Scholars@Duke
Whitney O'Neill Lane

Whitney O'Neill Lane

Assistant Professor of Surgery
Surgery, Plastic, Maxillofacial, and Oral Surgery
whitney.lane@duke.edu
Box 90999, Durham, NC 27708-0999
B203 LSRC, Durham, NC 27708

Selected Publications

Double Medial Circumflex Femoral Artery Perforator Flaps for Unilateral Breast Reconstruction-A Case Report.

Journal Article Microsurgery · November 2024 Thigh-based free flaps are a common second-line options in autologous breast reconstruction when the abdominal donor site is unavailable. While the profunda artery perforator (PAP) flap and gracilis-based flaps are most commonly utilized in this scenario, ... Full text Link to item Cite

Guideline Awareness Disparities in Plastic Surgery: A Survey of American Society of Plastic Surgeons.

Journal Article Plast Reconstr Surg Glob Open · August 2022 UNLABELLED: The American Society of Plastic Surgeons (ASPS) clinical practice guidelines were constructed to help direct evidence-based surgical management in plastic surgery. Societal member awareness of the recommendations for breast reconstruction has y ... Full text Link to item Cite

Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma.

Journal Article Cancer Med · January 2022 INTRODUCTION: Current standard of care for most intermediate and high-grade soft-tissue sarcomas (STS) includes limb-preserving surgical resection with either neoadjuvant radiation therapy (NRT) or adjuvant radiation therapy. To date, there have been a few ... Full text Link to item Cite

Patient Perspectives on the Financial Costs and Burdens of Breast Cancer Surgery.

Journal Article JCO Oncol Pract · June 2021 PURPOSE: Although financial toxicity is a well-documented aspect of cancer care, little is known about how patients narratively characterize financial experiences related to breast cancer treatment. We sought to examine these patient experiences through mi ... Full text Link to item Cite

Where advocacy meets patient-centered care-cost considerations in breast reconstruction decision-making.

Journal Article Gland Surg · January 2021 Cancer care in the United States is unquestionably expensive. In 2017, annual costs related to cancer-related treatment reached $180 billion. There is clear evidence that the increased cost of cancer care translates to financial hardship. This hardship is ... Full text Link to item Cite

Does facility volume influence survival in patients with primary malignant bone tumors of the vertebral column? A comparative cohort study.

Journal Article Spine J · July 2020 BACKGROUND CONTEXT: Facility volume has been correlated with survival in many cancers. This relationship has not been established in primary malignant bone tumors of the vertebral column (BTVC). PURPOSE: To investigate whether facility patient volume is as ... Full text Open Access Link to item Cite

Identifying Factors Most Important to Lower Extremity Trauma Patients: Key Concepts from the Development of a Patient-Reported Outcome Instrument for Lower Extremity Trauma, The LIMB-Q.

Journal Article Plast Reconstr Surg · May 2020 BACKGROUND: Severe lower extremity injuries are challenging to treat. The aspects of limb salvage and amputation most important to patients are not well-defined. This study's aim is to develop a conceptual framework for a patient-reported outcome instrumen ... Full text Link to item Cite

Epidemiologic and survival trends in adult primary bone tumors of the spine.

Journal Article Spine J · December 2019 BACKGROUND CONTEXT: Malignant primary spinal tumors are rare making it difficult to perform large studies comparing epidemiologic, survival, and treatment trends. We investigated the largest registry of primary bone tumors, the National Cancer Database (NC ... Full text Open Access Link to item Cite

Perspectives on the Costs of Cancer Care: A Survey of the American Society of Breast Surgeons.

Conference Ann Surg Oncol · October 2019 BACKGROUND: Cancer treatment costs are not routinely addressed in shared decisions for breast cancer surgery. Thus, we sought to characterize cost awareness and communication among surgeons treating breast cancer. METHODS: We conducted a self-administered, ... Full text Link to item Cite

Cost of Reconstruction: A Qualitative Study of Women after Breast Cancer

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · October 1, 2019 Link to item Cite

Decline in Racial Disparities in Postmastectomy Breast Reconstruction: A Surveillance, Epidemiology, and End Results Analysis from 1998 to 2014.

Journal Article Plast Reconstr Surg · June 2019 BACKGROUND: Despite increasing emphasis on reducing racial disparities in breast cancer care in the United States, it remains unknown whether access to breast reconstruction has improved over time. The authors characterized contemporary patterns of breast ... Full text Link to item Cite

The Influence of Marital Status on Contemporary Patterns of Postmastectomy Breast Reconstruction.

Journal Article J Plast Reconstr Aesthet Surg · May 2019 BACKGROUND: Marital status is known to influence quality of life, survival, and treatment decision-making after breast cancer diagnosis. We aimed to determine whether relationship status impacts contemporary patterns of immediate breast reconstruction. MET ... Full text Link to item Cite

Perioperative Treatment with a Prolyl Hydroxylase Inhibitor Reduces Necrosis in a Rat Ischemic Skin Flap Model.

Journal Article Plast Reconstr Surg · April 2019 BACKGROUND: The hypoxia-inducible factor (HIF) pathway, regulated by prolyl hydroxylase, is central to tissue adaptation to ischemia. The authors tested whether the prolyl hydroxylase inhibitor dimethyloxalylglycine reduces skin flap necrosis. METHODS: Dor ... Full text Link to item Cite

Surgical Resection of the Primary Tumor in Women With De Novo Stage IV Breast Cancer: Contemporary Practice Patterns and Survival Analysis.

