Yuliya Vladimirovna Lokhnygina

Yuliya Vladimirovna Lokhnygina
Assistant Professor of Biostatistics and Bioinformatics

Statistical methods in clinical trials, survival analysis, adaptive designs, adaptive treatment strategies, causal inference in observational studies, semiparametric inference

Current Appointments & Affiliations

Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2014
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2004

Contact Information

2400 Pratt Street, 7057 North Pavilion, Durham, NC 27705
Duke Box 3850, Durham, NC 27710
yuliya.lokhnygina@duke.edu (919) 668-7814

Background
Education, Training, & Certifications
- Ph.D., North Carolina State University 2004
- M.S., Cornell University 2001
- M.S., Moscow Institute of Physics and Technology 1999
Duke Appointment History
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2004 - 2014
- Instructor, Temporary of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2004
Research
Selected Grants
- Prevention of Surgical Site Infection using Statistical Process Control Charts awarded by Agency for Healthcare Research and Quality 2015 - 2020
- RFTOP #2018 Domain 2-B-0001 Base Period awarded by Centers for Disease Control and Prevention 2018 - 2020
- Improving antibiotic use through implementation and evaluation of Core Elements of Hospital Antibiotic Stewardship Programs (Domain 2) awarded by Centers for Disease Control and Prevention 2016 - 2019
- Administrative Claims-based Efficiencies for the Advancement of Regulatory Sciences awarded by Burroughs Wellcome Fund 2014 - 2019
- Metals in the Trial to Assess Chelation Therapy 2 (TACT2M) awarded by Mount Sinai School of Medicine 2016 - 2019
- Duke CTSA (UL1) awarded by National Institutes of Health 2013 - 2018
- BRIDGE DCC awarded by National Institutes of Health 2008 - 2017
- A Four-arm Prospective, Multicenter Study to Assess the Clinical Efficacy, Effectiveness, and Feasibility of Enhanced Ro awarded by Centers for Disease Control and Prevention 2011 - 2016
- Evaluation of the Efficacy of Personal Protective Equipment and Antiseptic Impregnated Clothing in Reducing Exposure of Health Care Personnel to Acquisition and Transmission of Viral and Bacterial Pat awarded by Centers for Disease Control and Prevention 2015 - 2016
- IPA-Yuliya Lokhnygina awarded by Durham Veterans Affairs Medical Center 2012 - 2014
- PROPRANOLOL AS ANTI-ADHESIVE THERAPY IN SCD awarded by National Institutes of Health 2010 - 2012
- Cohort Study of Patients at Risk for C. diff Infections awarded by Centers for Disease Control and Prevention 2011 - 2012
- CTSA UL awarded by National Institutes of Health 2006 - 2012
- STICH Statistics and Data Coordinating Center awarded by National Institutes of Health 2002 - 2011
- General Clinical Research Center awarded by National Institutes of Health 1998 - 2006
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Sharma, A, Sun, J-L, Lokhnygina, Y, Roe, MT, Ahmad, T, Desai, NR, and Blazing, MA. "Patient Phenotypes, Cardiovascular Risk, and Ezetimibe Treatment in Patients After Acute Coronary Syndromes (from IMPROVE-IT)." The American Journal of Cardiology (January 25, 2019). Full Text
  - Navar, AM, Roe, MT, White, JA, Cannon, CP, Lokhnygina, Y, Newby, LK, Giugliano, RP, Tershakovec, AM, Braunwald, E, Califf, RM, and Blazing, MA. "Medication Discontinuation in the IMPROVE-IT Trial." Circulation. Cardiovascular Quality and Outcomes 12, no. 1 (January 2019): e005041-null. Full Text
  - Ambrosy, AP, Cerbin, LP, Fudim, M, Clare, RM, Lokhnygina, Y, Braunwald, E, Califf, RM, Cannon, CP, Tershakovec, AM, Roe, MT, and Blazing, MA. "Natural History of Patients Postacute Coronary Syndrome Based on Heart Failure Status." The American Journal of Cardiology 122, no. 9 (November 2018): 1451-1458. Full Text
  - Mentz, RJ, Bethel, MA, Merrill, P, Lokhnygina, Y, Buse, JB, Chan, JC, Felício, JS, Goodman, SG, Choi, J, Gustavson, SM, Iqbal, N, Lopes, RD, Maggioni, AP, Öhman, P, Pagidipati, NJ, Poulter, NR, Ramachandran, A, Reicher, B, Holman, RR, Hernandez, AF, and EXSCEL Study Group, . "Effect of Once-Weekly Exenatide on Clinical Outcomes According to Baseline Risk in Patients With Type 2 Diabetes Mellitus: Insights From the EXSCEL Trial." Journal of the American Heart Association 7, no. 19 (October 2018): e009304-null. Full Text
  - Anderson, DJ, Moehring, RW, Weber, DJ, Lewis, SS, Chen, LF, Schwab, JC, Becherer, P, Blocker, M, Triplett, PF, Knelson, LP, Lokhnygina, Y, Rutala, WA, Sexton, DJ, and CDC Prevention Epicenters Program, . "Effectiveness of targeted enhanced terminal room disinfection on hospital-wide acquisition and infection with multidrug-resistant organisms and Clostridium difficile: a secondary analysis of a multicentre cluster randomised controlled trial with crossover design (BETR Disinfection)." The Lancet. Infectious Diseases 18, no. 8 (August 2018): 845-853. Full Text
  - Davis, TME, Mulder, H, Lokhnygina, Y, Aschner, P, Chuang, L-M, Raffo Grado, CA, Standl, E, Peterson, ED, Holman, RR, and TECOS Study Group, . "Effect of race on the glycaemic response to sitagliptin: Insights from the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS)." Diabetes, Obesity & Metabolism 20, no. 6 (June 2018): 1427-1434. Full Text
  - Husain, AM, Lee, JW, Kolls, BJ, Hirsch, LJ, Halford, JJ, Gupta, PK, Minazad, Y, Jones, JM, LaRoche, SM, Herman, ST, Swisher, CB, Sinha, SR, Palade, A, Dombrowski, KE, Gallentine, WB, Hahn, CD, Gerard, EE, Bhapkar, M, Lokhnygina, Y, Westover, MB, and Critical Care EEG Monitoring Research Consortium, . "Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures." Annals of Neurology 83, no. 6 (June 2018): 1174-1185. Full Text
  - Moehring, RW, Dodds Ashley, ES, Ren, X, Lokhnygina, Y, Baker, AW, Jones, TM, Lewis, SS, Sexton, DJ, Anderson, DJ, and Centers for Disease Control and Prevention Epicenters Program, . "Denominator Matters in Estimating Antimicrobial Use: A Comparison of Days Present and Patient Days." Infection control and hospital epidemiology (March 26, 2018): 1-4. Full Text
  - Anderson, DJ, Knelson, LP, Moehring, RW, Lewis, SS, Weber, DJ, Chen, LF, Triplett, PF, Blocker, M, Cooney, RM, Schwab, JC, Lokhnygina, Y, Rutala, WA, Sexton, DJ, and CDC Prevention Epicenters Program, . "Implementation Lessons Learned From the Benefits of Enhanced Terminal Room (BETR) Disinfection Study: Process and Perceptions of Enhanced Disinfection with Ultraviolet Disinfection Devices." Infection Control and Hospital Epidemiology 39, no. 2 (February 2018): 157-163. Full Text
