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Global versus tract-specific components of cerebral white matter integrity: relation to adult age and perceptual-motor speed.

Publication ,  Journal Article
Johnson, MA; Diaz, MT; Madden, DJ
Published in: Brain Struct Funct
September 2015

Although age-related differences in white matter have been well documented, the degree to which regional, tract-specific effects can be distinguished from global, brain-general effects is not yet clear. Similarly, the manner in which global and regional differences in white matter integrity contribute to age-related differences in cognition has not been well established. To address these issues, we analyzed diffusion tensor imaging measures from 52 younger adults (18-28) and 64 older adults (60-85). We conducted principal component analysis on each diffusion measure, using data from eight individual tracts. Two components were observed for fractional anisotropy: the first comprised high loadings from the superior longitudinal fasciculi and corticospinal tracts, and the second comprised high loadings from the optic radiations. In contrast, variation in axial, radial, and mean diffusivities yielded a single-component solution in each case, with high loadings from most or all tracts. For fractional anisotropy, the complementary results of multiple components and variability in component loadings across tracts suggest regional variation. However, for the diffusivity indices, the single component with high loadings from most or all of the tracts suggests primarily global, brain-general variation. Further analyses indicated that age was a significant mediator of the relation between each component and perceptual-motor speed. These data suggest that individual differences in white matter integrity and their relation to age-related differences in perceptual-motor speed represent influences that are beyond the level of individual tracts, but the extent to which regional or global effects predominate may differ between anisotropy and diffusivity measures.

Duke Scholars

Published In

Brain Struct Funct

DOI

EISSN

1863-2661

Publication Date

September 2015

Volume

220

Issue

5

Start / End Page

2705 / 2720

Location

Germany

Related Subject Headings

  • Young Adult
  • White Matter
  • Pyramidal Tracts
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Nerve Fibers, Myelinated
  • Motor Activity
  • Male
  • Humans
  • Female
 

Citation

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ICMJE
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Johnson, M. A., Diaz, M. T., & Madden, D. J. (2015). Global versus tract-specific components of cerebral white matter integrity: relation to adult age and perceptual-motor speed. Brain Struct Funct, 220(5), 2705–2720. https://doi.org/10.1007/s00429-014-0822-9
Johnson, Micah A., Michele T. Diaz, and David J. Madden. “Global versus tract-specific components of cerebral white matter integrity: relation to adult age and perceptual-motor speed.Brain Struct Funct 220, no. 5 (September 2015): 2705–20. https://doi.org/10.1007/s00429-014-0822-9.
Johnson, Micah A., et al. “Global versus tract-specific components of cerebral white matter integrity: relation to adult age and perceptual-motor speed.Brain Struct Funct, vol. 220, no. 5, Sept. 2015, pp. 2705–20. Pubmed, doi:10.1007/s00429-014-0822-9.
Journal cover image

Published In

Brain Struct Funct

DOI

EISSN

1863-2661

Publication Date

September 2015

Volume

220

Issue

5

Start / End Page

2705 / 2720

Location

Germany

Related Subject Headings

  • Young Adult
  • White Matter
  • Pyramidal Tracts
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Nerve Fibers, Myelinated
  • Motor Activity
  • Male
  • Humans
  • Female