Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Resident, Psychiatry, University of Duisburg Essen (Germany) 1993 - 1994
  • Resident, Neurology, University of Duisburg Essen (Germany) 1991 - 1993
  • Resident, Neurology, University of Tubingen (Germany) 1989 - 1991
  • Ph.D., Ruhr-Universitat Bochum (Germany) 1990
  • Medicine/Surgery/Neurology Intenship, Surgery, Hôtel-Dieu de Paris 1988 - 1989
  • M.D., University of Cologne (Germany 1989
  • Medicine/Surgery/Neurology Intenship, Neurology, University Hospital Zurich 1988
• 

  Duke Appointment History

  • Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 2011 - 2015
  • Associate Professor of Neurology, Neurology, Headache and Pain, Neurology 2014 - 2015
  • Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2014 - 2015
  • Associate Professor of Neurology, Neurology, Headache and Pain, Neurology 2011 - 2014
  • Assistant Professor of Medicine, Neurology, Clinical Science Departments 2004 - 2011
  • Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 2004 - 2011
• Recognition
• 

  In the News

  • APR 25, 2017

    Clinical Practice Today

    Multidisciplinary Taskforce Shares Best Practices in MS Care

  • FEB 28, 2017

    Clinical Practice Today

    Trigeminal Neuralgia in a Middle-Aged Woman

  • JUN 3, 2016

    WFDD

    Duke researchers discover a new class of pain reliever

  • JUN 1, 2016

    Scientists Discover and Test New Class of Pain Relievers

  • JUN 1, 2016

    The Daily Beast

    These new painkillers could replace opioids

  • APR 20, 2016

    Co.Exist

    Scientists find the skin cell that makes us itch, paving the way for treatments

  • MAR 14, 2016

    Motherboard

    We're a whole lot closer to a cure for itching

  • MAR 11, 2016

    Skin Has the Nerve to Tell You to Scratch

  • OCT 19, 2015

    Canada Journal

    Discovery made on how the brain prevents dehydration

  • OCT 15, 2015

    Research IDs Key Protein in How Brain Controls Body Hydration and Temperature

  • NOV 10, 2014

    How Cartilage Cells Sense Forceful Injury

  • AUG 29, 2014

    Surprising New Role for Calcium in Sensing Pain

  • AUG 19, 2013

    The Charlotte Observer

    Scientists ID molecule that makes sunburn hurt

  • AUG 7, 2013

    TIME

    An end to sunburn pain: Scientists say it’s possible

  • AUG 7, 2013

    London Daily Mail

    Could this be the answer to sunburn?
• Research
• 

  Selected Grants

  • Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Novel pathways regulating calcium mediated contractility and inflammation in the pregnant uterus awarded by Stanford University 2018 - 2020
  • Not SciFi: How to Get Rid of Trigeminal Neuralgia awarded by The Facial Pain Research Foundation 2018 - 2020
  • Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2019
  • Biomedical Researcher Development Scholarship (BRDS) Research Career Development Award (K12) awarded by University of North Carolina - Chapel Hill 2015 - 2018
  • Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
  • Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
  • Molecular Mechanisms of Regulation of Sodium-Appetite in Mammals awarded by Texas Biomedical Research Institute 2016 - 2017
  • Small molecule targeting of dual TRP channels to attenuate inflammation and fibrosis awarded by North Carolina Biotechnology Center 2016 - 2017
  • Engineering cartilage mechanotransduction for treatment of chondrocyte injury awarded by National Institutes of Health 2014 - 2017
  • Not SciFi: How to Get Rid of Trigeminal Neuralgia awarded by The Facial Pain Research Foundation 2016 - 2017
  • Transdermal pain therapy with ELSM11 (formulated ketoprofen) in a spectrum of pre-clinical pain models awarded by Achelios Therapeutics 2014 - 2016
  • Masticatory sensitization of trigeminal ganglion sensory neurons awarded by National Institutes of Health 2014 - 2016
  • Control of trigeminal touch sensory circuit assembly awarded by National Institutes of Health 2009 - 2016
  • Training in Fundamental &Translational Neuroscience awarded by National Institutes of Health 2005 - 2016
  • Commitment of Funds for NCBC Grant (3834531) awarded by Achelios Therapeutics 2012 - 2015
  • Small Molecule Therapy to Inhibit Osteoarthritis Progression in the Aging awarded by Cytex Therapeutics Inc. 2013 - 2015
  • TRP and AQP Channels: Modulation of Function, Raft Location by Membrane Lipids awarded by National Institutes of Health 1980 - 2015
  • Mechanical and Osmotic Signaling in Chondrocytes awarded by National Institutes of Health 2001 - 2015
  • Molecular Mechanisms of Regulation of Sodium-Appetite in Mammals awarded by G. Harold & Leila Y. Mathers Foundation 2014 - 2015
  • Live-Animal Micro-CT System awarded by National Institutes of Health 2012 - 2014
  • Role of trpv4 in trigeminally mediated nociception awarded by National Institutes of Health 2007 - 2012
  • Sex-specific gene regulation of neuronal chloride co-transporter, kcc2 awarded by National Institutes of Health 2009 - 2012
  • COPAS BIOSORT Worm Sorter awarded by National Institutes of Health 2009 - 2010
  • Molecular studies of osmotic neural sensing awarded by National Institute of Mental Health 2002 - 2006
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Gilchrist, CL, Leddy, HA, Kaye, L, Case, ND, Rothenberg, KE, Little, D, Liedtke, W, Hoffman, BD, and Guilak, F. "TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension." Proceedings of the National Academy of Sciences of the United States of America 116, no. 6 (February 2019): 1992-1997.  Full Text
