Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Post Doctoral Fellow, Md Anderson Cancer Center, University of Texas Medical School at Houston 2010 - 2012
  • Post-Doctoral Fellow, Duke University 2006 - 2010
  • Ph.D., Duke University 2006
• 

  Duke Appointment History

  • Instructor, Temporary in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2012
• Research
• 

  Selected Grants

  • Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2021
  • A Neoepitope Subunit Vaccine Targeting the Mutated Estrogen Receptor Ligand Binding Domain to Treat and Prevent Endocrine Resistant ER+ Breast Cancer awarded by Department of Defense 2018 - 2021
  • Oncogenic Signaling Networks awarded by Department of Defense 2012 - 2020
  • Immunotherapeutic Targeting of a Therapy Resistant Oncogenic HER2 Isoform awarded by Susan G. Komen Breast Cancer Foundation 2017 - 2020
  • Study of LAMP Vaccines in HER2+ Breast Cancer awarded by Immunomic Therapeutics, Inc. 2017 - 2019
  • Investigating Adaptive Immune Recognition of Dormant Disseminated Tumor Cells awarded by Fred Hutchinson Cancer Research Center 2017 - 2019
  • Mechanisms of Action and Resistance to PD-1 Immunotherapies in Breast Cancer awarded by Merck 2017 - 2018
  • Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Crosby, EJ, Gwin, W, Blackwell, K, Marcom, PK, Chang, S, Maecker, HT, Broadwater, G, Hyslop, T, Kim, S, Rogatko, A, Lubkov, V, Snyder, JC, Osada, T, Hobeika, AC, Morse, MA, Lyerly, HK, and Hartman, ZC. "Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 25, no. 9 (May 2019): 2725-2736.  Full Text  Open Access Copy
    • Lyerly, HK, Osada, T, and Hartman, ZC. "Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 25, no. 1 (January 2019): 9-11.  Full Text
    • Osada, T, Hartman, ZC, Wei, J, Lei, G, Hobeika, AC, Gwin, WR, Diniz, MA, Spector, N, Clay, TM, Chen, W, Morse, MA, and Lyerly, HK. "Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers." Breast Cancer Research : Bcr 20, no. 1 (August 9, 2018): 90-null.  Full Text
    • Crosby, EJ, Wei, J, Yang, XY, Lei, G, Wang, T, Liu, C-X, Agarwal, P, Korman, AJ, Morse, MA, Gouin, K, Knott, SRV, Lyerly, HK, and Hartman, ZC. "Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors." Oncoimmunology 7, no. 5 (January 19, 2018): e1421891-null.  Full Text
    • Osada, T, Kaneko, K, Gwin, WR, Morse, MA, Hobeika, A, Pogue, BW, Hartman, ZC, Hughes, PF, Haystead, T, and Lyerly, HK. "In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 23, no. 24 (December 2017): 7531-7542.  Full Text
    • Shuptrine, CW, Ajina, R, Fertig, EJ, Jablonski, SA, Kim Lyerly, H, Hartman, ZC, and Weiner, LM. "An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection." Cancer immunology, immunotherapy : CII 66, no. 12 (December 2017): 1529-1544.  Full Text
    • Osada, T, Morse, MA, Hobeika, A, Diniz, MA, Gwin, WR, Hartman, Z, Wei, J, Guo, H, Yang, X-Y, Liu, C-X, Kaneko, K, Broadwater, G, and Lyerly, HK. "Vaccination targeting human HER3 alters the phenotype of infiltrating T cells and responses to immune checkpoint inhibition." Oncoimmunology 6, no. 6 (January 2017): e1315495-null.  Full Text
    • Ren, J, Gwin, WR, Zhou, X, Wang, X, Huang, H, Jiang, N, Zhou, L, Agarwal, P, Hobeika, A, Crosby, E, Hartman, ZC, Morse, MA, H Eng, K, and Lyerly, HK. "Adaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy." Oncoimmunology 6, no. 4 (January 2017): e1264563-null.  Full Text
    • Turpin, J, Ling, C, Crosby, EJ, Hartman, ZC, Simond, AM, Chodosh, LA, Rennhack, JP, Andrechek, ER, Ozcelik, J, Hallett, M, Mills, GB, Cardiff, RD, Gray, JW, Griffith, OL, and Muller, WJ. "The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment." Oncogene 35, no. 47 (November 2016): 6053-6064.  Full Text
