Yuliya Vladimirovna Lokhnygina

Yuliya Vladimirovna Lokhnygina
Associate Professor of Biostatistics & Bioinformatics

Statistical methods in clinical trials, survival analysis, adaptive designs, adaptive treatment strategies, causal inference in observational studies, semiparametric inference

Current Appointments & Affiliations

Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2022
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2004

Contact Information

200 Morris Street, 6126 200 Morris, Durham, NC 27701
Duke Box 3850, Durham, NC 27710
yuliya.lokhnygina@duke.edu (919) 668-7814

Background
Education, Training, & Certifications
- Ph.D., North Carolina State University 2004
- M.S., Cornell University 2001
- M.S., Moscow Institute of Physics and Technology (Russia) 1999
Previous Appointments & Affiliations
- Assistant Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2021
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2014 - 2020
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2004 - 2014
- Instructor, Temporary of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2004
Research
Selected Grants
- Improving Neonatal health Through Rapid malaria testing in Early Pregnancy with high-sensitivity Diagnostics (INTREPiD) awarded by National Institutes of Health 2022 - 2027
- Helping Patients Achieve Kidney Transplants through Health System Change awarded by Patient Centered Outcomes Research Institute 2022 - 2026
- Combined Use of Statistical Process Control and Whole Genome Sequencing to Detect and Investigate Nontuberculous Mycobacterial Clusters and Outbreaks (K08) awarded by National Institutes of Health 2021 - 2026
- RADx-UP CDCC awarded by National Institutes of Health 2020 - 2024
- Trial to Assess Chelation Therapy 2 (TACT2) DCC Competing Renewal awarded by National Center for Complementary and Integrative Health 2015 - 2024
- Limbix Spark: a CBT-based mobile intervention for adolescent depression (NIH FUNDING) awarded by Limbix 2021 - 2023
- Genetic basis of age-at-onset of Alzheimer disease awarded by University of Miami 2018 - 2022
- RFTOP #2018 Domain 2-B-0001 Option 2 awarded by Centers for Disease Control and Prevention 2021 - 2022
- Administrative Claims-based Efficiencies for the Advancement of Regulatory Sciences awarded by Burroughs Wellcome Fund 2014 - 2021
- RFTOP #2018 Domain 2-B-0001 Option 1 awarded by Centers for Disease Control and Prevention 2020 - 2021
- Metals in the Trial to Assess Chelation Therapy 2 (TACT2M) awarded by Mount Sinai Medical Center of Florida, Inc. 2016 - 2021
- Prevention of Surgical Site Infection using Statistical Process Control Charts awarded by Agency for Healthcare Research and Quality 2015 - 2020
- RFTOP #2018 Domain 2-B-0001 Base Period awarded by Centers for Disease Control and Prevention 2018 - 2020
- Improving antibiotic use through implementation and evaluation of Core Elements of Hospital Antibiotic Stewardship Programs (Domain 2) awarded by Centers for Disease Control and Prevention 2016 - 2019
- Duke CTSA (UL1) awarded by National Institutes of Health 2013 - 2018
- BRIDGE DCC awarded by National Institutes of Health 2008 - 2017
- A Four-arm Prospective, Multicenter Study to Assess the Clinical Efficacy, Effectiveness, and Feasibility of Enhanced Room Disinfection with Chlorine and UV light Using Clinical and Microbiologic Outcomes awarded by Centers for Disease Control and Prevention 2011 - 2016
- Evaluation of the Efficacy of Personal Protective Equipment and Antiseptic Impregnated Clothing in Reducing Exposure of Health Care Personnel to Acquisition and Transmission of Viral and Bacterial Pat awarded by Centers for Disease Control and Prevention 2015 - 2016
- VA Merit Grant- IPA Agreement awarded by Durham Veterans Affairs Medical Center 2012 - 2014
- PROPRANOLOL AS ANTI-ADHESIVE THERAPY IN SCD awarded by National Institutes of Health 2010 - 2012
- Cohort Study of Patients at Risk for Clostridium difficile Infection awarded by Centers for Disease Control and Prevention 2011 - 2012
- CTSA UL awarded by National Institutes of Health 2006 - 2012
- STICH Statistics and Data Coordinating Center awarded by National Institutes of Health 2002 - 2011
- General Clinical Research Center awarded by National Institutes of Health 1998 - 2006
External Relationships
- Taylor & Francis publishing co
- University of Pittsburgh Medical Center
Publications & Artistic Works
Selected Publications
- Books
  - Chow, S. C., J. Shao, H. Wang, and Y. Lokhnygina. Sample size calculations in clinical research, third edition, 2017. https://doi.org/10.1201/9781315183084.
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- Academic Articles
  - Anderson, Deverick J., Rebekah W. Moehring, Alice Parish, Michael Z. David, Kevin Hsueh, Leigh Cressman, Pam Tolomeo, et al. “The Impact of Centers for Medicare & Medicaid Services SEP-1 Core Measure Implementation on Antibacterial Utilization: A Retrospective Multicenter Longitudinal Cohort Study With Interrupted Time-Series Analysis.” Clin Infect Dis 75, no. 3 (August 31, 2022): 503–11. https://doi.org/10.1093/cid/ciab937.
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  - Stevens, Susanna R., Matthew W. Segar, Ambarish Pandey, Yuliya Lokhnygina, Jennifer B. Green, Darren K. McGuire, Eberhard Standl, Eric D. Peterson, and Rury R. Holman. “Development and validation of a model to predict cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke in patients with type 2 diabetes mellitus and established atherosclerotic cardiovascular disease.” Cardiovasc Diabetol 21, no. 1 (August 27, 2022): 166. https://doi.org/10.1186/s12933-022-01603-8.
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  - Davis, Timothy M. E., Anna Giczewska, Yuliya Lokhnygina, Robert J. Mentz, Naveed Sattar, Rury R. Holman, and Rury R. EXSCEL Study Group. “Effect of race on cardiometabolic responses to once-weekly exenatide: insights from the Exenatide Study of Cardiovascular Event Lowering (EXSCEL).” Cardiovasc Diabetol 21, no. 1 (June 27, 2022): 116. https://doi.org/10.1186/s12933-022-01555-z.
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  - Segar, Matthew W., Kershaw V. Patel, Anne S. Hellkamp, Muthiah Vaduganathan, Yuliya Lokhnygina, Jennifer B. Green, Siu-Hin Wan, et al. “Validation of the WATCH-DM and TRS-HFDM Risk Scores to Predict the Risk of Incident Hospitalization for Heart Failure Among Adults With Type 2 Diabetes: A Multicohort Analysis.” J Am Heart Assoc 11, no. 11 (June 7, 2022): e024094. https://doi.org/10.1161/JAHA.121.024094.
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  - Hardin, Olga, Yuliya Lokhnygina, and Rebecca H. Buckley. “Long-Term Clinical Outcomes of Severe Combined Immunodeficiency Patients Given Nonablative Marrow Transplants.” J Allergy Clin Immunol Pract 10, no. 4 (April 2022): 1077–83. https://doi.org/10.1016/j.jaip.2021.11.032.
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  - Fordyce, Christopher B., Robert P. Giugliano, Christopher P. Cannon, Matthew T. Roe, Abhinav Sharma, Courtney Page, Jennifer A. White, Yuliya Lokhnygina, Eugene Braunwald, and Michael A. Blazing. “Cardiovascular Events and Long-Term Risk of Sudden Death Among Stabilized Patients After Acute Coronary Syndrome: Insights From IMPROVE-IT.” J Am Heart Assoc 11, no. 4 (February 15, 2022): e022733. https://doi.org/10.1161/JAHA.121.022733.
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  - Moehring, Rebekah W., Elizabeth S Dodds Ashley, Angelina E. Davis, April Pridgen Dyer, Alice Parish, Xinru Ren, Yuliya Lokhnygina, Lauri A. Hicks, Arjun Srinivasan, and Deverick J. Anderson. “Development of an Electronic Definition for De-escalation of Antibiotics in Hospitalized Patients.” Clin Infect Dis 73, no. 11 (December 6, 2021): e4507–14. https://doi.org/10.1093/cid/ciaa932.
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  - Samsky, Marc D., Robert J. Mentz, Amanda Stebbins, Yuliya Lokhnygina, Aaron W. Aday, Neha J. Pagidipati, W Schuyler Jones, et al. “Polyvascular disease and increased risk of cardiovascular events in patients with type 2 diabetes: Insights from the EXSCEL trial.” Atherosclerosis 338 (December 2021): 1–6. https://doi.org/10.1016/j.atherosclerosis.2021.10.011.
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  - Weissler, E Hope, Robert M. Clare, Yuliya Lokhnygina, John B. Buse, Shaun G. Goodman, Brian Katona, Nayyar Iqbal, et al. “Predicting major adverse limb events in individuals with type 2 diabetes: Insights from the EXSCEL trial.” Diabet Med 38, no. 10 (October 2021): e14552. https://doi.org/10.1111/dme.14552.
