary carcinogenesis in rats fed different amounts and types of fat." Cancer Res 41, no. 9 Pt 2 (September 1981): 3735-3737. Link to Item
- Rogers, AE, and Wetsel, WC. "Mammary Carcinogenesis In Rats Fed Different Amounts And Types Of Fat." Cancer Research 41 (September 1, 1981): 3735-3737.
- Wetsel, WC, Rogers, AE, and Newberne, PM. "Dietary fat and DMBA mammary carcinogenesis in rats." Cancer Detect Prev 4, no. 1-4 (1981): 535-543. Link to Item
- Wetsel, WC, and Rogers, AE. "Effect of dietary fat on mammary carcinogenesis and serum prolactin in rats." Federation Proceedings 39, no. 3 II (January 1, 1980): 3248-null.
- Treichler, FR, and Wetsel, WC. "Pressure influences on air-licking behavior of rats." Physiological Psychology 6, no. 3 (January 1, 1978): 399-402. Full Text
- Treichler, FR, Wetsel, WC, and Lesner, SA. "Some characteristics of concurrent discrimination and retention by monkeys." Learning and Motivation 8, no. 2 (January 1, 1977): 213-228. Full Text
- Wetsel, WC, Riccio, DC, and Hinderliter, CF. "Effects of artificial rewarming upon hypothermia-induced retrograde amnesia." Physiological Psychology 4, no. 2 (January 1, 1976): 201-206. Full Text
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Book Sections
- Rodriguiz, RM, and Wetsel, WC. "Assessments of cognitive deficits in mutant mice." In Animal Models of Cognitive Impairment, 223-282. January 1, 2006.
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