Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of North Carolina - Chapel Hill 1968
• 

  Previous Appointments & Affiliations

  • Associate Professor in Medicine, Medicine, Clinical Pharmacology, Medicine 1999 - 2013
  • Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2000 - 2012
  • Interim Chair, Department of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2000 - 2005
  • Professor of Community and Family Medicine with Tenure, Family Medicine and Community Health, Clinical Science Departments 1999 - 2000
  • Chief, Division of Biometry in the Department of Community and Family Medicine, Family Medicine and Community Health, Clinical Science Departments 1977 - 2000
  • Associate Professor of Community and Family Medicine with tenure, Family Medicine and Community Health, Clinical Science Departments 1980 - 1999
  • Associate Professor in Medicine, Medicine, Clinical Science Departments 1994 - 1999
• Research
• 

  Selected Grants

  • The Clinical Research/Reproductive Scientist Training Program (CREST) awarded by University of Colorado - Denver 2018 - 2023
  • Clinical Research/Reproductive Scientist Training (CREST) Program awarded by National Institutes of Health 2015 - 2016
  • Clinical Research/Reproductive Scientist Training (CREST) Program awarded by National Institutes of Health 2014 - 2015
  • Clinical Research/Reproductive Scientist Training (CREST) Program awarded by National Institutes of Health 2013 - 2014
  • Develop Training in the principles, methods, and ethics of clinical research under the Clinical Research Reproductive Scientist Training (CREST) awarded by National Institutes of Health 2013 - 2014
  • Develop Training in the principles, methods, and ethics of clinical research under the Clinical Research Reproductive Scientist Training (CREST) awarded by National Institutes of Health 2013
  • CTSA UL awarded by National Institutes of Health 2006 - 2012
  • Develop Training in the principles, methods, and ethics of clinical research under the Clinical Research Reproductive Scientist Training (CREST) awarded by National Institutes of Health 2009 - 2012
  • IPA for Linda Sanders awarded by Department of Veterans Affairs 2007 - 2010
  • Development & Implemenation of a Model for On-Line Training awarded by National Institutes of Health 2007 - 2008
  • Curriculum Design- Purchase Order awarded by National Institutes of Health 2005 - 2008
  • Mentored Clinical Research Scholar Program awarded by National Institutes of Health 2002 - 2006
  • Distance Learning Models for Clinical Research Training awarded by National Institutes of Health 1999 - 2006
  • Race Differences in Prevalence and Incidence of Dementia awarded by National Institutes of Health 1991 - 2002
  • Intravenous Doxycycline For Rheumatoid Arthritis awarded by National Institutes of Health 1994 - 1998
  • Cognitive Behavioral Treatments For Arthritis Pain awarded by National Institutes of Health 1993 - 1998
  • General Clinical Research Center awarded by National Institutes of Health 1992 - 1995
  • Consortium To Establish A Registry For Alzheimer'S Disease awarded by National Institutes of Health 1986 - 1995
  • Consortium To Establish A Registry For Alzheimer'S Disease awarded by National Institutes of Health 1992 - 1994
  • Ipa Assignment Agreement awarded by Department of Veterans Affairs 1988 - 1989
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Page, Richard L., Edward L. C. Pritchett, Stuart Connolly, William E. Wilkinson, and William E. SVA-4 Investigators. “Azimilide for the treatment of atrial fibrillation, atrial flutter, and paroxysmal supraventricular tachycardia: results of a randomized trial and insights on the concordance of symptoms and recurrent arrhythmias.” J Cardiovasc Electrophysiol 19, no. 2 (February 2008): 172–77. https://doi.org/10.1111/j.1540-8167.2007.00985.x.
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    • Kerr, Charles R., Stuart J. Connolly, Peter Kowey, Richard L. Page, Edward L. C. Pritchett, Mikhail Y. Ruda, Witold Ruzyllo, William E. Wilkinson, and William E. A-STAR Investigators. “Efficacy of azimilide for the maintenance of sinus rhythm in patients with paroxysmal atrial fibrillation in the presence and absence of structural heart disease.” Am J Cardiol 98, no. 2 (July 15, 2006): 215–18. https://doi.org/10.1016/j.amjcard.2006.01.084.
