Wolfgang Bernhard Liedtke
Adjunct Professor in the Department of Neurology
Research Interests in the Liedtke-Lab:
Visit the lab's website, download papers and read Dr. Liedtke's CV here.
- Pain/ nociception
- Sensory transduction and -transmission
- TRP ion channels
- Water and salt equilibrium regulated by the central nervous system
Visit the lab's website, download papers and read Dr. Liedtke's CV here.
Current Appointments & Affiliations
- Adjunct Professor in the Department of Neurology, Neurology, Headache and Pain, Neurology 2021
- Professor of Neurobiology, Neurobiology, Basic Science Departments 2016
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2011
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019
Contact Information
- 201G Bryan Res Bldg, Durham, NC 27710
- Duke Box 2900, Durham, NC 27710
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wolfgang@neuro.duke.edu
(919) 684-0058
- Background
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Education, Training, & Certifications
- Resident, Psychiatry, University of Duisburg Essen (Germany) 1993 - 1994
- Resident, Neurology, University of Duisburg Essen (Germany) 1991 - 1993
- Resident, Neurology, University of Tubingen (Germany) 1989 - 1991
- Ph.D., Ruhr-Universitat Bochum (Germany) 1990
- Medicine/Surgery/Neurology Intenship, Surgery, Hôtel-Dieu de Paris (France) 1988 - 1989
- M.D., University of Cologne, Faculty of Medicine (Germany) 1989
- Medicine/Surgery/Neurology Intenship, Neurology, University Hospital Zurich (Switzerland) 1988
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Previous Appointments & Affiliations
- Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2016 - 2021
- Professor of Neurology, Neurology, Headache and Pain, Neurology 2016 - 2021
- Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 2011 - 2015
- Associate Professor of Neurology, Neurology, Headache and Pain, Neurology 2014 - 2015
- Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2014 - 2015
- Associate Professor of Neurology, Neurology, Headache and Pain, Neurology 2011 - 2014
- Assistant Professor of Medicine, Neurology, Clinical Science Departments 2004 - 2011
- Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 2004 - 2011
- Recognition
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In the News
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APR 5, 2021 -
MAR 22, 2021 -
APR 25, 2017 Clinical Practice Today -
FEB 28, 2017 Clinical Practice Today -
JUN 3, 2016 WFDD -
JUN 1, 2016 -
JUN 1, 2016 The Daily Beast -
APR 20, 2016 Co.Exist -
APR 20, 2016 Co.Exist -
MAR 14, 2016 Motherboard -
MAR 11, 2016 -
OCT 19, 2015 Canada Journal -
OCT 19, 2015 Canada Journal -
OCT 15, 2015 -
NOV 10, 2014 -
AUG 29, 2014 -
AUG 19, 2013 The Charlotte Observer -
AUG 7, 2013 TIME -
AUG 7, 2013 London Daily Mail
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- Research
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Selected Grants
- Duke Pain Early-phase Research Clinical Center (PERC) awarded by National Institutes of Health 2019 - 2024
- COVID-19 Fast Grant awarded by George Mason University 2020 - 2021
- Deconstructing Cartilage Mechanotransduction by Piezo Channels awarded by National Institutes of Health 2020 - 2021
- Novel pathways regulating calcium mediated contractility and inflammation in the pregnant uterus awarded by Stanford University 2018 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Not SciFi: How to Get Rid of Trigeminal Neuralgia awarded by The Facial Pain Research Foundation 2018 - 2020
- Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2019
- Biomedical Researcher Development Scholarship (BRDS) Research Career Development Award (K12) awarded by University of North Carolina - Chapel Hill 2015 - 2018
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- Molecular Mechanisms of Regulation of Sodium-Appetite in Mammals awarded by Texas Biomedical Research Institute 2016 - 2017
- Small molecule targeting of dual TRP channels to attenuate inflammation and fibrosis awarded by North Carolina Biotechnology Center 2016 - 2017
- Engineering cartilage mechanotransduction for treatment of chondrocyte injury awarded by National Institutes of Health 2014 - 2017
- Transdermal pain therapy with ELSM11 (formulated ketoprofen) in a spectrum of pre-clinical pain models awarded by Achelios Therapeutics 2014 - 2016
- Masticatory sensitization of trigeminal ganglion sensory neurons awarded by National Institutes of Health 2014 - 2016
- Control of trigeminal touch sensory circuit assembly awarded by National Institutes of Health 2009 - 2016
- Training in Fundamental &Translational Neuroscience awarded by National Institutes of Health 2005 - 2016
- Commitment of Funds for NCBC Grant (3834531) awarded by Achelios Therapeutics 2012 - 2015
- Small Molecule Therapy to Inhibit Osteoarthritis Progression in the Aging awarded by Cytex Therapeutics Inc. 2013 - 2015
- TRP and AQP Channels: Modulation of Function, Raft Location by Membrane Lipids awarded by National Institutes of Health 1980 - 2015
- Mechanical and Osmotic Signaling in Chondrocytes awarded by National Institutes of Health 2001 - 2015
- Molecular Mechanisms of Regulation of Sodium-Appetite in Mammals awarded by G. Harold & Leila Y. Mathers Foundation 2014 - 2015
- Live-Animal Micro-CT System awarded by National Institutes of Health 2012 - 2014
- Role of trpv4 in trigeminally mediated nociception awarded by National Institutes of Health 2007 - 2012
- Sex-specific gene regulation of neuronal chloride co-transporter, kcc2 awarded by National Institutes of Health 2009 - 2012
- COPAS BIOSORT Worm Sorter awarded by National Institutes of Health 2009 - 2010
- Molecular studies of osmotic neural sensing awarded by National Institute of Mental Health 2002 - 2006
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Erfinanda, Lasti, Lin Zou, Birgitt Gutbier, Laura Kneller, Sarah Weidenfeld, Laura Michalick, Disi Lei, et al. “Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation.” Sci Transl Med 14, no. 674 (December 7, 2022): eabg8577. https://doi.org/10.1126/scitranslmed.abg8577.Full Text Link to Item
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Liedtke, Wolfgang. “Mechanistic contribution of CaV3.2 calcium channels to trigeminal neuralgia pathophysiology not clarified.” F1000research 11 (June 29, 2022): 718–718. https://doi.org/10.12688/f1000research.122997.1.Full Text
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Zhang, Yang, Pengfei Liang, Liheng Yang, Ke Zoe Shan, Liping Feng, Yong Chen, Wolfgang Liedtke, Carolyn B. Coyne, and Huanghe Yang. “Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion.” Elife 11 (June 7, 2022). https://doi.org/10.7554/eLife.78840.Full Text Open Access Copy Link to Item
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Liedtke, Wolfgang. “Mechanistic contribution of CaV3.2 calcium channels to trigeminal neuralgia pathophysiology not clarified.” F1000research 11 (January 2022): 718. https://doi.org/10.12688/f1000research.122997.2.Full Text
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Willard, Vincent P., Holly A. Leddy, Daniel Palmer, Chia-Lung Wu, Wolfgang Liedtke, and Farshid Guilak. “Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis.” Stem Cells 39, no. 11 (November 2021): 1447–56. https://doi.org/10.1002/stem.3440.Full Text Link to Item
