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Regulatory T cells are redirected to kill glioblastoma by an EGFRviii-targeted bispecific antibody

Publication ,  Journal Article
Choi, BD; Gedeon, PC; Sanchez-Perez, L; Bigner, DD; Sampson, JH
Published in: OncoImmunology
December 1, 2013
Published version (DOI)

Regulatory T cells (Tregs) play a central role in in tumor escape from immunosurveillance. We report that a bispecific T-cell engager (BiTE) targeting a mutated form of the epidermal growth factor receptor, i.e., EGFRvIII, potently redirects Tregs to kill glioblastoma through the granzyme-perforin pathway. © 2013 Landes Bioscience.

Duke Scholars

Darell Doty Bigner
Author Darell Doty Bigner Neurosurgery
John Howard Sampson
Author John Howard Sampson Neurosurgery

Published In

OncoImmunology

DOI

10.4161/onci.26757

EISSN

2162-402X

ISSN

2162-4011

Publication Date

December 1, 2013

Volume

2

Issue

12

Start / End Page

1 / 2

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3204 Immunology
  • 1112 Oncology and Carcinogenesis
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Choi, B. D., Gedeon, P. C., Sanchez-Perez, L., Bigner, D. D., & Sampson, J. H. (2013). Regulatory T cells are redirected to kill glioblastoma by an EGFRviii-targeted bispecific antibody. OncoImmunology, 2(12), 1–2. https://doi.org/10.4161/onci.26757
Choi, B. D., P. C. Gedeon, L. Sanchez-Perez, D. D. Bigner, and J. H. Sampson. “Regulatory T cells are redirected to kill glioblastoma by an EGFRviii-targeted bispecific antibody.” OncoImmunology 2, no. 12 (December 1, 2013): 1–2. https://doi.org/10.4161/onci.26757.
Choi BD, Gedeon PC, Sanchez-Perez L, Bigner DD, Sampson JH. Regulatory T cells are redirected to kill glioblastoma by an EGFRviii-targeted bispecific antibody. OncoImmunology. 2013 Dec 1;2(12):1–2.
Choi, B. D., et al. “Regulatory T cells are redirected to kill glioblastoma by an EGFRviii-targeted bispecific antibody.” OncoImmunology, vol. 2, no. 12, Dec. 2013, pp. 1–2. Scopus, doi:10.4161/onci.26757.
Choi BD, Gedeon PC, Sanchez-Perez L, Bigner DD, Sampson JH. Regulatory T cells are redirected to kill glioblastoma by an EGFRviii-targeted bispecific antibody. OncoImmunology. 2013 Dec 1;2(12):1–2.

Published In

OncoImmunology

DOI

10.4161/onci.26757

EISSN

2162-402X

ISSN

2162-4011

Publication Date

December 1, 2013

Volume

2

Issue

12

Start / End Page

1 / 2

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3204 Immunology
  • 1112 Oncology and Carcinogenesis
  • 1107 Immunology