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Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth.

Publication ,  Journal Article
Kotula, JW; Sun, J; Li, M; Pratico, ED; Fereshteh, MP; Ahrens, DP; Sullenger, BA; Kovacs, JJ
Published in: PLoS One
2014

UNLABELLED: β-arrestins, ubiquitous cellular scaffolding proteins that act as signaling mediators of numerous critical cellular pathways, are attractive therapeutic targets because they promote tumorigenesis in several tumor models. However, targeting scaffolding proteins with traditional small molecule drugs has been challenging. Inhibition of β-arrestin 2 with a novel aptamer impedes multiple oncogenic signaling pathways simultaneously. Additionally, delivery of the β-arrestin 2-targeting aptamer into leukemia cells through coupling to a recently described cancer cell-specific delivery aptamer, inhibits multiple β-arrestin-mediated signaling pathways known to be required for chronic myelogenous leukemia (CML) disease progression, and impairs tumorigenic growth in CML patient samples. The ability to target scaffolding proteins such as β-arrestin 2 with RNA aptamers may prove beneficial as a therapeutic strategy. HIGHLIGHTS: An RNA aptamer inhibits β-arrestin 2 activity.Inhibiting β-arrestin 2 impedes multiple tumorigenic pathways simultaneously.The therapeutic aptamer is delivered to cancer cells using a cell-specific DNA aptamer.Targeting β-arrestin 2 inhibits tumor progression in CML models and patient samples.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2014

Volume

9

Issue

4

Start / End Page

e93441

Location

United States

Related Subject Headings

  • beta-Arrestins
  • beta-Arrestin 2
  • Signal Transduction
  • Leukemia
  • K562 Cells
  • Humans
  • General Science & Technology
  • Cell Proliferation
  • Cell Line, Tumor
  • Arrestins
 

Citation

APA
Chicago
ICMJE
MLA
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Kotula, J. W., Sun, J., Li, M., Pratico, E. D., Fereshteh, M. P., Ahrens, D. P., … Kovacs, J. J. (2014). Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth. PLoS One, 9(4), e93441. https://doi.org/10.1371/journal.pone.0093441
Kotula, Jonathan W., Jinpeng Sun, Margie Li, Elizabeth D. Pratico, Mark P. Fereshteh, Douglas P. Ahrens, Bruce A. Sullenger, and Jeffrey J. Kovacs. “Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth.PLoS One 9, no. 4 (2014): e93441. https://doi.org/10.1371/journal.pone.0093441.
Kotula JW, Sun J, Li M, Pratico ED, Fereshteh MP, Ahrens DP, et al. Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth. PLoS One. 2014;9(4):e93441.
Kotula, Jonathan W., et al. “Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth.PLoS One, vol. 9, no. 4, 2014, p. e93441. Pubmed, doi:10.1371/journal.pone.0093441.
Kotula JW, Sun J, Li M, Pratico ED, Fereshteh MP, Ahrens DP, Sullenger BA, Kovacs JJ. Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth. PLoS One. 2014;9(4):e93441.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2014

Volume

9

Issue

4

Start / End Page

e93441

Location

United States

Related Subject Headings

  • beta-Arrestins
  • beta-Arrestin 2
  • Signal Transduction
  • Leukemia
  • K562 Cells
  • Humans
  • General Science & Technology
  • Cell Proliferation
  • Cell Line, Tumor
  • Arrestins