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Yeo, Michele, Yong Chen, Changyu Jiang, Gang Chen, Kaiyuan Wang, Sharat Chandra, Andrey Bortsov, et al. “Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission.” Nat Commun 12, no. 1 (October 27, 2021): 6208. https://doi.org/10.1038/s41467-021-26270-3.Full Text Link to Item
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Kanugula, Anantha K., Ravi K. Adapala, Anurag Jamaiyar, Nina Lenkey, Brianna D. Guarino, Wolfgang Liedtke, Liya Yin, Sailaja Paruchuri, and Charles K. Thodeti. “Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity.” Angiogenesis 24, no. 3 (August 2021): 647–56. https://doi.org/10.1007/s10456-021-09775-9.Full Text Link to Item
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Chen, Yong, Zi-Long Wang, Michele Yeo, Qiao-Juan Zhang, Ana E. López-Romero, Hui-Ping Ding, Xin Zhang, et al. “Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.” Gastroenterology 161, no. 1 (July 2021): 301-317.e16. https://doi.org/10.1053/j.gastro.2021.03.049.Full Text Link to Item
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Lee, Whasil, Robert J. Nims, Alireza Savadipour, Qiaojuan Zhang, Holly A. Leddy, Fang Liu, Amy L. McNulty, Yong Chen, Farshid Guilak, and Wolfgang B. Liedtke. “Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.” Proc Natl Acad Sci U S A 118, no. 13 (March 30, 2021). https://doi.org/10.1073/pnas.2001611118.Full Text Open Access Copy Link to Item
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Nims, Robert J., Lara Pferdehirt, Noelani B. Ho, Alireza Savadipour, Jeremiah Lorentz, Sima Sohi, Jordan Kassab, et al. “A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues.” Sci Adv 7, no. 5 (January 2021). https://doi.org/10.1126/sciadv.abd9858.Full Text Link to Item
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Rosenkranz, S. C., A. Shaposhnykov, O. Schnapauff, L. Epping, V. Vieira, K. Heidermann, B. Schattling, et al. “TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation.” Frontiers in Cell and Developmental Biology 8 (August 27, 2020). https://doi.org/10.3389/fcell.2020.00849.Full Text
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Naik, S. K., K. Pattanaik, J. Eich, V. Sparr, M. Hauptmann, B. Kalsdorf, N. Reiling, et al. “Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium tuberculosis Early and Late in Infection.” Iscience 23, no. 6 (June 26, 2020). https://doi.org/10.1016/j.isci.2020.101206.Full Text
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Kuebler, Wolfgang M., Sven-Eric Jordt, and Wolfgang B. Liedtke. “Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach.” American Journal of Physiology. Lung Cellular and Molecular Physiology 318, no. 6 (June 2020): L1239–43. https://doi.org/10.1152/ajplung.00161.2020.Full Text
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Swain, Sandip M., Joelle M-J Romac, Rafiq A. Shahid, Stephen J. Pandol, Wolfgang Liedtke, Steven R. Vigna, and Rodger A. Liddle. “TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.” J Clin Invest 130, no. 5 (May 1, 2020): 2527–41. https://doi.org/10.1172/JCI134111.Full Text Link to Item
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Ottolini, Matteo, Kwangseok Hong, Eric L. Cope, Zdravka Daneva, Leon J. DeLalio, Jennifer D. Sokolowski, Corina Marziano, et al. “Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity.” Circulation 141, no. 16 (April 21, 2020): 1318–33. https://doi.org/10.1161/CIRCULATIONAHA.119.043385.Full Text Link to Item
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Xu, Biao, Mengna Zhang, Xuerui Shi, Run Zhang, Dan Chen, Yong Chen, Zilong Wang, et al. “The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors.” Br J Pharmacol 177, no. 1 (January 2020): 93–109. https://doi.org/10.1111/bph.14848.Full Text Link to Item
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Gilchrist, Christopher L., Holly A. Leddy, Laurel Kaye, Natasha D. Case, Katheryn E. Rothenberg, Dianne Little, Wolfgang Liedtke, Brenton D. Hoffman, and Farshid Guilak. “TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension.” Proc Natl Acad Sci U S A 116, no. 6 (February 5, 2019): 1992–97. https://doi.org/10.1073/pnas.1811095116.Full Text Link to Item
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Arredondo Zamarripa, David, Ramsés Noguez Imm, Ana María Bautista Cortés, Osvaldo Vázquez Ruíz, Michela Bernardini, Alessandra Fiorio Pla, Dimitra Gkika, et al. “Author Correction: Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference.” Sci Rep 8, no. 1 (June 20, 2018): 9652. https://doi.org/10.1038/s41598-018-27642-4.Full Text Link to Item
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Rodriguez, Erica, Katsuyasu Sakurai, Jennie Xu, Yong Chen, Koji Toda, Shengli Zhao, Bao-Xia Han, et al. “Publisher Correction: A craniofacial-specific monosynaptic circuit enables heightened affective pain.” Nat Neurosci 21, no. 6 (June 2018): 896. https://doi.org/10.1038/s41593-018-0103-7.Full Text Link to Item
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Ciura, Sorana, Masha Prager-Khoutorsky, Zahra S. Thirouin, Joshua C. Wyrosdic, James E. Olson, Wolfgang Liedtke, and Charles W. Bourque. “Trpv4 Mediates Hypotonic Inhibition of Central Osmosensory Neurons via Taurine Gliotransmission.” Cell Rep 23, no. 8 (May 22, 2018): 2245–53. https://doi.org/10.1016/j.celrep.2018.04.090.Full Text Link to Item
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Mannaa, Marwan, Lajos Markó, András Balogh, Emilia Vigolo, Gabriele N’diaye, Mario Kaßmann, Laura Michalick, et al. “Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion.” Sci Rep 8, no. 1 (March 20, 2018): 4878. https://doi.org/10.1038/s41598-018-23165-0.Full Text Link to Item
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Moore, Carlene, Rupali Gupta, Sven-Eric Jordt, Yong Chen, and Wolfgang B. Liedtke. “Regulation of Pain and Itch by TRP Channels.” Neurosci Bull 34, no. 1 (February 2018): 120–42. https://doi.org/10.1007/s12264-017-0200-8.Full Text Link to Item
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Rodriguez, Erica, Katsuyasu Sakurai, Jennie Xu, Yong Chen, Koji Toda, Shengli Zhao, Bao-Xia Han, et al. “A craniofacial-specific monosynaptic circuit enables heightened affective pain.” Nat Neurosci 20, no. 12 (December 2017): 1734–43. https://doi.org/10.1038/s41593-017-0012-1.Full Text Open Access Copy Link to Item
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Arredondo Zamarripa, David, Ramsés Noguez Imm, Ana María Bautista Cortés, Osvaldo Vázquez Ruíz, Michela Bernardini, Alessandra Fiorio Pla, Dimitra Gkika, et al. “Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference.” Sci Rep 7, no. 1 (October 12, 2017): 13094. https://doi.org/10.1038/s41598-017-13621-8.Full Text Link to Item
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Benemei, Silvia, Francesco De Logu, Simone Li Puma, Ilaria Maddalena Marone, Elisabetta Coppi, Filippo Ugolini, Wolfgang Liedtke, et al. “The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel.” Br J Pharmacol 174, no. 17 (September 2017): 2897–2911. https://doi.org/10.1111/bph.13917.Full Text Link to Item
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Chen, Yong, Carlene D. Moore, Jennifer Y. Zhang, Russell P. Hall, Amanda S. MacLeod, and Wolfgang Liedtke. “TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.” The Journal of Investigative Dermatology 137, no. 4 (April 2017): 801–4. https://doi.org/10.1016/j.jid.2016.12.013.Full Text