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  - Barbery, Carlos E., Anna Giczewska, Jennifer White, Yuliya Lokhnygina, Robert John Mentz, Rury R. Holman, Neha Pagidipati, Adrian F. Hernandez, and W Schuyler Jones. “Effect of once-weekly exenatide on hospitalization for acute coronary syndrome or coronary revascularization in patients with type 2 diabetes mellitus.” Am Heart J 239 (September 2021): 59–63. https://doi.org/10.1016/j.ahj.2021.03.013.
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  - Kolitsopoulos, Francesca, Sara Ramaker, Scott Compton, Samuel Broderick, John Orazem, Weihang Bao, Yuliya Lokhnygina, and Phillip Chappell. “Sertraline Pediatric Registry for the Evaluation of Safety: Design and Clinical Characteristics of Pediatric Patients Prescribed Sertraline.” J Child Adolesc Psychopharmacol 31, no. 6 (August 2021): 411–20. https://doi.org/10.1089/cap.2020.0170.
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  - Patel, Priyesh A., Cynthia L. Green, Yuliya Lokhnygina, Jared Christensen, Carmelo A. Milano, Joseph G. Rogers, Chetan B. Patel, Lynne M. Koweek, and Melissa A. Daubert. “Cardiac computed tomography improves the identification of cardiomechanical complications among patients with suspected left ventricular assist device malfunction.” J Cardiovasc Comput Tomogr 15, no. 3 (May 2021): 260–67. https://doi.org/10.1016/j.jcct.2020.08.008.
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  - Swaminathan, Aparna C., Hongmei Zhu, Victor Tapson, Yuliya Lokhnygina, Abby Poms, Zach Kelleher, Elijah Gaspard, et al. “Treatment-related biomarkers in pulmonary hypertension patients on oral therapies.” Respir Res 21, no. 1 (November 19, 2020): 304. https://doi.org/10.1186/s12931-020-01566-y.
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  - Anderson, Deverick J., Iulian Ilieş, Katherine Foy, Nicole Nehls, James C. Benneyan, Yuliya Lokhnygina, and Arthur W. Baker. “Early recognition and response to increases in surgical site infections using optimized statistical process control charts-the Early 2RIS Trial: a multicenter cluster randomized controlled trial with stepped wedge design.” Trials 21, no. 1 (October 28, 2020): 894. https://doi.org/10.1186/s13063-020-04802-4.
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  - Baggio, Laurie L., Elodie M. Varin, Jacqueline A. Koehler, Xiemin Cao, Yuliya Lokhnygina, Susanna R. Stevens, Rury R. Holman, and Daniel J. Drucker. “Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans.” Nat Commun 11, no. 1 (July 28, 2020): 3766. https://doi.org/10.1038/s41467-020-17556-z.
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  - Marquis-Gravel, Guillaume, Frederik Dalgaard, Aaron D. Jones, Yuliya Lokhnygina, Stefan K. James, Robert A. Harrington, Lars Wallentin, et al. “Post-Discharge Bleeding and Mortality Following Acute Coronary Syndromes With or Without PCI.” J Am Coll Cardiol 76, no. 2 (July 14, 2020): 162–71. https://doi.org/10.1016/j.jacc.2020.05.031.
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  - Bethel, M Angelyn, Susanna R. Stevens, John B. Buse, Jasmine Choi, Stephanie M. Gustavson, Nayyar Iqbal, Yuliya Lokhnygina, et al. “Exploring the Possible Impact of Unbalanced Open-Label Drop-In of Glucose-Lowering Medications on EXSCEL Outcomes.” Circulation 141, no. 17 (April 28, 2020): 1360–70. https://doi.org/10.1161/CIRCULATIONAHA.119.043353.
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  - Standl, Eberhard, Susanna R. Stevens, Yuliya Lokhnygina, M Angelyn Bethel, John B. Buse, Stephanie M. Gustavson, Aldo P. Maggioni, et al. “Confirming the Bidirectional Nature of the Association Between Severe Hypoglycemic and Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL.” Diabetes Care 43, no. 3 (March 2020): 643–52. https://doi.org/10.2337/dc19-1079.
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  - Nanna, Michael G., Ann Marie Navar, Robert P. Giugliano, Jennifer A. White, Yuliya Lokhnygina, Yale B. Mitchel, Thomas A. Musliner, Christopher P. Cannon, and Michael A. Blazing. “Muscle Complaints or Events in Patients Randomized to Simvastatin or Ezetimibe/Simvastatin.” J Am Coll Cardiol 75, no. 7 (February 25, 2020): 835–37. https://doi.org/10.1016/j.jacc.2019.12.022.
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  - Bethel, M Angelyn, Robert J. Mentz, Peter Merrill, John B. Buse, Juliana C. Chan, Shaun G. Goodman, Nayyar Iqbal, et al. “Microvascular and Cardiovascular Outcomes According to Renal Function in Patients Treated With Once-Weekly Exenatide: Insights From the EXSCEL Trial.” Diabetes Care 43, no. 2 (February 2020): 446–52. https://doi.org/10.2337/dc19-1065.
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  - Black-Maier, Eric, Benjamin A. Steinberg, Kevin M. Trulock, Frances Wang, Yuliya Lokhnygina, Wanda O’Neal, Sana Al-Khatib, et al. “Effectiveness of catheter ablation of atrial fibrillation according to heart failure etiology.” J Arrhythm 36, no. 1 (February 2020): 84–92. https://doi.org/10.1002/joa3.12291.
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  - Sutter, Joanne S., Yuliya Lokhnygina, James P. Daubert, Tristram Bahnson, Kevin Jackson, Jason I. Koontz, Albert Y. Sun, et al. “Safety and efficacy outcomes of left atrial posterior wall isolation compared to pulmonary vein isolation and pulmonary vein isolation with linear ablation for the treatment of persistent atrial fibrillation.” Am Heart J 220 (February 2020): 89–96. https://doi.org/10.1016/j.ahj.2019.11.010.
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  - Brennan, J Matthew, Lisa Wruck, Michael J. Pencina, Robert M. Clare, Renato D. Lopes, John H. Alexander, Sean O’Brien, et al. “Claims-based cardiovascular outcome identification for clinical research: Results from 7 large randomized cardiovascular clinical trials.” Am Heart J 218 (December 2019): 110–22. https://doi.org/10.1016/j.ahj.2019.09.002.
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  - Fudim, Marat, Jennifer White, Neha J. Pagidipati, Yuliya Lokhnygina, Julio Wainstein, Jan Murin, Nayyar Iqbal, et al. “Effect of Once-Weekly Exenatide in Patients With Type 2 Diabetes Mellitus With and Without Heart Failure and Heart Failure-Related Outcomes: Insights From the EXSCEL Trial.” Circulation 140, no. 20 (November 12, 2019): 1613–22. https://doi.org/10.1161/CIRCULATIONAHA.119.041659.
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  - Yarrington, Michael E., Deverick J. Anderson, Elizabeth Dodds Ashley, Travis Jones, Angelina Davis, Melissa Johnson, Yuliya Lokhnygina, Daniel J. Sexton, and Rebekah W. Moehring. “Impact of FDA black box warning on fluoroquinolone and alternative antibiotic use in southeastern US hospitals.” Infect Control Hosp Epidemiol 40, no. 11 (November 2019): 1297–1300. https://doi.org/10.1017/ice.2019.247.
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  - Nauck, Michael A., Darren K. McGuire, Karen S. Pieper, Yuliya Lokhnygina, Timo E. Strandberg, Axel Riefflin, Tuncay Delibasi, et al. “Sitagliptin does not reduce the risk of cardiovascular death or hospitalization for heart failure following myocardial infarction in patients with diabetes: observations from TECOS.” Cardiovasc Diabetol 18, no. 1 (September 3, 2019): 116. https://doi.org/10.1186/s12933-019-0921-2.
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  - Bach, Richard G., Christopher P. Cannon, Robert P. Giugliano, Jennifer A. White, Yuliya Lokhnygina, Erin A. Bohula, Robert M. Califf, Eugene Braunwald, and Michael A. Blazing. “Effect of Simvastatin-Ezetimibe Compared With Simvastatin Monotherapy After Acute Coronary Syndrome Among Patients 75 Years or Older: A Secondary Analysis of a Randomized Clinical Trial.” Jama Cardiol 4, no. 9 (September 1, 2019): 846–54. https://doi.org/10.1001/jamacardio.2019.2306.
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  - Guimarães, Patrícia O., Eric D. Peterson, Susanna R. Stevens, Yuliya Lokhnygina, Jennifer B. Green, Darren K. McGuire, Rury R. Holman, and Renato D. Lopes. “Antithrombotic treatment gap among patients with atrial fibrillation and type 2 diabetes.” Int J Cardiol 289 (August 15, 2019): 58–62. https://doi.org/10.1016/j.ijcard.2019.04.085.