    • Arredondo Zamarripa, D, Noguez Imm, R, Bautista Cortés, AM, Vázquez Ruíz, O, Bernardini, M, Fiorio Pla, A, Gkika, D, Prevarskaya, N, López-Casillas, F, Liedtke, W, Clapp, C, and Thébault, S. "Author Correction: Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: Diabetic milieu makes a difference (Scientific Reports (2017) DOI: 10.1038/s41598-017-13621-8." Scientific Reports 8, no. 1 (December 1, 2018).  Full Text
    • Rodriguez, E, Sakurai, K, Xu, J, Chen, Y, Toda, K, Zhao, S, Han, B-X, Ryu, D, Yin, H, Liedtke, W, and Wang, F. "Publisher Correction: A craniofacial-specific monosynaptic circuit enables heightened affective pain." Nature Neuroscience 21, no. 6 (June 2018): 896-null.  Full Text
    • Ciura, S, Prager-Khoutorsky, M, Thirouin, ZS, Wyrosdic, JC, Olson, JE, Liedtke, W, and Bourque, CW. "Trpv4 Mediates Hypotonic Inhibition of Central Osmosensory Neurons via Taurine Gliotransmission." Cell Reports 23, no. 8 (May 22, 2018): 2245-2253.  Full Text
    • Mannaa, M, Markó, L, Balogh, A, Vigolo, E, N'diaye, G, Kaßmann, M, Michalick, L, Weichelt, U, Schmidt-Ott, KM, Liedtke, WB, Huang, Y, Müller, DN, Kuebler, WM, and Gollasch, M. "Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion." Scientific Reports 8, no. 1 (March 20, 2018): 4878-null.  Full Text
    • Moore, C, Gupta, R, Jordt, S-E, Chen, Y, and Liedtke, WB. "Regulation of Pain and Itch by TRP Channels." Neuroscience Bulletin 34, no. 1 (February 2018): 120-142. (Review)  Full Text
    • Arredondo Zamarripa, D, Noguez Imm, R, Bautista Cortés, AM, Vázquez Ruíz, O, Bernardini, M, Fiorio Pla, A, Gkika, D, Prevarskaya, N, López-Casillas, F, Liedtke, W, Clapp, C, and Thébault, S. "Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: Diabetic milieu makes a difference." Scientific Reports 7, no. 1 (December 1, 2017).  Full Text
    • Rodriguez, E, Sakurai, K, Xu, J, Chen, Y, Toda, K, Zhao, S, Han, B-X, Ryu, D, Yin, H, Liedtke, W, and Wang, F. "A craniofacial-specific monosynaptic circuit enables heightened affective pain." Nature Neuroscience 20, no. 12 (December 2017): 1734-1743.  Full Text  Open Access Copy
    • Benemei, S, De Logu, F, Li Puma, S, Marone, IM, Coppi, E, Ugolini, F, Liedtke, W, Pollastro, F, Appendino, G, Geppetti, P, Materazzi, S, and Nassini, R. "The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel." British Journal of Pharmacology 174, no. 17 (September 2017): 2897-2911.  Full Text
    • Chen, Y, Moore, CD, Zhang, JY, Hall, RP, MacLeod, AS, and Liedtke, W. "TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis." The Journal of Investigative Dermatology 137, no. 4 (April 2017): 801-804.  Full Text
    • Liedtke, WB. "Deconstructing mammalian thermoregulation." Proceedings of the National Academy of Sciences of the United States of America 114, no. 8 (February 8, 2017): 1765-1767.  Full Text
    • Michalick, L, Erfinanda, L, Weichelt, U, van der Giet, M, Liedtke, W, and Kuebler, WM. "Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo." Anesthesiology 126, no. 2 (February 2017): 300-311.  Full Text
    • Lee, W, Guilak, F, and Liedtke, W. "Role of Piezo Channels in Joint Health and Injury." Current Topics in Membranes 79 (January 11, 2017): 263-273. (Review)  Full Text
    • Seth, RK, Das, S, Dattaroy, D, Chandrashekaran, V, Alhasson, F, Michelotti, G, Nagarkatti, M, Nagarkatti, P, Diehl, AM, Bell, PD, Liedtke, W, and Chatterjee, S. "TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity." Free radical biology & medicine 102 (January 2017): 260-273.  Full Text
    • Solís-López, A, Kriebs, U, Marx, A, Mannebach, S, Liedtke, WB, Caterina, MJ, Freichel, M, and Tsvilovskyy, VV. "Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells." PLoS ONE 12, no. 2 (January 2017): e0171366-.  Full Text
    • Kanju, P, and Liedtke, W. "Pleiotropic function of TRPV4 ion channels in the central nervous system." Experimental Physiology 101, no. 12 (December 2016): 1472-1476. (Review)  Full Text
    • Watanabe, K, Tubbs, RS, Satoh, S, Zomorodi, AR, Liedtke, W, Labidi, M, Friedman, AH, and Fukushima, T. "Isolated Deep Ear Canal Pain: Possible Role of Auricular Branch of Vagus Nerve-Case Illustrations with Cadaveric Correlation." World Neurosurgery 96 (December 2016): 293-301.  Full Text
    • O'Conor, CJ, Ramalingam, S, Zelenski, NA, Benefield, HC, Rigo, I, Little, D, Wu, C-L, Chen, D, Liedtke, W, McNulty, AL, and Guilak, F. "Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis." Scientific Reports 6 (July 8, 2016): 29053-null.  Full Text
    • Kanju, P, Chen, Y, Lee, W, Yeo, M, Lee, SH, Romac, J, Shahid, R, Fan, P, Gooden, DM, Simon, SA, Spasojevic, I, Mook, RA, Liddle, RA, Guilak, F, and Liedtke, WB. "Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain." Scientific Reports 6 (June 2016): 26894-null.  Full Text  Open Access Copy
    • Chen, Y, Fang, Q, Wang, Z, Zhang, JY, MacLeod, AS, Hall, RP, and Liedtke, WB. "Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch." The Journal of Biological Chemistry 291, no. 19 (May 2016): 10252-10262.  Full Text  Open Access Copy
    • Yin, J, Michalick, L, Tang, C, Tabuchi, A, Goldenberg, N, Dan, Q, Awwad, K, Wang, L, Erfinanda, L, Nouailles, G, Witzenrath, M, Vogelzang, A, Lv, L, Lee, WL, Zhang, H, Rotstein, O, Kapus, A, Szaszi, K, Fleming, I, Liedtke, WB, Kuppe, H, and Kuebler, WM. "Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury." American Journal of Respiratory Cell and Molecular Biology 54, no. 3 (March 2016): 370-383.  Full Text
    • Lee, W, Leddy, H, McNulty, A, Guilak, F, and Liedtke, W. "Inflammatory Cytokine Il-1α Up-Regulates Piezo1 and Hyper-Sensitizes Chondrocytes to Compression." Biophysical Journal 110, no. 3 (February 16, 2016): 349a-349a.
