Current Appointments & Affiliations
Research Scientist, Senior
Center for Population Health & Aging,
Duke Population Research Institute
Recent Publications
Exogenous exposures shape genetic predisposition to lipids, Alzheimer's, and coronary heart disease in the MLXIPL gene locus.
Journal Article Aging · April 2023 Associations of single nucleotide polymorphisms (SNPs) of the MLXIPL lipid gene with Alzheimer's (AD) and coronary heart disease (CHD) and potentially causal mediation effects of their risk factors, high-density lipoprotein cholesterol (HDL-C) and t ... Full text CiteAPOE ɛ4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages.
Journal Article Aging cell · December 2022 Age-related diseases characteristic of post-reproductive life, aging, and life span are the examples of polygenic non-Mendelian traits with intricate genetic architectures. Polygenicity of these traits implies that multiple variants can impact their risks ... Full text CiteGenome-wide analysis identified abundant genetic modulators of contributions of the apolipoprotein E alleles to Alzheimer's disease risk.
Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · November 2022 IntroductionThe apolipoprotein E (APOE) ε2 and ε4 alleles have beneficial and adverse impacts on Alzheimer's disease (AD), respectively, with incomplete penetrance, which may be modulated by other genetic variants.MethodsWe examined wheth ... Full text CiteRecent Grants
Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic context
ResearchStatistician · Awarded by National Institutes of Health · 2020 - 2026Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseases
ResearchStatistician · Awarded by National Institute on Aging · 2020 - 2026ApoE2 and protective molecular signatures in Alzheimer's disease and aging
ResearchStatistician · Awarded by National Institutes of Health · 2018 - 2025View All Grants