    • Mazumdar, A, Poage, GM, Shepherd, J, Tsimelzon, A, Hartman, ZC, Den Hollander, P, Hill, J, Zhang, Y, Chang, J, Hilsenbeck, SG, Fuqua, S, Kent Osborne, C, Mills, GB, and Brown, PH. "Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion." Breast cancer research and treatment 158, no. 3 (August 2016): 441-454.  Full Text
    • Zhao, J, Zhao, D, Poage, GM, Mazumdar, A, Zhang, Y, Hill, JL, Hartman, ZC, Savage, MI, Mills, GB, and Brown, PH. "Death-associated protein kinase 1 promotes growth of p53-mutant cancers." The Journal of Clinical Investigation 125, no. 7 (July 2015): 2707-2720.  Full Text
    • Osada, T, Nagaoka, K, Takahara, M, Yang, XY, Liu, C-X, Guo, H, Roy Choudhury, K, Hobeika, A, Hartman, Z, Morse, MA, and Lyerly, HK. "Precision cancer immunotherapy: optimizing dendritic cell-based strategies to induce tumor antigen-specific T-cell responses against individual patient tumors." Journal of Immunotherapy (Hagerstown, Md. : 1997) 38, no. 4 (May 2015): 155-164.  Full Text
    • Barrott, JJ, Hughes, PF, Osada, T, Yang, X-Y, Hartman, ZC, Loiselle, DR, Spector, NL, Neckers, L, Rajaram, N, Hu, F, Ramanujam, N, Vaidyanathan, G, Zalutsky, MR, Lyerly, HK, and Haystead, TA. "Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells." Chem Biol 20, no. 9 (September 19, 2013): 1187-1197.  Full Text  Link to Item
    • Hartman, ZC, Poage, GM, den Hollander, P, Tsimelzon, A, Hill, J, Panupinthu, N, Zhang, Y, Mazumdar, A, Hilsenbeck, SG, Mills, GB, and Brown, PH. "Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8." Cancer Research 73, no. 11 (June 2013): 3470-3480.  Full Text
    • Poage, GM, Hartman, ZC, and Brown, PH. "Revealing targeted therapeutic opportunities in triple-negative breast cancers: A new strategy." Cell Cycle 12, no. 17 (2013): 2705-2706.  Full Text
    • Kessler, JD, Kahle, KT, Sun, T, Meerbrey, KL, Schlabach, MR, Schmitt, EM, Skinner, SO, Xu, Q, Li, MZ, Hartman, ZC, Rao, M, Yu, P, Dominguez-Vidana, R, Liang, AC, Solimini, NL, Bernardi, RJ, Yu, B, Hsu, T, Golding, I, Luo, J, Osborne, CK, Creighton, CJ, Hilsenbeck, SG, Schiff, R, Shaw, CA, Elledge, SJ, and Westbrook, TF. "A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis." Science 335, no. 6066 (January 20, 2012): 348-353.  Full Text
    • Hartman, ZC, Wei, J, Glass, OK, Guo, H, Lei, G, Yang, X-Y, Osada, T, Hobeika, A, Delcayre, A, Le Pecq, J-B, Morse, MA, Clay, TM, and Lyerly, HK. "Increasing vaccine potency through exosome antigen targeting." Vaccine 29, no. 50 (November 2011): 9361-9367.  Full Text
    • Xia, W, Liu, Z, Zong, R, Liu, L, Zhao, S, Bacus, SS, Mao, Y, He, J, Wulfkuhle, JD, Petricoin, EF, Osada, T, Yang, X-Y, Hartman, ZC, Clay, TM, Blackwell, KL, Lyerly, HK, and Spector, NL. "Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors." Molecular Cancer Therapeutics 10, no. 8 (August 2011): 1367-1374.  Full Text
    • Hartman, ZC, Yang, X-Y, Glass, O, Lei, G, Osada, T, Dave, SS, Morse, MA, Clay, TM, and Lyerly, HK. "HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis." Cancer Research 71, no. 13 (July 2011): 4380-4391.  Full Text
    • Clay, TM, Osada, T, Hartman, ZC, Hobeika, A, Devi, G, Morse, MA, and Lyerly, HK. "Polyclonal immune responses to antigens associated with cancer signaling pathways and new strategies to enhance cancer vaccines." Immunologic Research 49, no. 1-3 (April 2011): 235-247.  Full Text
    • Hartman, ZC, Osada, T, Glass, O, Yang, XY, Lei, G-J, Lyerly, HK, and Clay, TM. "Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity." Cancer Research 70, no. 18 (September 7, 2010): 7209-7220.  Full Text
    • Gabitzsch, ES, Xu, Y, Balint, JP, Hartman, ZC, Lyerly, HK, and Jones, FR. "Anti-tumor immunotherapy despite immunity to adenovirus using a novel adenoviral vector Ad5 [E1-, E2b-]-CEA." Cancer Immunology, Immunotherapy : Cii 59, no. 7 (July 2010): 1131-1135.  Full Text