    • Fichna, J, Poole, DP, Veldhuis, N, MacEachern, SJ, Saur, D, Zakrzewski, PK, Cygankiewicz, AI, Mokrowiecka, A, Małecka-Panas, E, Krajewska, WM, Liedtke, W, Steinhoff, MS, Timmermans, J-P, Bunnett, NW, Sharkey, KA, and Storr, MA. "Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission." Journal of Molecular Medicine (Berlin, Germany) 93, no. 12 (December 2015): 1297-1309.  Full Text
    • Zaelzer, C, Hua, P, Prager-Khoutorsky, M, Ciura, S, Voisin, DL, Liedtke, W, and Bourque, CW. "ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress." Cell Reports 13, no. 1 (October 2015): 23-30.  Full Text
    • Cenac, N, Bautzova, T, Le Faouder, P, Veldhuis, NA, Poole, DP, Rolland, C, Bertrand, J, Liedtke, W, Dubourdeau, M, Bertrand-Michel, J, Zecchi, L, Stanghellini, V, Bunnett, NW, Barbara, G, and Vergnolle, N. "Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome." Gastroenterology 149, no. 2 (August 2015): 433-44.e7.  Full Text
    • Goldenberg, NM, Wang, L, Ranke, H, Liedtke, W, Tabuchi, A, and Kuebler, WM. "TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction." Anesthesiology 122, no. 6 (June 2015): 1338-1348.  Full Text
    • Lin, MT, Jian, MY, Taylor, MS, Cioffi, DL, Yap, FC, Liedtke, W, and Townsley, MI. "Functional coupling of TRPV4, IK, and SK channels contributes to Ca²⁺-dependent endothelial injury in rodent lung." Pulmonary Circulation 5, no. 2 (June 1, 2015): 279-290.  Full Text
    • Zelenski, NA, Leddy, HA, Sanchez-Adams, J, Zhang, J, Bonaldo, P, Liedtke, W, and Guilak, F. "Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage." Arthritis & Rheumatology (Hoboken, N.J.) 67, no. 5 (May 2015): 1286-1294.  Full Text
    • Zhao, P, Lieu, T, Barlow, N, Sostegni, S, Haerteis, S, Korbmacher, C, Liedtke, W, Jimenez-Vargas, NN, Vanner, SJ, and Bunnett, NW. "Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain." The Journal of Biological Chemistry 290, no. 22 (May 2015): 13875-13887.  Full Text
    • Zhang, Y, Chen, Y, Liedtke, W, and Wang, F. "Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain." Molecular Pain 11 (April 10, 2015): 18-null.  Full Text  Open Access Copy
    • McNulty, AL, Leddy, HA, Liedtke, W, and Guilak, F. "TRPV4 as a therapeutic target for joint diseases." Naunyn-Schmiedeberg's archives of pharmacology 388, no. 4 (April 2015): 437-450. (Review)  Full Text
    • Chen, L, Kaßmann, M, Sendeski, M, Tsvetkov, D, Marko, L, Michalick, L, Riehle, M, Liedtke, WB, Kuebler, WM, Harteneck, C, Tepel, M, Patzak, A, and Gollasch, M. "Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature." Acta physiologica (Oxford, England) 213, no. 2 (February 2015): 481-491.  Full Text
    • Chen, L, Kaßmann, M, Sendeski, M, Tsvetkov, D, Marko, L, Michalick, L, Riehle, M, Liedtke, WB, Kuebler, WM, Harteneck, C, Tepel, M, Patzak, A, and Gollasch, M. "Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature." Acta Physiologica 213, no. 2 (February 1, 2015): 481-491.  Full Text
    • McNulty, AL, Leddy, HA, Liedtke, W, and Guilak, F. "TRPV4 as a therapeutic target for joint diseases." Naunyn-Schmiedeberg's Archives of Pharmacology 388, no. 4 (January 1, 2015): 437-450. (Review)  Full Text
    • Zaelzer, C, Hua, P, Prager-Khoutorsky, M, Ciura, S, Voisin, DL, Liedtke, W, and Bourque, CW. "δN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress." Cell Reports 13, no. 1 (2015): 23-30.  Full Text
    • Chen, Y, Kanju, P, Fang, Q, Lee, SH, Parekh, PK, Lee, W, Moore, C, Brenner, D, Gereau, RW, Wang, F, and Liedtke, W. "TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor." Pain 155, no. 12 (December 2014): 2662-2672.  Full Text  Open Access Copy
    • Liedtke, W. "A precisely defined role for the tip link-associated protein TMIE in the mechanoelectrical transduction channel complex of inner ear hair cells." Neuron 84, no. 5 (December 2014): 889-891.  Full Text
    • Lee, W, Leddy, HA, Chen, Y, Lee, SH, Zelenski, NA, McNulty, AL, Wu, J, Beicker, KN, Coles, J, Zauscher, S, Grandl, J, Sachs, F, Guilak, F, and Liedtke, WB. "Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage." Proceedings of the National Academy of Sciences of the United States of America 111, no. 47 (November 10, 2014): E5114-E5122.  Full Text  Open Access Copy
    • Lindy, AS, Parekh, PK, Zhu, R, Kanju, P, Chintapalli, SV, Tsvilovskyy, V, Patterson, RL, Anishkin, A, van Rossum, DB, and Liedtke, WB. "TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour." Nature communications 5 (September 2, 2014): 4734-.  Full Text  Open Access Copy
    • Liedtke, W, Zhang, JY, Hall, RP, and Steinhoff, M. "Keratinocyte growth regulation TRP-ed up over downregulated TRPV4?." The Journal of Investigative Dermatology 134, no. 9 (September 2014): 2310-2312.  Full Text
    • Zhao, P, Lieu, T, Barlow, N, Metcalf, M, Veldhuis, NA, Jensen, DD, Kocan, M, Sostegni, S, Haerteis, S, Baraznenok, V, Henderson, I, Lindström, E, Guerrero-Alba, R, Valdez-Morales, EE, Liedtke, W, McIntyre, P, Vanner, SJ, Korbmacher, C, and Bunnett, NW. "Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4." The Journal of Biological Chemistry 289, no. 39 (September 2014): 27215-27234.  Full Text
    • Leddy, HA, McNulty, AL, Lee, SH, Rothfusz, NE, Gloss, B, Kirby, ML, Hutson, MR, Cohn, DH, Guilak, F, and Liedtke, W. "Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 28, no. 6 (June 2014): 2525-2537.  Full Text
    • O'Conor, CJ, Leddy, HA, Benefield, HC, Liedtke, WB, and Guilak, F. "TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading." Proceedings of the National Academy of Sciences of the United States of America 111, no. 4 (January 13, 2014): 1316-1321.  Full Text