  - Bethel, MA, Patel, RA, Merrill, P, Lokhnygina, Y, Buse, JB, Mentz, RJ, Pagidipati, NJ, Chan, JC, Gustavson, SM, Iqbal, N, Maggioni, AP, Öhman, P, Poulter, NR, Ramachandran, A, Zinman, B, Hernandez, AF, Holman, RR, and EXSCEL Study Group, . "Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis." The Lancet. Diabetes & Endocrinology 6, no. 2 (February 2018): 105-113. Full Text
  - Kochar, A, Hellkamp, AS, Lokhnygina, Y, Jones, WS, Becker, RC, Berkowitz, SD, Breithardt, G, Fox, KAA, Halperin, JL, Hankey, GJ, Mahaffey, KW, Nessel, CC, Singer, DE, Piccini, JP, and Patel, MR. "Efficacy and safety of rivaroxaban compared with warfarin in patients with carotid artery disease and nonvalvular atrial fibrillation: Insights from the ROCKET AF trial." Clinical Cardiology 41, no. 1 (January 2018): 39-45. Full Text
  - Limkakeng, AT, Leahy, JC, Griffin, SM, Lokhnygina, Y, Jaffa, E, Christenson, RH, and Newby, LK. "Provocative biomarker stress test: stress-delta N-terminal pro-B type natriuretic peptide." Open Heart 5, no. 2 (January 2018): e000847-null. Full Text Open Access Copy
  - Sharma, A, Green, JB, Dunning, A, Lokhnygina, Y, Al-Khatib, SM, Lopes, RD, Buse, JB, Lachin, JM, Van de Werf, F, Armstrong, PW, Kaufman, KD, Standl, E, Chan, JCN, Distiller, LA, Scott, R, Peterson, ED, Holman, RR, and TECOS Study Group, . "Causes of Death in a Contemporary Cohort of Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease: Insights From the TECOS Trial." Diabetes Care 40, no. 12 (December 2017): 1763-1770. Full Text
  - Navar, AM, Gallup, DS, Lokhnygina, Y, Green, JB, McGuire, DK, Armstrong, PW, Buse, JB, Engel, SS, Lachin, JM, Standl, E, Van de Werf, F, Holman, RR, Peterson, ED, and TECOS Study Group, . "Hypertension Control in Adults With Diabetes Mellitus and Recurrent Cardiovascular Events: Global Results From the Trial Evaluating Cardiovascular Outcomes With Sitagliptin." Hypertension (Dallas, Tex. : 1979) 70, no. 5 (November 2017): 907-914. Full Text
  - Anderson, DJ, Addison, R, Lokhnygina, Y, Warren, B, Sharma-Kuinkel, B, Rojas, LJ, Rudin, SD, Lewis, SS, Moehring, RW, Weber, DJ, Rutala, WA, Bonomo, RA, Fowler, VG, Sexton, DJ, and CDC Prevention Epicenters Program, . "The Antimicrobial Scrub Contamination and Transmission (ASCOT) Trial: A Three-Arm, Blinded, Randomized Controlled Trial With Crossover Design to Determine the Efficacy of Antimicrobial-Impregnated Scrubs in Preventing Healthcare Provider Contamination." Infection control and hospital epidemiology 38, no. 10 (October 2017): 1147-1154. Full Text
  - Stanifer, JW, Charytan, DM, White, J, Lokhnygina, Y, Cannon, CP, Roe, MT, and Blazing, MA. "Benefit of Ezetimibe Added to Simvastatin in Reduced Kidney Function." Journal of the American Society of Nephrology : Jasn 28, no. 10 (October 2017): 3034-3043. Full Text Open Access Copy
  - Fanaroff, AC, Roe, MT, Clare, RM, Lokhnygina, Y, Navar, AM, Giugliano, RP, Wiviott, SD, Tershakovec, AM, Braunwald, E, and Blazing, MA. "Competing Risks of Cardiovascular Versus Noncardiovascular Death During Long-Term Follow-Up After Acute Coronary Syndromes." Journal of the American Heart Association 6, no. 9 (September 18, 2017). Full Text
  - Holman, RR, Bethel, MA, Mentz, RJ, Thompson, VP, Lokhnygina, Y, Buse, JB, Chan, JC, Choi, J, Gustavson, SM, Iqbal, N, Maggioni, AP, Marso, SP, Öhman, P, Pagidipati, NJ, Poulter, N, Ramachandran, A, Zinman, B, Hernandez, AF, and EXSCEL Study Group, . "Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes." The New England Journal of Medicine 377, no. 13 (September 14, 2017): 1228-1239. Full Text
  - Pagidipati, NJ, Navar, AM, Pieper, KS, Green, JB, Bethel, MA, Armstrong, PW, Josse, RG, McGuire, DK, Lokhnygina, Y, Cornel, JH, Halvorsen, S, Strandberg, TE, Delibasi, T, Holman, RR, Peterson, ED, and TECOS Study Group, . "Secondary Prevention of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus: International Insights From the TECOS Trial (Trial Evaluating Cardiovascular Outcomes With Sitagliptin)." Circulation 136, no. 13 (September 2017): 1193-1203. Full Text
  - Sun, Y, Hu, D, Stevens, S, Lokhnygina, Y, Becker, RC, Berkowitz, SD, Breithardt, G, Hacke, W, Halperin, JL, Hankey, GJ, Mahaffey, KW, Nessel, CC, Piccini, JP, Singer, DE, Fox, KAA, and Patel, MR. "Efficacy and safety of rivaroxaban versus warfarin in patients from mainland China with nonvalvular atrial fibrillation: A subgroup analysis from the ROCKET AF trial." Thrombosis Research 156 (August 2017): 184-190. Full Text
  - Balla, SR, Cyr, DD, Lokhnygina, Y, Becker, RC, Berkowitz, SD, Breithardt, G, Fox, KAA, Hacke, W, Halperin, JL, Hankey, GJ, Mahaffey, KW, Nessel, CC, Piccini, JP, Singer, DE, and Patel, MR. "Relation of Risk of Stroke in Patients With Atrial Fibrillation to Body Mass Index (from Patients Treated With Rivaroxaban and Warfarin in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation Trial)." The American Journal of Cardiology 119, no. 12 (June 2017): 1989-1996. Full Text
  - Harskamp, RE, Clare, RM, Ambrosio, G, Held, C, Lokhnygina, Y, Moliterno, DJ, White, HD, Aylward, PE, Armstrong, PW, Mahaffey, KW, Harrington, RA, Van de Werf, F, Wallentin, L, Strony, J, and Tricoci, P. "Use of thienopyridine prior to presentation with non-ST-segment elevation acute coronary syndrome and association with safety and efficacy of vorapaxar: insights from the TRACER trial." European Heart Journal. Acute Cardiovascular Care 6, no. 2 (March 2017): 155-163. Full Text
  - Lindner, SM, Fordyce, CB, Hellkamp, AS, Lokhnygina, Y, Piccini, JP, Breithardt, G, Mahaffey, KW, Singer, DE, Hacke, W, Halperin, JL, Hankey, GJ, Berkowitz, SD, Nessel, CC, Becker, RC, Fox, KAA, Patel, MR, and ROCKET AF Steering Committee and Investigators, . "Treatment Consistency Across Levels of Baseline Renal Function With Rivaroxaban or Warfarin: A ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) Analysis." Circulation 135, no. 10 (March 2017): 1001-1003. (Letter) Full Text
  - Valgimigli, M, Costa, F, Lokhnygina, Y, Clare, RM, Wallentin, L, Moliterno, DJ, Armstrong, PW, White, HD, Held, C, Aylward, PE, Van de Werf, F, Harrington, RA, Mahaffey, KW, and Tricoci, P. "Trade-off of myocardial infarction vs. bleeding types on mortality after acute coronary syndrome: lessons from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) randomized trial." European Heart Journal 38, no. 11 (March 2017): 804-810. Full Text
  - Anderson, DJ, Chen, LF, Weber, DJ, Moehring, RW, Lewis, SS, Triplett, PF, Blocker, M, Becherer, P, Schwab, JC, Knelson, LP, Lokhnygina, Y, Rutala, WA, Kanamori, H, Gergen, MF, Sexton, DJ, and CDC Prevention Epicenters Program, . "Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study." Lancet (London, England) 389, no. 10071 (February 2017): 805-814. Full Text
