Overview
My research efforts have been focused on identifying prognostic and therapeutic biomarkers in B-cell lymphoma. My research interests also include investigation of molecular and immune mechanisms underlying the poor clinical outcomes of lymphoma, the pathogenesis and evolution of drug resistant clones, and development of novel therapies for aggressive B-cell lymphoma.
Current Appointments & Affiliations
Assistant Professor in Pathology
·
2021 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways.
Journal Article Nat Commun · July 1, 2025 To determine the cellular and molecular basis of Castleman Disease (CD), we analyze the spatial proteome and transcriptome from a discovery (n = 9 cases) and validation (n = 13 cases) cohort of Unicentric CD, idiopathic Multicentric CD, HHV8-associated MCD ... Full text Link to item CiteCD151 interacts with integrin beta 2 in B cell lymphomas.
Journal Article Cell Mol Life Sci · June 4, 2025 CD151 is a broadly expressed four-transmembrane protein (tetraspanin) that interacts with laminin-binding integrins like integrin alpha 3 (ITGA3). CD151 drives tumor development and expression correlates with poor prognosis in solid cancers, but CD151 has ... Full text Link to item CitePractical microenvironment classification in diffuse large B cell lymphoma using digital pathology.
Journal Article Cell Rep Med · April 15, 2025 Diffuse large B cell lymphoma (DLBCL) is a heterogeneous B cell neoplasm with variable clinical outcomes influenced by both tumor-derived and lymphoma microenvironment (LME) alterations. A recent transcriptomic study identifies four DLBCL subtypes based on ... Full text Link to item CiteRecent Grants
PD-L1 Modifications in Cancer Diagnosis and Treatment
ResearchCo Investigator · Awarded by Baylor College of Medicine · 2025 - 2030Spatially resolved, single cell biomarkers of B cell lymphoma
ResearchCo Investigator · Awarded by Cedars Sinai Medical Center · 2022 - 2026Genetic and Epigenetic Biomarkers for B-cell Lymphoma
ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2025View All Grants
Education, Training & Certifications
Michigan Technological University ·
2009
Ph.D.