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    • Pritchett, Edward L. C., Peter Kowey, Stuart Connolly, Richard L. Page, Charles Kerr, William E. Wilkinson, and William E. A-COMET-I Investigators. “Antiarrhythmic efficacy of azimilide in patients with atrial fibrillation. Maintenance of sinus rhythm after conversion to sinus rhythm.” Am Heart J 151, no. 5 (May 2006): 1043–49. https://doi.org/10.1016/j.ahj.2005.10.019.
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    • Weinberg, J Brice, Thomas Lang, William E. Wilkinson, David S. Pisetsky, and E William St Clair. “Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures.” Arthritis Res Ther 8, no. 5 (2006): R140. https://doi.org/10.1186/ar2030.
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    • Anderson, D. J., L. B. Goldstein, W. E. Wilkinson, G. R. Corey, C. H. Cabell, L. L. Sanders, and D. J. Sexton. “Stroke location, characterization, severity, and outcome in mitral vs aortic valve endocarditis.” Neurology 61, no. 10 (November 25, 2003): 1341–46. https://doi.org/10.1212/01.wnl.0000094359.47929.e4.
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    • Muir, Andrew J., Linda L. Sanders, Michael A. Heneghan, Paul C. Kuo, William E. Wilkinson, and Dawn Provenzale. “An examination of factors predicting prioritization for liver transplantation.” Liver Transpl 8, no. 10 (October 2002): 957–61. https://doi.org/10.1053/jlts.2002.35545.
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    • Pritchett, Edward L. C., Marcia C. Schulte, Daniel Schnell, Stephen R. Marcello, William E. Wilkinson, Richard L. Page, Stuart J. Connolly, and Stuart J. Azimilide Supraventricular Arrhythmia Program 3 (SVA-3) Investigators. “Effects of azimilide on heart rate and ECG conduction intervals during sinus rhythm in patients with a history of atrial fibrillation.” J Clin Pharmacol 42, no. 4 (April 2002): 388–94.
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    • Wilkinson, William E., and Eugene Z. Oddone. “Training physicians for careers in clinical research: a tailored educational experience.” Nat Biotechnol 20, no. 1 (January 2002): 99–100. https://doi.org/10.1038/nbt0102-99.
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    • St Clair, E. W., W. E. Wilkinson, D. S. Pisetsky, D. J. Sexton, R. Drew, V. B. Kraus, and R. A. Greenwald. “The effects of intravenous doxycycline therapy for rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial.” Arthritis Rheum 44, no. 5 (May 2001): 1043–47. https://doi.org/10.1002/1529-0131(200105)44:5<1043::AID-ANR183>3.0.CO;2-C.
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    • Muir, A. J., L. L. Sanders, W. E. Wilkinson, and K. Schmader. “Reducing medication regimen complexity: a controlled trial.” J Gen Intern Med 16, no. 2 (February 2001): 77–82. https://doi.org/10.1046/j.1525-1497.2001.016002077.x.
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    • Pritchett, E. L., R. L. Page, S. J. Connolly, S. R. Marcello, D. J. Schnell, and W. E. Wilkinson. “Antiarrhythmic effects of azimilide in atrial fibrillation: efficacy and dose-response. Azimilide Supraventricular Arrhythmia Program 3 (SVA-3) Investigators.” J Am Coll Cardiol 36, no. 3 (September 2000): 794–802. https://doi.org/10.1016/s0735-1097(00)00773-7.
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    • Al-Khatib, S. M., W. E. Wilkinson, L. L. Sanders, E. A. McCarthy, and E. L. Pritchett. “Observations on the transition from intermittent to permanent atrial fibrillation.” Am Heart J 140, no. 1 (July 2000): 142–45. https://doi.org/10.1067/mhj.2000.107547.
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    • Markert, M. L., C. B. Hicks, J. A. Bartlett, J. L. Harmon, L. P. Hale, M. L. Greenberg, G. Ferrari, et al. “Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection.” Aids Res Hum Retroviruses 16, no. 5 (March 20, 2000): 403–13. https://doi.org/10.1089/088922200309061.
