Scholars@Duke

• Research
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  Selected Grants

  • Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic context awarded by National Institutes of Health 2020 - 2025
  • Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseases awarded by National Institutes of Health 2020 - 2025
  • ApoE2 and protective molecular signatures in Alzheimer's disease and aging awarded by National Institutes of Health 2018 - 2023
  • Life Course and Genetic and Non-genetic Factors in Health and Survival awarded by National Institutes of Health 2015 - 2021
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Loika, Yury, Fan Feng, Elena Loiko, and Alexander M. Kulminski. “Mediation of the APOE associations with Alzheimer's and coronary heart diseases through body mass index and lipids.” Geroscience 44, no. 2 (April 2022): 1141–56. https://doi.org/10.1007/s11357-021-00458-3.
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    • Loika, Yury, Irina Irincheeva, Irina Culminskaya, Alireza Nazarian, and Alexander M. Kulminski. “Polygenic risk scores: pleiotropy and the effect of environment.” Geroscience 42, no. 6 (December 2020): 1635–47. https://doi.org/10.1007/s11357-020-00203-2.
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    • Kulminski, Alexander M., Yelena Kernogitski, Irina Culminskaya, Yury Loika, Konstantin G. Arbeev, Olivia Bagley, Matt Duan, et al. “Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits.” Aging Cell 16, no. 1 (February 2017): 61–72. https://doi.org/10.1111/acel.12526.
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    • Kulminski, Alexander M., Liang He, Irina Culminskaya, Yury Loika, Yelena Kernogitski, Konstantin G. Arbeev, Elena Loiko, et al. “Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.” Plos Genetics 12, no. 11 (November 10, 2016): e1006314. https://doi.org/10.1371/journal.pgen.1006314.
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    • Kulminski, Alexander M., Yury Loika, Irina Culminskaya, Konstantin G. Arbeev, Svetlana V. Ukraintseva, Eric Stallard, and Anatoliy I. Yashin. “Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency.” Scientific Reports 6 (October 14, 2016): 35390. https://doi.org/10.1038/srep35390.
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    • He, Liang, Yelena Kernogitski, Irina Kulminskaya, Yury Loika, Konstantin G. Arbeev, Elena Loiko, Olivia Bagley, et al. “Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.” Frontiers in Genetics 7 (January 2016): 179. https://doi.org/10.3389/fgene.2016.00179.
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  • Conference Papers

    • Loika, Y., Y. Kernogitski, I. Culminskaya, L. He, J. Huang, E. Loiko, and A. Kulminski. “Extensive Pleiotropy with Age-Related Disease Traits: The Candidate Gene Association Resource.” In Gerontologist, Vol. 56. OXFORD UNIV PRESS INC, 2016.
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    • “GENETIC PREDISPOSITION TO AGE-RELATED PHENOTYPES IN THE LIGHT OF EVOLUTION.” In The Gerontologist, 56:49–49. Oxford University Press (OUP), 2016. https://doi.org/10.1093/geront/gnw162.204.
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    • “PLEIOTROPIC META-ANALYSIS IDENTIFIES SHARED GENETIC CONNECTIONS BETWEEN DISTINCT AGE-RELATED TRAITS.” In The Gerontologist, 56:251–251. Oxford University Press (OUP), 2016. https://doi.org/10.1093/geront/gnw162.1006.
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    • “A NOVEL ALLELIC VARIANT IN A 2Q22 REGION CONFERS RISKS OF MAJOR HUMAN DISEASES AND MORTALITY.” In The Gerontologist, 56:266–266. Oxford University Press (OUP), 2016. https://doi.org/10.1093/geront/gnw162.1072.
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    • Kulminski, Alexander M., Yury Loika, Irina Culminskaya, Konstantin G. Arbeev, and Anatoliy I. Yashin. “Unfolding heterogeneity of complex traits has strong potential for advancing GWAS.” In Genetic Epidemiology, 39:562–562. WILEY-BLACKWELL, 2015.
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    • “PLEIOTROPIC EFFECTS OF GENES ON AGE-RELATED PHENOTYPES: INSIGHTS FROM GERONTOLOGICAL APPROACHES.” In The Gerontologist, 55:460–61. Oxford University Press (OUP), 2015. https://doi.org/10.1093/geront/gnv195.07.
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