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  - Sharma, Abhinav, Jie-Lena Sun, Yuliya Lokhnygina, Matthew T. Roe, Tariq Ahmad, Nihar R. Desai, and Michael A. Blazing. “Patient Phenotypes, Cardiovascular Risk, and Ezetimibe Treatment in Patients After Acute Coronary Syndromes (from IMPROVE-IT).” Am J Cardiol 123, no. 8 (April 15, 2019): 1193–1201. https://doi.org/10.1016/j.amjcard.2019.01.034.
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  - Doll, Jacob A., W Schuyler Jones, Yuliya Lokhnygina, Sara Culpepper, Robin L. Parks, Christy Calhoun, David H. Au, and Manesh R. Patel. “PREPARED Study: A Study of Shared Decision-Making for Coronary Artery Disease.” Circ Cardiovasc Qual Outcomes 12, no. 2 (February 2019): e005244. https://doi.org/10.1161/CIRCOUTCOMES.118.005244.
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  - Navar, Ann Marie, Matthew T. Roe, Jennifer A. White, Christopher P. Cannon, Yuliya Lokhnygina, L Kristin Newby, Robert P. Giugliano, et al. “Medication Discontinuation in the IMPROVE-IT Trial.” Circ Cardiovasc Qual Outcomes 12, no. 1 (January 2019): e005041. https://doi.org/10.1161/CIRCOUTCOMES.118.005041.
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  - Ambrosy, Andrew P., Lukasz P. Cerbin, Marat Fudim, Robert M. Clare, Yuliya Lokhnygina, Eugene Braunwald, Robert M. Califf, et al. “Natural History of Patients Postacute Coronary Syndrome Based on Heart Failure Status.” Am J Cardiol 122, no. 9 (November 1, 2018): 1451–58. https://doi.org/10.1016/j.amjcard.2018.07.034.
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  - Mentz, Robert J., M Angelyn Bethel, Peter Merrill, Yuliya Lokhnygina, John B. Buse, Juliana C. Chan, João S. Felício, et al. “Effect of Once-Weekly Exenatide on Clinical Outcomes According to Baseline Risk in Patients With Type 2 Diabetes Mellitus: Insights From the EXSCEL Trial.” J Am Heart Assoc 7, no. 19 (October 2, 2018): e009304. https://doi.org/10.1161/JAHA.118.009304.
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  - Anderson, Deverick J., Rebekah W. Moehring, David J. Weber, Sarah S. Lewis, Luke F. Chen, J Conrad Schwab, Paul Becherer, et al. “Effectiveness of targeted enhanced terminal room disinfection on hospital-wide acquisition and infection with multidrug-resistant organisms and Clostridium difficile: a secondary analysis of a multicentre cluster randomised controlled trial with crossover design (BETR Disinfection).” Lancet Infect Dis 18, no. 8 (August 2018): 845–53. https://doi.org/10.1016/S1473-3099(18)30278-0.
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  - Davis, Timothy M. E., Hillary Mulder, Yuliya Lokhnygina, Pablo Aschner, Lee-Ming Chuang, Carlos A. Raffo Grado, Eberhard Standl, Eric D. Peterson, Rury R. Holman, and Rury R. TECOS Study Group. “Effect of race on the glycaemic response to sitagliptin: Insights from the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS).” Diabetes Obes Metab 20, no. 6 (June 2018): 1427–34. https://doi.org/10.1111/dom.13242.
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  - Husain, Aatif M., Jong W. Lee, Bradley J. Kolls, Lawrence J. Hirsch, Jonathan J. Halford, Puneet K. Gupta, Yafa Minazad, et al. “Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures.” Ann Neurol 83, no. 6 (June 2018): 1174–85. https://doi.org/10.1002/ana.25249.
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  - Moehring, Rebekah W., Elizabeth S. Dodds Ashley, Xinru Ren, Yuliya Lokhnygina, Arthur W. Baker, Travis M. Jones, Sarah S. Lewis, Daniel J. Sexton, Deverick J. Anderson, and Deverick J. Centers for Disease Control and Prevention Epicenters Program. “Denominator Matters in Estimating Antimicrobial Use: A Comparison of Days Present and Patient Days.” Infect Control Hosp Epidemiol 39, no. 5 (May 2018): 612–15. https://doi.org/10.1017/ice.2018.54.
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  - Anderson, Deverick J., Lauren P. Knelson, Rebekah W. Moehring, Sarah S. Lewis, David J. Weber, Luke F. Chen, Patricia F. Triplett, et al. “Implementation Lessons Learned From the Benefits of Enhanced Terminal Room (BETR) Disinfection Study: Process and Perceptions of Enhanced Disinfection with Ultraviolet Disinfection Devices.” Infect Control Hosp Epidemiol 39, no. 2 (February 2018): 157–63. https://doi.org/10.1017/ice.2017.268.
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  - Bethel, M Angelyn, Rishi A. Patel, Peter Merrill, Yuliya Lokhnygina, John B. Buse, Robert J. Mentz, Neha J. Pagidipati, et al. “Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis.” Lancet Diabetes Endocrinol 6, no. 2 (February 2018): 105–13. https://doi.org/10.1016/S2213-8587(17)30412-6.
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  - Kochar, Ajar, Anne S. Hellkamp, Yuliya Lokhnygina, W Schuyler Jones, Richard C. Becker, Scott D. Berkowitz, Günter Breithardt, et al. “Efficacy and safety of rivaroxaban compared with warfarin in patients with carotid artery disease and nonvalvular atrial fibrillation: Insights from the ROCKET AF trial.” Clin Cardiol 41, no. 1 (January 2018): 39–45. https://doi.org/10.1002/clc.22846.
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  - Limkakeng, Alexander T., J Clancy Leahy, S Michelle Griffin, Yuliya Lokhnygina, Elias Jaffa, Robert H. Christenson, and L Kristin Newby. “Provocative biomarker stress test: stress-delta N-terminal pro-B type natriuretic peptide.” Open Heart 5, no. 2 (2018): e000847. https://doi.org/10.1136/openhrt-2018-000847.
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  - Sharma, Abhinav, Jennifer B. Green, Allison Dunning, Yuliya Lokhnygina, Sana M. Al-Khatib, Renato D. Lopes, John B. Buse, et al. “Causes of Death in a Contemporary Cohort of Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease: Insights From the TECOS Trial.” Diabetes Care 40, no. 12 (December 2017): 1763–70. https://doi.org/10.2337/dc17-1091.
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  - Navar, Ann Marie, Dianne S. Gallup, Yuliya Lokhnygina, Jennifer B. Green, Darren K. McGuire, Paul W. Armstrong, John B. Buse, et al. “Hypertension Control in Adults With Diabetes Mellitus and Recurrent Cardiovascular Events: Global Results From the Trial Evaluating Cardiovascular Outcomes With Sitagliptin.” Hypertension 70, no. 5 (November 2017): 907–14. https://doi.org/10.1161/HYPERTENSIONAHA.117.09482.
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  - Anderson, Deverick J., Rachel Addison, Yuliya Lokhnygina, Bobby Warren, Batu Sharma-Kuinkel, Laura J. Rojas, Susan D. Rudin, et al. “The Antimicrobial Scrub Contamination and Transmission (ASCOT) Trial: A Three-Arm, Blinded, Randomized Controlled Trial With Crossover Design to Determine the Efficacy of Antimicrobial-Impregnated Scrubs in Preventing Healthcare Provider Contamination.” Infect Control Hosp Epidemiol 38, no. 10 (October 2017): 1147–54. https://doi.org/10.1017/ice.2017.181.
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  - Stanifer, John W., David M. Charytan, Jennifer White, Yuliya Lokhnygina, Christopher P. Cannon, Matthew T. Roe, and Michael A. Blazing. “Benefit of Ezetimibe Added to Simvastatin in Reduced Kidney Function.” J Am Soc Nephrol 28, no. 10 (October 2017): 3034–43. https://doi.org/10.1681/ASN.2016090957.
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  - Holman, Rury R., M Angelyn Bethel, Robert J. Mentz, Vivian P. Thompson, Yuliya Lokhnygina, John B. Buse, Juliana C. Chan, et al. “Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.” N Engl J Med 377, no. 13 (September 28, 2017): 1228–39. https://doi.org/10.1056/NEJMoa1612917.
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  - Pagidipati, Neha J., Ann Marie Navar, Karen S. Pieper, Jennifer B. Green, M Angelyn Bethel, Paul W. Armstrong, Robert G. Josse, et al. “Secondary Prevention of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus: International Insights From the TECOS Trial (Trial Evaluating Cardiovascular Outcomes With Sitagliptin).” Circulation 136, no. 13 (September 26, 2017): 1193–1203. https://doi.org/10.1161/CIRCULATIONAHA.117.027252.