  - Buse, JB, Bethel, MA, Green, JB, Stevens, SR, Lokhnygina, Y, Aschner, P, Grado, CR, Tankova, T, Wainstein, J, Josse, R, Lachin, JM, Engel, SS, Patel, K, Peterson, ED, Holman, RR, and TECOS Study Group, . "Pancreatic Safety of Sitagliptin in the TECOS Study." Diabetes Care 40, no. 2 (February 2017): 164-170. Full Text
  - Blazing, MA, Giugliano, RP, de Lemos, JA, Cannon, CP, Tonkin, A, Ballantyne, CM, Lewis, BS, Musliner, TA, Tershakovec, AM, Lokhnygina, Y, White, JA, Reist, C, McCagg, A, and Braunwald, E. "On-treatment analysis of the Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT)." American Heart Journal 182 (December 2016): 89-96. Full Text
  - Shah, R, Hellkamp, A, Lokhnygina, Y, Becker, RC, Berkowitz, SD, Breithardt, G, Hacke, W, Halperin, JL, Hankey, GJ, Fox, KAA, Nessel, CC, Mahaffey, KW, Piccini, JP, Singer, DE, Patel, MR, and ROCKET AF Steering Committee Investigators, . "Use of concomitant aspirin in patients with atrial fibrillation: Findings from the ROCKET AF trial." American Heart Journal 179 (September 2016): 77-86. Full Text
  - Åkerblom, A, Clare, RM, Lokhnygina, Y, Wallentin, L, Held, C, Van de Werf, F, Moliterno, DJ, Patel, UD, Leonardi, S, Armstrong, PW, Harrington, RA, White, HD, Aylward, PE, Mahaffey, KW, and Tricoci, P. "Albuminuria and cardiovascular events in patients with acute coronary syndromes: Results from the TRACER trial." American heart journal 178 (August 2016): 1-8. Full Text
  - Breithardt, G, Baumgartner, H, Berkowitz, SD, Hellkamp, AS, Piccini, JP, Lokhnygina, Y, Halperin, JL, Singer, DE, Hankey, GJ, Hacke, W, Becker, RC, Nessel, CC, Mahaffey, KW, Califf, RM, Fox, KAA, Patel, MR, and ROCKET AF Steering Committee & Investigators, . "Native valve disease in patients with non-valvular atrial fibrillation on warfarin or rivaroxaban." Heart (British Cardiac Society) 102, no. 13 (July 2016): 1036-1043. Full Text
  - Fordyce, CB, Hellkamp, AS, Lokhnygina, Y, Lindner, SM, Piccini, JP, Becker, RC, Berkowitz, SD, Breithardt, G, Fox, KAA, Mahaffey, KW, Nessel, CC, Singer, DE, Patel, MR, and ROCKET AF Steering Committee and Investigators, . "On-Treatment Outcomes in Patients With Worsening Renal Function With Rivaroxaban Compared With Warfarin: Insights From ROCKET AF." Circulation 134, no. 1 (July 2016): 37-47. Full Text
  - Lakey, WC, Greyshock, NG, Kelley, CE, Siddiqui, MA, Ahmad, U, Lokhnygina, YV, and Guyton, JR. "Statin intolerance in a referral lipid clinic." Journal of Clinical Lipidology 10, no. 4 (July 2016): 870-879.e3. Full Text
  - Li, F, Lokhnygina, Y, Murray, DM, Heagerty, PJ, and DeLong, ER. "An evaluation of constrained randomization for the design and analysis of group-randomized trials." Statistics in Medicine 35, no. 10 (May 2016): 1565-1579. Full Text
  - McGuire, DK, Van de Werf, F, Armstrong, PW, Standl, E, Koglin, J, Green, JB, Bethel, MA, Cornel, JH, Lopes, RD, Halvorsen, S, Ambrosio, G, Buse, JB, Josse, RG, Lachin, JM, Pencina, MJ, Garg, J, Lokhnygina, Y, Holman, RR, Peterson, ED, and Trial Evaluating Cardiovascular Outcomes With Sitagliptin (TECOS) Study Group, . "Association Between Sitagliptin Use and Heart Failure Hospitalization and Related Outcomes in Type 2 Diabetes Mellitus: Secondary Analysis of a Randomized Clinical Trial." Jama Cardiology 1, no. 2 (May 2016): 126-135. Full Text
  - Farber, SH, Hatef, J, Han, JL, Marky, AH, Xie, J, Huang, K, Verla, T, Lokhnygina, Y, Collins, TA, and Lad, SP. "Implantable Neurostimulation for Headache Disorders: Effect on Healthcare Utilization and Expenditures." Neuromodulation : Journal of the International Neuromodulation Society 19, no. 3 (April 2016): 319-328. Full Text
  - Hess, PL, Wojdyla, DM, Al-Khatib, SM, Lokhnygina, Y, Wallentin, L, Armstrong, PW, Roe, MT, Ohman, EM, Harrington, RA, Alexander, JH, White, HD, Van de Werf, F, Piccini, JP, Held, C, Aylward, PE, Moliterno, DJ, Mahaffey, KW, and Tricoci, P. "Sudden Cardiac Death After Non-ST-Segment Elevation Acute Coronary Syndrome." Jama Cardiology 1, no. 1 (April 2016): 73-79. Full Text
  - Murphy, SA, Cannon, CP, Blazing, MA, Giugliano, RP, White, JA, Lokhnygina, Y, Reist, C, Im, K, Bohula, EA, Isaza, D, Lopez-Sendon, J, Dellborg, M, Kher, U, Tershakovec, AM, and Braunwald, E. "Reduction in Total Cardiovascular Events With Ezetimibe/Simvastatin Post-Acute Coronary Syndrome: The IMPROVE-IT Trial." Journal of the American College of Cardiology 67, no. 4 (February 2016): 353-361. Full Text
  - Halim, SA, Clare, RM, Newby, LK, Lokhnygina, Y, Schweiger, MJ, Hof, AW, Hochman, JS, James, SK, White, HD, Widimsky, P, Betriu, A, Bode, C, Giugliano, RP, Harrington, RA, and Zeymer, U. "Frequency, clinical and angiographic characteristics, and outcomes of high-risk non-ST-segment elevation acute coronary syndromes patients with left circumflex culprit lesions." International Journal of Cardiology 203 (January 2016): 708-713. Full Text
  - Petraglia, FW, Farber, SH, Han, JL, Verla, T, Gallis, J, Lokhnygina, Y, Parente, B, Hickey, P, Turner, DA, and Lad, SP. "Comparison of Bilateral vs. Staged Unilateral Deep Brain Stimulation (DBS) in Parkinson's Disease in Patients Under 70 Years of Age." Neuromodulation : Journal of the International Neuromodulation Society 19, no. 1 (January 2016): 31-37. Full Text
  - Bansilal, S, Bloomgarden, Z, Halperin, JL, Hellkamp, AS, Lokhnygina, Y, Patel, MR, Becker, RC, Breithardt, G, Hacke, W, Hankey, GJ, Nessel, CC, Singer, DE, Berkowitz, SD, Piccini, JP, Mahaffey, KW, Fox, KAA, and ROCKET AF Steering Committee and Investigators, . "Efficacy and safety of rivaroxaban in patients with diabetes and nonvalvular atrial fibrillation: the Rivaroxaban Once-daily, Oral, Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF Trial)." American Heart Journal 170, no. 4 (October 2015): 675-682.e8. Full Text
  - Nicolau, JC, Bhatt, DL, Roe, MT, Lokhnygina, Y, Neely, B, Corbalán, R, Leiva-Pons, JL, Martinez, F, Goodman, SG, Winters, KJ, Verheugt, FWA, Armstrong, PW, White, HD, Fox, KAA, Prabhakaran, D, Ohman, EM, and TRILOGY ACS investigators, . "Concomitant proton-pump inhibitor use, platelet activity, and clinical outcomes in patients with acute coronary syndromes treated with prasugrel versus clopidogrel and managed without revascularization: insights from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes trial." American Heart Journal 170, no. 4 (October 2015): 683-694.e3. Full Text
