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The prognostic role of body mass index on mortality amongst the middle-aged and elderly: a competing risk analysis.

Publication ,  Journal Article
Ghaem Maralani, H; Tai, BC; Wong, TY; Tai, ES; Li, J; Wang, JJ; Mitchell, P
Published in: Diabetes Res Clin Pract
January 2014

AIMS: To determine the relationship between body mass index (BMI) including its 5-year changes and mortality, and compare the results obtained using Cox and competing risks models. METHODS: Our study subjects included 2216 persons aged ≥49 years who participated in the Blue Mountains Eye Study, Australia between 1992 and 1994, and returned for further follow-up examinations between 1997 and 1999. We examined the relationship between BMI and mortality using cubic spline. The Cox and competing risks models were used to assess the associations between baseline BMI and its 5-year changes with all-cause and cause-specific mortality. RESULTS: Amongst subjects aged ≤70 years, the relationship between BMI and all-cause mortality was U-shaped. For those aged >70 years, an L-shaped relationship was seen with no elevation in risk amongst the overweight/obese. Based on the competing risks model, obesity at baseline was associated with increased risk of cardiovascular death and reduction in BMI at 5-year was linked to an increase risk of cancer death amongst those aged ≤70 years. The cause-specific Cox model showed that reduction in BMI at 5-year was associated with cancer-death regardless of age, and with cardiovascular deaths among subjects aged ≤70 years. Cox regression model showed larger magnitude of effect with wider confidence interval as compared with competing risks model. CONCLUSIONS: Conditions associated with obesity are more likely to affect mortality among subjects aged ≤70 years, but not among those aged over 70 years. Cox model shows larger magnitude of effect in comparison with competing risks model.

Duke Scholars

Published In

Diabetes Res Clin Pract

DOI

EISSN

1872-8227

Publication Date

January 2014

Volume

103

Issue

1

Start / End Page

42 / 50

Location

Ireland

Related Subject Headings

  • Survival Rate
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Prognosis
  • Overweight
  • Obesity
  • Male
  • Humans
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Ghaem Maralani, H., Tai, B. C., Wong, T. Y., Tai, E. S., Li, J., Wang, J. J., & Mitchell, P. (2014). The prognostic role of body mass index on mortality amongst the middle-aged and elderly: a competing risk analysis. Diabetes Res Clin Pract, 103(1), 42–50. https://doi.org/10.1016/j.diabres.2013.11.025
Ghaem Maralani, Haleh, Bee Choo Tai, Tien Y. Wong, E Shyong Tai, Jialiang Li, Jie Jin Wang, and Paul Mitchell. “The prognostic role of body mass index on mortality amongst the middle-aged and elderly: a competing risk analysis.Diabetes Res Clin Pract 103, no. 1 (January 2014): 42–50. https://doi.org/10.1016/j.diabres.2013.11.025.
Ghaem Maralani H, Tai BC, Wong TY, Tai ES, Li J, Wang JJ, et al. The prognostic role of body mass index on mortality amongst the middle-aged and elderly: a competing risk analysis. Diabetes Res Clin Pract. 2014 Jan;103(1):42–50.
Ghaem Maralani, Haleh, et al. “The prognostic role of body mass index on mortality amongst the middle-aged and elderly: a competing risk analysis.Diabetes Res Clin Pract, vol. 103, no. 1, Jan. 2014, pp. 42–50. Pubmed, doi:10.1016/j.diabres.2013.11.025.
Ghaem Maralani H, Tai BC, Wong TY, Tai ES, Li J, Wang JJ, Mitchell P. The prognostic role of body mass index on mortality amongst the middle-aged and elderly: a competing risk analysis. Diabetes Res Clin Pract. 2014 Jan;103(1):42–50.
Journal cover image

Published In

Diabetes Res Clin Pract

DOI

EISSN

1872-8227

Publication Date

January 2014

Volume

103

Issue

1

Start / End Page

42 / 50

Location

Ireland

Related Subject Headings

  • Survival Rate
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Prognosis
  • Overweight
  • Obesity
  • Male
  • Humans
  • Follow-Up Studies