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  - Fanaroff, Alexander C., Matthew T. Roe, Robert M. Clare, Yuliya Lokhnygina, Ann Marie Navar, Robert P. Giugliano, Stephen D. Wiviott, Andrew M. Tershakovec, Eugene Braunwald, and Michael A. Blazing. “Competing Risks of Cardiovascular Versus Noncardiovascular Death During Long-Term Follow-Up After Acute Coronary Syndromes.” J Am Heart Assoc 6, no. 9 (September 18, 2017). https://doi.org/10.1161/JAHA.117.005840.
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  - Sun, Yihong, Dayi Hu, Susanna Stevens, Yuliya Lokhnygina, Richard C. Becker, Scott D. Berkowitz, Günter Breithardt, et al. “Efficacy and safety of rivaroxaban versus warfarin in patients from mainland China with nonvalvular atrial fibrillation: A subgroup analysis from the ROCKET AF trial.” Thromb Res 156 (August 2017): 184–90. https://doi.org/10.1016/j.thromres.2017.04.010.
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  - Balla, Somasekhara R., Derek D. Cyr, Yuliya Lokhnygina, Richard C. Becker, Scott D. Berkowitz, Günter Breithardt, Keith A. A. Fox, et al. “Relation of Risk of Stroke in Patients With Atrial Fibrillation to Body Mass Index (from Patients Treated With Rivaroxaban and Warfarin in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation Trial).” Am J Cardiol 119, no. 12 (June 15, 2017): 1989–96. https://doi.org/10.1016/j.amjcard.2017.03.028.
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  - Valgimigli, Marco, Francesco Costa, Yuliya Lokhnygina, Robert M. Clare, Lars Wallentin, David J. Moliterno, Paul W. Armstrong, et al. “Trade-off of myocardial infarction vs. bleeding types on mortality after acute coronary syndrome: lessons from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) randomized trial.” Eur Heart J 38, no. 11 (March 14, 2017): 804–10. https://doi.org/10.1093/eurheartj/ehw525.
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  - Lindner, Samuel M., Christopher B. Fordyce, Anne S. Hellkamp, Yuliya Lokhnygina, Jonathan P. Piccini, Günter Breithardt, Kenneth W. Mahaffey, et al. “Treatment Consistency Across Levels of Baseline Renal Function With Rivaroxaban or Warfarin: A ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) Analysis.” Circulation 135, no. 10 (March 7, 2017): 1001–3. https://doi.org/10.1161/CIRCULATIONAHA.116.024666.
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  - Harskamp, Ralf E., Robert M. Clare, Giuseppe Ambrosio, Claes Held, Yuliya Lokhnygina, David J. Moliterno, Harvey D. White, et al. “Use of thienopyridine prior to presentation with non-ST-segment elevation acute coronary syndrome and association with safety and efficacy of vorapaxar: insights from the TRACER trial.” Eur Heart J Acute Cardiovasc Care 6, no. 2 (March 2017): 155–63. https://doi.org/10.1177/2048872616633880.
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  - Limkakeng, Alexander T., Weiying Drake, Yuliya Lokhnygina, Harvey P. Meyers, Daniel Shogilev, Robert H. Christenson, and L Kristin Newby. “Myocardial Ischemia on Exercise Stress Echocardiography Testing Is Not Associated with Changes in Troponin T Concentrations.” J Appl Lab Med 1, no. 5 (March 1, 2017): 532–43. https://doi.org/10.1373/jalm.2016.021667.
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  - Anderson, Deverick J., Luke F. Chen, David J. Weber, Rebekah W. Moehring, Sarah S. Lewis, Patricia F. Triplett, Michael Blocker, et al. “Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study.” Lancet 389, no. 10071 (February 25, 2017): 805–14. https://doi.org/10.1016/S0140-6736(16)31588-4.
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  - Buse, John B., M Angelyn Bethel, Jennifer B. Green, Susanna R. Stevens, Yuliya Lokhnygina, Pablo Aschner, Carlos Raffo Grado, et al. “Pancreatic Safety of Sitagliptin in the TECOS Study.” Diabetes Care 40, no. 2 (February 2017): 164–70. https://doi.org/10.2337/dc15-2780.
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  - Blazing, Michael A., Robert P. Giugliano, James A. de Lemos, Christopher P. Cannon, Andrew Tonkin, Christie M. Ballantyne, Basil S. Lewis, et al. “On-treatment analysis of the Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT).” Am Heart J 182 (December 2016): 89–96. https://doi.org/10.1016/j.ahj.2016.09.004.
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  - Shah, Rohan, Anne Hellkamp, Yuliya Lokhnygina, Richard C. Becker, Scott D. Berkowitz, Günter Breithardt, Werner Hacke, et al. “Use of concomitant aspirin in patients with atrial fibrillation: Findings from the ROCKET AF trial.” Am Heart J 179 (September 2016): 77–86. https://doi.org/10.1016/j.ahj.2016.05.019.
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  - Åkerblom, Axel, Robert M. Clare, Yuliya Lokhnygina, Lars Wallentin, Claes Held, Frans Van de Werf, David J. Moliterno, et al. “Albuminuria and cardiovascular events in patients with acute coronary syndromes: Results from the TRACER trial.” Am Heart J 178 (August 2016): 1–8. https://doi.org/10.1016/j.ahj.2016.04.013.
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  - Fordyce, Christopher B., Anne S. Hellkamp, Yuliya Lokhnygina, Samuel M. Lindner, Jonathan P. Piccini, Richard C. Becker, Scott D. Berkowitz, et al. “On-Treatment Outcomes in Patients With Worsening Renal Function With Rivaroxaban Compared With Warfarin: Insights From ROCKET AF.” Circulation 134, no. 1 (July 5, 2016): 37–47. https://doi.org/10.1161/CIRCULATIONAHA.116.021890.
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  - Lakey, Wanda C., Nicole G. Greyshock, Carly E. Kelley, Mohammad A. Siddiqui, Umar Ahmad, Yuliya V. Lokhnygina, and John R. Guyton. “Statin intolerance in a referral lipid clinic.” J Clin Lipidol 10, no. 4 (July 2016): 870-879.e3. https://doi.org/10.1016/j.jacl.2016.03.004.
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  - Breithardt, Günter, Helmut Baumgartner, Scott D. Berkowitz, Anne S. Hellkamp, Jonathan P. Piccini, Yuliya Lokhnygina, Jonathan L. Halperin, et al. “Native valve disease in patients with non-valvular atrial fibrillation on warfarin or rivaroxaban.” Heart 102, no. 13 (July 1, 2016): 1036–43. https://doi.org/10.1136/heartjnl-2015-308120.
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  - Li, Fan, Yuliya Lokhnygina, David M. Murray, Patrick J. Heagerty, and Elizabeth R. DeLong. “An evaluation of constrained randomization for the design and analysis of group-randomized trials.” Stat Med 35, no. 10 (May 10, 2016): 1565–79. https://doi.org/10.1002/sim.6813.
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  - McGuire, Darren K., Frans Van de Werf, Paul W. Armstrong, Eberhard Standl, Joerg Koglin, Jennifer B. Green, M Angelyn Bethel, et al. “Association Between Sitagliptin Use and Heart Failure Hospitalization and Related Outcomes in Type 2 Diabetes Mellitus: Secondary Analysis of a Randomized Clinical Trial.” Jama Cardiol 1, no. 2 (May 1, 2016): 126–35. https://doi.org/10.1001/jamacardio.2016.0103.
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  - Hess, Paul L., Daniel M. Wojdyla, Sana M. Al-Khatib, Yuliya Lokhnygina, Lars Wallentin, Paul W. Armstrong, Matthew T. Roe, et al. “Sudden Cardiac Death After Non-ST-Segment Elevation Acute Coronary Syndrome.” Jama Cardiol 1, no. 1 (April 1, 2016): 73–79. https://doi.org/10.1001/jamacardio.2015.0359.
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  - Farber, S Harrison, Jeffrey Hatef, Jing L. Han, Andrew H. Marky, Jichun Xie, Kevin Huang, Terence Verla, Yuliya Lokhnygina, Timothy A. Collins, and Shivanand P. Lad. “Implantable Neurostimulation for Headache Disorders: Effect on Healthcare Utilization and Expenditures.” Neuromodulation 19, no. 3 (April 2016): 319–28. https://doi.org/10.1111/ner.12393.
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  - Murphy, Sabina A., Christopher P. Cannon, Michael A. Blazing, Robert P. Giugliano, Jennifer A. White, Yuliya Lokhnygina, Craig Reist, et al. “Reduction in Total Cardiovascular Events With Ezetimibe/Simvastatin Post-Acute Coronary Syndrome: The IMPROVE-IT Trial.” J Am Coll Cardiol 67, no. 4 (February 2, 2016): 353–61. https://doi.org/10.1016/j.jacc.2015.10.077.
