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Impact of perioperative blood pressure variability on health resource utilization after cardiac surgery: an analysis of the ECLIPSE trials.

Publication ,  Journal Article
Aronson, S; Levy, JH; Lumb, PD; Fontes, M; Wang, Y; Crothers, TA; Sulham, KA; Navetta, MS
Published in: J Cardiothorac Vasc Anesth
June 2014

OBJECTIVE: To examine the impact of blood pressure control on hospital health resource utilization using data from the ECLIPSE trials. DESIGN: Post-hoc analysis of data from 3 prospective, open-label, randomized clinical trials (ECLIPSE trials). SETTING: Sixty-one medical centers in the United States. PARTICIPANTS: Patients 18 years or older undergoing cardiac surgery. INTERVENTIONS: Clevidipine was compared with nitroglycerin, sodium nitroprusside, and nicardipine. MEASUREMENTS AND MAIN RESULTS: The ECLIPSE trials included 3 individual randomized open-label studies comparing clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine. Blood pressure control was assessed as the integral of the cumulative area under the curve (AUC) outside specified systolic blood pressure ranges, such that lower AUC represents less variability. This analysis examined surgery duration, time to extubation, as well as intensive care unit (ICU) and hospital length of stay (LOS) in patients with AUC≤10 mmHg×min/h compared to patients with AUC>10 mmHg×min/h. One thousand four hundred ten patients were included for analysis; 736 patients (52%) had an AUC≤10 mmHg×min/h, and 674 (48%) had an AUC>10 mmHg×min/h. The duration of surgery and ICU LOS were similar between groups. Time to extubation and postoperative LOS were both significantly shorter (p = 0.05 and p<0.0001, respectively) in patients with AUC≤10. Multivariate analysis demonstrates AUC≤10 was significantly and independently associated with decreased time to extubation (hazard ratio 1.132, p = 0.0261) and postoperative LOS (hazard ratio 1.221, p = 0.0006). CONCLUSIONS: Based on data derived from the ECLIPSE studies, increased perioperative BP variability is associated with delayed time to extubation and increased postoperative LOS.

Duke Scholars

Published In

J Cardiothorac Vasc Anesth

DOI

EISSN

1532-8422

Publication Date

June 2014

Volume

28

Issue

3

Start / End Page

579 / 585

Location

United States

Related Subject Headings

  • Socioeconomic Factors
  • Sex Factors
  • Risk Assessment
  • Prospective Studies
  • Postoperative Care
  • Perioperative Period
  • Middle Aged
  • Male
  • Humans
  • Health Resources
 

Citation

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MLA
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Aronson, S., Levy, J. H., Lumb, P. D., Fontes, M., Wang, Y., Crothers, T. A., … Navetta, M. S. (2014). Impact of perioperative blood pressure variability on health resource utilization after cardiac surgery: an analysis of the ECLIPSE trials. J Cardiothorac Vasc Anesth, 28(3), 579–585. https://doi.org/10.1053/j.jvca.2014.01.004
Aronson, Solomon, Jerrold H. Levy, Philip D. Lumb, Manuel Fontes, Yamei Wang, Tracy A. Crothers, Katherine A. Sulham, and Marco S. Navetta. “Impact of perioperative blood pressure variability on health resource utilization after cardiac surgery: an analysis of the ECLIPSE trials.J Cardiothorac Vasc Anesth 28, no. 3 (June 2014): 579–85. https://doi.org/10.1053/j.jvca.2014.01.004.
Aronson S, Levy JH, Lumb PD, Fontes M, Wang Y, Crothers TA, et al. Impact of perioperative blood pressure variability on health resource utilization after cardiac surgery: an analysis of the ECLIPSE trials. J Cardiothorac Vasc Anesth. 2014 Jun;28(3):579–85.
Aronson, Solomon, et al. “Impact of perioperative blood pressure variability on health resource utilization after cardiac surgery: an analysis of the ECLIPSE trials.J Cardiothorac Vasc Anesth, vol. 28, no. 3, June 2014, pp. 579–85. Pubmed, doi:10.1053/j.jvca.2014.01.004.
Aronson S, Levy JH, Lumb PD, Fontes M, Wang Y, Crothers TA, Sulham KA, Navetta MS. Impact of perioperative blood pressure variability on health resource utilization after cardiac surgery: an analysis of the ECLIPSE trials. J Cardiothorac Vasc Anesth. 2014 Jun;28(3):579–585.
Journal cover image

Published In

J Cardiothorac Vasc Anesth

DOI

EISSN

1532-8422

Publication Date

June 2014

Volume

28

Issue

3

Start / End Page

579 / 585

Location

United States

Related Subject Headings

  • Socioeconomic Factors
  • Sex Factors
  • Risk Assessment
  • Prospective Studies
  • Postoperative Care
  • Perioperative Period
  • Middle Aged
  • Male
  • Humans
  • Health Resources