    • Moore, C, Cevikbas, F, Pasolli, HA, Chen, Y, Kong, W, Kempkes, C, Parekh, P, Lee, SH, Kontchou, NA, Yeh, I, Jokerst, NM, Fuchs, E, Steinhoff, M, and Liedtke, WB. "Erratum: UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling (Proceedings of the National Academy of Sciences of the United States of America)." Proceedings of the National Academy of Sciences of the United States of America 110, no. 38 (October 17, 2013): 15502-null.  Full Text
    • Xia, Y, Fu, Z, Hu, J, Huang, C, Paudel, O, Cai, S, Liedtke, W, and Sham, JSK. "TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension." American Journal of Physiology. Cell Physiology 305, no. 7 (October 2013): C704-C715.  Full Text
    • Moore, C, Cevikbas, F, Pasolli, HA, Chen, Y, Kong, W, Kempkes, C, Parekh, P, Lee, SH, Kontchou, N-A, Yeh, I, Jokerst, NM, Fuchs, E, Steinhoff, M, and Liedtke, WB. "UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling." Proceedings of the National Academy of Sciences of the United States of America 110, no. 34 (August 8, 2013): E3225-E3234.  Full Text  Open Access Copy
    • Chen, Y, Williams, SH, McNulty, AL, Hong, JH, Lee, SH, Rothfusz, NE, Parekh, PK, Moore, C, Gereau, RW, Taylor, AB, Wang, F, Guilak, F, and Liedtke, W. "Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion." Pain 154, no. 8 (August 2013): 1295-1304.  Full Text  Open Access Copy
    • O’Conor, CJ, Benefield, HC, Liedtke, W, and Guilak, F. "Osmotic or Chemical Activation of the TRPV4 Ion Channel Enhances the Development of Chondrocyte-Based Tissue Engineered Cartilage." Volume 1b: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub Cellular Biophysics; Multiscale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions (June 26, 2013).  Full Text
    • Fariss, MW, Gilmour, MI, Reilly, CA, Liedtke, W, and Ghio, AJ. "Emerging mechanistic targets in lung injury induced by combustion-generated particles." Toxicological Sciences 133, no. 1 (May 1, 2013): 196-null.  Full Text
    • Liedtke, W, Yeo, M, Zhang, H, Wang, Y, Gignac, M, Miller, S, Berglund, K, and Liu, J. "Highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter KCC2." Small 9, no. 7 (April 8, 2013): 1066-1075.  Full Text  Link to Item
    • Dunn, KM, Hill-Eubanks, DC, Liedtke, WB, and Nelson, MT. "TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses." Proceedings of the National Academy of Sciences of the United States of America 110, no. 15 (April 2013): 6157-6162.  Full Text
    • Fariss, MW, Gilmour, MI, Reilly, CA, Liedtke, W, and Ghio, AJ. "Emerging mechanistic targets in lung injury induced by combustion-generated particles." Toxicological Sciences : an Official Journal of the Society of Toxicology 132, no. 2 (April 2013): 253-267. (Review)  Full Text
    • Yeo, M, Berglund, K, Hanna, M, Guo, JU, Kittur, J, Torres, MD, Abramowitz, J, Busciglio, J, Gao, Y, Birnbaumer, L, and Liedtke, WB. "Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter." Proceedings of the National Academy of Sciences of the United States of America 110, no. 11 (March 2013): 4315-4320.  Full Text
    • O'Conor, CJ, Griffin, TM, Liedtke, W, and Guilak, F. "Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet." Annals of the Rheumatic Diseases 72, no. 2 (February 2013): 300-304.  Full Text
    • Poole, DP, Amadesi, S, Veldhuis, NA, Abogadie, FC, Lieu, T, Darby, W, Liedtke, W, Lew, MJ, McIntyre, P, and Bunnett, NW. "Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling." The Journal of Biological Chemistry 288, no. 8 (February 2013): 5790-5802.  Full Text
    • Chen, Y, Williams, SH, McNulty, AL, Hong, JH, Lee, SH, Rothfusz, NE, Parekh, PK, Moore, C, IV, RWG, Taylor, AB, Wang, F, Guilak, F, and Liedtke, W. "Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion." Pain 154, no. 8 (2013): 1295-1304.  Full Text
    • O'Conor, CJ, Griffin, TM, Liedtke, W, and Guilak, F. "Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet." Annals of the Rheumatic Diseases 72, no. 2 (2013): 300-304.  Full Text
    • Yeo, M, Patisaul, H, and Liedtke, W. "Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity." Epigenetics 8, no. 11 (2013): 1128-1132.  Full Text
    • Ye, L, Kleiner, S, Wu, J, Sah, R, Gupta, RK, Banks, AS, Cohen, P, Khandekar, MJ, Boström, P, Mepani, RJ, Laznik, D, Kamenecka, TM, Song, X, Liedtke, W, Mootha, VK, Puigserver, P, Griffin, PR, Clapham, DE, and Spiegelman, BM. "TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis." Cell 151, no. 1 (September 2012): 96-110.  Full Text
    • Sonkusare, SK, Bonev, AD, Ledoux, J, Liedtke, W, Kotlikoff, MI, Heppner, TJ, Hill-Eubanks, DC, and Nelson, MT. "Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function." Science (New York, N.Y.) 336, no. 6081 (May 2012): 597-601.  Full Text
    • Bourque, CW, Guilak, F, and Liedtke, W. "A TRP that makes us feel hyper." J Physiol 590, no. 8 (April 15, 2012): 1779-1780.  Full Text  Link to Item
    • Yang, X-R, Lin, AHY, Hughes, JM, Flavahan, NA, Cao, Y-N, Liedtke, W, and Sham, JSK. "Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension." American Journal of Physiology. Lung Cellular and Molecular Physiology 302, no. 6 (March 2012): L555-L568.  Full Text
    • Ciura, S, Liedtke, W, and Bourque, CW. "Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 31, no. 41 (October 2011): 14669-14676.  Full Text
    • Liedtke, WB, McKinley, MJ, Walker, LL, Zhang, H, Pfenning, AR, Drago, J, Hochendoner, SJ, Hilton, DL, Lawrence, AJ, and Denton, DA. "Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite." Proc Natl Acad Sci U S A 108, no. 30 (July 26, 2011): 12509-12514.  Full Text  Link to Item
    • Li, J, Kanju, P, Patterson, M, Chew, W-L, Cho, S-H, Gilmour, I, Oliver, T, Yasuda, R, Ghio, A, Simon, SA, and Liedtke, W. "TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles." Environmental Health Perspectives 119, no. 6 (June 2011): 784-793.  Full Text  Open Access Copy