  - Daneshmand, MA, Krishnamoorthy, A, Samsky, MD, Felker, GM, Pura, JA, Lokhnygina, Y, Hernandez, AF, Rosenberg, PB, Blue, LJ, Schroder, JN, Rogers, JG, Milano, CA, and Patel, CB. "Comparison of 2-Year Outcomes of Extended Criteria Cardiac Transplantation Versus Destination Left Ventricular Assist Device Therapy Using Continuous Flow." The American journal of cardiology 116, no. 4 (August 2015): 573-579. Full Text
  - Wieslander, B, Nijveldt, R, Klem, I, Lokhnygina, Y, Pura, J, Wagner, GS, Ugander, M, and Atwater, BD. "Evaluation of Selvester QRS score for use in presence of conduction abnormalities in a broad population." American heart journal 170, no. 2 (August 2015): 346-352. Full Text
  - Bagai, A, Huang, Z, Lokhnygina, Y, Harrington, RA, Armstrong, PW, Strony, J, White, HD, Leonardi, S, Held, C, Van de Werf, F, Wallentin, L, Tricoci, P, and Mahaffey, KW. "Magnitude of troponin elevation and long-term clinical outcomes in acute coronary syndrome patients treated with and without revascularization." Circulation. Cardiovascular interventions 8, no. 6 (June 2015): e002314-. Full Text
  - Washam, JB, Stevens, SR, Lokhnygina, Y, Halperin, JL, Breithardt, G, Singer, DE, Mahaffey, KW, Hankey, GJ, Berkowitz, SD, Nessel, CC, Fox, KAA, Califf, RM, Piccini, JP, Patel, MR, and ROCKET AF Steering Committee and Investigators, . "Digoxin use in patients with atrial fibrillation and adverse cardiovascular outcomes: a retrospective analysis of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF)." Lancet (London, England) 385, no. 9985 (June 2015): 2363-2370. Full Text
  - Cornel, JH, Tricoci, P, Lokhnygina, Y, Moliterno, DJ, Wallentin, L, Armstrong, PW, Aylward, PE, Clare, RM, Chen, E, Leonardi, S, Van de Werf, F, White, HD, Held, C, Strony, J, Mahaffey, KW, and Harrington, RA. "Glycoprotein IIb/IIIa Receptor Inhibitors in Combination With Vorapaxar, a Platelet Thrombin Receptor Antagonist, Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes (from the TRACER Trial)." The American journal of cardiology 115, no. 10 (May 2015): 1325-1332. Full Text
  - Verla, T, Marky, A, Farber, H, Petraglia, FW, Gallis, J, Lokhnygina, Y, Parente, B, Hickey, P, Turner, DA, and Lad, SP. "Impact of advancing age on post-operative complications of deep brain stimulation surgery for essential tremor." Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 22, no. 5 (May 2015): 872-876. Full Text
  - Singer, DE, Hellkamp, AS, Yuan, Z, Lokhnygina, Y, Patel, MR, Piccini, JP, Hankey, GJ, Breithardt, G, Halperin, JL, Becker, RC, Hacke, W, Nessel, CC, Mahaffey, KW, Fox, KAA, Califf, RM, and ROCKET AF Investigators, . "Alternative calculations of individual patient time in therapeutic range while taking warfarin: results from the ROCKET AF trial." Journal of the American Heart Association 4, no. 3 (March 3, 2015): e001349-null. Full Text
  - Bakal, JA, Roe, MT, Ohman, EM, Goodman, SG, Fox, KAA, Zheng, Y, Westerhout, CM, Hochman, JS, Lokhnygina, Y, Brown, EB, and Armstrong, PW. "Applying novel methods to assess clinical outcomes: insights from the TRILOGY ACS trial." European Heart Journal 36, no. 6 (February 2015): 385-92a. Full Text
  - Huang, KT, Martin, J, Marky, A, Chagoya, G, Hatef, J, Hazzard, MA, Thomas, SM, Lokhnygina, Y, and Lad, SP. "A national survey of spinal cord stimulation trial-to-permanent conversion rates." Neuromodulation : Journal of the International Neuromodulation Society 18, no. 2 (February 2015): 133-139. Full Text
  - Steinberg, BA, Hellkamp, AS, Lokhnygina, Y, Patel, MR, Breithardt, G, Hankey, GJ, Becker, RC, Singer, DE, Halperin, JL, Hacke, W, Nessel, CC, Berkowitz, SD, Mahaffey, KW, Fox, KAA, Califf, RM, Piccini, JP, and ROCKET-AF Steering Committee and Investigators, . "Higher risk of death and stroke in patients with persistent vs. paroxysmal atrial fibrillation: results from the ROCKET-AF Trial." European Heart Journal 36, no. 5 (February 2015): 288-296. Full Text
  - Ahmad, T, Wang, T, O'Brien, EC, Samsky, MD, Pura, JA, Lokhnygina, Y, Rogers, JG, Hernandez, AF, Craig, D, Bowles, DE, Milano, CA, Shah, SH, Januzzi, JL, Felker, GM, and Patel, CB. "Effects of left ventricular assist device support on biomarkers of cardiovascular stress, fibrosis, fluid homeostasis, inflammation, and renal injury." Jacc. Heart Failure 3, no. 1 (January 2015): 30-39. Full Text
  - Cornel, JH, Tricoci, P, Lokhnygina, Y, Moliterno, DJ, Wallentin, L, Armstrong, PW, Aylward, PE, Clare, RM, Chen, E, Leonardi, S, Van De Werf, F, White, HD, Held, C, Strony, J, Mahaffey, KW, and Harrington, RA. "Glycoprotein IIb/IIIa receptor inhibitors in combination with vorapaxar, a platelet thrombin receptor antagonist, among patients with non-ST-segment elevation acute coronary syndromes (from the TRACER trial)." American Journal of Cardiology 115, no. 10 (January 1, 2015): 1325-1332. Full Text
  - Huang, KT, Martin, J, Marky, A, Chagoya, G, Hatef, J, Hazzard, MA, Thomas, SM, Lokhnygina, Y, and Lad, SP. "A national survey of spinal cord stimulation trial-to-permanent conversion rates." Neuromodulation 18, no. 2 (January 1, 2015): 133-139. (Review) Full Text
  - Verla, T, Marky, A, Farber, H, Petraglia, FW, Gallis, J, Lokhnygina, Y, Parente, B, Hickey, P, Turner, DA, and Lad, SP. "Impact of advancing age on post-operative complications of deep brain stimulation surgery for essential tremor." Journal of Clinical Neuroscience 22, no. 5 (January 1, 2015): 872-876. Full Text
  - Breithardt, G, Baumgartner, H, Berkowitz, SD, Hellkamp, AS, Piccini, JP, Stevens, SR, Lokhnygina, Y, Patel, MR, Halperin, JL, Singer, DE, Hankey, GJ, Hacke, W, Becker, RC, Nessel, CC, Mahaffey, KW, Fox, KAA, Califf, RM, and ROCKET AF Steering Committee & Investigators, . "Clinical characteristics and outcomes with rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation but underlying native mitral and aortic valve disease participating in the ROCKET AF trial." European Heart Journal 35, no. 47 (December 2014): 3377-3385. Full Text
  - Tricoci, P, Lokhnygina, Y, Huang, Z, Van de Werf, F, Cornel, JH, Chen, E, Wallentin, L, Held, C, Aylward, PE, Moliterno, DJ, Jennings, LK, White, HD, Armstrong, PW, Harrington, RA, Strony, J, and Mahaffey, KW. "Vorapaxar with or without clopidogrel after non-ST-segment elevation acute coronary syndromes: results from the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome trial." American Heart Journal 168, no. 6 (December 2014): 869-77.e1. Full Text
  - Babu, R, Thomas, S, Hazzard, MA, Lokhnygina, YV, Friedman, AH, Gottfried, ON, Isaacs, RE, Boakye, M, Patil, CG, Bagley, CA, Haglund, MM, and Lad, SP. "Morbidity, mortality, and health care costs for patients undergoing spine surgery following the ACGME resident duty-hour reform: Clinical article." Journal of Neurosurgery. Spine 21, no. 4 (October 2014): 502-515. Full Text
