The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus.
Publication
, Journal Article
Diab, DL; D'Alessio, DA
Published in: Curr Diab Rep
June 2010
The gastrointestinal hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), termed incretins, are essential regulators of normal glucose homeostasis. Research indicates that the incretin effect is impaired in type 2 diabetes, and this seems to be a consequence rather than a cause of type 2 diabetes. This review describes the defects in the incretin system seen in diabetic patients and discusses the potential roles of GIP and GLP-1 in the pathogenesis of type 2 diabetes. In addition, new information on clinical applications that exploit the enteroinsular axis to control blood glucose is discussed.
Duke Scholars
Published In
Curr Diab Rep
DOI
EISSN
1539-0829
Publication Date
June 2010
Volume
10
Issue
3
Start / End Page
192 / 198
Location
United States
Related Subject Headings
- Insulin
- Incretins
- Hypoglycemic Agents
- Humans
- Gastrointestinal Hormones
- Endocrinology & Metabolism
- Diabetes Mellitus, Type 2
- Animals
- 3210 Nutrition and dietetics
- 3202 Clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Diab, D. L., & D’Alessio, D. A. (2010). The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus. Curr Diab Rep, 10(3), 192–198. https://doi.org/10.1007/s11892-010-0114-6
Diab, Dima L., and David A. D’Alessio. “The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus.” Curr Diab Rep 10, no. 3 (June 2010): 192–98. https://doi.org/10.1007/s11892-010-0114-6.
Diab DL, D’Alessio DA. The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus. Curr Diab Rep. 2010 Jun;10(3):192–8.
Diab, Dima L., and David A. D’Alessio. “The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus.” Curr Diab Rep, vol. 10, no. 3, June 2010, pp. 192–98. Pubmed, doi:10.1007/s11892-010-0114-6.
Diab DL, D’Alessio DA. The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus. Curr Diab Rep. 2010 Jun;10(3):192–198.
Published In
Curr Diab Rep
DOI
EISSN
1539-0829
Publication Date
June 2010
Volume
10
Issue
3
Start / End Page
192 / 198
Location
United States
Related Subject Headings
- Insulin
- Incretins
- Hypoglycemic Agents
- Humans
- Gastrointestinal Hormones
- Endocrinology & Metabolism
- Diabetes Mellitus, Type 2
- Animals
- 3210 Nutrition and dietetics
- 3202 Clinical sciences