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Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition?

Publication ,  Journal Article
Voss, MW; Erickson, KI; Prakash, RS; Chaddock, L; Malkowski, E; Alves, H; Kim, JS; Morris, KS; White, SM; Wójcicki, TR; Hu, L; Szabo, A ...
Published in: Neuropsychologia
April 2010

Over the next 20 years the number of Americans diagnosed with dementia is expected to more than double (CDC, 2007). It is, therefore, an important public health initiative to understand what factors contribute to the longevity of a healthy mind. Both default mode network (DMN) function and increased aerobic fitness have been associated with better cognitive performance and reduced incidence of Alzheimer's disease among older adults. Here we examine the association between aerobic fitness, functional connectivity in the DMN, and cognitive performance. Results showed significant age-related deficits in functional connectivity in both local and distributed DMN pathways. However, in a group of healthy elderly adults, almost half of the age-related disconnections showed increased functional connectivity as a function of aerobic fitness level. Finally, we examine the hypothesis that functional connectivity in the DMN is one source of variance in the relationship between aerobic fitness and cognition. Results demonstrate instances of both specific and global DMN connectivity mediating the relationship between fitness and cognition. We provide the first evidence for functional connectivity as a source of variance in the association between aerobic fitness and cognition, and discuss results in the context of neurobiological theories of cognitive aging and disease.

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Published In

Neuropsychologia

DOI

EISSN

1873-3514

Publication Date

April 2010

Volume

48

Issue

5

Start / End Page

1394 / 1406

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Space Perception
  • Severity of Illness Index
  • Respiratory Tract Diseases
  • Neuropsychological Tests
  • Nerve Net
  • Memory Disorders
  • Male
  • Magnetic Resonance Imaging
  • Humans
 

Citation

APA
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Voss, M. W., Erickson, K. I., Prakash, R. S., Chaddock, L., Malkowski, E., Alves, H., … Kramer, A. F. (2010). Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition? Neuropsychologia, 48(5), 1394–1406. https://doi.org/10.1016/j.neuropsychologia.2010.01.005
Voss, Michelle W., Kirk I. Erickson, Ruchika S. Prakash, Laura Chaddock, Edward Malkowski, Heloisa Alves, Jennifer S. Kim, et al. “Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition?Neuropsychologia 48, no. 5 (April 2010): 1394–1406. https://doi.org/10.1016/j.neuropsychologia.2010.01.005.
Voss MW, Erickson KI, Prakash RS, Chaddock L, Malkowski E, Alves H, et al. Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition? Neuropsychologia. 2010 Apr;48(5):1394–406.
Voss, Michelle W., et al. “Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition?Neuropsychologia, vol. 48, no. 5, Apr. 2010, pp. 1394–406. Pubmed, doi:10.1016/j.neuropsychologia.2010.01.005.
Voss MW, Erickson KI, Prakash RS, Chaddock L, Malkowski E, Alves H, Kim JS, Morris KS, White SM, Wójcicki TR, Hu L, Szabo A, Klamm E, McAuley E, Kramer AF. Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition? Neuropsychologia. 2010 Apr;48(5):1394–1406.
Journal cover image

Published In

Neuropsychologia

DOI

EISSN

1873-3514

Publication Date

April 2010

Volume

48

Issue

5

Start / End Page

1394 / 1406

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Space Perception
  • Severity of Illness Index
  • Respiratory Tract Diseases
  • Neuropsychological Tests
  • Nerve Net
  • Memory Disorders
  • Male
  • Magnetic Resonance Imaging
  • Humans