  - DeLong, MR, Huang, KT, Gallis, J, Lokhnygina, Y, Parente, B, Hickey, P, Turner, DA, and Lad, SP. "Effect of advancing age on outcomes of deep brain stimulation for Parkinson disease." Jama Neurology 71, no. 10 (October 2014): 1290-1295. Full Text
  - Piccini, JP, Al-Khatib, SM, Wojdyla, DM, Shaw, LK, Horton, JR, Lokhnygina, Y, Anstrom, KJ, DeWald, T, Allen-LaPointe, N, Steinberg, BA, Thomas, K, Daubert, JP, and Peterson, ED. "Comparison of safety of sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease." The American Journal of Cardiology 114, no. 5 (September 2014): 716-722. Full Text
  - Valgimigli, M, Tricoci, P, Huang, Z, Aylward, PE, Armstrong, PW, Van de Werf, F, Leonardi, S, White, HD, Widimsky, P, Harrington, RA, Cequier, A, Chen, E, Lokhnygina, Y, Wallentin, L, Strony, J, Mahaffey, KW, and Moliterno, DJ. "Usefulness and safety of vorapaxar in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention (from the TRACER Trial)." The American Journal of Cardiology 114, no. 5 (September 2014): 665-673. Full Text
  - White, HD, Huang, Z, Tricoci, P, Van de Werf, F, Wallentin, L, Lokhnygina, Y, Moliterno, DJ, Aylward, PE, Mahaffey, KW, and Armstrong, PW. "Reduction in overall occurrences of ischemic events with vorapaxar: results from TRACER." Journal of the American Heart Association 3, no. 4 (July 10, 2014). Full Text
  - Halperin, JL, Hankey, GJ, Wojdyla, DM, Piccini, JP, Lokhnygina, Y, Patel, MR, Breithardt, G, Singer, DE, Becker, RC, Hacke, W, Paolini, JF, Nessel, CC, Mahaffey, KW, Califf, RM, and Fox, KAA. "Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the rivaroxaban once daily, oral, direct factor xa inhibition compared with vitamin k antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF)." Circulation 130, no. 2 (July 8, 2014): 138-146. Full Text
  - Halperin, JL, Hankey, GJ, Wojdyla, DM, Piccini, JP, Lokhnygina, Y, Patel, MR, Breithardt, G, Singer, DE, Becker, RC, Hacke, W, Paolini, JF, Nessel, CC, Mahaffey, KW, Califf, RM, Fox, KAA, and ROCKET AF Steering Committee and Investigators, . "Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF)." Circulation 130, no. 2 (July 2014): 138-146. Full Text
  - Piccini, JP, Garg, J, Patel, MR, Lokhnygina, Y, Goodman, SG, Becker, RC, Berkowitz, SD, Breithardt, G, Hacke, W, Halperin, JL, Hankey, GJ, Nessel, CC, Mahaffey, KW, Singer, DE, Califf, RM, Fox, KAA, and ROCKET AF Investigators, . "Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial." European Heart Journal 35, no. 28 (July 2014): 1873-1880. Full Text
  - Sherwood, MW, Douketis, JD, Patel, MR, Piccini, JP, Hellkamp, AS, Lokhnygina, Y, Spyropoulos, AC, Hankey, GJ, Singer, DE, Nessel, CC, Mahaffey, KW, Fox, KAA, Califf, RM, and Becker, RC. "Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: Results from the rivaroxaban once daily, oral, direct factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF)." Circulation 129, no. 18 (May 6, 2014): 1850-1859. Full Text
  - Hankey, GJ, Stevens, SR, Piccini, JP, Lokhnygina, Y, Mahaffey, KW, Halperin, JL, Patel, MR, Breithardt, G, Singer, DE, Becker, RC, Berkowitz, SD, Paolini, JF, Nessel, CC, Hacke, W, Fox, KAA, Califf, RM, and ROCKET AF Steering Committee and Investigators, . "Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation." Stroke 45, no. 5 (May 2014): 1304-1312. Full Text
  - Hankey, GJ, Stevens, SR, Piccini, JP, Lokhnygina, Y, Mahaffey, KW, Halperin, JL, Patel, MR, Breithardt, G, Singer, DE, Becker, RC, Berkowitz, SD, Paolini, JF, Nessel, CC, Hacke, W, Fox, KAA, and Califf, RM. "Intracranial Hemorrhage Among Patients With Atrial Fibrillation Anticoagulated With Warfarin or Rivaroxaban." Stroke 45, no. 5 (May 2014): 1304-1312. Full Text
  - Sharma, R, Macy, S, Richardson, K, Lokhnygina, Y, and Laskowitz, DT. "A blood-based biomarker panel to detect acute stroke." Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association 23, no. 5 (May 2014): 910-918. Full Text
  - Sherwood, MW, Douketis, JD, Patel, MR, Piccini, JP, Hellkamp, AS, Lokhnygina, Y, Spyropoulos, AC, Hankey, GJ, Singer, DE, Nessel, CC, Mahaffey, KW, Fox, KAA, Califf, RM, Becker, RC, and ROCKET AF Investigators, . "Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF)." Circulation 129, no. 18 (May 2014): 1850-1859. Full Text
  - Allen LaPointe, NM, Lokhnygina, Y, Rimmler, J, Sanders, GD, Peterson, ED, and Al-Khatib, SM. "Use Of Rate And Rhythm Control Drugs In Patients Younger Than 65 Years With Atrial Fibrillation." Journal of Atrial Fibrillation 7, no. 1 (January 2014): 22-30.
  - Steinberg, BA, Hellkamp, AS, Lokhnygina, Y, Halperin, JL, Breithardt, G, Passman, R, Hankey, GJ, Patel, MR, Becker, RC, Singer, DE, Hacke, W, Berkowitz, SD, Nessel, CC, Mahaffey, KW, Fox, KAA, Califf, RM, and Piccini, JP. "Use and outcomes of antiarrhythmic therapy in patients with atrial fibrillation receiving oral anticoagulation: Results from the ROCKET AF trial." Heart Rhythm 11, no. 6 (January 1, 2014): 925-932. Full Text
  - Tricoci, P, Lokhnygina, Y, Huang, Z, Van De Werf, F, Cornel, JH, Chen, E, Wallentin, L, Held, C, Aylward, PE, Moliterno, DJ, Jennings, LK, White, HD, Armstrong, PW, Harrington, RA, Strony, J, and Mahaffey, KW. "Vorapaxar with or without clopidogrel after non-ST-segment elevation acute coronary syndromes: Results from the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome trial." American Heart Journal 168, no. 6 (January 1, 2014): 869-877.e1. Full Text
  - "Adherence to guideline recommendations for antiarrhythmic drugs in atrial fibrillation." American Heart Journal 166, no. 5 (November 1, 2013): 871-878. Full Text
  - Allen LaPointe, NM, Lokhnygina, Y, Sanders, GD, Peterson, ED, and Al-Khatib, SM. "Adherence to guideline recommendations for antiarrhythmic drugs in atrial fibrillation." American Heart Journal 166, no. 5 (November 2013): 871-878. Full Text
  - Bagai, A, White, JA, Lokhnygina, Y, Giugliano, RP, Van de Werf, F, Montalescot, G, Armstrong, PW, Tricoci, P, Gibson, CM, Califf, RM, Harrington, RA, and Newby, LK. "Routine early eptifibatide versus delayed provisional use at percutaneous coronary intervention in high-risk non-ST-segment elevation acute coronary syndromes patients: an analysis from the Early Glycoprotein IIb/IIIa Inhibition in Non-ST-Segment Elevation Acute Coronary Syndrome trial." American Heart Journal 166, no. 3 (September 2013): 466-473. Full Text