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Liedtke, Wolfgang B. “Deconstructing mammalian thermoregulation.” Proc Natl Acad Sci U S A 114, no. 8 (February 21, 2017): 1765–67. https://doi.org/10.1073/pnas.1620579114.Full Text Link to Item
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Michalick, Laura, Lasti Erfinanda, Ulrike Weichelt, Markus van der Giet, Wolfgang Liedtke, and Wolfgang M. Kuebler. “Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo.” Anesthesiology 126, no. 2 (February 2017): 300–311. https://doi.org/10.1097/ALN.0000000000001443.Full Text Link to Item
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Lee, W., F. Guilak, and W. Liedtke. “Role of Piezo Channels in Joint Health and Injury.” Curr Top Membr 79 (2017): 263–73. https://doi.org/10.1016/bs.ctm.2016.10.003.Full Text Link to Item
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Seth, Ratanesh K., Suvarthi Das, Diptadip Dattaroy, Varun Chandrashekaran, Firas Alhasson, Gregory Michelotti, Mitzi Nagarkatti, et al. “TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity.” Free Radic Biol Med 102 (January 2017): 260–73. https://doi.org/10.1016/j.freeradbiomed.2016.11.047.Full Text Link to Item
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Solís-López, A., U. Kriebs, A. Marx, S. Mannebach, W. B. Liedtke, M. J. Caterina, M. Freichel, and V. V. Tsvilovskyy. “Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells.” Plos One 12, no. 2 (2017): e0171366. https://doi.org/10.1371/journal.pone.0171366.Full Text Link to Item
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Kanju, Patrick, and Wolfgang Liedtke. “Pleiotropic function of TRPV4 ion channels in the central nervous system.” Exp Physiol 101, no. 12 (December 1, 2016): 1472–76. https://doi.org/10.1113/EP085790.Full Text Link to Item
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Watanabe, Kentaro, R Shane Tubbs, Shunsuke Satoh, Ali R. Zomorodi, Wolfgang Liedtke, Moujahed Labidi, Allan H. Friedman, and Takanori Fukushima. “Isolated Deep Ear Canal Pain: Possible Role of Auricular Branch of Vagus Nerve-Case Illustrations with Cadaveric Correlation.” World Neurosurg 96 (December 2016): 293–301. https://doi.org/10.1016/j.wneu.2016.08.102.Full Text Link to Item
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O’Conor, Christopher J., Sendhilnathan Ramalingam, Nicole A. Zelenski, Halei C. Benefield, Isaura Rigo, Dianne Little, Chia-Lung Wu, et al. “Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis.” Sci Rep 6 (July 8, 2016): 29053. https://doi.org/10.1038/srep29053.Full Text Link to Item
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Kanju, Patrick, Yong Chen, Whasil Lee, Michele Yeo, Suk Hee Lee, Joelle Romac, Rafiq Shahid, et al. “Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.” Sci Rep 6 (June 1, 2016): 26894. https://doi.org/10.1038/srep26894.Full Text Open Access Copy Link to Item
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Chen, Yong, Quan Fang, Zilong Wang, Jennifer Y. Zhang, Amanda S. MacLeod, Russell P. Hall, and Wolfgang B. Liedtke. “Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.” J Biol Chem 291, no. 19 (May 6, 2016): 10252–62. https://doi.org/10.1074/jbc.M116.716464.Full Text Open Access Copy Link to Item
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Yin, Jun, Laura Michalick, Christine Tang, Arata Tabuchi, Neil Goldenberg, Qinghong Dan, Khader Awwad, et al. “Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury.” Am J Respir Cell Mol Biol 54, no. 3 (March 2016): 370–83. https://doi.org/10.1165/rcmb.2014-0225OC.Full Text Link to Item
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Lee, W., H. Leddy, A. McNulty, F. Guilak, and W. Liedtke. “Inflammatory Cytokine Il-1α Up-Regulates Piezo1 and Hyper-Sensitizes Chondrocytes to Compression.” Biophysical Journal 110, no. 3 (February 16, 2016): 349a-349a.
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Fichna, J., D. P. Poole, N. Veldhuis, S. J. MacEachern, D. Saur, P. K. Zakrzewski, A. I. Cygankiewicz, et al. “Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission.” J Mol Med (Berl) 93, no. 12 (December 2015): 1297–1309. https://doi.org/10.1007/s00109-015-1336-5.Full Text Link to Item
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Zaelzer, Cristian, Pierce Hua, Masha Prager-Khoutorsky, Sorana Ciura, Daniel L. Voisin, Wolfgang Liedtke, and Charles W. Bourque. “ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress.” Cell Rep 13, no. 1 (October 6, 2015): 23–30. https://doi.org/10.1016/j.celrep.2015.08.061.Full Text Link to Item
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Cenac, Nicolas, Tereza Bautzova, Pauline Le Faouder, Nicholas A. Veldhuis, Daniel P. Poole, Corinne Rolland, Jessica Bertrand, et al. “Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.” Gastroenterology 149, no. 2 (August 2015): 433-44.e7. https://doi.org/10.1053/j.gastro.2015.04.011.Full Text Link to Item
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Lin, M. T., M. Y. Jian, M. S. Taylor, D. L. Cioffi, F. C. Yap, W. Liedtke, and M. I. Townsley. “Functional coupling of TRPV4, IK, and SK channels contributes to Ca2+-dependent endothelial injury in rodent lung.” Pulmonary Circulation 5, no. 2 (June 1, 2015): 279–90. https://doi.org/10.1086/680166.Full Text
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Goldenberg, Neil M., Liming Wang, Hannes Ranke, Wolfgang Liedtke, Arata Tabuchi, and Wolfgang M. Kuebler. “TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction.” Anesthesiology 122, no. 6 (June 2015): 1338–48. https://doi.org/10.1097/ALN.0000000000000647.Full Text Link to Item
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Zhao, Peishen, TinaMarie Lieu, Nicholas Barlow, Silvia Sostegni, Silke Haerteis, Christoph Korbmacher, Wolfgang Liedtke, Nestor N. Jimenez-Vargas, Stephen J. Vanner, and Nigel W. Bunnett. “Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.” J Biol Chem 290, no. 22 (May 29, 2015): 13875–87. https://doi.org/10.1074/jbc.M115.642736.Full Text Link to Item
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Zelenski, Nicole A., Holly A. Leddy, Johannah Sanchez-Adams, Jinzi Zhang, Paolo Bonaldo, Wolfgang Liedtke, and Farshid Guilak. “Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage.” Arthritis Rheumatol 67, no. 5 (May 2015): 1286–94. https://doi.org/10.1002/art.39034.Full Text Link to Item
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Zhang, Yi, Yong Chen, Wolfgang Liedtke, and Fan Wang. “Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain.” Mol Pain 11 (April 10, 2015): 18. https://doi.org/10.1186/s12990-015-0017-2.Full Text Open Access Copy Link to Item
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McNulty, Amy L., Holly A. Leddy, Wolfgang Liedtke, and Farshid Guilak. “TRPV4 as a therapeutic target for joint diseases.” Naunyn Schmiedebergs Arch Pharmacol 388, no. 4 (April 2015): 437–50. https://doi.org/10.1007/s00210-014-1078-x.Full Text Link to Item
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Chen, L., M. Kaßmann, M. Sendeski, D. Tsvetkov, L. Marko, L. Michalick, M. Riehle, et al. “Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature.” Acta Physiol (Oxf) 213, no. 2 (February 2015): 481–91. https://doi.org/10.1111/apha.12355.Full Text Link to Item