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  - Halim, Sharif A., Robert M. Clare, L Kristin Newby, Yuliya Lokhnygina, Marc J. Schweiger, Arnoud W. Hof, Judith S. Hochman, et al. “Frequency, clinical and angiographic characteristics, and outcomes of high-risk non-ST-segment elevation acute coronary syndromes patients with left circumflex culprit lesions.” Int J Cardiol 203 (January 15, 2016): 708–13. https://doi.org/10.1016/j.ijcard.2015.11.036.
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  - Petraglia, Frank W., S Harrison Farber, Jing L. Han, Terence Verla, John Gallis, Yuliya Lokhnygina, Beth Parente, Patrick Hickey, Dennis A. Turner, and Shivanand P. Lad. “Comparison of Bilateral vs. Staged Unilateral Deep Brain Stimulation (DBS) in Parkinson's Disease in Patients Under 70 Years of Age.” Neuromodulation 19, no. 1 (January 2016): 31–37. https://doi.org/10.1111/ner.12351.
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  - Bansilal, Sameer, Zachary Bloomgarden, Jonathan L. Halperin, Anne S. Hellkamp, Yuliya Lokhnygina, Manesh R. Patel, Richard C. Becker, et al. “Efficacy and safety of rivaroxaban in patients with diabetes and nonvalvular atrial fibrillation: the Rivaroxaban Once-daily, Oral, Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF Trial).” Am Heart J 170, no. 4 (October 2015): 675-682.e8. https://doi.org/10.1016/j.ahj.2015.07.006.
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  - Nicolau, Jose Carlos, Deepak L. Bhatt, Matthew T. Roe, Yuliya Lokhnygina, Benjamin Neely, Ramón Corbalán, José L. Leiva-Pons, et al. “Concomitant proton-pump inhibitor use, platelet activity, and clinical outcomes in patients with acute coronary syndromes treated with prasugrel versus clopidogrel and managed without revascularization: insights from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes trial.” Am Heart J 170, no. 4 (October 2015): 683-694.e3. https://doi.org/10.1016/j.ahj.2015.05.017.
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  - Daneshmand, Mani A., Arun Krishnamoorthy, Marc D. Samsky, G Michael Felker, John A. Pura, Yuliya Lokhnygina, Adrian F. Hernandez, et al. “Comparison of 2-Year Outcomes of Extended Criteria Cardiac Transplantation Versus Destination Left Ventricular Assist Device Therapy Using Continuous Flow.” Am J Cardiol 116, no. 4 (August 15, 2015): 573–79. https://doi.org/10.1016/j.amjcard.2015.05.016.
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  - Wieslander, Björn, Robin Nijveldt, Igor Klem, Yuliya Lokhnygina, John Pura, Galen S. Wagner, Martin Ugander, and Brett D. Atwater. “Evaluation of Selvester QRS score for use in presence of conduction abnormalities in a broad population.” Am Heart J 170, no. 2 (August 2015): 346–52. https://doi.org/10.1016/j.ahj.2015.05.005.
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  - Washam, Jeffrey B., Susanna R. Stevens, Yuliya Lokhnygina, Jonathan L. Halperin, Günter Breithardt, Daniel E. Singer, Kenneth W. Mahaffey, et al. “Digoxin use in patients with atrial fibrillation and adverse cardiovascular outcomes: a retrospective analysis of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF).” Lancet 385, no. 9985 (June 13, 2015): 2363–70. https://doi.org/10.1016/S0140-6736(14)61836-5.
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  - Bagai, Akshay, Zhen Huang, Yuliya Lokhnygina, Robert A. Harrington, Paul W. Armstrong, John Strony, Harvey D. White, et al. “Magnitude of troponin elevation and long-term clinical outcomes in acute coronary syndrome patients treated with and without revascularization.” Circ Cardiovasc Interv 8, no. 6 (June 2015): e002314. https://doi.org/10.1161/CIRCINTERVENTIONS.115.002314.
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  - Cornel, Jan H., Pierluigi Tricoci, Yuliya Lokhnygina, David J. Moliterno, Lars Wallentin, Paul W. Armstrong, Philip E. Aylward, et al. “Glycoprotein IIb/IIIa Receptor Inhibitors in Combination With Vorapaxar, a Platelet Thrombin Receptor Antagonist, Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes (from the TRACER Trial).” Am J Cardiol 115, no. 10 (May 15, 2015): 1325–32. https://doi.org/10.1016/j.amjcard.2015.02.043.
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  - Verla, Terence, Andrew Marky, Harrison Farber, Frank W. Petraglia, John Gallis, Yuliya Lokhnygina, Beth Parente, Patrick Hickey, Dennis A. Turner, and Shivanand P. Lad. “Impact of advancing age on post-operative complications of deep brain stimulation surgery for essential tremor.” J Clin Neurosci 22, no. 5 (May 2015): 872–76. https://doi.org/10.1016/j.jocn.2014.11.005.
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  - Singer, Daniel E., Anne S. Hellkamp, Zhong Yuan, Yuliya Lokhnygina, Manesh R. Patel, Jonathan P. Piccini, Graeme J. Hankey, et al. “Alternative calculations of individual patient time in therapeutic range while taking warfarin: results from the ROCKET AF trial.” J Am Heart Assoc 4, no. 3 (March 3, 2015): e001349. https://doi.org/10.1161/JAHA.114.001349.
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  - Bakal, Jeffrey A., Matthew T. Roe, E Magnus Ohman, Shaun G. Goodman, Keith A. A. Fox, Yinggan Zheng, Cynthia M. Westerhout, et al. “Applying novel methods to assess clinical outcomes: insights from the TRILOGY ACS trial.” Eur Heart J 36, no. 6 (February 7, 2015): 385-92a. https://doi.org/10.1093/eurheartj/ehu262.
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  - Steinberg, Benjamin A., Anne S. Hellkamp, Yuliya Lokhnygina, Manesh R. Patel, Günter Breithardt, Graeme J. Hankey, Richard C. Becker, et al. “Higher risk of death and stroke in patients with persistent vs. paroxysmal atrial fibrillation: results from the ROCKET-AF Trial.” Eur Heart J 36, no. 5 (February 1, 2015): 288–96. https://doi.org/10.1093/eurheartj/ehu359.
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  - Huang, Kevin T., Joel Martin, Andrew Marky, Gustavo Chagoya, Jeff Hatef, Matthew A. Hazzard, Steven M. Thomas, Yuliya Lokhnygina, and Shivanand P. Lad. “A national survey of spinal cord stimulation trial-to-permanent conversion rates.” Neuromodulation 18, no. 2 (February 2015): 133–39. https://doi.org/10.1111/ner.12199.
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  - Ahmad, Tariq, Teresa Wang, Emily C. O’Brien, Marc D. Samsky, John A. Pura, Yuliya Lokhnygina, Joseph G. Rogers, et al. “Effects of left ventricular assist device support on biomarkers of cardiovascular stress, fibrosis, fluid homeostasis, inflammation, and renal injury.” Jacc Heart Fail 3, no. 1 (January 2015): 30–39. https://doi.org/10.1016/j.jchf.2014.06.013.
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  - Breithardt, Günter, Helmut Baumgartner, Scott D. Berkowitz, Anne S. Hellkamp, Jonathan P. Piccini, Susanna R. Stevens, Yuliya Lokhnygina, et al. “Clinical characteristics and outcomes with rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation but underlying native mitral and aortic valve disease participating in the ROCKET AF trial.” Eur Heart J 35, no. 47 (December 14, 2014): 3377–85. https://doi.org/10.1093/eurheartj/ehu305.
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  - Tricoci, Pierluigi, Yuliya Lokhnygina, Zhen Huang, Frans Van de Werf, Jan H. Cornel, Edmond Chen, Lars Wallentin, et al. “Vorapaxar with or without clopidogrel after non-ST-segment elevation acute coronary syndromes: results from the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome trial.” Am Heart J 168, no. 6 (December 2014): 869-77.e1. https://doi.org/10.1016/j.ahj.2014.09.002.
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  - Babu, Ranjith, Steven Thomas, Matthew A. Hazzard, Yuliya V. Lokhnygina, Allan H. Friedman, Oren N. Gottfried, Robert E. Isaacs, et al. “Morbidity, mortality, and health care costs for patients undergoing spine surgery following the ACGME resident duty-hour reform: Clinical article.” J Neurosurg Spine 21, no. 4 (October 2014): 502–15. https://doi.org/10.3171/2014.5.SPINE13283.