  - Piccini, JP, Stevens, SR, Chang, Y, Singer, DE, Lokhnygina, Y, Go, AS, Patel, MR, Mahaffey, KW, Halperin, JL, Breithardt, G, Hankey, GJ, Hacke, W, Becker, RC, Nessel, CC, Fox, KAA, Califf, RM, and ROCKET AF Steering Committee and Investigators, . "Response to letter regarding article, "renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R2CHADS2 index in the ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) study cohorts"." Circulation 128, no. 11 (September 2013): e172-e173. (Letter) Full Text
  - Wiviott, SD, White, HD, Ohman, EM, Fox, KAA, Armstrong, PW, Prabhakaran, D, Hafley, G, Lokhnygina, Y, Boden, WE, Hamm, C, Clemmensen, P, Nicolau, JC, Menozzi, A, Ruzyllo, W, Widimsky, P, Oto, A, Leiva-Pons, J, Pavlides, G, Winters, KJ, Roe, MT, and Bhatt, DL. "Prasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a secondary, prespecified analysis of the TRILOGY ACS trial." Lancet (London, England) 382, no. 9892 (August 2013): 605-613. Full Text
  - Chan, MY, Sun, J-L, Newby, LK, Lokhnygina, Y, White, HD, Moliterno, DJ, Théroux, P, Ohman, EM, Simoons, ML, Mahaffey, KW, Pieper, KS, Giugliano, RP, Armstrong, PW, Califf, RM, Van de Werf, F, and Harrington, RA. "Trends in clinical trials of non-ST-segment elevation acute coronary syndromes over 15 years." International Journal of Cardiology 167, no. 2 (July 2013): 548-554. (Review) Full Text
  - Chiu, SJ, Lokhnygina, Y, Dubis, AM, Dubra, A, Carroll, J, Izatt, JA, and Farsiu, S. "Automatic cone photoreceptor segmentation using graph theory and dynamic programming." Biomedical Optics Express 4, no. 6 (June 2013): 924-937. Full Text
  - Leonardi, S, Stebbins, A, Lopes, RD, Lokhnygina, Y, Todd, M, Bhatt, DL, Stone, GW, Lincoff, AM, Dauerman, HL, Gibson, CM, White, HD, Parikh, KH, Gruberg, L, Herrmann, HC, McLaurin, BT, Goodman, SG, and Mahaffey, KW. "Quantification of the effect of clopidogrel on enzymatic infarct size related to a percutaneous coronary intervention in patients with acute coronary syndromes: insights from the CHAMPION percutaneous coronary intervention trial." Coronary Artery Disease 24, no. 4 (June 2013): 321-327. Full Text
  - Piccini, JP, Stevens, SR, Lokhnygina, Y, Patel, MR, Halperin, JL, Singer, DE, Hankey, GJ, Hacke, W, Becker, RC, Nessel, CC, Mahaffey, KW, Fox, KAA, Califf, RM, Breithardt, G, and ROCKET AF Steering Committee & Investigators, . "Outcomes after cardioversion and atrial fibrillation ablation in patients treated with rivaroxaban and warfarin in the ROCKET AF trial." Journal of the American College of Cardiology 61, no. 19 (May 2013): 1998-2006. Full Text
  - Piccini, JP, White, JA, Mehta, RH, Lokhnygina, Y, Al-Khatib, SM, Tricoci, P, Califf, RM, Harrington, RA, Newby, LK, Pollack, CV, Montalescot, G, Van de Werf, F, Gibson, CM, and Giugliano, RP. "Response to letter regarding article, “sustained ventricular tachycardia and ventricular fibrillation complicating non–ST-segment elevation acute coronary syndromes”." Circulation 127, no. 20 (May 2013): e634-null. (Letter) Full Text
  - Ozment, CP, Mamo, LB, Campbell, ML, Lokhnygina, Y, Ghio, AJ, and Turi, JL. "Transfusion-related biologic effects and free hemoglobin, heme, and iron." Transfusion 53, no. 4 (April 2013): 732-740. Full Text Link to Item
  - Brooks, AJ, Lokhnygina, Y, Meade, CS, Potter, JS, Calsyn, DA, and Greenfield, SF. "Racial/ethnic differences in the rates and correlates of HIV risk behaviors among drug abusers." The American Journal on Addictions 22, no. 2 (March 2013): 136-147. Full Text
  - Singer, DE, Hellkamp, AS, Piccini, JP, Mahaffey, KW, Lokhnygina, Y, Pan, G, Halperin, JL, Becker, RC, Breithardt, G, Hankey, GJ, Hacke, W, Nessel, CC, Patel, MR, Califf, RM, Fox, KAA, and ROCKET AF Investigators, . "Impact of global geographic region on time in therapeutic range on warfarin anticoagulant therapy: data from the ROCKET AF clinical trial." Journal of the American Heart Association 2, no. 1 (February 19, 2013): e000067-null. Full Text
  - Patel, MR, Hellkamp, AS, Lokhnygina, Y, Piccini, JP, Zhang, Z, Mohanty, S, Singer, DE, Hacke, W, Breithardt, G, Halperin, JL, Hankey, GJ, Becker, RC, Nessel, CC, Berkowitz, SD, Califf, RM, Fox, KAA, and Mahaffey, KW. "Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: analysis from the ROCKET AF trial (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation)." Journal of the American College of Cardiology 61, no. 6 (February 2013): 651-658. Full Text
  - Bagai, A, White, JA, Lokhnygina, Y, Giugliano, RP, Werf, FVD, Montalescot, G, Armstrong, PW, Tricoci, P, Gibson, CM, Califf, RM, Harrington, RA, and Newby, LK. "Routine early eptifibatide versus delayed provisional use at percutaneous coronary intervention in high-risk non-ST-segment elevation acute coronary syndromes patients: An analysis from the Early Glycoprotein IIb/IIIa Inhibition in Non-ST-Segment Elevation Acute Coronary Syndrome trial." American Heart Journal 166, no. 3 (2013): 466-473.e1. Full Text
  - Chan, MY, Sun, J-L, Newby, LK, Lokhnygina, Y, White, HD, Moliterno, DJ, Théroux, P, Ohman, EM, Simoons, ML, Mahaffey, KW, Pieper, KS, Giugliano, RP, Armstrong, PW, Califf, RM, Werf, FVD, and Harrington, RA. "Trends in clinical trials of non-ST-segment elevation acute coronary syndromes over 15 years." International Journal of Cardiology 167, no. 2 (2013): 548-554. Full Text
  - Leonardi, S, Stebbins, A, Lopes, RD, Lokhnygina, Y, Todd, M, Bhatt, DL, Stone, GW, Lincoff, AM, Dauerman, HL, Gibson, CM, White, HD, Parikh, KH, Gruberg, L, Herrmann, HC, McLaurin, BT, Goodman, SG, and Mahaffey, KW. "Quantification of the effect of clopidogrel on enzymatic infarct size related to a percutaneous coronary intervention in patients with acute coronary syndromes: Insights from the CHAMPION percutaneous coronary intervention trial." Coronary Artery Disease 24, no. 4 (2013): 321-327. Full Text
  - Lopes, RD, Lokhnygina, Y, Hasselblad, V, Newby, KL, Yow, E, Granger, CB, Armstrong, PW, Hochman, JS, Mills, JS, Ruzyllo, W, and Mahaffey, KW. "Methods of creatine kinase-MB analysis to predict mortality in patients with myocardial infarction treated with reperfusion therapy." Trials 14 (January 2013): 123-null. Full Text Open Access Copy
  - Ozment, CP, Mamo, LB, Campbell, ML, Lokhnygina, Y, Ghio, AJ, and Turi, JL. "Transfusion-related biologic effects and free hemoglobin, heme, and iron." Transfusion 53, no. 4 (2013): 732-740. Full Text
  - Piccini, JP, Stevens, SR, Chang, Y, Singer, DE, Lokhnygina, Y, Go, AS, Patel, MR, Mahaffey, KW, Halperin, JL, Breithardt, G, Hankey, GJ, Hacke, W, Becker, RC, Nessel, CC, Fox, KAA, Califf, RM, and ROCKET AF Steering Committee and Investigators, . "Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts." Circulation 127, no. 2 (January 2013): 224-232. Full Text