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Liedtke, Wolfgang. “A precisely defined role for the tip link-associated protein TMIE in the mechanoelectrical transduction channel complex of inner ear hair cells.” Neuron 84, no. 5 (December 3, 2014): 889–91. https://doi.org/10.1016/j.neuron.2014.11.015.Full Text Link to Item
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Chen, Yong, Patrick Kanju, Quan Fang, Suk Hee Lee, Puja K. Parekh, Whasil Lee, Carlene Moore, et al. “TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.” Pain 155, no. 12 (December 2014): 2662–72. https://doi.org/10.1016/j.pain.2014.09.033.Full Text Open Access Copy Link to Item
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Lee, Whasil, Holly A. Leddy, Yong Chen, Suk Hee Lee, Nicole A. Zelenski, Amy L. McNulty, Jason Wu, et al. “Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.” Proc Natl Acad Sci U S A 111, no. 47 (November 25, 2014): E5114–22. https://doi.org/10.1073/pnas.1414298111.Full Text Open Access Copy Link to Item
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Zhao, Peishen, TinaMarie Lieu, Nicholas Barlow, Matthew Metcalf, Nicholas A. Veldhuis, Dane D. Jensen, Martina Kocan, et al. “Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.” J Biol Chem 289, no. 39 (September 26, 2014): 27215–34. https://doi.org/10.1074/jbc.M114.599712.Full Text Link to Item
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Lindy, Amanda S., Puja K. Parekh, Richard Zhu, Patrick Kanju, Sree V. Chintapalli, Volodymyr Tsvilovskyy, Randen L. Patterson, Andriy Anishkin, Damian B. van Rossum, and Wolfgang B. Liedtke. “TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.” Nat Commun 5 (September 2, 2014): 4734. https://doi.org/10.1038/ncomms5734.Full Text Open Access Copy Link to Item
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Liedtke, Wolfgang, Jennifer Y. Zhang, Russell P. Hall, and Martin Steinhoff. “Keratinocyte growth regulation TRP-ed up over downregulated TRPV4?” J Invest Dermatol 134, no. 9 (September 2014): 2310–12. https://doi.org/10.1038/jid.2014.250.Full Text Link to Item
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Leddy, Holly A., Amy L. McNulty, Suk Hee Lee, Nicole E. Rothfusz, Bernd Gloss, Margaret L. Kirby, Mary R. Hutson, Daniel H. Cohn, Farshid Guilak, and Wolfgang Liedtke. “Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations.” Faseb J 28, no. 6 (June 2014): 2525–37. https://doi.org/10.1096/fj.13-245936.Full Text Link to Item
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O’Conor, Christopher J., Holly A. Leddy, Halei C. Benefield, Wolfgang B. Liedtke, and Farshid Guilak. “TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading.” Proc Natl Acad Sci U S A 111, no. 4 (January 28, 2014): 1316–21. https://doi.org/10.1073/pnas.1319569111.Full Text Link to Item
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O’Conor, C. J., H. C. Benefield, W. Liedtke, and F. Guilak. “Osmotic or chemical activation of the TRPV4 ion channel enhances the development of chondrocyte-based tissue engineered cartilage.” Asme 2013 Summer Bioengineering Conference, Sbc 2013 1 B (December 1, 2013). https://doi.org/10.1115/SBC2013-14042.Full Text
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Yeo, Michele, Heather Patisaul, and Wolfgang Liedtke. “Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity.” Epigenetics 8, no. 11 (November 2013): 1128–32. https://doi.org/10.4161/epi.26406.Full Text Link to Item
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Moore, C., F. Cevikbas, H. A. Pasolli, Y. Chen, W. Kong, C. Kempkes, P. Parekh, et al. “Erratum: UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling (Proceedings of the National Academy of Sciences of the United States of America).” Proceedings of the National Academy of Sciences of the United States of America 110, no. 38 (October 17, 2013): 15502. https://doi.org/10.1073/pnas.1315603110.Full Text
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Xia, Yang, Zhenzhen Fu, Jinxing Hu, Chun Huang, Omkar Paudel, Shaoxi Cai, Wolfgang Liedtke, and James S. K. Sham. “TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension.” Am J Physiol Cell Physiol 305, no. 7 (October 1, 2013): C704–15. https://doi.org/10.1152/ajpcell.00099.2013.Full Text Link to Item
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Moore, Carlene, Ferda Cevikbas, H Amalia Pasolli, Yong Chen, Wei Kong, Cordula Kempkes, Puja Parekh, et al. “UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.” Proc Natl Acad Sci U S A 110, no. 34 (August 20, 2013): E3225–34. https://doi.org/10.1073/pnas.1312933110.Full Text Open Access Copy Link to Item
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Chen, Yong, Susan H. Williams, Amy L. McNulty, Ji Hee Hong, Suk Hee Lee, Nicole E. Rothfusz, Puja K. Parekh, et al. “Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.” Pain 154, no. 8 (August 2013): 1295–1304. https://doi.org/10.1016/j.pain.2013.04.004.Full Text Open Access Copy Link to Item
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Fariss, M. W., M. I. Gilmour, C. A. Reilly, W. Liedtke, and A. J. Ghio. “Emerging mechanistic targets in lung injury induced by combustion-generated particles.” Toxicological Sciences 133, no. 1 (May 1, 2013): 196. https://doi.org/10.1093/toxsci/kft074.Full Text
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Dunn, Kathryn M., David C. Hill-Eubanks, Wolfgang B. Liedtke, and Mark T. Nelson. “TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses.” Proc Natl Acad Sci U S A 110, no. 15 (April 9, 2013): 6157–62. https://doi.org/10.1073/pnas.1216514110.Full Text Link to Item
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Liedtke, Wolfgang, Michele Yeo, Hongbo Zhang, Yiding Wang, Michelle Gignac, Sara Miller, Ken Berglund, and Jie Liu. “Highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter KCC2.” Small 9, no. 7 (April 8, 2013): 1066–75. https://doi.org/10.1002/smll.201201994.Full Text Link to Item
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Fariss, Marc W., M Ian Gilmour, Christopher A. Reilly, Wolfgang Liedtke, and Andrew J. Ghio. “Emerging mechanistic targets in lung injury induced by combustion-generated particles.” Toxicol Sci 132, no. 2 (April 2013): 253–67. https://doi.org/10.1093/toxsci/kft001.Full Text Link to Item
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Yeo, Michele, Ken Berglund, Michael Hanna, Junjie U. Guo, Jaya Kittur, Maria D. Torres, Joel Abramowitz, et al. “Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter.” Proc Natl Acad Sci U S A 110, no. 11 (March 12, 2013): 4315–20. https://doi.org/10.1073/pnas.1300959110.Full Text Link to Item
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Poole, Daniel P., Silvia Amadesi, Nicholas A. Veldhuis, Fe C. Abogadie, TinaMarie Lieu, William Darby, Wolfgang Liedtke, Michael J. Lew, Peter McIntyre, and Nigel W. Bunnett. “Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.” J Biol Chem 288, no. 8 (February 22, 2013): 5790–5802. https://doi.org/10.1074/jbc.M112.438184.Full Text Link to Item
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O’Conor, Christopher J., Timothy M. Griffin, Wolfgang Liedtke, and Farshid Guilak. “Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet.” Ann Rheum Dis 72, no. 2 (February 2013): 300–304. https://doi.org/10.1136/annrheumdis-2012-202272.Full Text Link to Item
