Overview
Dr. Thompson's research focuses on the development and deployment of proteomics and metabolomics mass spectrometry techniques for the analysis of biological systems. He served as the Assistant Director of the Proteomics and Metabolomics Shared Resource in the Duke School of Medicine from 2007-2021. He currently maintains collaborations in metabolomics and proteomics research at Duke, and develops new tools for chemical analysis as a Principal Scientist at 908 Devices in Carrboro, NC.
Current Appointments & Affiliations
Adjunct Assistant Professor in the Department of Pharmacology and Cancer Biology
·
2021 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Recent Publications
Capillary Electrophoresis-High Resolution Mass Spectrometry for Measuring In Vivo Arginine Isotope Incorporation in Alzheimer's Disease Mouse Models.
Journal Article J Am Soc Mass Spectrom · June 2, 2021 Immune-based metabolic reprogramming of arginine utilization in the brain contributes to the neuronal pathology associated with Alzheimer's disease (AD). To enable our long-term goals of differentiation of AD mouse model genotypes, ages, and sexes based on ... Full text Open Access Link to item CiteA metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure.
Journal Article Sci Rep · May 18, 2021 Acute respiratory failure (ARF) requiring mechanical ventilation, a complicating factor in sepsis and other disorders, is associated with high morbidity and mortality. Despite its severity and prevalence, treatment options are limited. In light of accumula ... Full text Link to item CiteKPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway.
Journal Article Circ Res · April 30, 2021 [Figure: see text]. ... Full text Link to item CiteRecent Grants
Gender and APOE genotype interact to alter immune regulated metabolism in AD
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2019 - 2024Identification of Novel Bioactive Lipid Metabolites for Predicting Liver-related Outcomes in Persons Co-Infected with HIV and HCV (R01)
ResearchResearch Analyst · Awarded by National Institutes of Health · 2017 - 2024Development of an S-acylation assay for monitoring CLN1 Batten Disease clinical trials and progression of other neurological disorders
ResearchCo Investigator · Awarded by Circumvent Pharmaceutical · 2021 - 2024View All Grants
Education, Training & Certifications
University of North Carolina, Chapel Hill ·
2006
Ph.D.