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Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial.

Publication ,  Journal Article
Ng, K; Scott, JB; Drake, BF; Chan, AT; Hollis, BW; Chandler, PD; Bennett, GG; Giovannucci, EL; Gonzalez-Suarez, E; Meyerhardt, JA; Emmons, KM ...
Published in: The American journal of clinical nutrition
March 2014

Association studies have suggested that lower circulating 25-hydroxyvitamin D [25(OH)D] in African Americans may partially underlie higher rates of cardiovascular disease and cancer in this population. Nonetheless, the relation between vitamin D supplementation and 25(OH)D concentrations in African Americans remains undefined.Our primary objective was to determine the dose-response relation between vitamin D and plasma 25(OH)D.A total of 328 African Americans in Boston, MA, were enrolled over 3 winters from 2007 to 2010 and randomly assigned to receive a placebo or 1000, 2000, or 4000 IU vitamin D₃/d for 3 mo. Subjects completed sociodemographic and dietary questionnaires, and plasma samples were drawn at baseline and 3 and 6 mo.Median plasma 25(OH)D concentrations at baseline were 15.1, 16.2, 13.9, and 15.7 ng/mL for subjects randomly assigned to receive the placebo or 1000, 2000, or 4000 IU/d, respectively (P = 0.63). The median plasma 25(OH)D concentration at 3 mo differed significantly between supplementation arms at 13.7, 29.7, 34.8, and 45.9 ng/mL, respectively (P < 0.001). An estimated 1640 IU vitamin D₃/d was needed to raise the plasma 25(OH)D concentration to ≥ 20 ng/mL in ≥ 97.5% of participants, whereas a dose of 4000 IU/d was needed to achieve concentrations ≥ 33 ng/mL in ≥ 80% of subjects. No significant hypercalcemia was seen in a subset of participants.Within African Americans, an estimated 1640 IU vitamin D₃/d was required to achieve concentrations of plasma 25(OH)D recommended by the Institute of Medicine, whereas 4000 IU/d was needed to reach concentrations predicted to reduce cancer and cardiovascular disease risk in prospective observational studies. These results may be helpful for informing future trials of disease prevention.

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Published In

The American journal of clinical nutrition

DOI

EISSN

1938-3207

ISSN

0002-9165

Publication Date

March 2014

Volume

99

Issue

3

Start / End Page

587 / 598

Related Subject Headings

  • Vitamin D Deficiency
  • Seasons
  • Risk Factors
  • Patient Dropouts
  • Nutrition & Dietetics
  • Neoplasms
  • Middle Aged
  • Male
  • Lost to Follow-Up
  • Intention to Treat Analysis
 

Citation

APA
Chicago
ICMJE
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Ng, K., Scott, J. B., Drake, B. F., Chan, A. T., Hollis, B. W., Chandler, P. D., … Fuchs, C. S. (2014). Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial. The American Journal of Clinical Nutrition, 99(3), 587–598. https://doi.org/10.3945/ajcn.113.067777
Ng, Kimmie, Jamil B. Scott, Bettina F. Drake, Andrew T. Chan, Bruce W. Hollis, Paulette D. Chandler, Gary G. Bennett, et al. “Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial.The American Journal of Clinical Nutrition 99, no. 3 (March 2014): 587–98. https://doi.org/10.3945/ajcn.113.067777.
Ng K, Scott JB, Drake BF, Chan AT, Hollis BW, Chandler PD, et al. Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial. The American journal of clinical nutrition. 2014 Mar;99(3):587–98.
Ng, Kimmie, et al. “Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial.The American Journal of Clinical Nutrition, vol. 99, no. 3, Mar. 2014, pp. 587–98. Epmc, doi:10.3945/ajcn.113.067777.
Ng K, Scott JB, Drake BF, Chan AT, Hollis BW, Chandler PD, Bennett GG, Giovannucci EL, Gonzalez-Suarez E, Meyerhardt JA, Emmons KM, Fuchs CS. Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial. The American journal of clinical nutrition. 2014 Mar;99(3):587–598.
Journal cover image

Published In

The American journal of clinical nutrition

DOI

EISSN

1938-3207

ISSN

0002-9165

Publication Date

March 2014

Volume

99

Issue

3

Start / End Page

587 / 598

Related Subject Headings

  • Vitamin D Deficiency
  • Seasons
  • Risk Factors
  • Patient Dropouts
  • Nutrition & Dietetics
  • Neoplasms
  • Middle Aged
  • Male
  • Lost to Follow-Up
  • Intention to Treat Analysis