    • Ryskamp, DA, Witkovsky, P, Barabas, P, Huang, W, Koehler, C, Akimov, NP, Lee, SH, Chauhan, S, Xing, W, Rentería, RC, Liedtke, W, and Krizaj, D. "The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 31, no. 19 (May 2011): 7089-7101.  Full Text
    • Pritschow, BW, Lange, T, Kasch, J, Kunert-Keil, C, Liedtke, W, and Brinkmeier, H. "Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca²⁺ influx and muscle fatigue." Pflugers Archiv European Journal of Physiology 461, no. 1 (2011): 115-122.  Full Text
    • Clark, AL, Votta, BJ, Kumar, S, Liedtke, W, and Guilak, F. "Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice." Arthritis Rheum 62, no. 10 (October 2010): 2973-2983.  Full Text  Link to Item
    • Ceppa, E, Cattaruzza, F, Lyo, V, Amadesi, S, Pelayo, J-C, Poole, DP, Vaksman, N, Liedtke, W, Cohen, DM, Grady, EF, Bunnett, NW, and Kirkwood, KS. "Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice." American Journal of Physiology. Gastrointestinal and Liver Physiology 299, no. 3 (September 2010): G556-G571.  Full Text
    • Hamanaka, K, Jian, M-Y, Townsley, MI, King, JA, Liedtke, W, Weber, DS, Eyal, FG, Clapp, MM, and Parker, JC. "TRPV4 channels augment macrophage activation and ventilator-induced lung injury." American Journal of Physiology. Lung Cellular and Molecular Physiology 299, no. 3 (September 2010): L353-L362.  Full Text
    • Shukla, AK, Kim, J, Ahn, S, Xiao, K, Shenoy, SK, Liedtke, W, and Lefkowitz, RJ. "Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4." The Journal of Biological Chemistry 285, no. 39 (September 2010): 30115-30125.  Full Text
    • Guilak, F, Leddy, HA, and Liedtke, W. "Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system?." Annals of the New York Academy of Sciences 1192 (March 2010): 404-409. (Review)  Full Text
    • Vergnolle, N, Cenac, N, Altier, C, Cellars, L, Chapman, K, Zamponi, GW, Materazzi, S, Nassini, R, Liedtke, W, Cattaruzza, F, Grady, EF, Geppetti, P, and Bunnett, NW. "A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation." British Journal of Pharmacology 159, no. 5 (March 2010): 1161-1173.  Full Text
    • Phan, MN, Leddy, HA, Votta, BJ, Kumar, S, Levy, DS, Lipshutz, DB, Lee, SH, Liedtke, W, and Guilak, F. "Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes." Arthritis and Rheumatism 60, no. 10 (October 2009): 3028-3037.  Full Text
    • Wu, S, Jian, M-Y, Xu, Y-C, Zhou, C, Al-Mehdi, A-B, Liedtke, W, Shin, H-S, and Townsley, MI. "Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium." American Journal of Physiology. Lung Cellular and Molecular Physiology 297, no. 4 (October 2009): L650-L657.  Full Text
    • Earley, S, Pauyo, T, Drapp, R, Tavares, MJ, Liedtke, W, and Brayden, JE. "TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure." American Journal of Physiology. Heart and Circulatory Physiology 297, no. 3 (September 2009): H1096-H1102.  Full Text
    • Guilak, F, Cohen, DM, Estes, BT, Gimble, JM, Liedtke, W, and Chen, CS. "Control of stem cell fate by physical interactions with the extracellular matrix." Cell Stem Cell 5, no. 1 (July 2009): 17-26. (Review)  Full Text
    • Li, J, Ghio, AJ, Cho, S-H, Brinckerhoff, CE, Simon, SA, and Liedtke, W. "Diesel exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a beta-arrestin-dependent manner via activation of RAS." Environ Health Perspect 117, no. 3 (March 2009): 400-409.  Full Text  Open Access Copy  Link to Item
    • Liedtke, WB. "AN UPDATE ON TRPV4-MEDIATED SIGNALING IN HEALTH AND DISEASE." JOURNAL OF PHYSIOLOGICAL SCIENCES 59 (2009): 93-93.  Link to Item
    • Yeo, M, Berglund, K, Augustine, G, and Liedtke, W. "Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride." Journal of Neuroscience 29, no. 46 (2009): 14652-14662.  Full Text
    • Cenac, N, Altier, C, Chapman, K, Liedtke, W, Zamponi, G, and Vergnolle, N. "Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms." Gastroenterology 135, no. 3 (September 2008): 937-946.e2.  Full Text
    • Simon, SA, and Liedtke, W. "How irritation: The role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways." Journal of Clinical Investigation 118, no. 7 (July 1, 2008): 2383-2386.  Full Text
    • Simon, SA, and Liedtke, W. "How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways." The Journal of Clinical Investigation 118, no. 7 (July 2008): 2383-2386.  Full Text
    • Brierley, SM, Page, AJ, Hughes, PA, Adam, B, Liebregts, T, Cooper, NJ, Holtmann, G, Liedtke, W, and Blackshaw, LA. "Selective role for TRPV4 ion channels in visceral sensory pathways." Gastroenterology 134, no. 7 (June 2008): 2059-2069.  Full Text
    • Sipe, WEB, Brierley, SM, Martin, CM, Phillis, BD, Cruz, FB, Grady, EF, Liedtke, W, Cohen, DM, Vanner, S, Blackshaw, LA, and Bunnett, NW. "Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia." American Journal of Physiology. Gastrointestinal and Liver Physiology 294, no. 5 (May 2008): G1288-G1298.  Full Text
    • Jian, M-Y, King, JA, Al-Mehdi, A-B, Liedtke, W, and Townsley, MI. "High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4." American Journal of Respiratory Cell and Molecular Biology 38, no. 4 (April 2008): 386-392.  Full Text
    • Liu, X, Bandyopadhyay, BC, Nakamoto, T, Singh, BB, Liedtke, W, Melvin, JE, and Ambudkar, IS. "A role for AQP5 in activation of TRPV4 by hypotonicity: Concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery (Journal of Biological Chemistry (2006) 281, (15485-15495))." Journal of Biological Chemistry 283, no. 6 (February 8, 2008): 3688-null.
    • Liedtke, W. "Molecular mechanisms of TRPV4-mediated neural signaling." Annals of the New York Academy of Sciences 1144 (2008): 42-52.  Full Text
