Adjusting for misclassification in a stratified biomarker clinical trial.
Publication
, Journal Article
Liu, C; Liu, A; Hu, J; Yuan, V; Halabi, S
Published in: Stat Med
August 15, 2014
Clinical trials utilizing predictive biomarkers have become a research focus in personalized medicine. We investigate the effects of biomarker misclassification on the design and analysis of stratified biomarker clinical trials. For a variety of inference problems including marker-treatment interaction in particular, we show that marker misclassification may have profound adverse effects on the coverage of confidence intervals, power of the tests, and required sample sizes. For each inferential problem, we propose methods to adjust for the classification errors.
Duke Scholars
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Published In
Stat Med
DOI
EISSN
1097-0258
Publication Date
August 15, 2014
Volume
33
Issue
18
Start / End Page
3100 / 3113
Location
England
Related Subject Headings
- Statistics & Probability
- Sample Size
- Precision Medicine
- Neoplasms
- Models, Statistical
- Kidney Neoplasms
- Interleukin-6
- Humans
- Confidence Intervals
- Clinical Trials, Phase III as Topic
Citation
APA
Chicago
ICMJE
MLA
NLM
Liu, C., Liu, A., Hu, J., Yuan, V., & Halabi, S. (2014). Adjusting for misclassification in a stratified biomarker clinical trial. Stat Med, 33(18), 3100–3113. https://doi.org/10.1002/sim.6164
Liu, Chunling, Aiyi Liu, Jiang Hu, Vivian Yuan, and Susan Halabi. “Adjusting for misclassification in a stratified biomarker clinical trial.” Stat Med 33, no. 18 (August 15, 2014): 3100–3113. https://doi.org/10.1002/sim.6164.
Liu C, Liu A, Hu J, Yuan V, Halabi S. Adjusting for misclassification in a stratified biomarker clinical trial. Stat Med. 2014 Aug 15;33(18):3100–13.
Liu, Chunling, et al. “Adjusting for misclassification in a stratified biomarker clinical trial.” Stat Med, vol. 33, no. 18, Aug. 2014, pp. 3100–13. Pubmed, doi:10.1002/sim.6164.
Liu C, Liu A, Hu J, Yuan V, Halabi S. Adjusting for misclassification in a stratified biomarker clinical trial. Stat Med. 2014 Aug 15;33(18):3100–3113.
Published In
Stat Med
DOI
EISSN
1097-0258
Publication Date
August 15, 2014
Volume
33
Issue
18
Start / End Page
3100 / 3113
Location
England
Related Subject Headings
- Statistics & Probability
- Sample Size
- Precision Medicine
- Neoplasms
- Models, Statistical
- Kidney Neoplasms
- Interleukin-6
- Humans
- Confidence Intervals
- Clinical Trials, Phase III as Topic