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  - DeLong, Michael R., Kevin T. Huang, John Gallis, Yuliya Lokhnygina, Beth Parente, Patrick Hickey, Dennis A. Turner, and Shivanand P. Lad. “Effect of advancing age on outcomes of deep brain stimulation for Parkinson disease.” Jama Neurol 71, no. 10 (October 2014): 1290–95. https://doi.org/10.1001/jamaneurol.2014.1272.
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  - Piccini, Jonathan P., Sana M. Al-Khatib, Daniel M. Wojdyla, Linda K. Shaw, John R. Horton, Yuliya Lokhnygina, Kevin J. Anstrom, et al. “Comparison of safety of sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease.” Am J Cardiol 114, no. 5 (September 1, 2014): 716–22. https://doi.org/10.1016/j.amjcard.2014.06.004.
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  - Valgimigli, Marco, Pierluigi Tricoci, Zhen Huang, Philip E. Aylward, Paul W. Armstrong, Frans Van de Werf, Sergio Leonardi, et al. “Usefulness and safety of vorapaxar in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention (from the TRACER Trial).” Am J Cardiol 114, no. 5 (September 1, 2014): 665–73. https://doi.org/10.1016/j.amjcard.2014.05.054.
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  - Piccini, Jonathan P., Jyotsna Garg, Manesh R. Patel, Yuliya Lokhnygina, Shaun G. Goodman, Richard C. Becker, Scott D. Berkowitz, et al. “Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial.” Eur Heart J 35, no. 28 (July 21, 2014): 1873–80. https://doi.org/10.1093/eurheartj/ehu083.
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  - White, Harvey D., Zhen Huang, Pierluigi Tricoci, Frans Van de Werf, Lars Wallentin, Yuliya Lokhnygina, David J. Moliterno, Philip E. Aylward, Kenneth W. Mahaffey, and Paul W. Armstrong. “Reduction in overall occurrences of ischemic events with vorapaxar: results from TRACER.” J Am Heart Assoc 3, no. 4 (July 10, 2014). https://doi.org/10.1161/JAHA.114.001032.
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  - Halperin, Jonathan L., Graeme J. Hankey, Daniel M. Wojdyla, Jonathan P. Piccini, Yuliya Lokhnygina, Manesh R. Patel, Günter Breithardt, et al. “Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF).” Circulation 130, no. 2 (July 8, 2014): 138–46. https://doi.org/10.1161/CIRCULATIONAHA.113.005008.
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  - Steinberg, Benjamin A., Anne S. Hellkamp, Yuliya Lokhnygina, Jonathan L. Halperin, Günter Breithardt, Rod Passman, Graeme J. Hankey, et al. “Use and outcomes of antiarrhythmic therapy in patients with atrial fibrillation receiving oral anticoagulation: results from the ROCKET AF trial.” Heart Rhythm 11, no. 6 (June 2014): 925–32. https://doi.org/10.1016/j.hrthm.2014.03.006.
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  - Sherwood, Matthew W., James D. Douketis, Manesh R. Patel, Jonathan P. Piccini, Anne S. Hellkamp, Yuliya Lokhnygina, Alex C. Spyropoulos, et al. “Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF).” Circulation 129, no. 18 (May 6, 2014): 1850–59. https://doi.org/10.1161/CIRCULATIONAHA.113.005754.
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  - Hankey, Graeme J., Susanna R. Stevens, Jonathan P. Piccini, Yuliya Lokhnygina, Kenneth W. Mahaffey, Jonathan L. Halperin, Manesh R. Patel, et al. “Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation.” Stroke 45, no. 5 (May 2014): 1304–12. https://doi.org/10.1161/STROKEAHA.113.004506.
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  - Sharma, Richa, Stephanie Macy, Kara Richardson, Yuliya Lokhnygina, and Daniel T. Laskowitz. “A blood-based biomarker panel to detect acute stroke.” J Stroke Cerebrovasc Dis 23, no. 5 (May 2014): 910–18. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.07.034.
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  - Allen LaPointe, Nancy M., Yuliya Lokhnygina, Jacqueline Rimmler, Gillian D. Sanders, Eric D. Peterson, and Sana M. Al-Khatib. “Use Of Rate And Rhythm Control Drugs In Patients Younger Than 65 Years With Atrial Fibrillation.” J Atr Fibrillation 7, no. 1 (2014): 22–30.
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  - Allen LaPointe, Nancy M., Yuliya Lokhnygina, Gillian D. Sanders, Eric D. Peterson, and Sana M. Al-Khatib. “Adherence to guideline recommendations for antiarrhythmic drugs in atrial fibrillation.” Am Heart J 166, no. 5 (November 2013): 871–78. https://doi.org/10.1016/j.ahj.2013.08.010.
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  - Piccini, Jonathan P., Susanna R. Stevens, Yuchiao Chang, Daniel E. Singer, Yuliya Lokhnygina, Alan S. Go, Manesh R. Patel, et al. “Response to letter regarding article, "renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R2CHADS2 index in the ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) study cohorts".” Circulation 128, no. 11 (September 10, 2013): e172–73. https://doi.org/10.1161/CIRCULATIONAHA.113.004013.
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  - Bagai, Akshay, Jennifer A. White, Yuliya Lokhnygina, Robert P. Giugliano, Frans Van de Werf, Gilles Montalescot, Paul W. Armstrong, et al. “Routine early eptifibatide versus delayed provisional use at percutaneous coronary intervention in high-risk non-ST-segment elevation acute coronary syndromes patients: an analysis from the Early Glycoprotein IIb/IIIa Inhibition in Non-ST-Segment Elevation Acute Coronary Syndrome trial.” Am Heart J 166, no. 3 (September 2013): 466–73. https://doi.org/10.1016/j.ahj.2013.05.019.
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  - Wiviott, Stephen D., Harvey D. White, E Magnus Ohman, Keith A. A. Fox, Paul W. Armstrong, Dorairaj Prabhakaran, Gail Hafley, et al. “Prasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a secondary, prespecified analysis of the TRILOGY ACS trial.” Lancet 382, no. 9892 (August 17, 2013): 605–13. https://doi.org/10.1016/S0140-6736(13)61451-8.
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  - Chan, Mark Y., Jie-Lena Sun, L Kristin Newby, Yuliya Lokhnygina, Harvey D. White, David J. Moliterno, Pierre Théroux, et al. “Trends in clinical trials of non-ST-segment elevation acute coronary syndromes over 15 years.” Int J Cardiol 167, no. 2 (July 31, 2013): 548–54. https://doi.org/10.1016/j.ijcard.2012.01.065.
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  - Chiu, Stephanie J., Yuliya Lokhnygina, Adam M. Dubis, Alfredo Dubra, Joseph Carroll, Joseph A. Izatt, and Sina Farsiu. “Automatic cone photoreceptor segmentation using graph theory and dynamic programming.” Biomed Opt Express 4, no. 6 (June 1, 2013): 924–37. https://doi.org/10.1364/BOE.4.000924.
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  - Leonardi, Sergio, Amanda Stebbins, Renato D. Lopes, Yuliya Lokhnygina, Meredith Todd, Deepak L. Bhatt, Gregg W. Stone, et al. “Quantification of the effect of clopidogrel on enzymatic infarct size related to a percutaneous coronary intervention in patients with acute coronary syndromes: insights from the CHAMPION percutaneous coronary intervention trial.” Coron Artery Dis 24, no. 4 (June 2013): 321–27. https://doi.org/10.1097/MCA.0b013e32835f2fbd.
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  - Piccini, Jonathan P., Jennifer A. White, Rajendra H. Mehta, Yuliya Lokhnygina, Sana M. Al-Khatib, Pierluigi Tricoci, Robert M. Califf, et al. “Response to letter regarding article, “sustained ventricular tachycardia and ventricular fibrillation complicating non–ST-segment elevation acute coronary syndromes”.” Circulation 127, no. 20 (May 21, 2013): e634. https://doi.org/10.1161/circulationaha.112.147546.
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  - Piccini, Jonathan P., Susanna R. Stevens, Yuliya Lokhnygina, Manesh R. Patel, Jonathan L. Halperin, Daniel E. Singer, Graeme J. Hankey, et al. “Outcomes after cardioversion and atrial fibrillation ablation in patients treated with rivaroxaban and warfarin in the ROCKET AF trial.” J Am Coll Cardiol 61, no. 19 (May 14, 2013): 1998–2006. https://doi.org/10.1016/j.jacc.2013.02.025.
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  - Lopes, Renato D., Yuliya Lokhnygina, Victor Hasselblad, Kristin L. Newby, Eric Yow, Christopher B. Granger, Paul W. Armstrong, et al. “Methods of creatine kinase-MB analysis to predict mortality in patients with myocardial infarction treated with reperfusion therapy.” Trials 14 (May 2, 2013): 123. https://doi.org/10.1186/1745-6215-14-123.