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    • Kirkland, K. B., J. P. Briggs, S. L. Trivette, W. E. Wilkinson, and D. J. Sexton. “The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs.” Infect Control Hosp Epidemiol 20, no. 11 (November 1999): 725–30. https://doi.org/10.1086/501572.
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    • Pritchett, E. L., and W. E. Wilkinson. “Effect of dofetilide on survival in patients with supraventricular arrhythmias.” Am Heart J 138, no. 5 Pt 1 (November 1999): 994–97. https://doi.org/10.1016/s0002-8703(99)70029-3.
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    • St Clair, E. W., S. A. Moak, W. E. Wilkinson, L. Sanders, T. Lang, and R. A. Greenwald. “A cross sectional analysis of 5 different markers of collagen degradation in rheumatoid arthritis.” J Rheumatol 25, no. 8 (August 1998): 1472–79.
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    • Dodds, G. A., W. E. Wilkinson, R. A. Greenfield, A. Natale, J. Kisslo, and E. L. Pritchett. “Evaluation of the effect of transthoracic cardioversion from ventricular tachycardia to sinus rhythm on left atrial mechanical function.” Am J Cardiol 78, no. 12 (December 15, 1996): 1436–39. https://doi.org/10.1016/s0002-9149(97)89298-3.
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    • St Clair, E. W., W. E. Wilkinson, T. Lang, L. Sanders, M. A. Misukonis, G. S. Gilkeson, D. S. Pisetsky, D. I. Granger, and J. B. Weinberg. “Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients.” J Exp Med 184, no. 3 (September 1, 1996): 1173–78. https://doi.org/10.1084/jem.184.3.1173.
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    • Hamer, M. E., W. E. Wilkinson, E. A. McCarthy, R. L. Page, and E. L. Pritchett. “Heart rate during spontaneous and induced paroxysmal supraventricular tachycardia.” Pacing Clin Electrophysiol 18, no. 12 Pt 1 (December 1995): 2155–57. https://doi.org/10.1111/j.1540-8159.1995.tb04641.x.
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    • Welsh, K. A., G. Fillenbaum, W. Wilkinson, A. Heyman, R. C. Mohs, Y. Stern, L. Harrell, S. D. Edland, and D. Beekly. “Neuropsychological test performance in African-American and white patients with Alzheimer's disease.” Neurology 45, no. 12 (December 1995): 2207–11. https://doi.org/10.1212/wnl.45.12.2207.
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    • Hulette, C., S. Mirra, W. Wilkinson, A. Heyman, G. Fillenbaum, and C. Clark. “The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part IX. A prospective cliniconeuropathologic study of Parkinson's features in Alzheimer's disease.” Neurology 45, no. 11 (November 1995): 1991–95. https://doi.org/10.1212/wnl.45.11.1991.
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    • Kirkland, K. B., W. E. Wilkinson, and D. J. Sexton. “Therapeutic delay and mortality in cases of Rocky Mountain spotted fever.” Clin Infect Dis 20, no. 5 (May 1995): 1118–21. https://doi.org/10.1093/clinids/20.5.1118.
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    • Hamer, M. E., W. E. Wilkinson, W. K. Clair, R. L. Page, E. A. McCarthy, and E. L. Pritchett. “Incidence of symptomatic atrial fibrillation in patients with paroxysmal supraventricular tachycardia.” J Am Coll Cardiol 25, no. 5 (April 1995): 984–88. https://doi.org/10.1016/0735-1097(94)00512-o.
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    • Fillenbaum, G. G., W. E. Wilkinson, K. A. Welsh, and R. C. Mohs. “Discrimination between stages of Alzheimer's disease with subsets of Mini-Mental State Examination items. An analysis of Consortium to Establish a Registry for Alzheimer's Disease data.” Arch Neurol 51, no. 9 (September 1994): 916–21. https://doi.org/10.1001/archneur.1994.00540210088017.
