Scholars@Duke
Darryl Craig Zeldin

Darryl Craig Zeldin

Adjunct Professor in the Department of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
zeldin@niehs.nih.gov
NIEHS Box 12233, RTP, NC 27709

Selected Publications

CYP2C29 monooxygenase promotes CDAA-HFD-induced liver fibrosis.

Journal Article Free Radic Biol Med · November 19, 2025 Cytochrome P450 (CYP) monooxygenases (predominately the CYP2C and CYP2J isoforms) catalyze the oxidative metabolism of polyunsaturated fatty acids to generate epoxy fatty acids (EpFAs) and fatty acid diols, which are bioactive lipid signaling molecules tha ... Full text Link to item Cite

The gut microbiota mediates epoxy eicosanoid metabolism in the colon.

Journal Article J Biol Chem · July 2025 The metabolism of polyunsaturated fatty acids by cytochrome P450 (CYP) mono-oxygenases generates fatty acid epoxides, which are endogenous lipid mediators with potent actions to regulate inflammation, immune responses, vascular tone, and other critical bio ... Full text Link to item Cite

Serum antioxidant vitamins and respiratory morbidity and mortality: a pooled analysis.

Journal Article Respir Res · June 9, 2022 BACKGROUND: Oxidative stress plays a key role in the pathogenesis of respiratory diseases; however, studies on antioxidant vitamins and respiratory outcomes have been conflicting. We evaluated whether lower serum levels of vitamins A, C, D, and E are assoc ... Full text Link to item Cite

Role of linoleic acid-derived oxylipins in cancer.

Journal Article Cancer Metastasis Rev · September 2020 Full text Link to item Cite

Association of urinary levels of bisphenols F and S used as bisphenol A substitutes with asthma and hay fever outcomes.

Journal Article Environ Res · April 2020 BACKGROUND: Bisphenols F (BPF) and S (BPS) are bisphenol A (BPA) analogs used as substitutes in consumer products. Despite previous reports of BPA's association with asthma, no studies have examined its structural analogs in relation to asthma and allergy ... Full text Link to item Cite

Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene.

Journal Article J Autoimmun · February 2020 BACKGROUND: Because immune responses are sensitive to environmental changes that drive selection of genetic variants, we hypothesized that polymorphisms of some xenobiotic response and immune response genes may be associated with specific types of immune-m ... Full text Link to item Cite

Vascular characterization of mice with endothelial expression of cytochrome P450 4F2.

Journal Article FASEB J · July 2014 Cytochrome P450 (CYP) 4A and 4F enzymes metabolize arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). Although CYP4A-derived 20-HETE is known to have prohypertensive and proangiogenic properties, the effects of CYP4F-derived metabolites are not ... Full text Link to item Cite

Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide.

Journal Article Am J Respir Cell Mol Biol · October 2001 Bacterial lipopolysaccharide (LPS) is a risk factor for exacerbation of asthma and causes airway inflammation. The aim of this study was to examine the effects of disruption of prostaglandin (PG) H synthase (PGHS)-1 and PGHS-2 genes on pulmonary responses ... Full text Link to item Cite

CYP2J subfamily cytochrome P450s in the gastrointestinal tract: expression, localization, and potential functional significance.

Journal Article Mol Pharmacol · June 1997 Our laboratory recently described a new human cytochrome P450 arachidonic acid epoxygenase (CYP2J2) and the corresponding rat homologue (CYP2J3), both of which were expressed in extrahepatic tissues. Northern analysis of RNA prepared from the human and rat ... Full text Link to item Cite

CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance.

Journal Article Mol Pharmacol · November 1996 Cytochrome P450 (P450) monooxygenases catalyze the epoxidation of arachidonic acid to form epoxyeicosatrienoic acids, which modulate bronchial smooth muscle tone and airway transepithelial ion transport. We recently described a new human P450 arachidonic a ... Link to item Cite