Yike Jiang

Journal Article Ann Clin Transl Neurol · December 18, 2025 BACKGROUND: Pediatric anti-NMDA receptor encephalitis (pNMDARE) is an autoantibody-mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to ... Full text Open Access Link to item Cite

Clinical phenotype and outcomes in autoimmune encephalitis after herpes simplex virus encephalitis: A systematic review and meta-analysis.

Journal Article J Infect · September 2025 BACKGROUND: Autoimmune encephalitis after herpes simplex virus encephalitis (HSVE-AE) represents the intersection of central nervous system infection and autoimmunity. Defining the phenotype and the safety and effectiveness of immunotherapy in HSVE-AE woul ... Full text Link to item Cite

Isolated Psychiatric Symptoms in Children With Anti-N-Methyl-d Aspartate Receptor Encephalitis.

Journal Article Pediatr Neurol · October 2024 BACKGROUND: Isolated psychiatric symptoms can be the initial symptom of pediatric anti-N-methyl-d-aspartate (NMDA) receptor autoimmune encephalitis (pNMDARE). Here we report on the prevalence of isolated psychiatric symptoms in pNMDARE. We also assess whet ... Full text Link to item Cite

What the SARS-CoV-2 Pandemic Has Taught Us About Immunosuppression, Vaccinations, and Immune Dysregulation: The Rheumatology Experience.

Journal Article Curr Allergy Asthma Rep · April 2024 PURPOSE OF REVIEW: This review reflects on the impact of the COVID-19 pandemic on the field of rheumatology, emphasizing resulting insights related to the risks of viral infections in immunosuppressed patients, vaccine immunogenicity in immunocompromised p ... Full text Link to item Cite

Infectious profiles in pediatric anti-N-methyl-d-aspartate receptor encephalitis.

Journal Article J Neuroimmunol · August 15, 2023 Anti-N-methyl-d-aspartate receptor autoimmune encephalitis (NMDAR AE) is an antibody-mediated neurological disorder that may be caused by post-herpes simplex virus-1 meningoencephalitis (HSV ME) and ovarian teratomas, although most pediatric cases are idio ... Full text Link to item Cite

Microglia C-lectin/selectin' neurons to eat.

Journal Article Immunity · February 14, 2023 β-glucosylceramide (β-GlcCer) accumulates in Gaucher disease, but how β-GlcCer, a Mincle ligand, causes characteristic neuroinflammation and neuronopathy is poorly understood. In this issue of Immunity, Shimizu et al. reveal that Mincle-dependent activatio ... Full text Link to item Cite

SARS-CoV-2 Infection Is Not Associated With Pediatric Appendicitis.

Journal Article Pediatr Infect Dis J · August 1, 2022 Although case reports have suggested an association between severe acute respiratory distress syndrome coronavirus 2 and appendicitis, we found that the overall incidence of appendicitis was stable throughout the pandemic at our tertiary pediatric hospital ... Full text Link to item Cite

Improving Care for Childhood Obesity: A Quality Improvement Initiative.

Journal Article Pediatr Qual Saf · 2021 UNLABELLED: Obesity affected 13.7 million children in the United States in 2015. The American Academy of Pediatrics (AAP) offers an evidence-based approach to obesity management, but adherence to recommendations is suboptimal. Our objective was to improve ... Full text Link to item Cite

The Natural History of X-Linked Lymphoproliferative Disease (XLP1): Lessons from a Long-Term Survivor.

Journal Article Case Reports Immunol · 2020 X-linked lymphoproliferative disease (XLP1) is a rare primary immunodeficiency characterized by EBV-triggered immune dysregulation, lymphoproliferation, dysgammaglobulinemia, and lymphoma. Early childhood mortality from overwhelming inflammation is expecte ... Full text Link to item Cite

Preventing iatrogenic gelatin anaphylaxis.

Journal Article Ann Allergy Asthma Immunol · October 2019 OBJECTIVE: To assess the iatrogenic risks of gelatin allergy and identify resources for patient management. DATA SOURCES: A literature review was performed using PubMed and public databases provided by the National Library of Medicine. STUDY SELECTIONS: Re ... Full text Link to item Cite

Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity.

Journal Article Sci Transl Med · April 10, 2019 Neonatal herpes simplex virus (nHSV) infections cause devastating morbidity and mortality in infants. Most nHSV cases are associated with primary maternal infection, consistent with the hypothesis that maternal immunity is protective. In humans, we found H ... Full text Link to item Cite

Preventing neonatal herpes infections through maternal immunization.

Journal Article Future Virol · December 2017 Full text Link to item Cite

Maternal Antiviral Immunoglobulin Accumulates in Neural Tissue of Neonates To Prevent HSV Neurological Disease.

Journal Article mBio · July 5, 2017 While antibody responses to neurovirulent pathogens are critical for clearance, the extent to which antibodies access the nervous system to ameliorate infection is poorly understood. In this study on herpes simplex virus 1 (HSV-1), we demonstrate that HSV- ... Full text Link to item Cite

Dendritic Cell Autophagy Contributes to Herpes Simplex Virus-Driven Stromal Keratitis and Immunopathology.

Journal Article mBio · October 27, 2015 UNLABELLED: Herpetic stromal keratitis (HSK) is a blinding ocular disease that is initiated by HSV-1 and characterized by chronic inflammation in the cornea. Although HSK immunopathology of the cornea is well documented in animal models, events preceding t ... Full text Link to item Cite

Transcriptional and translational downregulation of thioredoxin interacting protein is required for metabolic reprogramming during G1

Journal Article Genes and Cancer · December 1, 2010 Growth factor signaling drives increased glucose uptake and glycolysis-the Warburg effect-that supports macromolecular synthesis necessary for cell growth and proliferation. Thioredoxin interacting protein (TXNIP), a direct and glucose-induced transcriptio ... Full text Cite