Journal Article Ann Surg · March 2019 OBJECTIVE: We evaluated patterns of surgical care and their association with overall survival among a contemporary cohort of women with stage IV breast cancer. BACKGROUND: Surgical resection of the primary tumor remains controversial among women with stage ... Full text Link to item Cite

Revisiting the Role of Radiation Therapy in Chondrosarcoma: A National Cancer Database Study.

Journal Article Sarcoma · 2019 BACKGROUND: Although chondrosarcomas (CS) are mostly considered radioresistant, advancements in radiotherapy have brought attention to its use in these patients. Using the largest registry of primary bone tumors, the National Cancer Database (NCDB), we sou ... Full text Link to item Cite

The quality of breast cancer quality measures.

Conference Journal of Clinical Oncology · October 20, 2018 108 Background: To assess quality in breast cancer care, standardized metrics are needed. Many accepted breast performance metrics are based on evidence-based practice; however, most fail to reflect patient choice in treatment de ... Full text Cite

Preoperative radiation therapy in the surgical management of gastric and junctional adenocarcinoma: Should lymph node retrieval guidelines be altered?

Journal Article J Surg Oncol · June 2018 BACKGROUND: Although surgery remains the cornerstone of gastric cancer therapy, the use of radiation therapy (RT) is increasingly being employed to optimize outcomes. We sought to assess outcomes following use of RT for the treatment of gastric adenocarcin ... Full text Link to item Cite

Extent of axillary surgery in women with Stage IV breast cancer

Conference ANNALS OF SURGICAL ONCOLOGY · June 1, 2018 Link to item Cite

The Effect of Hospital Volume on Breast Cancer Mortality.

Journal Article Ann Surg · February 2018 OBJECTIVE: The aim of this study was to determine whether hospital volume was associated with mortality in breast cancer, and what thresholds of case volume impacted survival. BACKGROUND: Prior literature has demonstrated improved survival with treatment a ... Full text Link to item Cite

Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database.

Journal Article Lancet Oncol · July 2016 BACKGROUND: Recruitment into clinical trials for retroperitoneal sarcoma has been challenging, resulting in termination of the only randomised multicentre trial in the USA investigating perioperative radiotherapy. Nonetheless, use of radiotherapy for retro ... Full text Link to item Cite

Analysis of perioperative radiation therapy in the surgical treatment of primary and recurrent retroperitoneal sarcoma.

Journal Article J Surg Oncol · September 2015 Featured Publication BACKGROUND: Radiation therapy (RT) is increasingly utilized in conjunction with surgery for the treatment of retroperitoneal soft tissue sarcomas (RPS). Despite multiple theoretical advantages of RT, its role in the surgical management of this disease rema ... Full text Link to item Cite

Metastatic ampullary adenocarcinoma presenting as a hydrocele: a case report.

Journal Article JOP · May 27, 2014 Featured Publication CONTEXT: Metastases from ampullary malignancies are common, but spread to the testicle and paratesticular tissue is exceedingly rare with only 2 reported cases in the literature. CASE REPORT: We report a case of a 70 year-old male with a history of ampulla ... Full text Link to item Cite

Parallel-plate flow chamber and continuous flow circuit to evaluate endothelial progenitor cells under laminar flow shear stress.

Journal Article J Vis Exp · January 17, 2012 Featured Publication The overall goal of this method is to describe a technique to subject adherent cells to laminar flow conditions and evaluate their response to well quantifiable fluid shear stresses. Our flow chamber design and flow circuit (Fig. 1) contains a transparent ... Full text Link to item Cite

Use of autologous blood-derived endothelial progenitor cells at point-of-care to protect against implant thrombosis in a large animal model.

Journal Article Biomaterials · November 2011 Featured Publication Titanium (Ti) is commonly utilized in many cardiovascular devices, e.g. as a component of Nitinol stents, intra- and extracorporeal mechanical circulatory assist devices, but is associated with the risk of thromboemboli formation. We propose to solve this ... Full text Link to item Cite

Autologous endothelial progenitor cell-seeding technology and biocompatibility testing for cardiovascular devices in large animal model.

Journal Article J Vis Exp · September 9, 2011 Featured Publication Implantable cardiovascular devices are manufactured from artificial materials (e.g. titanium (Ti), expanded polytetrafluoroethylene), which pose the risk of thromboemboli formation. We have developed a method to line the inside surface of Ti tubes with aut ... Full text Link to item Cite

The biocompatibility of titanium cardiovascular devices seeded with autologous blood-derived endothelial progenitor cells: EPC-seeded antithrombotic Ti implants.

Journal Article Biomaterials · January 2011 Featured Publication Implantable and extracorporeal cardiovascular devices are commonly made from titanium (Ti) (e.g. Ti-coated Nitinol stents and mechanical circulatory assist devices). Endothelializing the blood-contacting Ti surfaces of these devices would provide them with ... Full text Link to item Cite

Autologous endothelial progenitor cell-seeding technology and biocompatibility testing for cardiovascular devices in large animal model

Journal Article Journal of Visualized Experiments · January 1, 2011 Implantable cardiovascular devices are manufactured from artificial materials (e.g. titanium (Ti), expanded polytetrafluoroethylene), which pose the risk of thromboemboli formation. We have developed a method to line the inside surface of Ti tubes with aut ... Full text Cite