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Ye, Li, Sandra Kleiner, Jun Wu, Rajan Sah, Rana K. Gupta, Alexander S. Banks, Paul Cohen, et al. “TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.” Cell 151, no. 1 (September 28, 2012): 96–110. https://doi.org/10.1016/j.cell.2012.08.034.Full Text Link to Item
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Sonkusare, Swapnil K., Adrian D. Bonev, Jonathan Ledoux, Wolfgang Liedtke, Michael I. Kotlikoff, Thomas J. Heppner, David C. Hill-Eubanks, and Mark T. Nelson. “Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.” Science 336, no. 6081 (May 4, 2012): 597–601. https://doi.org/10.1126/science.1216283.Full Text Link to Item
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Bourque, Charles W., Farshid Guilak, and Wolfgang Liedtke. “A TRP that makes us feel hyper.” J Physiol 590, no. 8 (April 15, 2012): 1779–80. https://doi.org/10.1113/jphysiol.2012.229187.Full Text Link to Item
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Yang, Xiao-Ru, Amanda H. Y. Lin, Jennifer M. Hughes, Nicholas A. Flavahan, Yuan-Ning Cao, Wolfgang Liedtke, and James S. K. Sham. “Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension.” Am J Physiol Lung Cell Mol Physiol 302, no. 6 (March 15, 2012): L555–68. https://doi.org/10.1152/ajplung.00005.2011.Full Text Link to Item
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Ciura, Sorana, Wolfgang Liedtke, and Charles W. Bourque. “Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4.” J Neurosci 31, no. 41 (October 12, 2011): 14669–76. https://doi.org/10.1523/JNEUROSCI.1420-11.2011.Full Text Link to Item
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Liedtke, Wolfgang B., Michael J. McKinley, Lesley L. Walker, Hao Zhang, Andreas R. Pfenning, John Drago, Sarah J. Hochendoner, Donald L. Hilton, Andrew J. Lawrence, and Derek A. Denton. “Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite.” Proc Natl Acad Sci U S A 108, no. 30 (July 26, 2011): 12509–14. https://doi.org/10.1073/pnas.1109199108.Full Text Link to Item
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Li, Jinju, Patrick Kanju, Michael Patterson, Wei-Leong Chew, Seung-Hyun Cho, Ian Gilmour, Tim Oliver, et al. “TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.” Environ Health Perspect 119, no. 6 (June 2011): 784–93. https://doi.org/10.1289/ehp.1002807.Full Text Open Access Copy Link to Item
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Ryskamp, Daniel A., Paul Witkovsky, Peter Barabas, Wei Huang, Christopher Koehler, Nikolay P. Akimov, Suk Hee Lee, et al. “The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells.” J Neurosci 31, no. 19 (May 11, 2011): 7089–7101. https://doi.org/10.1523/JNEUROSCI.0359-11.2011.Full Text Link to Item
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Pritschow, Bernd W., Thom Lange, Joachim Kasch, Christiane Kunert-Keil, Wolfgang Liedtke, and Heinrich Brinkmeier. “Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigue.” Pflugers Arch 461, no. 1 (January 2011): 115–22. https://doi.org/10.1007/s00424-010-0883-4.Full Text Link to Item
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Clark, Andrea L., Bartholomew J. Votta, Sanjay Kumar, Wolfgang Liedtke, and Farshid Guilak. “Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice.” Arthritis Rheum 62, no. 10 (October 2010): 2973–83. https://doi.org/10.1002/art.27624.Full Text Link to Item
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Shukla, Arun K., Jihee Kim, Seungkirl Ahn, Kunhong Xiao, Sudha K. Shenoy, Wolfgang Liedtke, and Robert J. Lefkowitz. “Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4.” J Biol Chem 285, no. 39 (September 24, 2010): 30115–25. https://doi.org/10.1074/jbc.M110.141549.Full Text Link to Item
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Ceppa, Eugene, Fiore Cattaruzza, Victoria Lyo, Silvia Amadesi, Juan-Carlos Pelayo, Daniel P. Poole, Natalya Vaksman, et al. “Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice.” Am J Physiol Gastrointest Liver Physiol 299, no. 3 (September 2010): G556–71. https://doi.org/10.1152/ajpgi.00433.2009.Full Text Link to Item
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Hamanaka, Kazutoshi, Ming-Yuan Jian, Mary I. Townsley, Judy A. King, Wolfgang Liedtke, David S. Weber, Fabien G. Eyal, Mary M. Clapp, and James C. Parker. “TRPV4 channels augment macrophage activation and ventilator-induced lung injury.” Am J Physiol Lung Cell Mol Physiol 299, no. 3 (September 2010): L353–62. https://doi.org/10.1152/ajplung.00315.2009.Full Text Link to Item
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Vergnolle, N., N. Cenac, C. Altier, L. Cellars, K. Chapman, G. W. Zamponi, S. Materazzi, et al. “A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation.” Br J Pharmacol 159, no. 5 (March 2010): 1161–73. https://doi.org/10.1111/j.1476-5381.2009.00590.x.Full Text Link to Item
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Guilak, Farshid, Holly A. Leddy, and Wolfgang Liedtke. “Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system?” Ann N Y Acad Sci 1192 (March 2010): 404–9. https://doi.org/10.1111/j.1749-6632.2010.05389.x.Full Text Link to Item
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Yeo, Michele, Ken Berglund, George Augustine, and Wolfgang Liedtke. “Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride.” J Neurosci 29, no. 46 (November 18, 2009): 14652–62. https://doi.org/10.1523/JNEUROSCI.2934-09.2009.Full Text Link to Item
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Wu, Songwei, Ming-Yuan Jian, Yan-Chun Xu, Chun Zhou, Abu-Bakr Al-Mehdi, Wolfgang Liedtke, Hee-Sup Shin, and Mary I. Townsley. “Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium.” Am J Physiol Lung Cell Mol Physiol 297, no. 4 (October 2009): L650–57. https://doi.org/10.1152/ajplung.00015.2009.Full Text Link to Item
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Phan, Mimi N., Holly A. Leddy, Bartholomew J. Votta, Sanjay Kumar, Dana S. Levy, David B. Lipshutz, Suk Hee Lee, Wolfgang Liedtke, and Farshid Guilak. “Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes.” Arthritis Rheum 60, no. 10 (October 2009): 3028–37. https://doi.org/10.1002/art.24799.Full Text Link to Item
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Earley, Scott, Thierry Pauyo, Rebecca Drapp, Matthew J. Tavares, Wolfgang Liedtke, and Joseph E. Brayden. “TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure.” Am J Physiol Heart Circ Physiol 297, no. 3 (September 2009): H1096–1102. https://doi.org/10.1152/ajpheart.00241.2009.Full Text Link to Item
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Guilak, Farshid, Daniel M. Cohen, Bradley T. Estes, Jeffrey M. Gimble, Wolfgang Liedtke, and Christopher S. Chen. “Control of stem cell fate by physical interactions with the extracellular matrix.” Cell Stem Cell 5, no. 1 (July 2, 2009): 17–26. https://doi.org/10.1016/j.stem.2009.06.016.Full Text Link to Item
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Li, Jinju, Andrew J. Ghio, Seung-Hyun Cho, Constance E. Brinckerhoff, Sidney A. Simon, and Wolfgang Liedtke. “Diesel exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a beta-arrestin-dependent manner via activation of RAS.” Environ Health Perspect 117, no. 3 (March 2009): 400–409. https://doi.org/10.1289/ehp.0800311.Full Text Open Access Copy Link to Item