    • Morse, MA, Wei, J, Hartman, Z, Xia, W, Ren, X-R, Lei, G, Barry, WT, Osada, T, Hobeika, AC, Peplinski, S, Jiang, H, Devi, GR, Chen, W, Spector, N, Amalfitano, A, Lyerly, HK, and Clay, TM. "Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo." International Journal of Cancer 126, no. 12 (June 2010): 2893-2903.  Full Text
    • Hartman, ZC, Wei, J, Osada, T, Glass, O, Lei, G, Yang, X-Y, Peplinski, S, Kim, D-W, Xia, W, Spector, N, Marks, J, Barry, W, Hobeika, A, Devi, G, Amalfitano, A, Morse, MA, Lyerly, HK, and Clay, TM. "An adenoviral vaccine encoding full-length inactivated human Her2 exhibits potent immunogenicty and enhanced therapeutic efficacy without oncogenicity." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 16, no. 5 (March 2010): 1466-1477.  Full Text
    • Seregin, SS, Aldhamen, YA, Appledorn, DM, Hartman, ZC, Schuldt, NJ, Scott, J, Godbehere, S, Jiang, H, Frank, MM, and Amalfitano, A. "Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo." Blood 116, no. 10 (2010): 1669-1677.  Full Text
    • Seregin, SS, Hartman, ZC, Appledorn, DM, Godbehere, S, Jiang, H, Frank, MM, and Amalfitano, A. "Novel adenovirus vectors 'Capsid-Displaying' a human complement inhibitor." Journal of Innate Immunity 2, no. 4 (2010): 353-359.  Full Text
    • Osada, T, Yang, XY, Hartman, ZC, Glass, O, Hodges, BL, Niedzwiecki, D, Morse, MA, Lyerly, HK, Amalfitano, A, and Clay, TM. "Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity." Cancer Gene Ther 16, no. 9 (September 2009): 673-682.  Full Text  Link to Item
    • Osada, T, Woo, CY, McKinney, M, Yang, XY, Lei, G, Labreche, HG, Hartman, ZC, Niedzwiecki, D, Chao, N, Amalfitano, A, Morse, MA, Lyerly, HK, and Clay, TM. "Induction of Wilms' tumor protein (WT1)-specific antitumor immunity using a truncated WT1-expressing adenovirus vaccine." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 15, no. 8 (April 7, 2009): 2789-2796.  Full Text
    • Cohen, TJ, Barrientos, T, Hartman, ZC, Garvey, SM, Cox, GA, and Yao, T-P. "The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 23, no. 1 (January 2009): 99-106.  Full Text
    • Hartman, ZC, Appledorn, DM, Serra, D, Glass, O, Mendelson, TB, Clay, TM, and Amalfitano, A. "Replication-attenuated Human Adenoviral Type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system." Virology 374, no. 2 (May 2008): 453-467.  Full Text
    • Hartman, ZC, Appledorn, DM, and Amalfitano, A. "Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications." Virus Research 132, no. 1-2 (March 2008): 1-14. (Review)  Full Text
    • Hartman, ZC, Black, EP, and Amalfitano, A. "Adenoviral infection induces a multi-faceted innate cellular immune response that is mediated by the toll-like receptor pathway in A549 cells." Virology 358, no. 2 (February 2007): 357-372.  Full Text
    • Hartman, ZC, Kiang, A, Everett, RS, Serra, D, Yang, XY, Clay, TM, and Amalfitano, A. "Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo." Journal of Virology 81, no. 4 (February 2007): 1796-1812.  Full Text
    • Kiang, A, Hartman, ZC, Everett, RS, Serra, D, Jiang, H, Frank, MM, and Amalfitano, A. "Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system." Molecular Therapy : the Journal of the American Society of Gene Therapy 14, no. 4 (October 2006): 588-598.  Full Text
    • Kiang, A, Hartman, ZC, Liao, S, Xu, F, Serra, D, Palmer, DJ, Ng, P, and Amalfitano, A. "Fully deleted adenovirus persistently expressing GAA accomplishes long-term skeletal muscle glycogen correction in tolerant and nontolerant GSD-II mice." Mol Ther 13, no. 1 (January 2006): 127-134.  Full Text  Link to Item

