Yiran Guo

Journal Article Cancer treatment and research · January 2023 Dynamic regulation of the chromatin state by Polycomb Repressive Complex 2 (PRC2) provides an important mean for epigenetic gene control that can profoundly influence normal development and cell lineage specification. PRC2 and PRC2-induced methylation of h ... Full text Cite

Histone H3 proline 16 hydroxylation regulates mammalian gene expression.

Journal Article Nature genetics · November 2022 Histone post-translational modifications (PTMs) are important for regulating various DNA-templated processes. Here, we report the existence of a histone PTM in mammalian cells, namely histone H3 with hydroxylation of proline at residue 16 (H3P16oh), which ... Full text Cite

Modulation of the high-order chromatin structure by Polycomb complexes

Journal Article Frontiers in Cell and Developmental Biology · October 5, 2022 The multi-subunit Polycomb Repressive Complex (PRC) 1 and 2 act, either independently or synergistically, to maintain and enforce a repressive state of the target chromatin, thereby regulating the processes of cell lineage specification and organismal deve ... Full text Cite

Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations.

Journal Article Nat Commun · July 22, 2022 DNA methyltransferase DNMT3B plays an essential role in establishment of DNA methylation during embryogenesis. Mutations of DNMT3B are associated with human diseases, notably the immunodeficiency, centromeric instability and facial anomalies (ICF) syndrome ... Full text Link to item Cite

Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 'Readout', and Phase Separation-Based Compaction.

Journal Article Trends Genet · June 2021 Modulation of chromatin structure and/or modification by Polycomb repressive complexes (PRCs) provides an important means to partition the genome into functionally distinct subdomains and to regulate the activity of the underlying genes. Both the enzymatic ... Full text Link to item Cite

A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing.

Journal Article Nucleic Acids Res · May 7, 2021 Trimethylation of histone H3 lysine 27 (H3K27me3) is important for gene silencing and imprinting, (epi)genome organization and organismal development. In a prevalent model, the functional readout of H3K27me3 in mammalian cells is achieved through the H3K27 ... Full text Link to item Cite

DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.

Journal Article Nat Commun · May 3, 2021 DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. However, it remains elusive how these two chromati ... Full text Link to item Cite

ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.

Journal Article Nat Commun · February 16, 2021 Recurring chromosomal translocation t(10;17)(p15;q21) present in a subset of human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed ZMYND11-MBTD1 (ZM); however, its function remains undetermined. Here, we show that ZM confers pr ... Full text Link to item Cite

BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis.

Journal Article Nat Genet · December 2020 Trimethylated histone H3 lysine 27 (H3K27me3) regulates gene repression, cell-fate determination and differentiation. We report that a conserved bromo-adjacent homology (BAH) module of BAHCC1 (BAHCC1BAH) 'recognizes' H3K27me3 specifically and enforces sile ... Full text Link to item Cite

Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation.

Journal Article Proc Natl Acad Sci U S A · August 4, 2020 In mammals, repressive histone modifications such as trimethylation of histone H3 Lys9 (H3K9me3), frequently coexist with DNA methylation, producing a more stable and silenced chromatin state. However, it remains elusive how these epigenetic modifications ... Full text Link to item Cite

Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.

Journal Article Nat Commun · July 3, 2020 Mammalian DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive methylation activities. However, the related molecular basis remains undetermined. Through comprehensi ... Full text Link to item Cite

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.

Journal Article Nat Commun · July 3, 2020 Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of acute myeloid leukemia (AML) and poor survival rate. Here, we report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and is inhibited by small ... Full text Link to item Cite