William Bryan

Journal Article J Am Geriatr Soc · February 2024 BACKGROUND: Falls are the most common medication-related safety event in older adults. Deprescribing fall risk-increasing drugs (FRIDs) may mitigate fall risk. This study assesses the effects of an innovative deprescribing program in reducing FRID burden a ... Full text Link to item Cite

Resident involvement in cataract surgery at the Veterans Health Administration: complications, case complexity, and the role of experience.

Journal Article J Cataract Refract Surg · March 1, 2023 PURPOSE: To characterize intraoperative complications, case complexity, and changes in complication rates with surgical experience for cataract surgeries involving residents at the Veterans Health Administration (VHA). SETTING: All VHA facilities where cat ... Full text Link to item Cite

Development of a specialty medication clinical dashboard to improve tumor necrosis factor-α inhibitor safety and adherence monitoring.

Journal Article Am J Health Syst Pharm · April 1, 2022 PURPOSE: To describe the development of a pilot specialty medication clinical dashboard targeting tumor necrosis factor (TNF)-α inhibitor therapy. SUMMARY: This was a quality improvement project conducted between August 2019 and April 2020. The dashboard w ... Full text Link to item Cite

Evaluation of trends in continuous peripheral nerve block utilization for total knee arthroplasty within and outside the Veterans Affairs Healthcare System.

Journal Article Reg Anesth Pain Med · January 2022 Full text Link to item Cite

Role of memantine in the prophylactic treatment of episodic migraine: A systematic review.

Journal Article Headache · September 2021 OBJECTIVE: The purpose of this systematic review is to assess the efficacy and safety of memantine for the prophylactic treatment of episodic migraine. BACKGROUND: Migraine is a prevalent chronic disease with significant costs to the health care system. Al ... Full text Link to item Cite

Proton pump inhibitor usage reduces sustained viral response rates for veterans with HIV/HCV coinfection on ledipasvir/sofosbuvir: a real-world study from a multicentre VA cohort.

Journal Article J Viral Hepat · April 2021 Previous studies have reported an association of proton pump inhibitor (PPI) use and decreased sustained viral response rate (SVR) in patients taking ledipasvir/sofosbuvir (LDV/SOF). The relationship between PPI usage and SVR is less clear in patients with ... Full text Link to item Cite

Effects of Acetaminophen, NSAIDs, Gabapentinoids, and Their Combinations on Postoperative Pulmonary Complications After Total Hip or Knee Arthroplasty.

Journal Article Pain Med · October 1, 2020 OBJECTIVE: Multimodal analgesia has gained popularity in total hip arthroplasty (THA) and total knee arthroplasty (TKA), but large multicenter studies evaluating specific analgesic combinations are lacking. DESIGN: A retrospective study using the Premier H ... Full text Open Access Link to item Cite

Impact of prophylactic oseltamivir on INR in patients on stable warfarin therapy.

Journal Article J Thromb Thrombolysis · August 2020 Influenza prophylaxis with oseltamivir is recommended for exposed high-risk patients. Patients with many comorbidities have an increased likelihood of co-administration of oseltamivir and warfarin. Evidence of a drug interaction is conflicting in the liter ... Full text Link to item Cite

Dose-Dependent Association of Gabapentinoids with Pulmonary Complications After Total Hip and Knee Arthroplasties.

Journal Article J Bone Joint Surg Am · February 5, 2020 BACKGROUND: Gabapentinoids are commonly prescribed in perioperative multimodal analgesia protocols. Despite widespread use, the optimal dose to reduce opioid consumption while minimizing risks is unknown. We assessed dose-dependent effects of gabapentinoid ... Full text Link to item Cite

Association 'Between Gabapentinoids on the Day of Colorectal Surgery and Adverse Postoperative Respiratory Outcomes.

Journal Article Ann Surg · December 2019 OBJECTIVE: The aim of this study was to determine the association between gabapentinoids on the day of surgery and adverse postoperative outcomes in patients undergoing colorectal surgery in the United States. BACKGROUND: Gabapentinoids, gabapentin and pre ... Full text Link to item Cite

Trends in Chronic Opioid Use Around Inpatient Surgery Within the Veterans Health Administration.

Journal Article JAMA Surg · December 1, 2019 This study assesses outcomes of veterans who have undergone inpatient surgery since the Veterans Health Administration’s opioid safety initiative was initiated. ... Full text Link to item Cite

New Persistent Opioid Use After Postoperative Intensive Care in US Veterans.

Journal Article JAMA Surg · August 1, 2019 This study uses medical records of more than 800 000 US veterans treated in the intensive care unit after surgery to determine the rate at which these patients developed new persistent opioid use. ... Full text Link to item Cite

Impact of an Opioid Safety Initiative on Patients Undergoing Total Knee Arthroplasty: A Time Series Analysis.

Journal Article Anesthesiology · August 2019 BACKGROUND: The Opioid Safety Initiative decreased high-dose prescriptions across the Veterans Health Administration. This study sought to examine the impact of this intervention (i.e., the Opioid Safety Initiative) on pain scores and opioid prescriptions ... Full text Link to item Cite

Freedom From Opioids After Total Knee Arthroplasty.

