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Xin Zhang

Assistant Professor in Orthopaedic Surgery
Orthopaedic Surgery

Current Appointments & Affiliations


Assistant Professor in Orthopaedic Surgery · 2021 - Present Orthopaedic Surgery, Clinical Science Departments
Member of Duke Molecular Physiology Institute · 2019 - Present Duke Molecular Physiology Institute, Institutes and Centers

Recent Publications


Extracellular vesicles in osteoarthritis synovial fluid contain both transmembrane and intravesical TNF-α

Journal Article Osteoarthritis and Cartilage Open · June 1, 2025 Objective: We previously identified extracellular vesicles (EVs) as a key source of TNF-α in the plasma of both knee osteoarthritis (OA) patients and healthy individuals. Building on these findings, this study aimed to evaluate the presence of surface-boun ... Full text Cite

Plasma extracellular vesicles carry immune system-related peptides that predict human longevity.

Journal Article Geroscience · April 2025 Extracellular vesicles (EVs) play crucial roles in aging. In this National Institutes on Aging-funded study, we sought to identify circulating extracellular vesicle (EV) biomarkers indicative of longevity. The plasma EV proteome of 48 older adults (mean ag ... Full text Link to item Cite

Immune System-Related Plasma Pathogenic Extracellular Vesicle Subpopulations Predict Osteoarthritis Progression.

Journal Article Int J Mol Sci · November 21, 2024 Certain molecules found on the surface or within the cargo of extracellular vesicles (EVs) are linked to osteoarthritis (OA) severity and progression. We aimed to identify plasma pathogenic EV subpopulations that can predict knee radiographic OA (rOA) prog ... Full text Link to item Cite
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Recent Grants


Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers

ResearchCo Investigator · Awarded by National Institute on Aging · 2021 - 2025

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Education, Training & Certifications


Tongji Medical College (China) · 2001 M.D.