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Liedtke, Wolfgang B. “AN UPDATE ON TRPV4-MEDIATED SIGNALING IN HEALTH AND DISEASE.” Journal of Physiological Sciences 59 (January 1, 2009): 93–93.Link to Item
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Liedtke, Wolfgang. “Molecular mechanisms of TRPV4-mediated neural signaling.” Ann N Y Acad Sci 1144 (November 2008): 42–52. https://doi.org/10.1196/annals.1418.012.Full Text Link to Item
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Cenac, Nicolas, Christophe Altier, Kevin Chapman, Wolfgang Liedtke, Gerald Zamponi, and Nathalie Vergnolle. “Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.” Gastroenterology 135, no. 3 (September 2008): 937-946.e2. https://doi.org/10.1053/j.gastro.2008.05.024.Full Text Link to Item
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Lorenzo, Ivan M., Wolfgang Liedtke, Michael J. Sanderson, and Miguel A. Valverde. “TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells.” Proc Natl Acad Sci U S A 105, no. 34 (August 26, 2008): 12611–16. https://doi.org/10.1073/pnas.0803970105.Full Text Link to Item
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Simon, S. A., and W. Liedtke. “How irritation: The role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways.” Journal of Clinical Investigation 118, no. 7 (July 1, 2008): 2383–86. https://doi.org/10.1172/JC136111.Full Text
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Simon, Sidney A., and Wolfgang Liedtke. “How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways.” J Clin Invest 118, no. 7 (July 2008): 2383–86. https://doi.org/10.1172/JCI36111.Full Text Link to Item
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Brierley, Stuart M., Amanda J. Page, Patrick A. Hughes, Birgit Adam, Tobias Liebregts, Nicole J. Cooper, Gerald Holtmann, Wolfgang Liedtke, and L Ashley Blackshaw. “Selective role for TRPV4 ion channels in visceral sensory pathways.” Gastroenterology 134, no. 7 (June 2008): 2059–69. https://doi.org/10.1053/j.gastro.2008.01.074.Full Text Link to Item
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Sipe, Walter E. B., Stuart M. Brierley, Christopher M. Martin, Benjamin D. Phillis, Francisco Bautista Cruz, Eileen F. Grady, Wolfgang Liedtke, et al. “Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia.” Am J Physiol Gastrointest Liver Physiol 294, no. 5 (May 2008): G1288–98. https://doi.org/10.1152/ajpgi.00002.2008.Full Text Link to Item
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Yin, Jun, Julia Hoffmann, Stephanie M. Kaestle, Nils Neye, Liming Wang, Joerg Baeurle, Wolfgang Liedtke, et al. “Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4.” Circ Res 102, no. 8 (April 25, 2008): 966–74. https://doi.org/10.1161/CIRCRESAHA.107.168724.Full Text Link to Item
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Jian, Ming-Yuan, Judy A. King, Abu-Bakr Al-Mehdi, Wolfgang Liedtke, and Mary I. Townsley. “High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4.” Am J Respir Cell Mol Biol 38, no. 4 (April 2008): 386–92. https://doi.org/10.1165/rcmb.2007-0192OC.Full Text Link to Item
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Liu, X., B. C. Bandyopadhyay, T. Nakamoto, B. B. Singh, W. Liedtke, J. E. Melvin, and I. S. Ambudkar. “A role for AQP5 in activation of TRPV4 by hypotonicity: Concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery (Journal of Biological Chemistry (2006) 281, (15485-15495)).” Journal of Biological Chemistry 283, no. 6 (February 8, 2008): 3688.
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Gevaert, Thomas, Joris Vriens, Andrei Segal, Wouter Everaerts, Tania Roskams, Karel Talavera, Grzegorz Owsianik, et al. “Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding.” J Clin Invest 117, no. 11 (November 2007): 3453–62. https://doi.org/10.1172/JCI31766.Full Text Link to Item
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Hamanaka, Kazutoshi, Ming-Yuan Jian, David S. Weber, Diego F. Alvarez, Mary I. Townsley, Abu B. Al-Mehdi, Judy A. King, Wolfgang Liedtke, and James C. Parker. “TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs.” Am J Physiol Lung Cell Mol Physiol 293, no. 4 (October 2007): L923–32. https://doi.org/10.1152/ajplung.00221.2007.Full Text Link to Item
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Hartmannsgruber, Veronika, Willm-Thomas Heyken, Michael Kacik, Anuradha Kaistha, Ivica Grgic, Christian Harteneck, Wolfgang Liedtke, Joachim Hoyer, and Ralf Köhler. “Arterial response to shear stress critically depends on endothelial TRPV4 expression.” Plos One 2, no. 9 (September 5, 2007): e827. https://doi.org/10.1371/journal.pone.0000827.Full Text Link to Item
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Liedtke, Wolfgang. “Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals.” Exp Physiol 92, no. 3 (May 2007): 507–12. https://doi.org/10.1113/expphysiol.2006.035642.Full Text Link to Item
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Liu, Lieju, Lei Chen, Wolfgang Liedtke, and S. A. Simon. “Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons.” J Neurophysiol 97, no. 3 (March 2007): 2001–15. https://doi.org/10.1152/jn.00887.2006.Full Text Link to Item
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Grant, Andrew D., Graeme S. Cottrell, Silvia Amadesi, Marcello Trevisani, Paola Nicoletti, Serena Materazzi, Christophe Altier, et al. “Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.” J Physiol 578, no. Pt 3 (February 1, 2007): 715–33. https://doi.org/10.1113/jphysiol.2006.121111.Full Text Link to Item
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Liedtke, W. “TRPV channels' role in osmotransduction and mechanotransduction.” Handb Exp Pharmacol, no. 179 (2007): 473–87. https://doi.org/10.1007/978-3-540-34891-7_28.Full Text Link to Item
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Liedtke, Wolfgang. “Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli.” J Endocrinol 191, no. 3 (December 2006): 515–23. https://doi.org/10.1677/joe.1.07000.Full Text Link to Item
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Alvarez, Diego F., Judy A. King, David Weber, Emile Addison, Wolfgang Liedtke, and Mary I. Townsley. “Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury.” Circ Res 99, no. 9 (October 27, 2006): 988–95. https://doi.org/10.1161/01.RES.0000247065.11756.19.Full Text Link to Item
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Liu, Xibao, Bidhan C. Bandyopadhyay, Tetsuji Nakamoto, Brij Singh, Wolfgang Liedtke, James E. Melvin, and Indu Ambudkar. “A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.” J Biol Chem 281, no. 22 (June 2, 2006): 15485–95. https://doi.org/10.1074/jbc.M600549200.Full Text Link to Item
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Liu, Lieju, T. M. Yang, Wolfgang Liedtke, and S. A. Simon. “Chronic IL-1beta signaling potentiates voltage-dependent sodium currents in trigeminal nociceptive neurons.” J Neurophysiol 95, no. 3 (March 2006): 1478–90. https://doi.org/10.1152/jn.00509.2005.Full Text Link to Item
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Phan, M., S. Pritchard, B. J. Votta, S. Kumar, W. Liedtke, and F. Guilak. “Functional characterization of an osmotically-sensitive ion channel, TRPV4, in articular chondrocytes.” Proceedings of the 2005 Summer Bioengineering Conference 2005 (December 1, 2005): 966–67.