Journal Article J Arthroplasty · May 2019 BACKGROUND: In the United States, opioids are commonly prescribed to treat knee pain after total knee arthroplasty (TKA). While surgery leads to decreased pain in most patients, a sizable minority continue to experience severe pain and consume opioids chro ... Full text Link to item Cite

An Interdisciplinary Academic Detailing Approach to Decrease Inappropriate Medication Prescribing by Physician Residents for Older Veterans Treated in the Emergency Department.

Journal Article J Pharm Pract · April 2019 OBJECTIVE: To evaluate the impact of an academic detailing intervention delivered as part of a quality improvement project by a physician-pharmacist pair on (1) self-reported confidence in prescribing for older adults and (2) rates of potentially inappropr ... Full text Link to item Cite

Economic Outcomes Associated with Safety Interventions by a Pharmacist-Adjudicated Prior Authorization Consult Service.

Journal Article J Manag Care Spec Pharm · March 2019 BACKGROUND: The establishment of a formulary management system ensures that health care professionals work together in an integrated patient care process to promote clinically sound, safe, and cost-effective medication therapy. Pharmacists have a foundatio ... Full text Link to item Cite

Pharmacy resident involvement in prior-authorization drug request adjudication.

Journal Article Am J Health Syst Pharm · December 1, 2018 PURPOSE: Results of a study to determine economic outcomes of pharmacy residents' involvement in prior-authorization drug request (PADR) adjudication within a Veterans Affairs (VA) healthcare system are reported. METHODS: A retrospective review was conduct ... Full text Link to item Cite

Evaluation of Hypoglycemia and Potential Risk Factors in a Veterans Affairs Community Living Center.

Journal Article Consult Pharm · January 1, 2018 OBJECTIVES: To describe hypoglycemic events in a Veterans Affairs (VA) community living center (CLC) population and to determine predictive risk factors associated with hypoglycemia. DESIGN: Retrospective, exploratory, observational chart review. SETTING: ... Full text Link to item Cite

Enhancing Quality of Provider Practices for Older Adults in the Emergency Department (EQUiPPED).

Journal Article J Am Geriatr Soc · July 2017 EQUiPPED is a multicomponent quality improvement initiative combining education, electronic clinical decision support, and individual provider feedback to influence prescribing and improve medication safety for older adults. The objective here was to evalu ... Full text Link to item Cite

Evaluating the Impact of Medication Safety Alerts on Prescribing of Potentially Inappropriate Medications for Older Veterans in an Ambulatory Care Setting.

Journal Article J Pharm Pract · February 2017 Potentially inappropriate medications (PIMs) have been associated with poor outcomes in older adults. Electronic health record (EHR)-based interventions may be an effective way to reduce PIM prescribing. The main objective of this study was to evaluate cha ... Full text Link to item Cite

Economic Outcomes Associated with a Pharmacist-Adjudicated Formulary Consult Service in a Veterans Affairs Medical Center.

Journal Article J Manag Care Spec Pharm · September 2016 BACKGROUND: Several cost analysis studies have been conducted looking at clinical and economic outcomes associated with clinical pharmacist services in a variety of health care settings. However, there is a paucity of data regarding the economic impact of ... Full text Link to item Cite

Impact of Clinical Pharmacy Specialists on the Design and Implementation of a Quality Improvement Initiative to Decrease Inappropriate Medications in a Veterans Affairs Emergency Department.

Journal Article J Manag Care Spec Pharm · January 2016 BACKGROUND: As the proportion of older adult patients who interface with the health care system grows, clinical pharmacy specialists (CPS) have a pivotal role in reducing potentially inappropriate medication (PIM) use in this population. OBJECTIVES: To (a) ... Full text Link to item Cite

Enhancing the Quality of Prescribing Practices for Older Veterans Discharged from the Emergency Department (EQUiPPED): Preliminary Results from Enhancing Quality of Prescribing Practices for Older Veterans Discharged from the Emergency Department, a Novel Multicomponent Interdisciplinary Quality Improvement Initiative.

Journal Article J Am Geriatr Soc · May 2015 Suboptimal medication prescribing for older adults has been described in a number of emergency department (ED) studies. Despite this, few studies have examined ED-targeted interventions aimed at reducing the use of potentially inappropriate medications (PI ... Full text Link to item Cite

Predictors of glycaemic control among HIV-positive veterans with diabetes.

Conference Int J STD AIDS · March 2015 Antiretroviral therapy has decreased HIV-related mortality. However, the incidence of diabetes as a co-morbidity is increasing as HIV-positive patients age. The purpose of this study was to assess the correlation between markers of HIV-infection and diabet ... Full text Link to item Cite

Impact of phosphodiesterase type 5 inhibitor treatment on the rates of sexually transmitted diseases in a Veterans Affairs Medical Center patient population.

Journal Article J Pharm Pract · February 2014 OBJECTIVE: The objective of this study was to investigate whether the rates of sexually transmitted diseases (STDs) are higher in a veteran population prescribed phosphodiesterase type 5 (PDE5) inhibitors for erectile dysfunction compared to individuals no ... Full text Link to item Cite