Yarui Diao

My research program, ‘Regeneration Genomics’, is dedicated to unraveling the gene regulatory mechanisms that drive cell fate changes in development and regeneration. In our quest to decode the fundamental principles of gene regulation, I have been developing several cutting-edge genomic tools, such as CREST-seq, CARGO-BioID, HiCAR, and scHiCAR that benefit both our own research and the broader scientific community.

My passion for this research was sparked during my PhD training with Dr. Zhenguo Wu in the Hong Kong University of Science and Technology (HKUST), where I explored the epigenetic mechanism underlying skeletal muscle regeneration using mice as model organisms. This experience highlighted the crucial role of non-coding gene regulatory elements, such as enhancers, in controlling stem cell fate in regeneration and many diseases. To deepen my research expertise in epigenetics and genomics, I joined Dr. Bing Ren’s lab at UC San Diego (now at New York Genome Center) as a Human Frontier Science Program (HFSP) Postdoctoral Fellow. As a trainee, I published eight first-authored papers in strong journals, including PNAS, Cell Stem Cell, Dev Cell, Genome Research, Nature Methods, and Nature Genetics, demonstrating my solid training in stem cell biology, regeneration, epigenetics, and genomics.

After my postdoc training, with eight faculty job offers in the US, I decided to establish my independent lab at Duke Cell Biology in September 2018. Since then, I have built a research program focused on both human pluripotent stem cells and muscle stem cells and their “niche” in regeneration, aging, and degenerative disorders, combining mechanistic studies with genomic technologies. Over the past five years, our recent discoveries include: (1) the function and regulation of non-coding cis-regulatory elements, including transposable elements, in cell fate control in both human pluripotent stem cells and muscle stem cells (Nature Genetics 2023; JCB 2023; Nature Cell Biology 2025); (2) the pathological role of macrophage and FAPs in muscular dystrophy and Peripheral Artery Disease (PAD) (Genome Medicine 2023; JVS-VS 2025; Nature Communications, minor revision; Cell Stem Cell, minor revision); (3) the development of novel 3D genome, proteomics, and single cell multi-omics tools to map chromatin architecture and protein–DNA interactions (Molecular Cell 2022, Nature Genetics 2023, Nature Biotechnolog 2026). As a PI, I have published ten senior-author papers and contributed to over 20 collaborative publications.

I am also committed to mentoring, teaching, and service. My PhD students have received research awards and progressed to postdoctoral positions in top research institutions in the US, and my former postdocs have obtained tenure-track faculty positions and established their independent labs. At Duke, I have received the Recognition of Teaching Excellence in 2023, 2024. I serve as Co-Chair of the Admissions Committee for the Cell and Molecular Biology (CMB) PhD Program. I also co-organized the 2023 Triangle Regenerative Biology Symposium and Duke’s Single Cell Colloquia (2022, 2025) to promote local scientific communications.

Complete list of my published work can be found here:
https://www.ncbi.nlm.nih.gov/myncbi/yarui.diao.1/bibliography/public/

Diao lab website: https://diaolab.github.io/