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    • Hamer, M. E., W. K. Clair, W. E. Wilkinson, R. A. Greenfield, E. L. Pritchett, and R. L. Page. “Evaluation of outpatients experiencing implantable cardioverter defibrillator shocks associated with minimal symptoms.” Pacing Clin Electrophysiol 17, no. 5 Pt 1 (May 1994): 938–43. https://doi.org/10.1111/j.1540-8159.1994.tb01436.x.
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    • Page, R. L., W. E. Wilkinson, W. K. Clair, E. A. McCarthy, and E. L. Pritchett. “Asymptomatic arrhythmias in patients with symptomatic paroxysmal atrial fibrillation and paroxysmal supraventricular tachycardia.” Circulation 89, no. 1 (January 1994): 224–27. https://doi.org/10.1161/01.cir.89.1.224.
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    • Pritchett, E. L., W. E. Wilkinson, W. K. Clair, and E. A. McCarthy. “Comparison of mortality in patients treated with propafenone to those treated with a variety of antiarrhythmic drugs for supraventricular arrhythmias.” Am J Cardiol 72, no. 1 (July 1, 1993): 108–10. https://doi.org/10.1016/0002-9149(93)90231-z.
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    • Clair, W. K., W. E. Wilkinson, E. A. McCarthy, R. L. Page, and E. L. Pritchett. “Spontaneous occurrence of symptomatic paroxysmal atrial fibrillation and paroxysmal supraventricular tachycardia in untreated patients.” Circulation 87, no. 4 (April 1993): 1114–22. https://doi.org/10.1161/01.cir.87.4.1114.
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    • Coffey, C. E., W. E. Wilkinson, R. D. Weiner, J. C. Ritchie, and M. Aque. “The dexamethasone suppression test and quantitative cerebral anatomy in depression.” Biol Psychiatry 33, no. 6 (March 15, 1993): 442–49. https://doi.org/10.1016/0006-3223(93)90172-a.
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    • Coffey, C. E., W. E. Wilkinson, R. D. Weiner, I. A. Parashos, W. T. Djang, M. C. Webb, G. S. Figiel, and C. E. Spritzer. “Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study.” Arch Gen Psychiatry 50, no. 1 (January 1993): 7–16. https://doi.org/10.1001/archpsyc.1993.01820130009002.
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    • Davis, P. C., L. Gray, M. Albert, W. Wilkinson, J. Hughes, A. Heyman, M. Gado, A. J. Kumar, S. Destian, and C. Lee. “The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part III. Reliability of a standardized MRI evaluation of Alzheimer's disease.” Neurology 42, no. 9 (September 1992): 1676–80. https://doi.org/10.1212/wnl.42.9.1676.
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    • Clair, W. K., W. E. Wilkinson, E. A. McCarthy, and E. L. Pritchett. “Treatment of paroxysmal supraventricular tachycardia with oral diltiazem.” Clin Pharmacol Ther 51, no. 5 (May 1992): 562–65. https://doi.org/10.1038/clpt.1992.63.
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    • Page, R. L., J. M. Wharton, W. E. Wilkinson, I. M. Friedman, W. D. Claypool, A. Karim, K. G. Kowalski, S. J. McDonald, P. Gardiner, and E. L. Pritchett. “Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics.” Clin Pharmacol Ther 51, no. 4 (April 1992): 371–78. https://doi.org/10.1038/clpt.1992.36.
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    • Coffey, C. E., W. E. Wilkinson, I. A. Parashos, S. A. Soady, R. J. Sullivan, L. J. Patterson, G. S. Figiel, M. C. Webb, C. E. Spritzer, and W. T. Djang. “Quantitative cerebral anatomy of the aging human brain: a cross-sectional study using magnetic resonance imaging.” Neurology 42, no. 3 Pt 1 (March 1992): 527–36. https://doi.org/10.1212/wnl.42.3.527.
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    • Coffey, C. E., R. D. Weiner, W. T. Djang, G. S. Figiel, S. A. Soady, L. J. Patterson, P. D. Holt, C. E. Spritzer, and W. E. Wilkinson. “Brain anatomic effects of electroconvulsive therapy. A prospective magnetic resonance imaging study.” Arch Gen Psychiatry 48, no. 11 (November 1991): 1013–21. https://doi.org/10.1001/archpsyc.1991.01810350053008.