  - Saxon, AJ, Ling, W, Hillhouse, M, Thomas, C, Hasson, A, Ang, A, Doraimani, G, Tasissa, G, Lokhnygina, Y, Leimberger, J, Bruce, RD, McCarthy, J, Wiest, K, McLaughlin, P, Bilangi, R, Cohen, A, Woody, G, and Jacobs, P. "Buprenorphine/Naloxone and methadone effects on laboratory indices of liver health: A randomized trial." Drug and Alcohol Dependence 128, no. 1-2 (2013): 71-76. Full Text
  - Prakalapakorn, SG, Freedman, SF, Lokhnygina, Y, Gandhi, NG, Holgado, S, Chen, BB, and El-Dairi, MA. "Longitudinal reproducibility of optical coherence tomography measurements in children." J AAPOS 16, no. 6 (December 2012): 523-528. Full Text Link to Item
  - Roe, MT, Armstrong, PW, Fox, KAA, White, HD, Prabhakaran, D, Goodman, SG, Cornel, JH, Bhatt, DL, Clemmensen, P, Martinez, F, Ardissino, D, Nicolau, JC, Boden, WE, Gurbel, PA, Ruzyllo, W, Dalby, AJ, McGuire, DK, Leiva-Pons, JL, Parkhomenko, A, Gottlieb, S, Topacio, GO, Hamm, C, Pavlides, G, Goudev, AR, Oto, A, Tseng, C-D, Merkely, B, Gasparovic, V, Corbalan, R, Cinteză, M, McLendon, RC, Winters, KJ, Brown, EB, Lokhnygina, Y, Aylward, PE, Huber, K, Hochman, JS, Ohman, EM, and TRILOGY ACS Investigators, . "Prasugrel versus clopidogrel for acute coronary syndromes without revascularization." The New England Journal of Medicine 367, no. 14 (October 2012): 1297-1309. Full Text
  - Piccini, JP, White, JA, Mehta, RH, Lokhnygina, Y, Al-Khatib, SM, Tricoci, P, Pollack, CV, Montalescot, G, Van de Werf, F, Gibson, CM, Giugliano, RP, Califf, RM, Harrington, RA, and Newby, LK. "Sustained ventricular tachycardia and ventricular fibrillation complicating non-ST-segment-elevation acute coronary syndromes." Circulation 126, no. 1 (July 2012): 41-49. Full Text
  - Jolicœur, EM, Sketch, MJ, Wojdyla, DM, Javaheri, SP, Nosib, S, Lokhnygina, Y, Patel, MR, Shaw, LK, and Tcheng, JE. "Percutaneous coronary interventions and cardiovascular outcomes for patients with chronic total occlusions." Catheter Cardiovasc Interv 79, no. 4 (March 1, 2012): 603-612. Full Text Link to Item
  - Mills, JS, Mahaffey, KW, Lokhnygina, Y, Nicolau, JC, Ruzyllo, W, Adams, PX, Todaro, TG, Armstrong, PW, Granger, CB, and CARDINAL investigators, . "Prediction of enzymatic infarct size in ST-segment elevation myocardial infarction." Coronary Artery Disease 23, no. 2 (March 2012): 118-125. Full Text
  - Roe, MT, White, JA, Kaul, P, Tricoci, P, Lokhnygina, Y, Miller, CD, van't Hof, AW, Montalescot, G, James, SK, Saucedo, J, Ohman, EM, Pollack, CV, Hochman, JS, Armstrong, PW, Giugliano, RP, Harrington, RA, Van de Werf, F, Califf, RM, and Newby, LK. "Regional patterns of use of a medical management strategy for patients with non-ST-segment elevation acute coronary syndromes: insights from the EARLY ACS Trial." Circulation. Cardiovascular Quality and Outcomes 5, no. 2 (March 2012): 205-213. Full Text
  - Saxon, AJ, Ling, W, Hillhouse, M, Thomas, C, Hasson, A, Ang, A, Doraimani, G, Tasissa, G, Lokhnygina, Y, Leimberger, J, and al, E. "Buprenorphine/Naloxone and methadone effects on laboratory indices of liver health: A randomized trial." Drug and Alcohol Dependence (2012). Full Text
  - Tricoci, P, Huang, Z, Held, C, Moliterno, DJ, Armstrong, PW, Van de Werf, F, White, HD, Aylward, PE, Wallentin, L, Chen, E, Lokhnygina, Y, Pei, J, Leonardi, S, Rorick, TL, Kilian, AM, Jennings, LHK, Ambrosio, G, Bode, C, Cequier, A, Cornel, JH, Diaz, R, Erkan, A, Huber, K, Hudson, MP, Jiang, L, Jukema, JW, Lewis, BS, Lincoff, AM, Montalescot, G, Nicolau, JC, Ogawa, H, Pfisterer, M, Prieto, JC, Ruzyllo, W, Sinnaeve, PR, Storey, RF, Valgimigli, M, Whellan, DJ, Widimsky, P, Strony, J, Harrington, RA, Mahaffey, KW, and TRACER Investigators, . "Thrombin-receptor antagonist vorapaxar in acute coronary syndromes." The New England Journal of Medicine 366, no. 1 (January 2012): 20-33. Full Text
  - Mahaffey, KW, Pieper, KS, Lokhnygina, Y, Califf, RM, Antman, EM, Kleiman, NS, Goodman, SG, White, HD, Rao, SV, Hochman, JS, Cohen, M, Col, JJ, Roe, MT, Ferguson, JJ, and SYNERGY Investigators, . "The impact of postrandomization crossover of therapy in acute coronary syndromes care." Circulation. Cardiovascular Quality and Outcomes 4, no. 2 (March 2011): 211-219. Full Text
  - Brooks, A, Meade, CS, Potter, JS, Lokhnygina, Y, Calsyn, DA, and Greenfield, SF. "Gender differences in the rates and correlates of HIV risk behaviors among drug abusers." Substance Use & Misuse 45, no. 14 (December 2010): 2444-2469. Full Text
  - Hursting, MJ, Pai, PJ, McCracken, JE, Hwang, F, Suvarna, S, Lokhnygina, Y, Bandarenko, N, and Arepally, GM. "Platelet factor 4/heparin antibodies in blood bank donors." American Journal of Clinical Pathology 134, no. 5 (November 2010): 774-780. Full Text
  - Tillmann, HL, Thompson, AJ, Patel, K, Wiese, M, Tenckhoff, H, Nischalke, HD, Lokhnygina, Y, Kullig, U, Göbel, U, Capka, E, Wiegand, J, Schiefke, I, Güthoff, W, Grüngreiff, K, König, I, Spengler, U, McCarthy, J, Shianna, KV, Goldstein, DB, McHutchison, JG, Timm, J, Nattermann, J, and German Anti-D Study Group, . "A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice." Gastroenterology 139, no. 5 (November 2010): 1586-1592.e1. Full Text
  - Chin, CT, Roe, MT, Fox, KAA, Prabhakaran, D, Marshall, DA, Petitjean, H, Lokhnygina, Y, Brown, E, Armstrong, PW, White, HD, Ohman, EM, and TRILOGY ACS Steering Committee, . "Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial." American Heart Journal 160, no. 1 (July 2010): 16-22.e1. Full Text
  - Califf, RM, Lokhnygina, Y, Cannon, CP, Stepanavage, ME, McCabe, CH, Musliner, TA, Pasternak, RC, Blazing, MA, Giugliano, RP, Harrington, RA, and Braunwald, E. "An update on the IMProved reduction of outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design." American Heart Journal 159, no. 5 (May 2010): 705-709. Full Text
  - Unroe, KT, Pfeiffenberger, T, Riegelhaupt, S, Jastrzembski, J, Lokhnygina, Y, and Colón-Emeric, C. "Inpatient medication reconciliation at admission and discharge: A retrospective cohort study of age and other risk factors for medication discrepancies." The American Journal of Geriatric Pharmacotherapy 8, no. 2 (April 2010): 115-126. Full Text
  - Carter-Edwards, L, Bastian, LA, Revels, J, Durham, H, Lokhnygina, Y, Amamoo, MA, and Ostbye, T. "Body image and body satisfaction differ by race in overweight postpartum mothers." Journal of Women'S Health 19, no. 2 (February 2010): 305-311. Full Text Open Access Copy
  - Railey, MD, Lokhnygina, Y, and Buckley, RH. "Long-term clinical outcome of patients with severe combined immunodeficiency who received related donor bone marrow transplants without pretransplant chemotherapy or post-transplant GVHD prophylaxis." J Pediatr 155, no. 6 (December 2009): 834-840.e1. Full Text Link to Item