    • Lorenzo, IM, Liedtke, W, Sanderson, MJ, and Valverde, MA. "TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells." Proceedings of the National Academy of Sciences of the United States of America 105, no. 34 (2008): 12611-12616.  Full Text
    • Yin, J, Hoffmann, J, Kaestle, SM, Neye, N, Wang, L, Baeurle, J, Liedtke, W, Wu, S, Kuppe, H, Pries, AR, and Kuebler, WM. "Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4." Circulation Research 102, no. 8 (2008): 966-974.  Full Text
    • Liedtke, W. "TRPV channels' role in osmotransduction and mechanotransduction." Handbook of Experimental Pharmacology 179 (December 1, 2007): 473-487.  Full Text
    • Gevaert, T, Vriens, J, Segal, A, Everaerts, W, Roskams, T, Talavera, K, Owsianik, G, Liedtke, W, Daelemans, D, Dewachter, I, Van Leuven, F, Voets, T, De Ridder, D, and Nilius, B. "Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding." The Journal of Clinical Investigation 117, no. 11 (November 2007): 3453-3462.  Full Text
    • Hamanaka, K, Jian, M-Y, Weber, DS, Alvarez, DF, Townsley, MI, Al-Mehdi, AB, King, JA, Liedtke, W, and Parker, JC. "TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs." American Journal of Physiology. Lung Cellular and Molecular Physiology 293, no. 4 (October 2007): L923-L932.  Full Text
    • Liu, L, Chen, L, Liedtke, W, and Simon, SA. "Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons." Journal of Neurophysiology 97, no. 3 (March 2007): 2001-2015.  Full Text
    • Grant, AD, Cottrell, GS, Amadesi, S, Trevisani, M, Nicoletti, P, Materazzi, S, Altier, C, Cenac, N, Zamponi, GW, Bautista-Cruz, F, Lopez, CB, Joseph, EK, Levine, JD, Liedtke, W, Vanner, S, Vergnolle, N, Geppetti, P, and Bunnett, NW. "Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice." The Journal of Physiology 578, no. Pt 3 (February 2007): 715-733.  Full Text
    • Hartmannsgruber, V, Heyken, W-T, Kacik, M, Kaistha, A, Grgic, I, Harteneck, C, Liedtke, W, Hoyer, J, and Köhler, R. "Arterial response to shear stress critically depends on endothelial TRPV4 expression." PLoS ONE 2, no. 9 (2007).  Full Text
    • Liedtke, W. "Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals." Experimental Physiology 92, no. 3 (2007): 507-512.  Full Text
    • Liedtke, W. "TRPV channels' role in osmotransduction and mechanotransduction." Handbook of Experimental Pharmacology 179 (2007): 473-487.  Full Text
    • Liedtke, W. "Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli." J Endocrinol 191, no. 3 (December 2006): 515-523. (Review)  Full Text  Link to Item
    • Alvarez, DF, King, JA, Weber, D, Addison, E, Liedtke, W, and Townsley, MI. "Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier." Circulation Research 99, no. 9 (October 27, 2006): 988-995. (Academic Article)  Full Text  Link to Item
    • Alvarez, DF, King, JA, Weber, D, Addison, E, Liedtke, W, and Townsley, MI. "Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury." Circulation Research 99, no. 9 (October 2006): 988-995.  Full Text
    • Liu, X, Bandyopadhyay, BC, Nakamoto, T, Singh, B, Liedtke, W, Melvin, JE, and Ambudkar, I. "A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery." The Journal of Biological Chemistry 281, no. 22 (June 2006): 15485-15495.  Full Text
    • Liu, L, Yang, TM, Liedtke, W, and Simon, SA. "Chronic IL-1beta signaling potentiates voltage-dependent sodium currents in trigeminal nociceptive neurons." Journal of Neurophysiology 95, no. 3 (March 2006): 1478-1490.  Full Text
    • Liedtke, W, and Kim, C. "Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon!." Cell Mol Life Sci 62, no. 24 (December 2005): 2985-3001. (Review)  Full Text  Link to Item
    • Phan, M, Pritchard, S, Votta, BJ, Kumar, S, Liedtke, W, and Guilak, F. "Functional characterization of an osmotically-sensitive ion channel, TRPV4, in articular chondrocytes." Proceedings of the 2005 Summer Bioengineering Conference 2005 (December 1, 2005): 966-967.
    • Alessandri-Haber, N, Joseph, E, Dina, OA, Liedtke, W, and Levine, JD. "TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator." Pain 118, no. 1-2 (November 2005): 70-79.  Full Text  Link to Item
    • Liedtke, W. "TRPV4 as osmosensor: a transgenic approach." Pflugers Arch 451, no. 1 (October 2005): 176-180. (Review)  Full Text  Link to Item
    • Liedtke, W. "TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals." J Physiol 567, no. Pt 1 (August 15, 2005): 53-58. (Review)  Full Text  Link to Item
    • Ehrlich, M, Wisehart, A, Stein, HD, Liedtke, W, and Okie, S. "Chewing the fat [1]." Natural History 114, no. 4 (May 1, 2005): 9-null. (Letter)
    • Liedtke, W, and Simon, SA. "A possible role for TRPV4 receptors in asthma." Am J Physiol Lung Cell Mol Physiol 287, no. 2 (August 2004): L269-L271. (Review)  Full Text  Link to Item
    • Liedtke, W, Tobin, DM, Bargmann, CI, and Friedman, JM. "Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans." Proceedings of the National Academy of Sciences of the United States of America 100 Suppl 2 (November 2003): 14531-14536.  Full Text
    • Liedtke, W, and Friedman, JM. "Abnormal osmotic regulation in trpv4-/- mice." Proceedings of the National Academy of Sciences of the United States of America 100, no. 23 (November 2003): 13698-13703.  Full Text
    • Cohen, P, Miyazaki, M, Socci, ND, Hagge-Greenberg, A, Liedtke, W, Soukas, AA, Sharma, R, Hudgins, LC, Ntambi, JM, and Friedman, JM. "Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss." Science (New York, N.Y.) 297, no. 5579 (July 2002): 240-243.  Full Text
    • Liedtke, W, Leman, EE, Fyffe, REW, Raine, CS, and Schubart, UK. "Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems." The American Journal of Pathology 160, no. 2 (February 2002): 469-480.  Full Text
