Overview
I lead a functional genomics lab and my lab’s research is mainly focused on two areas: 1) developing new functional genomics tools to study genome structure and function; 2) using skeletal muscle regeneration and muscle stem cell as our model system to study gene regulation of tissue regeneration in health and diseases conditions, such as injury, muscular dystrophy, aging, and rhabdomyosarcoma. My research has been supported by Human Frontier Science Program (HFSP), V Foundation for Cancer Research, Alex's Lemonade Stand Foundation, Kahn program and Translating Duke Health, Glenn Foundation and American Federation for Aging Research (AFAR), Elsa. U Pardee foundation, Cancer Moonshot℠Research Initiatives and NIH.
Current Appointments & Affiliations
Assistant Professor of Cell Biology
·
2018 - Present
Cell Biology,
Basic Science Departments
Assistant Professor in Orthopaedic Surgery
·
2018 - Present
Orthopaedic Surgery,
Clinical Science Departments
Assistant Professor in Pathology
·
2021 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
2018 - Present
Duke Cancer Institute,
Institutes and Centers
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
Decoding heterogeneous single-cell perturbation responses.
Journal Article Nat Cell Biol · February 26, 2025 Understanding how cells respond differently to perturbation is crucial in cell biology, but existing methods often fail to accurately quantify and interpret heterogeneous single-cell responses. Here we introduce the perturbation-response score (PS), a meth ... Full text Link to item CiteUBE2N Is Essential for Maintenance of Skin Homeostasis and Suppression of Inflammation.
Journal Article J Invest Dermatol · December 2024 UBE2N, a Lys63 ubiquitin-conjugating enzyme, plays critical roles in embryogenesis and immune system development and function. However, its roles in adult epithelial tissue homeostasis and pathogenesis are unclear. We generated conditional mouse models tha ... Full text Link to item CiteSingle cell analysis of Idh mutant growth plates identifies cell populations responsible for longitudinal bone growth and enchondroma formation.
Journal Article Sci Rep · October 31, 2024 Enchondromas are a common tumor in bone that can occur as multiple lesions in enchondromatosis, which is associated with deformity of the affected bone. These lesions harbor somatic mutations in IDH and driving expression of a mutant Idh1 in Col2 expressin ... Full text Link to item CiteRecent Grants
Engineering Heterocellular Human Skeletal Muscle Tissues to Recreate and Study Native Stem Cell Niche Function
ResearchCollaborator · Awarded by National Institutes of Health · 2024 - 2029Chromatin dysregulation in neurodevelopmental disorders
ResearchCollaborator · Awarded by National Institutes of Health · 2024 - 2029Enhancing limb regeneration with gene therapy informed by comparative biology
ResearchCollaborator · Awarded by National Institutes of Health · 2024 - 2029View All Grants
Education, Training & Certifications
University of Hong Kong (China) ·
2011
Ph.D.