Scholars@Duke
William Thomas Clarke

William Thomas Clarke

Assistant Professor of Medicine
Medicine, Gastroenterology

Selected Publications

Comparison of Assays for Therapeutic Monitoring of Infliximab and Adalimumab in Patients With Inflammatory Bowel Diseases.

Journal Article Clin Gastroenterol Hepatol · April 2021 Comparison data regarding anti-tumor necrosis factor drug concentrations in inflammatory bowel disease (IBD) between the enzyme-linked immunosorbent assay (ELISA) and the homogenous mobility shift assay (HMSA) are scarce.1-3 As decisions in clinical practi ... Full text Link to item Cite

Clinical Impact of Corrections to Infliximab and Adalimumab Monitoring Results with the Homogeneous Mobility Shift Assay.

Journal Article J Clin Med · September 2, 2020 An upward drift for both infliximab and adalimumab concentrations measured by the homogenous mobility shift assay (HMSA) was previously reported. We aimed to investigate the impact of this drift on clinical care of patients with inflammatory bowel disease. ... Full text Link to item Cite

Metabolic syndrome and liver steatosis occur at lower body mass index in US Asian patients with chronic hepatitis B.

Journal Article J Viral Hepat · October 2019 We have previously shown that ultrasound identifies significant steatosis in patients with chronic HBV (CHB). However, the relationship between CHB, metabolic syndrome (MS) and steatosis is poorly understood. In this tertiary care, single-centre retrospect ... Full text Link to item Cite

Colorectal cancer surveillance in inflammatory bowel disease: Practice guidelines and recent developments.

Journal Article World J Gastroenterol · August 14, 2019 Patients with long-standing inflammatory bowel disease (IBD) involving at least 1/3 of the colon are at increased risk for colorectal cancer (CRC). Advancements in CRC screening and surveillance and improved treatment of IBD has reduced CRC incidence in pa ... Full text Link to item Cite

Updates in colorectal cancer screening in inflammatory bowel disease.

Journal Article Curr Opin Gastroenterol · July 2018 PURPOSE OF REVIEW: This review article will discuss the risk of colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD), as well as the current recommendations for CRC screening and surveillance in patients with ulcerative colitis or Croh ... Full text Link to item Cite

Patients with core antibody positive and surface antigen negative Hepatitis B (anti-HBc+, HBsAg-) on anti-TNF therapy have a low rate of reactivation.

Journal Article Clin Immunol · June 2018 Anti-TNF agents are widely used to treat immune-mediated disorders. Reactivation of Hepatitis B virus (HBV) is associated with immunosuppressive agents and biologics such as anti-TNF. There are limited data and differing guidelines for patients with negati ... Full text Link to item Cite

Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons.

Journal Article J Cell Sci · August 1, 2010 Syncoilin is an atypical type III intermediate filament (IF) protein, which is expressed in muscle and is associated with the dystrophin-associated protein complex. Here, we show that syncoilin is expressed in both the central and peripheral nervous system ... Full text Link to item Cite

Syncoilin isoform organization and differential expression in murine striated muscle.

Journal Article J Struct Biol · March 2009 Syncoilin is a 64kDa intermediate filament (IF) protein expressed in myocytes at the sarcolemma, perinucleus, myotendenous and neuromuscular junctions. Here we present a revised domain projection and structural analysis for the original isoform (sync-1) an ... Full text Link to item Cite

Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex.

Journal Article Cell Motil Cytoskeleton · June 2007 We previously described the Trypanin family of cytoskeleton-associated proteins that have been implicated in dynein regulation [Hill et al., J Biol Chem2000; 275(50):39369-39378; Hutchings et al., J Cell Biol2002;156(5):867-877; Rupp and Porter, J Cell Bio ... Full text Link to item Cite