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    • Pritchett, E. L., and W. E. Wilkinson. “Mortality in patients treated with flecainide and encainide for supraventricular arrhythmias.” Am J Cardiol 67, no. 11 (May 1, 1991): 976–80. https://doi.org/10.1016/0002-9149(91)90170-p.
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    • Pritchett, E. L., and W. E. Wilkinson. “New drug application strategies for supraventricular arrhythmias.” Clin Pharmacol Ther 49, no. 5 (May 1991): 481–87. https://doi.org/10.1038/clpt.1991.58.
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    • Pritchett, E. L., E. A. McCarthy, and W. E. Wilkinson. “Propafenone treatment of symptomatic paroxysmal supraventricular arrhythmias. A randomized, placebo-controlled, crossover trial in patients tolerating oral therapy.” Ann Intern Med 114, no. 7 (April 1, 1991): 539–44. https://doi.org/10.7326/0003-4819-114-7-539.
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    • Heinz, E. R., B. J. Crain, R. A. Radtke, P. C. Burger, A. H. Friedman, W. T. Djang, and W. E. Wilkinson. “MR imaging in patients with temporal lobe seizures: correlation of results with pathologic findings.” Ajr Am J Roentgenol 155, no. 3 (September 1990): 581–86. https://doi.org/10.2214/ajr.155.3.2117360.
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    • Hurwitz, J. L., L. D. German, D. L. Packer, J. M. Wharton, E. A. McCarthy, W. E. Wilkinson, E. N. Prystowsky, and E. L. Pritchett. “Occurrence of atrial fibrillation in patients with paroxysmal supraventricular tachycardia due to atrioventricular nodal reentry.” Pacing Clin Electrophysiol 13, no. 6 (June 1990): 705–10. https://doi.org/10.1111/j.1540-8159.1990.tb02094.x.
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    • Schildkraut, J. M., B. S. Hulka, and W. E. Wilkinson. “Oral contraceptives and breast cancer: A case-control study with hospital and community controls.” Obstetrics and Gynecology 76, no. 3 (January 1, 1990): 395–402.
    • Heinz, E. R., B. J. Crain, R. A. Radtke, P. C. Burger, A. H. Friedman, W. T. Djang, and W. E. Wilkinson. “MR imaging in patients with temporal lobe seizures: correlation of results with pathologic findings.” Ajnr Am J Neuroradiol 11, no. 4 (1990): 827–32.
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    • Greer, G. S., W. E. Wilkinson, E. A. McCarthy, and E. L. Pritchett. “Random and nonrandom behavior of symptomatic paroxysmal atrial fibrillation.” Am J Cardiol 64, no. 5 (August 1, 1989): 339–42. https://doi.org/10.1016/0002-9149(89)90531-6.
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    • Olsen, E. A., G. R. Lichtenstein, and W. E. Wilkinson. “Changes in serum lipids in patients with condylomata acuminata treated with interferon alfa-n1 (Wellferon).” J Am Acad Dermatol 19, no. 2 Pt 1 (August 1988): 286–89. https://doi.org/10.1016/s0190-9622(88)70173-5.
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    • Irwin, J. M., E. A. McCarthy, W. E. Wilkinson, and E. L. Pritchett. “Circadian occurrence of symptomatic paroxysmal supraventricular tachycardia in untreated patients.” Circulation 77, no. 2 (February 1988): 298–300. https://doi.org/10.1161/01.cir.77.2.298.
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    • Sherrier, R. H., C. Chiles, W. E. Wilkinson, G. A. Johnson, and C. E. Ravin. “Effects of image processing on nodule detection rates in digitized chest radiographs: ROC study of observer performance.” Radiology 166, no. 2 (February 1988): 447–50. https://doi.org/10.1148/radiology.166.2.3336719.
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    • Heyman, A., W. E. Wilkinson, B. J. Hurwitz, M. J. Helms, C. S. Haynes, C. M. Utley, and L. P. Gwyther. “Early-onset Alzheimer's disease: clinical predictors of institutionalization and death.” Neurology 37, no. 6 (June 1987): 980–84. https://doi.org/10.1212/wnl.37.6.980.