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  - Ozment, Caroline P., Lisa B. Mamo, Mary Lee Campbell, Yuliya Lokhnygina, Andrew J. Ghio, and Jennifer L. Turi. “Transfusion-related biologic effects and free hemoglobin, heme, and iron.” Transfusion 53, no. 4 (April 2013): 732–40. https://doi.org/10.1111/j.1537-2995.2012.03837.x.
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  - Brooks, Audrey J., Yuliya Lokhnygina, Christina S. Meade, Jennifer Sharpe Potter, Donald A. Calsyn, and Shelly F. Greenfield. “Racial/ethnic differences in the rates and correlates of HIV risk behaviors among drug abusers.” Am J Addict 22, no. 2 (March 2013): 136–47. https://doi.org/10.1111/j.1521-0391.2013.00303.x.
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  - Singer, Daniel E., Anne S. Hellkamp, Jonathan P. Piccini, Kenneth W. Mahaffey, Yuliya Lokhnygina, Guohua Pan, Jonathan L. Halperin, et al. “Impact of global geographic region on time in therapeutic range on warfarin anticoagulant therapy: data from the ROCKET AF clinical trial.” J Am Heart Assoc 2, no. 1 (February 19, 2013): e000067. https://doi.org/10.1161/JAHA.112.000067.
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  - Patel, Manesh R., Anne S. Hellkamp, Yuliya Lokhnygina, Jonathan P. Piccini, Zhongxin Zhang, Surya Mohanty, Daniel E. Singer, et al. “Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: analysis from the ROCKET AF trial (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation).” J Am Coll Cardiol 61, no. 6 (February 12, 2013): 651–58. https://doi.org/10.1016/j.jacc.2012.09.057.
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  - Saxon, Andrew J., Walter Ling, Maureen Hillhouse, Christie Thomas, Albert Hasson, Alfonso Ang, Geetha Doraimani, et al. “Buprenorphine/Naloxone and methadone effects on laboratory indices of liver health: a randomized trial.” Drug Alcohol Depend 128, no. 1–2 (February 1, 2013): 71–76. https://doi.org/10.1016/j.drugalcdep.2012.08.002.
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  - Piccini, Jonathan P., Susanna R. Stevens, YuChiao Chang, Daniel E. Singer, Yuliya Lokhnygina, Alan S. Go, Manesh R. Patel, et al. “Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts.” Circulation 127, no. 2 (January 15, 2013): 224–32. https://doi.org/10.1161/CIRCULATIONAHA.112.107128.
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  - Prakalapakorn, Sasapin G., Sharon F. Freedman, Yuliya Lokhnygina, Nandini G. Gandhi, Sandra Holgado, Bei Bei Chen, and Mays A. El-Dairi. “Longitudinal reproducibility of optical coherence tomography measurements in children.” J Aapos 16, no. 6 (December 2012): 523–28. https://doi.org/10.1016/j.jaapos.2012.08.011.
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  - Roe, Matthew T., Paul W. Armstrong, Keith A. A. Fox, Harvey D. White, Dorairaj Prabhakaran, Shaun G. Goodman, Jan H. Cornel, et al. “Prasugrel versus clopidogrel for acute coronary syndromes without revascularization.” N Engl J Med 367, no. 14 (October 4, 2012): 1297–1309. https://doi.org/10.1056/NEJMoa1205512.
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  - Piccini, Jonathan P., Jennifer A. White, Rajendra H. Mehta, Yuliya Lokhnygina, Sana M. Al-Khatib, Pierluigi Tricoci, Charles V. Pollack, et al. “Sustained ventricular tachycardia and ventricular fibrillation complicating non-ST-segment-elevation acute coronary syndromes.” Circulation 126, no. 1 (July 3, 2012): 41–49. https://doi.org/10.1161/CIRCULATIONAHA.111.071860.
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  - Mills, James S., Kenneth W. Mahaffey, Yuliya Lokhnygina, Jose C. Nicolau, Witold Ruzyllo, Peter X. Adams, Thomas G. Todaro, Paul W. Armstrong, Christopher B. Granger, and Christopher B. CARDINAL investigators. “Prediction of enzymatic infarct size in ST-segment elevation myocardial infarction.” Coron Artery Dis 23, no. 2 (March 2012): 118–25. https://doi.org/10.1097/MCA.0b013e32834e4f8f.
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  - Jolicœur, E Marc, Micheal J. Sketch, Daniel M. Wojdyla, Sean P. Javaheri, Shravan Nosib, Yuliya Lokhnygina, Manesh R. Patel, Linda K. Shaw, and James E. Tcheng. “Percutaneous coronary interventions and cardiovascular outcomes for patients with chronic total occlusions.” Catheter Cardiovasc Interv 79, no. 4 (March 1, 2012): 603–12. https://doi.org/10.1002/ccd.23269.
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  - Roe, Matthew T., Jennifer A. White, Padma Kaul, Pierluigi Tricoci, Yuliya Lokhnygina, Chadwick D. Miller, Arnoud W. van’t Hof, et al. “Regional patterns of use of a medical management strategy for patients with non-ST-segment elevation acute coronary syndromes: insights from the EARLY ACS Trial.” Circ Cardiovasc Qual Outcomes 5, no. 2 (March 1, 2012): 205–13. https://doi.org/10.1161/CIRCOUTCOMES.111.962332.
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  - Tricoci, Pierluigi, Zhen Huang, Claes Held, David J. Moliterno, Paul W. Armstrong, Frans Van de Werf, Harvey D. White, et al. “Thrombin-receptor antagonist vorapaxar in acute coronary syndromes.” N Engl J Med 366, no. 1 (January 5, 2012): 20–33. https://doi.org/10.1056/NEJMoa1109719.
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  - Mahaffey, Kenneth W., Karen S. Pieper, Yuliya Lokhnygina, Robert M. Califf, Elliott M. Antman, Neal S. Kleiman, Shaun G. Goodman, et al. “The impact of postrandomization crossover of therapy in acute coronary syndromes care.” Circ Cardiovasc Qual Outcomes 4, no. 2 (March 2011): 211–19. https://doi.org/10.1161/CIRCOUTCOMES.109.853598.
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  - Brooks, Audrey, Christina S. Meade, Jennifer Sharpe Potter, Yuliya Lokhnygina, Donald A. Calsyn, and Shelly F. Greenfield. “Gender differences in the rates and correlates of HIV risk behaviors among drug abusers.” Subst Use Misuse 45, no. 14 (December 2010): 2444–69. https://doi.org/10.3109/10826084.2010.490928.
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  - Hursting, Marcie J., Poulomi J. Pai, Julianna E. McCracken, Fred Hwang, Shayela Suvarna, Yuliya Lokhnygina, Nicholas Bandarenko, and Gowthami M. Arepally. “Platelet factor 4/heparin antibodies in blood bank donors.” Am J Clin Pathol 134, no. 5 (November 2010): 774–80. https://doi.org/10.1309/AJCPG0MNR5NGKNFX.
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  - Tillmann, Hans L., Alex J. Thompson, Keyur Patel, Manfred Wiese, Hannelore Tenckhoff, Hans D. Nischalke, Yuliya Lokhnygina, et al. “A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice.” Gastroenterology 139, no. 5 (November 2010): 1586-1592.e1. https://doi.org/10.1053/j.gastro.2010.07.005.
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  - Chin, Chee Tang, Matthew T. Roe, Keith A. A. Fox, Dorairaj Prabhakaran, Debra A. Marshall, Helene Petitjean, Yuliya Lokhnygina, et al. “Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial.” Am Heart J 160, no. 1 (July 2010): 16-22.e1. https://doi.org/10.1016/j.ahj.2010.04.022.
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  - Califf, Robert M., Yuliya Lokhnygina, Christopher P. Cannon, Michael E. Stepanavage, Carolyn H. McCabe, Thomas A. Musliner, Richard C. Pasternak, et al. “An update on the IMProved reduction of outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design.” Am Heart J 159, no. 5 (May 2010): 705–9. https://doi.org/10.1016/j.ahj.2010.03.004.
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  - Unroe, Kathleen Tschantz, Trista Pfeiffenberger, Sarah Riegelhaupt, Jennifer Jastrzembski, Yuliya Lokhnygina, and Cathleen Colón-Emeric. “Inpatient medication reconciliation at admission and discharge: A retrospective cohort study of age and other risk factors for medication discrepancies.” Am J Geriatr Pharmacother 8, no. 2 (April 2010): 115–26. https://doi.org/10.1016/j.amjopharm.2010.04.002.
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  - Carter-Edwards, Lori, Lori A. Bastian, Jessica Revels, Holiday Durham, Yuliya Lokhnygina, M Ahinee Amamoo, and Truls Ostbye. “Body image and body satisfaction differ by race in overweight postpartum mothers.” J Womens Health (Larchmt) 19, no. 2 (February 2010): 305–11. https://doi.org/10.1089/jwh.2008.1238.