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Liedtke, W., and C. Kim. “Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon!.” Cell Mol Life Sci 62, no. 24 (December 2005): 2985–3001. https://doi.org/10.1007/s00018-005-5181-5.Full Text Link to Item
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Alessandri-Haber, Nicole, Elizabeth Joseph, Olayinka A. Dina, Wolfgang Liedtke, and Jon D. Levine. “TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator.” Pain 118, no. 1–2 (November 2005): 70–79. https://doi.org/10.1016/j.pain.2005.07.016.Full Text Link to Item
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Liedtke, Wolfgang. “TRPV4 as osmosensor: a transgenic approach.” Pflugers Arch 451, no. 1 (October 2005): 176–80. https://doi.org/10.1007/s00424-005-1449-8.Full Text Link to Item
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Liedtke, Wolfgang. “TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals.” J Physiol 567, no. Pt 1 (August 15, 2005): 53–58. https://doi.org/10.1113/jphysiol.2005.088963.Full Text Link to Item
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Ehrlich, M., A. Wisehart, H. D. Stein, W. Liedtke, and S. Okie. “Chewing the fat [1].” Natural History 114, no. 4 (May 1, 2005): 9.
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Liedtke, Wolfgang, and S. A. Simon. “A possible role for TRPV4 receptors in asthma.” Am J Physiol Lung Cell Mol Physiol 287, no. 2 (August 2004): L269–71. https://doi.org/10.1152/ajplung.00153.2004.Full Text Link to Item
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Liedtke, Wolfgang, David M. Tobin, Cornelia I. Bargmann, and Jeffrey M. Friedman. “Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans.” Proc Natl Acad Sci U S A 100 Suppl 2, no. Suppl 2 (November 25, 2003): 14531–36. https://doi.org/10.1073/pnas.2235619100.Full Text Link to Item
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Liedtke, Wolfgang, and Jeffrey M. Friedman. “Abnormal osmotic regulation in trpv4-/- mice.” Proc Natl Acad Sci U S A 100, no. 23 (November 11, 2003): 13698–703. https://doi.org/10.1073/pnas.1735416100.Full Text Link to Item
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Laviano, Alessandro, Michael M. Meguid, and Filippo Rossi-Fanelli. “Energy expenditure and treating obesity.” Science 298, no. 5593 (October 18, 2002): 539–41. https://doi.org/10.1126/science.298.5593.539c.Full Text Link to Item
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Cohen, Paul, Makoto Miyazaki, Nicholas D. Socci, Aaron Hagge-Greenberg, Wolfgang Liedtke, Alexander A. Soukas, Ratnendra Sharma, Lisa C. Hudgins, James M. Ntambi, and Jeffrey M. Friedman. “Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.” Science 297, no. 5579 (July 12, 2002): 240–43. https://doi.org/10.1126/science.1071527.Full Text Link to Item
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Liedtke, Wolfgang, Elizabeth E. Leman, Robert E. W. Fyffe, Cedric S. Raine, and Ulrich K. Schubart. “Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems.” Am J Pathol 160, no. 2 (February 2002): 469–80. https://doi.org/10.1016/S0002-9440(10)64866-3.Full Text Link to Item
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Liedtke, W., Y. Choe, M. A. Martí-Renom, A. M. Bell, C. S. Denis, A. Sali, A. J. Hudspeth, J. M. Friedman, and S. Heller. “Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor.” Cell 103, no. 3 (October 27, 2000): 525–35. https://doi.org/10.1016/s0092-8674(00)00143-4.Full Text Link to Item
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Ness, S. L., W. Edelmann, T. D. Jenkins, W. Liedtke, A. K. Rustgi, and R. Kucherlapati. “Mouse keratin 4 is necessary for internal epithelial integrity.” J Biol Chem 273, no. 37 (September 11, 1998): 23904–11. https://doi.org/10.1074/jbc.273.37.23904.Full Text Link to Item
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Liedtke, W., B. Cannella, R. J. Mazzaccaro, J. M. Clements, K. M. Miller, K. W. Wucherpfennig, A. J. Gearing, and C. S. Raine. “Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors.” Ann Neurol 44, no. 1 (July 1998): 35–46. https://doi.org/10.1002/ana.410440110.Full Text Link to Item
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Liedtke, W., W. Edelmann, F. C. Chiu, R. Kucherlapati, and C. S. Raine. “Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion.” Am J Pathol 152, no. 1 (January 1998): 251–59.Link to Item
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Edelmann, W., K. Yang, A. Umar, J. Heyer, K. Lau, K. Fan, W. Liedtke, et al. “Mutation in the mismatch repair gene Msh6 causes cancer susceptibility.” Cell 91, no. 4 (November 14, 1997): 467–77. https://doi.org/10.1016/s0092-8674(00)80433-x.Full Text Link to Item
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Liedtke, W., G. Meyer, P. M. Faustmann, H. Warnatz, and C. S. Raine. “Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients.” Int Immunol 9, no. 7 (July 1997): 1031–41. https://doi.org/10.1093/intimm/9.7.1031.Full Text Link to Item
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Liedtke, W., W. Edelmann, P. L. Bieri, F. C. Chiu, N. J. Cowan, R. Kucherlapati, and C. S. Raine. “GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination.” Neuron 17, no. 4 (October 1996): 607–15. https://doi.org/10.1016/s0896-6273(00)80194-4.Full Text Link to Item
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Liedtke, W., and V. Limmroth. “Validity of brain MRI as the primary outcome criterion in multiple sclerosis phase II clinical trials.” Ann Neurol 39, no. 2 (February 1996): 276–77. https://doi.org/10.1002/ana.410390221.Full Text Link to Item
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Liedtke, W., K. Trübner, and K. Schwechheimer. “On the role of human herpesvirus 6 in viral latency in nervous tissue and in cerebral lymphoma.” J Neurol Sci 134, no. 1–2 (December 1995): 184–88. https://doi.org/10.1016/0022-510x(95)00248-6.Full Text Link to Item
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Liedtke, W., R. Malessa, P. M. Faustmann, and A. M. Eis-Hübinger. “Human herpesvirus 6 polymerase chain reaction findings in human immunodeficiency virus associated neurological disease and multiple sclerosis.” J Neurovirol 1, no. 3–4 (September 1995): 253–58. https://doi.org/10.3109/13550289509114021.Full Text Link to Item
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Ochs, G., and W. Liedtke. “Capsaicin.” Aktuelle Neurologie 22, no. 4 (January 1, 1995): 164–66. https://doi.org/10.1055/s-2007-1017914.Full Text
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Liedtke, W., L. Battistini, C. F. Brosnan, and C. S. Raine. “A comparison of methods for RNA extraction from lymphocytes for RT-PCR.” Pcr Methods Appl 4, no. 3 (December 1994): 185–87. https://doi.org/10.1101/gr.4.3.185.Full Text Link to Item
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Liedtke, W., K. Quabeck, D. W. Beelen, V. Straeten, and U. W. Schaefer. “Recurrent acute inflammatory demyelinating polyradiculitis after allogeneic bone marrow transplantation.” J Neurol Sci 125, no. 1 (August 1994): 110–11. https://doi.org/10.1016/0022-510x(94)90250-x.Full Text Link to Item
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Liedtke, W., B. Opalka, C. W. Zimmermann, and E. Schmid. “Different methods of sample preparation influence sensitivity of Mycobacterium tuberculosis and Borrelia burgdorferi PCR.” Pcr Methods Appl 3, no. 5 (April 1994): 301–4. https://doi.org/10.1101/gr.3.5.301.Full Text Link to Item
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Liedtke, W., B. Opalka, C. W. Zimmermann, and E. Schmid. “Different methods of sample preparation influence sensitivity of mycobacterium tuberculosis and borrelia burgdorferi PCR.” Genome Research 3, no. 5 (December 1, 1993): 301–4.
