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Null association between vitamin D and PSA levels among black men in a vitamin D supplementation trial.

Publication ,  Journal Article
Chandler, PD; Giovannucci, EL; Scott, JB; Bennett, GG; Ng, K; Chan, AT; Hollis, BW; Emmons, KM; Fuchs, CS; Drake, BF
Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
September 2014

Black men exhibit a high prevalence of vitamin D deficiency as well as a higher incidence of prostate cancer and higher mortality rates from prostate cancer than Whites. There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on prostate-specific antigen (PSA) in healthy Black men.During three winters from 2007 to 2010, 105 Black men (median age, 48.9 years) of Boston, MA were randomized into a four-arm, double-blind trial for 3 months of placebo, 1,000, 2,000, or 4,000 U of vitamin D3. At baseline and 3 months, free and total PSA was measured.With vitamin D supplementation, no significant differences in free and total PSA were observed; free PSA, -0.0004 ng/mL (P = 0.94) and total PSA, -0.004 ng/mL (P = 0.92) for each additional 1,000 U/d of vitamin D3.Within an unselected population of healthy Black men without a cancer diagnosis, we found no effect of vitamin D supplementation on free or total PSA.These findings support prior findings of no change in PSA with vitamin D supplementation and emphasize the need for new methods to assess the influence of vitamin D supplementation on prostate cancer prevention.

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Published In

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

DOI

EISSN

1538-7755

ISSN

1055-9965

Publication Date

September 2014

Volume

23

Issue

9

Start / End Page

1944 / 1947

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Risk Factors
  • Prostate-Specific Antigen
  • Prospective Studies
  • Middle Aged
  • Male
  • Kallikreins
  • Humans
  • Epidemiology
 

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Chandler, P. D., Giovannucci, E. L., Scott, J. B., Bennett, G. G., Ng, K., Chan, A. T., … Drake, B. F. (2014). Null association between vitamin D and PSA levels among black men in a vitamin D supplementation trial. Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 23(9), 1944–1947. https://doi.org/10.1158/1055-9965.epi-14-0522
Chandler, Paulette D., Edward L. Giovannucci, Jamil B. Scott, Gary G. Bennett, Kimmie Ng, Andrew T. Chan, Bruce W. Hollis, Karen M. Emmons, Charles S. Fuchs, and Bettina F. Drake. “Null association between vitamin D and PSA levels among black men in a vitamin D supplementation trial.Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 23, no. 9 (September 2014): 1944–47. https://doi.org/10.1158/1055-9965.epi-14-0522.
Chandler PD, Giovannucci EL, Scott JB, Bennett GG, Ng K, Chan AT, et al. Null association between vitamin D and PSA levels among black men in a vitamin D supplementation trial. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2014 Sep;23(9):1944–7.
Chandler, Paulette D., et al. “Null association between vitamin D and PSA levels among black men in a vitamin D supplementation trial.Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, vol. 23, no. 9, Sept. 2014, pp. 1944–47. Epmc, doi:10.1158/1055-9965.epi-14-0522.
Chandler PD, Giovannucci EL, Scott JB, Bennett GG, Ng K, Chan AT, Hollis BW, Emmons KM, Fuchs CS, Drake BF. Null association between vitamin D and PSA levels among black men in a vitamin D supplementation trial. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2014 Sep;23(9):1944–1947.

Published In

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

DOI

EISSN

1538-7755

ISSN

1055-9965

Publication Date

September 2014

Volume

23

Issue

9

Start / End Page

1944 / 1947

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Risk Factors
  • Prostate-Specific Antigen
  • Prospective Studies
  • Middle Aged
  • Male
  • Kallikreins
  • Humans
  • Epidemiology