Research Interests
Precision medicine for cancer, regeneration, microbiome, and gut-brain axis. Multi-omics approaches including organoid, epigenetics, CRISPR, single-cell, metabolomics, machine learning, droplet microfluidics, humanized immune model and intravital imaging.
Selected Grants
Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER)
Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2026Transcriptional reprogramming of lethal small cell prostate cancer
ResearchCollaborator · Awarded by Department of Defense · 2021 - 2024Effects of storage method on intestinal allograft immune profile and viability
ResearchCo Investigator · Awarded by Department of Defense · 2019 - 2024Mapping Epigenetic Memory of Exposure New To Observe (MEMENTO)
ResearchPrincipal Investigator · Awarded by Defense Advanced Research Projects Agency · 2019 - 2024Developing bacteria-derived therapies to cure inflammatory bowel diseases
ResearchCollaborator · Awarded by Hartwell Foundation · 2020 - 2023COVID Survivors Long Term Follow Up Study--WMD ECHO Detector
ResearchPrincipal Investigator · Awarded by Icahn School of Medicine at Mount Sinai · 2021 - 2023Developing a comprehensive model for peripheral nerve stimulation of gastrointestinal function
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2023EFRI CEE : Engineering Technologies to Determine Causal Relationships Between Chromatin Structure and Gene Regulation
ResearchCo-Principal Investigator · Awarded by National Science Foundation · 2018 - 2022An organotypic model recapitulating colon cancer microenvironment and metastasis
ResearchPrincipal Investigator · Awarded by University of Texas Southwestern Medical Center · 2017 - 2022A comprehensive research resource to define mechanisms underlying microbial regulation of host metabolism in pediatric obesity and obesity-targeted therapeutics
ResearchCo Investigator · Awarded by National Institutes of Health · 2016 - 2022Epigenomic Drivers of Drug Resistance in Pediatric Brain Tumors
ResearchPrincipal Investigator · Awarded by Ann & Robert H. Lurie Children's Hospital of Chicago · 2020 - 2021Human cell atlas along the gut-brain axis
ResearchPrincipal Investigator · Awarded by Chan Zuckerberg Initiative · 2019 - 2021Spatiotemporal and robustness regulation of the stem cell niche
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2021Establishing the molecular and cellular mechanisms of Lgr5 signaling for controlling cancer stem cell behavior
ResearchCollaborator · Awarded by National Institutes of Health · 2017 - 2021Bioinformatics and Computational Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2021Development of molecular diganostic assay for accurate dection of COVID19 infection
ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2020 - 2021HARDAC-M: Enabling memory-intensive computation for genomics
EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2020 - 2021Engineering Signaling Specificity to Program Intestinal Organoid Development
ResearchPrincipal Investigator · Awarded by Defense Advanced Research Projects Agency · 2016 - 2021Genetics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1979 - 2020Organization and Function of Cellular Structure
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020Stimulating anti-tumor immunity with cancer vaccine in mice with a humanized immune system
ResearchPrincipal Investigator · Awarded by Houston Methodist Research Institute · 2019 - 2020Closed-loop sacral nerve stimulation for inflammation - Phase I -
ResearchPrincipal Investigator · Awarded by Johns Hopkins University · 2015 - 2019Robustness of the Intestinal Stem Cell Niche
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2018Functional mapping of efferent gut neuroepithelial circuits
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2018Metabolic Reprogramming of Colon Cancer Liver Metastasis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2017External Relationships
- Terasaki Institute
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.