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Xin Zhang

Assistant Professor in Orthopaedic Surgery
Orthopaedic Surgery

Current Appointments & Affiliations


Assistant Professor in Orthopaedic Surgery · 2021 - Present Orthopaedic Surgery, Clinical Science Departments
Member of Duke Molecular Physiology Institute · 2019 - Present Duke Molecular Physiology Institute, Institutes and Centers

Recent Publications


Plasma Extracellular Vesicle Signatures of Metabolic Health and Exercise Response in a Pilot Study of Older Adults.

Journal Article Am J Physiol Cell Physiol · December 30, 2025 Extracellular vesicles (EVs) are key mediators of intercellular communication and regulators of cellular function, yet their roles in metabolic health and exercise response are poorly understood. This pilot study analyzed plasma from older adults (n=20) in ... Full text Link to item Cite

Immune System-Related Plasma Extracellular Vesicles are Strong Predictors of Human Longevity.

Journal Article Journal of Extracellular Vesicles · October 28, 2025 Full text Cite

Extracellular vesicles in osteoarthritis synovial fluid contain both transmembrane and intravesical TNF-α.

Journal Article Osteoarthr Cartil Open · June 2025 OBJECTIVE: We previously identified extracellular vesicles (EVs) as a key source of TNF-α in the plasma of both knee osteoarthritis (OA) patients and healthy individuals. Building on these findings, this study aimed to evaluate the presence of surface-boun ... Full text Link to item Cite
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Recent Grants


Proteomic Biomarkers Predicting Osteoarthritis Onset and Progression

ResearchCo-Principal Investigator · Awarded by Department of Defense · 2025 - 2027

Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers

ResearchCo Investigator · Awarded by National Institute on Aging · 2021 - 2026

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