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  - Railey, Mary Dell, Yuliya Lokhnygina, and Rebecca H. Buckley. “Long-term clinical outcome of patients with severe combined immunodeficiency who received related donor bone marrow transplants without pretransplant chemotherapy or post-transplant GVHD prophylaxis.” J Pediatr 155, no. 6 (December 2009): 834-840.e1. https://doi.org/10.1016/j.jpeds.2009.07.049.
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  - Hofmann, Alison M., Amy M. Scurlock, Stacie M. Jones, Kricia P. Palmer, Yuliya Lokhnygina, Pamela H. Steele, Janet Kamilaris, and A Wesley Burks. “Safety of a peanut oral immunotherapy protocol in children with peanut allergy.” J Allergy Clin Immunol 124, no. 2 (August 2009): 286-291.e6. https://doi.org/10.1016/j.jaci.2009.03.045.
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  - Califf, Robert M., Yuliya Lokhnygina, Eric J. Velazquez, John J. V. McMurray, Jeffrey D. Leimberger, Eldrin F. Lewis, Rafael Diaz, Jan Murin, and Marc A. Pfeffer. “Usefulness of beta blockers in high-risk patients after myocardial infarction in conjunction with captopril and/or valsartan (from the VALsartan In Acute Myocardial Infarction [VALIANT] trial).” Am J Cardiol 104, no. 2 (July 15, 2009): 151–57. https://doi.org/10.1016/j.amjcard.2009.03.020.
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  - Kandzari, David E., Sunil V. Rao, Jeffrey W. Moses, Vladimir Dzavik, Bradley H. Strauss, Michael J. Kutryk, Charles A. Simonton, et al. “Clinical and angiographic outcomes with sirolimus-eluting stents in total coronary occlusions: the ACROSS/TOSCA-4 (Approaches to Chronic Occlusions With Sirolimus-Eluting Stents/Total Occlusion Study of Coronary Arteries-4) trial.” Jacc Cardiovasc Interv 2, no. 2 (February 2009): 97–106. https://doi.org/10.1016/j.jcin.2008.10.013.
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  - Lokhnygina, Y., and A. A. Tsiatis. “Optimal two-stage group-sequential designs.” Journal of Statistical Planning and Inference 138, no. 2 (February 1, 2008): 489–99. https://doi.org/10.1016/j.jspi.2007.06.011.
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  - Thomas, Kevin L., Sana M. Al-Khatib, Yuliya Lokhnygina, Scott D. Solomon, Lars Kober, John J. V. McMurray, Robert M. Califf, and Eric J. Velazquez. “Amiodarone use after acute myocardial infarction complicated by heart failure and/or left ventricular dysfunction may be associated with excess mortality.” Am Heart J 155, no. 1 (January 2008): 87–93. https://doi.org/10.1016/j.ahj.2007.09.010.
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  - Tricoci, Pierluigi, Yuliya Lokhnygina, Lisa G. Berdan, Steven R. Steinhubl, Dietrich C. Gulba, Harvey D. White, Neal S. Kleiman, et al. “Time to coronary angiography and outcomes among patients with high-risk non ST-segment elevation acute coronary syndromes: results from the SYNERGY trial.” Circulation 116, no. 23 (December 4, 2007): 2669–77. https://doi.org/10.1161/CIRCULATIONAHA.107.690081.
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  - Hasselblad, Vic, Wendy Gattis Stough, Monica R. Shah, Yuliya Lokhnygina, Christopher M. O’Connor, Robert M. Califf, and Kirkwood F. Adams. “Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial.” Eur J Heart Fail 9, no. 10 (October 2007): 1064–69. https://doi.org/10.1016/j.ejheart.2007.07.011.
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  - Mehta, Rajendra H., Adam B. Greenbaum, Yuliya Lokhnygina, L Kristin Newby, Frans Van De Werf, Paul W. Armstrong, Karen S. Pieper, Robert M. Califf, Christopher B. Granger, and Robert A. Harrington. “Timing of death and myocardial infarction in patients with non-ST elevation acute coronary syndromes: insights from randomized clinical trials.” J Interv Cardiol 20, no. 5 (October 2007): 299–306. https://doi.org/10.1111/j.1540-8183.2007.00277.x.
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  - Lokhnygina, Yuliya, and Jeffrey D. Helterbrand. “Cox regression methods for two-stage randomization designs.” Biometrics 63, no. 2 (June 2007): 422–28. https://doi.org/10.1111/j.1541-0420.2007.00707.x.
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  - Sampson, Uchechukwu K., Marc A. Pfeffer, John J. V. McMurray, Yuliya Lokhnygina, Harvey D. White, Scott D. Solomon, and Scott D. VALIANT Trial Investigators. “Predictors of stroke in high-risk patients after acute myocardial infarction: insights from the VALIANT Trial.” Eur Heart J 28, no. 6 (March 2007): 685–91. https://doi.org/10.1093/eurheartj/ehl197.
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  - Barnhart, Huiman X., Yuliya Lokhnygina, Andrzej S. Kosinski, and Michael Haber. “Comparison of concordance correlation coefficient and coefficient of individual agreement in assessing agreement.” J Biopharm Stat 17, no. 4 (2007): 721–38. https://doi.org/10.1080/10543400701329497.
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  - Hasselblad, V., Y. Lokhnygina, and M. W. Krucoff. “Discussion of: Statistical and regulatory issues with the application of propensity score analysis to nonrandomized medical device clinical studies.” Journal of Biopharmaceutical Statistics 17, no. 1 (January 1, 2007): 19–21. https://doi.org/10.1080/10543400601044725.
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  - Hasselblad, V., and Y. Lokhnygina. “Tests for 2 × 2 tables in clinical trials.” Journal of Modern Applied Statistical Methods 6, no. 2 (January 1, 2007): 456–68. https://doi.org/10.22237/jmasm/1193890140.
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  - Niewoehner, Dennis E., Yuliya Lokhnygina, Kathryn Rice, Ware G. Kuschner, Amir Sharafkhaneh, George A. Sarosi, Peter Krumpe, Karen Pieper, and Steven Kesten. “Risk indexes for exacerbations and hospitalizations due to COPD.” Chest 131, no. 1 (January 2007): 20–28. https://doi.org/10.1378/chest.06-1316.
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  - White, Harvey D., Neal S. Kleiman, Kenneth W. Mahaffey, Yuliya Lokhnygina, Karen S. Pieper, Karen Chiswell, Marc Cohen, et al. “Efficacy and safety of enoxaparin compared with unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention in the Superior Yield of the New Strategy of Enoxaparin, Revascularization and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial.” Am Heart J 152, no. 6 (December 2006): 1042–50. https://doi.org/10.1016/j.ahj.2006.08.002.
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  - Lokhnygina, Y. “Discussion of the "Executive Summary of the PhRMA Working Group on adaptive designs in clinical drug development".” Journal of Biopharmaceutical Statistics 16, no. 3 (May 1, 2006): 287–88. https://doi.org/10.1080/10543400600609684.
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- Conference Papers
  - Washam, Jeffrey B., Anne S. Hellkamp, Yuliya Lokhnygina, Jonathan P. Piccini, Scott D. Berkowitz, Christopher C. Nessel, Richard C. Becker, et al. “Efficacy and Safety of Rivaroxaban Versus Warfarin in Patients Taking Nondihydropyridine Calcium Channel Blockers for Atrial Fibrillation (from the ROCKET AF Trial).” In Am J Cardiol, 120:588–94, 2017. https://doi.org/10.1016/j.amjcard.2017.05.026.
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  - Farhan, Serdar, Robert M. Clare, Rudolf Jarai, Robert P. Giugliano, Yuliya Lokhnygina, Robert A. Harrington, L. Kristin Newby, and Kurt Huber. “Fasting glucose, NT-proBNP, treatment with eptifibatide, and outcomes in non-ST-segment elevation acute coronary syndromes: An analysis from EARLY ACS.” In Int J Cardiol, 232:264–70, 2017. https://doi.org/10.1016/j.ijcard.2017.01.007.
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  - Ilowite, Norman T., Kristi Prather, Yuliya Lokhnygina, Laura E. Schanberg, Melissa Elder, Diana Milojevic, James W. Verbsky, et al. “Randomized, double-blind, placebo-controlled trial of the efficacy and safety of rilonacept in the treatment of systemic juvenile idiopathic arthritis.” In Arthritis Rheumatol, 66:2570–79, 2014. https://doi.org/10.1002/art.38699.
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  - Piccini, J. P., A. S. Hellkamp, Y. Lokhnygina, M. R. Patel, F. E. Harrell, D. E. Singer, R. C. Becker, et al. “Relationship between time in therapeutic range and comparative treatment effect of rivaroxaban and warfarin: Results from the ROCKET AF trial.” In Journal of the American Heart Association, Vol. 3, 2014. https://doi.org/10.1161/JAHA.113.000521.
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