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Zijun Yidan Xu-Monette

Assistant Professor in Pathology
Pathology
905 S LaSalle St, Snyderman GSRB1, Room 1010, Durham, NC 27710
905 S LaSalle St, Snyderman GSRB1, Room 1010, Durham, NC 27710

Overview


My research efforts have been focused on identifying prognostic and therapeutic biomarkers in B-cell lymphoma. My research interests also include investigation of molecular and immune mechanisms underlying the poor clinical outcomes of lymphoma, the pathogenesis and evolution of drug resistant clones, and development of novel therapies for aggressive B-cell lymphoma.

Current Appointments & Affiliations


Assistant Professor in Pathology · 2021 - Present Pathology, Clinical Science Departments
Member of the Duke Cancer Institute · 2019 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways.

Journal Article Nat Commun · July 1, 2025 To determine the cellular and molecular basis of Castleman Disease (CD), we analyze the spatial proteome and transcriptome from a discovery (n = 9 cases) and validation (n = 13 cases) cohort of Unicentric CD, idiopathic Multicentric CD, HHV8-associated MCD ... Full text Link to item Cite

CD151 interacts with integrin beta 2 in B cell lymphomas.

Journal Article Cell Mol Life Sci · June 4, 2025 CD151 is a broadly expressed four-transmembrane protein (tetraspanin) that interacts with laminin-binding integrins like integrin alpha 3 (ITGA3). CD151 drives tumor development and expression correlates with poor prognosis in solid cancers, but CD151 has ... Full text Link to item Cite

Practical microenvironment classification in diffuse large B cell lymphoma using digital pathology.

Journal Article Cell Rep Med · April 15, 2025 Diffuse large B cell lymphoma (DLBCL) is a heterogeneous B cell neoplasm with variable clinical outcomes influenced by both tumor-derived and lymphoma microenvironment (LME) alterations. A recent transcriptomic study identifies four DLBCL subtypes based on ... Full text Link to item Cite
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Recent Grants


PD-L1 Modifications in Cancer Diagnosis and Treatment

ResearchCo Investigator · Awarded by Baylor College of Medicine · 2025 - 2030

Spatially resolved, single cell biomarkers of B cell lymphoma

ResearchCo Investigator · Awarded by Cedars Sinai Medical Center · 2022 - 2026

Genetic and Epigenetic Biomarkers for B-cell Lymphoma

ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2025

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Education, Training & Certifications


Michigan Technological University · 2009 Ph.D.