
Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.
Publication
, Journal Article
Telen, MJ
Published in: Hematol Oncol Clin North Am
April 2014
The pathophysiology of vasoocclusion is thought to involve a wide variety of adhesive interactions involving erythrocytes, leukocytes, and the endothelium. Selectins are expressed by leukocytes, platelets, and the endothelium, among other tissues. They contribute to a wide variety of physiologically important cell-cell interactions, including adhesion of all types of blood cells to the endothelium. In vitro, in vivo, and early-phase clinical studies suggest that E-selectin and pan-selectin inhibitors may be promising new therapeutic agents for the treatment of vasoocclusion in sickle cell disease.
Duke Scholars
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Published In
Hematol Oncol Clin North Am
DOI
EISSN
1558-1977
Publication Date
April 2014
Volume
28
Issue
2
Start / End Page
341 / 354
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- L-Selectin
- Humans
- Glycolipids
- Endothelium, Vascular
- Endothelial Cells
- E-Selectin
- Cell Communication
- Cell Adhesion
- Arterial Occlusive Diseases
Citation
APA
Chicago
ICMJE
MLA
NLM
Telen, M. J. (2014). Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors. Hematol Oncol Clin North Am, 28(2), 341–354. https://doi.org/10.1016/j.hoc.2013.11.010
Telen, Marilyn J. “Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.” Hematol Oncol Clin North Am 28, no. 2 (April 2014): 341–54. https://doi.org/10.1016/j.hoc.2013.11.010.
Telen MJ. Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors. Hematol Oncol Clin North Am. 2014 Apr;28(2):341–54.
Telen, Marilyn J. “Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.” Hematol Oncol Clin North Am, vol. 28, no. 2, Apr. 2014, pp. 341–54. Pubmed, doi:10.1016/j.hoc.2013.11.010.
Telen MJ. Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors. Hematol Oncol Clin North Am. 2014 Apr;28(2):341–354.

Published In
Hematol Oncol Clin North Am
DOI
EISSN
1558-1977
Publication Date
April 2014
Volume
28
Issue
2
Start / End Page
341 / 354
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- L-Selectin
- Humans
- Glycolipids
- Endothelium, Vascular
- Endothelial Cells
- E-Selectin
- Cell Communication
- Cell Adhesion
- Arterial Occlusive Diseases