  • Conference Papers

    • Crosby, EJ, Lei, G, Wei, J, Yang, XY, Wang, T, Liu, C-X, Lyerly, HK, and Hartman, ZC. "Abstract A22: Augmentation of a novel adenoviral vaccine strategy by checkpoint inhibitors." Abstracts: AACR Special Conference on Tumor Immunology and Immunotherapy; October 1-4, 2017; Boston, MA.: American Association for Cancer Research, September 2018.  Full Text
    • Crosby, EJ, Wei, J, Yang, XY, Lei, G, Wang, T, Liu, C-X, Agarwal, P, Lyerly, HK, and Hartman, ZC. "Abstract A38: Checkpoint blockade elicits unique T cell expansion to promote tumor regression." Abstracts: AACR Special Conference on Tumor Immunology and Immunotherapy; October 20-23, 2016; Boston, MA.: American Association for Cancer Research, March 2017.  Full Text
    • Hartman, Z, Crosby, E, Wei, J-P, Yang, X-Y, Lei, G-J, Wang, T, Liu, C-X, Agarwal, P, Morse, M, and Lyerly, H. "Abstract P2-04-27: CTLA-4 and PD-1 checkpoint inhibitors enhance individually tailored adaptive anti-tumor immune responses to overcome tumor immunosuppression and effectively treat triple-negative breast cancer." February 15, 2017.  Full Text
    • Kessler, JD, Kahle, KT, Sun, T, Meerbrey, KL, Schlabach, MR, Schmitt, EM, Skinner, SO, Xu, Q, Li, MZ, Hartman, ZC, Rao, M, Yu, P, Dominguez-Vidana, R, Liang, AC, Solimin, NL, Bernardi, RJ, Yu, B, Hsu, T, Golding, I, Luo, J, Osborne, CK, Creighton, C, Hilsenbeck, SG, Schiff, R, Shaw, CA, Elledge, SJ, and Westbrook, TF. "A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis." April 15, 2012.  Full Text  Link to Item
    • Seregin, SS, Hartman, ZC, Appledorn, DM, Aldhamen, YA, Schuldt, NJ, Bujold, M, Godbehere, S, and Amalfitano, A. "Improved Safety Profile of Novel Adenovirus Based Vectors "Capsid-displaying" Complement Inhibitors: Increased Potential for Cardiovascular Gene Transfer Applications." November 3, 2009.  Link to Item
    • Osada, T, Labreche, H, Hartman, ZC, Serra, D, Morse, MA, Lyerly, HK, Amalfitano, A, and Clay, TM. "Replication-competent packaging-deficient [E1+, 100k-] adenoviral vector-transduced dendritic cells can efficiently induce antigen-specific immune responses." : AMER ASSOC CANCER RESEARCH, April 1, 2006.  Link to Item
    • Woo, CY, Osada, T, Yang, XY, Lei, G, McKinney, M, Labreche, H, Hartman, ZC, Amalfitano, A, Morse, MA, Lyerlyand, HK, and Clay, TM. "Induction of Wilms' tumor protein (WT1)-specific immunity using a WT1-expressing adenovirus vaccine." : AMER ASSOC CANCER RESEARCH, April 1, 2006.  Link to Item
    • Hartman, ZC, Mendelson, T, and Amalfitano, A. "19. A New, Plasmid-Based Adenoviral Vectoring System Derived from the Highly Immunogenic, Human Ad4 Strain." 2006.  Full Text
• Teaching & Mentoring
• 

  Recent Courses

  • PATHOL 793: Research Independent Study 2019

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