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Liedtke, W., A. May, R. Dux, P. M. Faustmann, and C. W. Zimmermann. “Mycobacterium tuberculosis polymerase chain reaction findings in neurosarcoidosis.” J Neurol Sci 120, no. 1 (December 1, 1993): 118–19. https://doi.org/10.1016/0022-510x(93)90035-w.Full Text Link to Item
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Liedtke, W., B. Opalka, C. W. Zimmermann, and E. Lignitz. “Age distribution of latent herpes simplex virus 1 and varicella-zoster virus genome in human nervous tissue.” J Neurol Sci 116, no. 1 (May 1993): 6–11. https://doi.org/10.1016/0022-510x(93)90082-a.Full Text Link to Item
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Liedtke, W., F. Muller, D. Petersen, and R. Klein. “Antineutrophil cytoplasmic antibodies associated with neurological vasculitic syndromes - Four cases.” Nervenheilkunde 12, no. 7 (January 1, 1993): 373–76.
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Liedtke, W., M. Weller, H. Wiethölter, and J. Dichgans. “Immunological abnormalities in the tears of multiple sclerosis patients.” Acta Neurol Scand 85, no. 3 (March 1992): 228–30. https://doi.org/10.1111/j.1600-0404.1992.tb04034.x.Full Text Link to Item
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Weller, M., W. Liedtke, D. Petersen, H. Opitz, and M. Poremba. “Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion.” Neurology 42, no. 2 (February 1992): 367–70. https://doi.org/10.1212/wnl.42.2.367.Full Text Link to Item
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Liedtke, W. “Inadequate antidiuretic hormone secretion after sagittal sinus thrombosis caused by protein S deficiency.” Stroke 22, no. 6 (June 1991): 819.Link to Item
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Brüssow, H., H. Werchau, L. Lerner, C. Mietens, W. Liedtke, J. Sidoti, and J. Sotek. “Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis.” J Infect Dis 158, no. 3 (September 1988): 588–95. https://doi.org/10.1093/infdis/158.3.588.Full Text Link to Item
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Brüssow, H., H. Werchau, W. Liedtke, L. Lerner, C. Mietens, J. Sidoti, and J. Sotek. “Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany.” J Infect Dis 157, no. 5 (May 1988): 1014–22. https://doi.org/10.1093/infdis/157.5.1014.Full Text Link to Item
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Grunert, B., H. J. Streckert, W. Liedtke, C. Houly, C. Mietens, and H. Werchau. “Development of a monoclonal antibody specific for serotype 3 rotavirus strains.” Eur J Clin Microbiol 6, no. 2 (April 1987): 136–41. https://doi.org/10.1007/BF02018194.Full Text Link to Item
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Book Sections
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Yeo, M., and W. Liedtke. “Genetic and environmental regulators of Kcc2/KCC2 gene expression.” In Neuronal Chloride Transporters in Health and Disease, 307–25, 2020. https://doi.org/10.1016/B978-0-12-815318-5.00013-3.Full Text
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Simon, S. A., and R. Gutierrez. “TRP channels at the periphery of the taste and trigeminal systems.” In Neurobiology of TRP Channels, 113–24, 2017. https://doi.org/10.4324/9781315152837.Full Text
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Liedtke, W. “TRP channels and osmoregulation: TRPV4-mediated signaling.” In TRP Channels in Health and Disease: Implications for Diagnosis and Therapy, 153–70, 2011.
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Digital Publications
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Kuebler, Wolfgang, Sven-Eric Jordt, and Wolfgang Liedtke. “COVID-19: Urgent Reconsideration of Lung Edema as a Preventable Outcome: Inhibition of TRPV4 As a Promising and Feasible Approach.,” March 23, 2020. https://doi.org/10.2139/ssrn.3558887.Full Text Link to Item
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Conference Papers
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Seth, Ratanesh K., Diptadip Dattaroy, Varun Chandrashekaran, Suvarthi Das, Firas Alhasson, Marcelo G. Bonini, Gregory A. Michelotti, et al. “TRPV4 prevents tissue injury in diseased fatty liver by blocking CYP2E1-mediated redox-toxicity via Kupffer cell-induced nitric oxide production.” In Hepatology, 64:793A-794A. WILEY, 2016.Link to Item
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Seth, Ratanesh Kumar, Suvarthi Das, Diptadip Dattaroy, Firas A. Alhasson, Gregory A. Michelotti, Mitzi Nagarkatti, Prakash Nagarkatti, et al. “TRPV4 Modulates CYP2E1 Function in Nonalcoholic Steatohepatitis Progression.” In Faseb Journal, Vol. 30. FEDERATION AMER SOC EXP BIOL, 2016.Link to Item
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Das, Suvarthi, Ratanesh K. Seth, Varun Chandrashekaran, Firas Alhasson, Diptadip Dattaroy, Gregory A. Michelotti, Prakash Nagarkatti, et al. “TRPV4 deficiency enhances TLR4 recruitment to lipid rafts exhibiting exacerbated stellate cell activation and fibrosis in experimental nonalcoholic steatohepatitis.” In Hepatology, 62:682A-682A. WILEY-BLACKWELL, 2015.Link to Item
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Seth, Ratanesh K., Suvarthi Das, Diptadip Dattaroy, Firas Alhasson, Phillip D. Bell, Gregory A. Michelotti, Mitzi Nagarkatti, et al. “TRPV4 regulates inflammation and Kupffer cell activation in nonalcoholic steatohepatitis by attenuation of CYP2E1-mediated oxidative stress.” In Hepatology, 62:1248A-1248A. WILEY-BLACKWELL, 2015.Link to Item
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Bauer, W., W. B. Liedtke, S. Waker, J. R. Saper, and C. J. Frangakis. “Topical Anti-Inflammatory Therapy in the Treatment of Acute Migraine; Role of Trigeminal Nerve Peripheral Fibers.” In Headache, 55:140–140. WILEY-BLACKWELL, 2015.Link to Item
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Klein, R. C., S. M. Goetz, W. B. Liedtke, S. D. Moore, and A. V. Peterchev. “Static magnetic field modulates excitatory activity in layer II/III pyramidal neurons of the rat motor cortex.” In International Ieee/Embs Conference on Neural Engineering, Ner, 1190–93, 2013. https://doi.org/10.1109/NER.2013.6696152.Full Text
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Sham, James S. K., Xiao-Ru Yang, Jennifer M. Hughes, Yuan-Ning Cao, Nicholas A. Flavahan, and Wolfgang Liedtke. “UPREGULATION OF TRPV4 CHANNELS IN PULMONARY ARTERIES CONTRIBUTES TO CHRONIC HYPOXIA INDUCED MYOGENIC TONE AND PULMONARY HYPERTENSION.” In Journal of Physiological Sciences, 59:264–264. SPRINGER TOKYO, 2009.Link to Item
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- Teaching & Mentoring
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Recent Courses
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