    • Laviano, A, Meguid, MM, Rossi-Fanelli, F, Cohen, P, Miyazaki, M, Hudgins, LC, Socci, ND, Ntambi, JM, Hagge-Greenberg, A, Liedtke, W, Soukas, AA, Sharma, R, and Friedman, JM. "Energy expenditure and treating obesity [2] (multiple letters)." Science 298, no. 5593 (2002): 539-541.
    • Liedtke, W, Choe, Y, Martí-Renom, MA, Bell, AM, Denis, CS, Sali, A, Hudspeth, AJ, Friedman, JM, and Heller, S. "Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor." Cell 103, no. 3 (October 2000): 525-535.  Full Text
    • Ness, SL, Edelmann, W, Jenkins, TD, Liedtke, W, Rustgi, AK, and Kucherlapati, R. "Mouse keratin 4 is necessary for internal epithelial integrity." J Biol Chem 273, no. 37 (September 11, 1998): 23904-23911.  Link to Item
    • Liedtke, W, Cannella, B, Mazzaccaro, RJ, Clements, JM, Miller, KM, Wucherpfennig, KW, Gearing, AJ, and Raine, CS. "Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors." Ann Neurol 44, no. 1 (July 1998): 35-46.  Full Text  Link to Item
    • Liedtke, W, Edelmann, W, Chiu, FC, Kucherlapati, R, and Raine, CS. "Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion." Am J Pathol 152, no. 1 (January 1998): 251-259.  Link to Item
    • Edelmann, W, Yang, K, Umar, A, Heyer, J, Lau, K, Fan, K, Liedtke, W, Cohen, PE, Kane, MF, Lipford, JR, Yu, N, Crouse, GF, Pollard, JW, Kunkel, T, Lipkin, M, Kolodner, R, and Kucherlapati, R. "Mutation in the mismatch repair gene Msh6 causes cancer susceptibility." Cell 91, no. 4 (November 14, 1997): 467-477.  Link to Item
    • Liedtke, W, Meyer, G, Faustmann, PM, Warnatz, H, and Raine, CS. "Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients." Int Immunol 9, no. 7 (July 1997): 1031-1041.  Link to Item
    • Liedtke, W, Edelmann, W, Bieri, PL, Chiu, FC, Cowan, NJ, Kucherlapati, R, and Raine, CS. "GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination." Neuron 17, no. 4 (October 1996): 607-615.  Link to Item
    • Liedtke, W, and Limmroth, V. "Validity of brain MRI as the primary outcome criterion in multiple sclerosis phase II clinical trials." Ann Neurol 39, no. 2 (February 1996): 276-277. (Letter)  Full Text  Link to Item
    • Liedtke, W, Trübner, K, and Schwechheimer, K. "On the role of human herpesvirus 6 in viral latency in nervous tissue and in cerebral lymphoma." J Neurol Sci 134, no. 1-2 (December 1995): 184-188.  Link to Item
    • Liedtke, W, Malessa, R, Faustmann, PM, and Eis-Hübinger, AM. "Human herpesvirus 6 polymerase chain reaction findings in human immunodeficiency virus associated neurological disease and multiple sclerosis." J Neurovirol 1, no. 3-4 (September 1995): 253-258.  Link to Item
    • Ochs, G, and Liedtke, W. "Capsaicin." Aktuelle Neurologie 22, no. 4 (January 1, 1995): 164-166.  Full Text
    • Liedtke, W, Battistini, L, Brosnan, CF, and Raine, CS. "A comparison of methods for RNA extraction from lymphocytes for RT-PCR." PCR Methods Appl 4, no. 3 (December 1994): 185-187.  Link to Item
    • Liedtke, W, Quabeck, K, Beelen, DW, Straeten, V, and Schaefer, UW. "Recurrent acute inflammatory demyelinating polyradiculitis after allogeneic bone marrow transplantation." J Neurol Sci 125, no. 1 (August 1994): 110-111.  Link to Item
    • Liedtke, W, Opalka, B, Zimmermann, CW, and Schmid, E. "Different methods of sample preparation influence sensitivity of Mycobacterium tuberculosis and Borrelia burgdorferi PCR." PCR Methods Appl 3, no. 5 (April 1994): 301-304.  Link to Item
    • Liedtke, W, Battistini, L, Brosnan, CF, and Raine, CS. "A comparison of for RNA extraction for RT-PCR." Genome Research 4, no. 3 (January 1, 1994): 185-187.  Full Text
    • Liedtke, W, May, A, Dux, R, Faustmann, PM, and Zimmermann, CW. "Mycobacterium tuberculosis polymerase chain reaction findings in neurosarcoidosis." J Neurol Sci 120, no. 1 (December 1, 1993): 118-119. (Letter)  Link to Item
    • Liedtke, W, Opalka, B, Zimmermann, CW, and Schmid, E. "Different methods of sample preparation influence sensitivity of mycobacterium tuberculosis and borrelia burgdorferi PCR." Genome Research 3, no. 5 (December 1, 1993): 301-304.
    • Liedtke, W, Opalka, B, Zimmermann, CW, and Lignitz, E. "Age distribution of latent herpes simplex virus 1 and varicella-zoster virus genome in human nervous tissue." J Neurol Sci 116, no. 1 (May 1993): 6-11.  Link to Item
    • Liedtke, W, Muller, F, Petersen, D, and Klein, R. "Antineutrophil cytoplasmic antibodies associated with neurological vasculitic syndromes - Four cases." Nervenheilkunde 12, no. 7 (1993): 373-376.
    • Liedtke, W, Weller, M, Wiethölter, H, and Dichgans, J. "Immunological abnormalities in the tears of multiple sclerosis patients." Acta Neurol Scand 85, no. 3 (March 1992): 228-230.  Link to Item
    • Weller, M, Liedtke, W, Petersen, D, Opitz, H, and Poremba, M. "Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion." Neurology 42, no. 2 (February 1992): 367-370.  Link to Item
    • Liedtke, W. "Inadequate antidiuretic hormone secretion after sagittal sinus thrombosis caused by protein S deficiency." Stroke 22, no. 6 (June 1991): 819-null. (Letter)  Full Text
    • Brüssow, H, Werchau, H, Lerner, L, Mietens, C, Liedtke, W, Sidoti, J, and Sotek, J. "Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis." J Infect Dis 158, no. 3 (September 1988): 588-595.  Link to Item
    • Brüssow, H, Werchau, H, Liedtke, W, Lerner, L, Mietens, C, Sidoti, J, and Sotek, J. "Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany." J Infect Dis 157, no. 5 (May 1988): 1014-1022.  Link to Item
    • Grunert, B, Streckert, HJ, Liedtke, W, Houly, C, Mietens, C, and Werchau, H. "Development of a monoclonal antibody specific for serotype 3 rotavirus strains." Eur J Clin Microbiol 6, no. 2 (April 1987): 136-141.  Link to Item