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    • Heyman, A., D. Schmechel, W. Wilkinson, H. Rogers, R. Krishnan, D. Holloway, K. Schultz, L. Gwyther, R. Peoples, and C. Utley. “Failure of long term high-dose lecithin to retard progression of early-onset Alzheimer's disease.” J Neural Transm Suppl 24 (1987): 279–86.
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    • Hulka, B. S., L. E. Chambless, W. E. Wilkinson, D. C. Deubner, and K. S. McCarty. “The authors reply.” American Journal of Epidemiology 123, no. 6 (January 1, 1986): 1118–19. https://doi.org/10.1093/oxfordjournals.aje.a114340.
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    • Hurwitz, B. J., A. Heyman, W. E. Wilkinson, C. S. Haynes, and C. M. Utley. “Comparison of amaurosis fugax and transient cerebral ischemia: a prospective clinical and arteriographic study.” Ann Neurol 18, no. 6 (December 1985): 698–704. https://doi.org/10.1002/ana.410180612.
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    • Heyman, A., W. E. Wilkinson, B. J. Hurwitz, C. S. Haynes, C. M. Utley, R. A. Rosati, J. G. Burch, and T. B. Gore. “Risk of ischemic heart disease in patients with TIA.” Neurology 34, no. 5 (May 1984): 626–30. https://doi.org/10.1212/wnl.34.5.626.
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    • Hulka, B. S., L. E. Chambless, W. E. Wilkinson, D. C. Deubner, and K. S. McCarty. “Hormonal and personal effects on estrogen receptors in breast cancer.” Am J Epidemiol 119, no. 5 (May 1984): 692–704. https://doi.org/10.1093/oxfordjournals.aje.a113790.
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    • Heyman, A., W. E. Wilkinson, J. A. Stafford, M. J. Helms, A. H. Sigmon, and T. Weinberg. “Alzheimer's disease: a study of epidemiological aspects.” Ann Neurol 15, no. 4 (April 1984): 335–41. https://doi.org/10.1002/ana.410150406.
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    • Gehlbach, S. H., W. E. Wilkinson, W. E. Hammond, N. E. Clapp, A. L. Finn, W. J. Taylor, and M. S. Rodell. “Improving drug prescribing in a primary care practice.” Med Care 22, no. 3 (March 1984): 193–201. https://doi.org/10.1097/00005650-198403000-00002.
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    • Wilkinson, W. E., S. H. Gehlbach, W. E. Hammond, and N. E. Clapp. “USING COMPUTER-GENERATED FEEDBACK TO IMPROVE PHYSICIAN PRESCRIBING.” Proceedings  Annual Symposium on Computer Applications in Medical Care, December 1, 1982, 76–78.
    • Hulka, B. S., L. E. Chambless, D. C. Deubner, and W. E. Wilkinson. “Breast cancer and estrogen replacement therapy.” Am J Obstet Gynecol 143, no. 6 (July 15, 1982): 638–44. https://doi.org/10.1016/0002-9378(82)90108-9.
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    • McCarty, K. S., J. W. Grant, N. Georgiade, W. Wilkinson, R. Graham, B. J. Ferguson, D. Deubner, and H. F. Seigler. “Immunoglobulin localization in benign and malignant lesions of the human mammary gland.” Cancer 48, no. 1 (July 1, 1981): 69–75. https://doi.org/10.1002/1097-0142(19810701)48:1<69::aid-cncr2820480115>3.0.co;2-m.
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    • Obrist, W. D., H. K. Thompson, H. S. Wang, and W. E. Wilkinson. “Regional cerebral blood flow estimated by 133-xenon inhalation.” Stroke 6, no. 3 (1975): 245–56. https://doi.org/10.1161/01.str.6.3.245.
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  • Conference Papers

    • Brice Weinberg, J., Thomas Lang, William E. Wilkinson, David S. Pisetsky, and E William St. Clair. “P132. Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures.” In Nitric Oxide, 14:61–61. Elsevier BV, 2006. https://doi.org/10.1016/j.niox.2006.04.199.
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