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J. Will Thompson

Adjunct Assistant Professor in the Department of Pharmacology and Cancer Biology
Pharmacology & Cancer Biology
Box 91009, 450 Research Drive, Durham, NC 27708
701 W Main St, Ste 320, Durham, NC 27701

Overview


Dr. Thompson's research focuses on the development and deployment of proteomics and metabolomics mass spectrometry techniques for the analysis of biological systems. He served as the Assistant Director of the Proteomics and Metabolomics Shared Resource in the Duke School of Medicine from 2007-2021. He currently maintains collaborations in metabolomics and proteomics research at Duke, and develops new tools for chemical analysis as a Principal Scientist at 908 Devices in Carrboro, NC.

Current Appointments & Affiliations


Adjunct Assistant Professor in the Department of Pharmacology and Cancer Biology · 2021 - Present Pharmacology & Cancer Biology, Basic Science Departments

Recent Publications


Capillary Electrophoresis-High Resolution Mass Spectrometry for Measuring In Vivo Arginine Isotope Incorporation in Alzheimer's Disease Mouse Models.

Journal Article J Am Soc Mass Spectrom · June 2, 2021 Immune-based metabolic reprogramming of arginine utilization in the brain contributes to the neuronal pathology associated with Alzheimer's disease (AD). To enable our long-term goals of differentiation of AD mouse model genotypes, ages, and sexes based on ... Full text Open Access Link to item Cite

A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure.

Journal Article Sci Rep · May 18, 2021 Acute respiratory failure (ARF) requiring mechanical ventilation, a complicating factor in sepsis and other disorders, is associated with high morbidity and mortality. Despite its severity and prevalence, treatment options are limited. In light of accumula ... Full text Link to item Cite
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Recent Grants


Gender and APOE genotype interact to alter immune regulated metabolism in AD

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2019 - 2024

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Education, Training & Certifications


University of North Carolina, Chapel Hill · 2006 Ph.D.