  • Book Sections

    • Simon, SA, and Gutierrez, R. "TRP channels at the periphery of the taste and trigeminal systems." In Neurobiology of TRP Channels, 113-124. January 1, 2017.  Full Text
    • Liedtke, W. "TRP channels and osmoregulation: TRPV4-mediated signaling." In TRP Channels in Health and Disease: Implications for Diagnosis and Therapy, 153-170. July 1, 2011.

  • Conference Papers

    • Seth, RK, Dattaroy, D, Chandrashekaran, V, Das, S, Alhasson, F, Bonini, MG, Michelotti, GA, Nagarkatti, M, Nagarkatti, P, Diehl, AM, Bell, PD, Liedtke, WB, and Chatterjee, S. "TRPV4 prevents tissue injury in diseased fatty liver by blocking CYP2E1-mediated redox-toxicity via Kupffer cell-induced nitric oxide production." October 2016.  Link to Item
    • Seth, RK, Das, S, Dattaroy, D, Alhasson, FA, Michelotti, GA, Nagarkatti, M, Nagarkatti, P, Be, PD, Liedtke, WB, Diehl, AM, and Chatterjee, S. "TRPV4 Modulates CYP2E1 Function in Nonalcoholic Steatohepatitis Progression." Experimental Biology Meeting. San Diego, CA. April 2, 2016 - April 6, 2016.: FEDERATION AMER SOC EXP BIOL, April 1, 2016.  Link to Item
    • Das, S, Seth, RK, Chandrashekaran, V, Alhasson, F, Dattaroy, D, Michelotti, GA, Nagarkatti, P, Bell, PD, Liedtke, WB, Diehl, A, Chatterjee, S, and Nagarkatti, M. "TRPV4 deficiency enhances TLR4 recruitment to lipid rafts exhibiting exacerbated stellate cell activation and fibrosis in experimental nonalcoholic steatohepatitis." October 2015.  Link to Item
    • Seth, RK, Das, S, Dattaroy, D, Alhasson, F, Bell, PD, Michelotti, GA, Nagarkatti, M, Nagarkatti, P, Liedtke, WB, Diehl, AM, and Chatterjee, S. "TRPV4 regulates inflammation and Kupffer cell activation in nonalcoholic steatohepatitis by attenuation of CYP2E1-mediated oxidative stress." October 2015.  Link to Item
    • Bauer, W, Liedtke, WB, Waker, S, Saper, JR, and Frangakis, CJ. "Topical Anti-Inflammatory Therapy in the Treatment of Acute Migraine; Role of Trigeminal Nerve Peripheral Fibers." May 2015.  Link to Item
    • Klein, RC, Goetz, SM, Liedtke, WB, Moore, SD, and Peterchev, AV. "Static magnetic field modulates excitatory activity in layer II/III pyramidal neurons of the rat motor cortex." December 1, 2013.  Full Text
    • Sham, JSK, Yang, X-R, Hughes, JM, Cao, Y-N, Flavahan, NA, and Liedtke, W. "UPREGULATION OF TRPV4 CHANNELS IN PULMONARY ARTERIES CONTRIBUTES TO CHRONIC HYPOXIA INDUCED MYOGENIC TONE AND PULMONARY HYPERTENSION." : SPRINGER TOKYO, January 1, 2009.  Link to Item
    • Liedtke, W, Tobin, DM, Bargmann, CI, and Friedman, JM. "Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans." November 15, 2003.

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