  - Hofmann, AM, Scurlock, AM, Jones, SM, Palmer, KP, Lokhnygina, Y, Steele, PH, Kamilaris, J, and Burks, AW. "Safety of a peanut oral immunotherapy protocol in children with peanut allergy." The Journal of Allergy and Clinical Immunology 124, no. 2 (August 2009): 286-291.e6. Full Text
  - Califf, RM, Lokhnygina, Y, Velazquez, EJ, McMurray, JJV, Leimberger, JD, Lewis, EF, Diaz, R, Murin, J, and Pfeffer, MA. "Usefulness of beta blockers in high-risk patients after myocardial infarction in conjunction with captopril and/or valsartan (from the VALsartan In Acute Myocardial Infarction [VALIANT] trial)." The American Journal of Cardiology 104, no. 2 (July 2009): 151-157. Full Text
  - Kandzari, DE, Rao, SV, Moses, JW, Dzavik, V, Strauss, BH, Kutryk, MJ, Simonton, CA, Garg, J, Lokhnygina, Y, Mancini, GBJ, Yeoh, E, Buller, CE, and ACROSS/TOSCA-4 Investigators, . "Clinical and angiographic outcomes with sirolimus-eluting stents in total coronary occlusions: the ACROSS/TOSCA-4 (Approaches to Chronic Occlusions With Sirolimus-Eluting Stents/Total Occlusion Study of Coronary Arteries-4) trial." JACC Cardiovasc Interv 2, no. 2 (February 2009): 97-106. Full Text Link to Item
  - Lokhnygina, Y, and Tsiatis, AA. "Optimal two-stage group-sequential designs." Journal of Statistical Planning and Inference 138, no. 2 (February 1, 2008): 489-499. Full Text
  - Thomas, KL, Al-Khatib, SM, Lokhnygina, Y, Solomon, SD, Kober, L, McMurray, JJV, Califf, RM, and Velazquez, EJ. "Amiodarone use after acute myocardial infarction complicated by heart failure and/or left ventricular dysfunction may be associated with excess mortality." American Heart Journal 155, no. 1 (January 2008): 87-93. Full Text
  - Tricoci, P, Lokhnygina, Y, Berdan, LG, Steinhubl, SR, Gulba, DC, White, HD, Kleiman, NS, Aylward, PE, Langer, A, Califf, RM, Ferguson, JJ, Antman, EM, Newby, LK, Harrington, RA, Goodman, SG, and Mahaffey, KW. "Time to coronary angiography and outcomes among patients with high-risk non ST-segment elevation acute coronary syndromes: results from the SYNERGY trial." Circulation 116, no. 23 (December 2007): 2669-2677. Full Text
  - Hasselblad, V, Gattis Stough, W, Shah, MR, Lokhnygina, Y, O'Connor, CM, Califf, RM, and Adams, KF. "Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial." European Journal of Heart Failure 9, no. 10 (October 2007): 1064-1069. Full Text
  - Mehta, RH, Greenbaum, AB, Lokhnygina, Y, Newby, LK, Van De Werf, F, Armstrong, PW, Pieper, KS, Califf, RM, Granger, CB, and Harrington, RA. "Timing of death and myocardial infarction in patients with non-ST elevation acute coronary syndromes: insights from randomized clinical trials." Journal of Interventional Cardiology 20, no. 5 (October 2007): 299-306. Full Text
  - Lokhnygina, Y, and Helterbrand, JD. "Cox regression methods for two-stage randomization designs." Biometrics 63, no. 2 (June 2007): 422-428. Full Text
  - Sampson, UK, Pfeffer, MA, McMurray, JJV, Lokhnygina, Y, White, HD, Solomon, SD, and VALIANT Trial Investigators, . "Predictors of stroke in high-risk patients after acute myocardial infarction: insights from the VALIANT Trial." Eur Heart J 28, no. 6 (March 2007): 685-691. Full Text Link to Item
  - Barnhart, HX, Lokhnygina, Y, Kosinski, AS, and Haber, M. "Comparison of concordance correlation coefficient and coefficient of individual agreement in assessing agreement." J Biopharm Stat 17, no. 4 (2007): 721-738. Full Text Link to Item
  - Hasselblad, V, Lokhnygina, Y, and Krucoff, MW. "Discussion of: Statistical and regulatory issues with the application of propensity score analysis to nonrandomized medical device clinical studies." Journal of Biopharmaceutical Statistics 17, no. 1 (January 1, 2007): 19-21. Full Text
  - Hasselblad, V, and Lokhnygina, Y. "Tests for 2 × 2 tables in clinical trials." Journal of Modern Applied Statistical Methods 6, no. 2 (January 1, 2007): 456-468. Full Text
  - Niewoehner, DE, Lokhnygina, Y, Rice, K, Kuschner, WG, Sharafkhaneh, A, Sarosi, GA, Krumpe, P, Pieper, K, and Kesten, S. "Risk indexes for exacerbations and hospitalizations due to COPD." Chest 131, no. 1 (January 2007): 20-28. Full Text Link to Item
  - White, HD, Kleiman, NS, Mahaffey, KW, Lokhnygina, Y, Pieper, KS, Chiswell, K, Cohen, M, Harrington, RA, Chew, DP, Petersen, JL, Berdan, LG, Aylward, PEG, Nessel, CC, Ferguson, JJ, and Califf, RM. "Efficacy and safety of enoxaparin compared with unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention in the Superior Yield of the New Strategy of Enoxaparin, Revascularization and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial." American Heart Journal 152, no. 6 (December 2006): 1042-1050. Full Text
  - Lokhnygina, Y. "Discussion of the "Executive Summary of the PhRMA Working Group on adaptive designs in clinical drug development"." Journal of Biopharmaceutical Statistics 16, no. 3 (May 1, 2006): 287-288. Full Text
- Conference Papers
  - Washam, JB, Hellkamp, AS, Lokhnygina, Y, Piccini, JP, Berkowitz, SD, Nessel, CC, Becker, RC, Breithardt, G, Fox, KAA, Halperin, JL, Hankey, GJ, Mahaffey, KW, Singer, DE, Patel, MR, and ROCKET AF Steering Committee and Investigators, . "Efficacy and Safety of Rivaroxaban Versus Warfarin in Patients Taking Nondihydropyridine Calcium Channel Blockers for Atrial Fibrillation (from the ROCKET AF Trial)." August 2017. Full Text
  - Farhan, S, Clare, RM, Jarai, R, Giugliano, RP, Lokhnygina, Y, Harrington, RA, Kristin Newby, L, and Huber, K. "Fasting glucose, NT-proBNP, treatment with eptifibatide, and outcomes in non-ST-segment elevation acute coronary syndromes: An analysis from EARLY ACS." April 2017. Full Text
  - Ilowite, NT, Prather, K, Lokhnygina, Y, Schanberg, LE, Elder, M, Milojevic, D, Verbsky, JW, Spalding, SJ, Kimura, Y, Imundo, LF, Punaro, MG, Sherry, DD, Tarvin, SE, Zemel, LS, Birmingham, JD, Gottlieb, BS, Miller, ML, O'Neil, K, Ruth, NM, Wallace, CA, Singer, NG, and Sandborg, CI. "Randomized, double-blind, placebo-controlled trial of the efficacy and safety of rilonacept in the treatment of systemic juvenile idiopathic arthritis." September 2014. Full Text
  - Piccini, JP, Hellkamp, AS, Lokhnygina, Y, Patel, MR, Harrell, FE, Singer, DE, Becker, RC, Breithardt, G, Halperin, JL, Hankey, GJ, Berkowitz, SD, Nessel, CC, Mahaffey, KW, Fox, KAA, and Califf, RM. "Relationship between time in therapeutic range and comparative treatment effect of rivaroxaban and warfarin: Results from the ROCKET AF trial." January 1, 2014. Full Text

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