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The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment.

Publication ,  Journal Article
Hockenberry, MJ; Taylor, OA; Pasvogel, A; Rodgers, C; McCarthy, K; Gundy, P; Montgomery, DW; Ribbeck, P; Scheurer, ME; Moore, IMK
Published in: Oncology nursing forum
July 2014

To explore the symptom trajectory during the first 16 months of childhood leukemia treatment and any associations with the oxidative stress pathway measured by cerebrospinal fluid (CSF) concentration of oxidized phosphatidylcholine (PC), the predominant glycerophospholipid in the brain and cell membranes.Prospective, longitudinal design.Two cancer centers in the southwestern United States.36 children (aged 3-14 years) newly diagnosed with acute lymphoblastic leukemia.Symptoms were measured using the Memorial Symptom Assessment Scale at six specific time points during treatment. Biochemical changes in oxidative stress were measured by oxidized PC in the CSF.Childhood cancer symptoms, oxidized PC.Significant differences were found in the number of symptoms experienced during the three phases of treatment. Symptom trajectory changes and influence of the oxidative stress pathway on symptom experiences were identified.Symptoms experienced during treatment for childhood leukemia are associated with increased oxidative stress.Children with leukemia experience symptoms throughout treatment. Physiologic measures indicate the influence of oxidative stress on symptoms.

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Published In

Oncology nursing forum

DOI

EISSN

1538-0688

ISSN

0190-535X

Publication Date

July 2014

Volume

41

Issue

4

Start / End Page

E238 / E247

Related Subject Headings

  • Vomiting
  • Severity of Illness Index
  • Prospective Studies
  • Pain
  • Oxidative Stress
  • Oncology Nursing
  • Nursing
  • Nausea
  • Mood Disorders
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Hockenberry, M. J., Taylor, O. A., Pasvogel, A., Rodgers, C., McCarthy, K., Gundy, P., … Moore, I. M. K. (2014). The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment. Oncology Nursing Forum, 41(4), E238–E247. https://doi.org/10.1188/14.onf.e238-e247
Hockenberry, Marilyn J., Olga A. Taylor, Alice Pasvogel, Cheryl Rodgers, Kathy McCarthy, Patricia Gundy, David W. Montgomery, Phillip Ribbeck, Michael E. Scheurer, and Ida M Ki Moore. “The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment.Oncology Nursing Forum 41, no. 4 (July 2014): E238–47. https://doi.org/10.1188/14.onf.e238-e247.
Hockenberry MJ, Taylor OA, Pasvogel A, Rodgers C, McCarthy K, Gundy P, et al. The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment. Oncology nursing forum. 2014 Jul;41(4):E238–47.
Hockenberry, Marilyn J., et al. “The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment.Oncology Nursing Forum, vol. 41, no. 4, July 2014, pp. E238–47. Epmc, doi:10.1188/14.onf.e238-e247.
Hockenberry MJ, Taylor OA, Pasvogel A, Rodgers C, McCarthy K, Gundy P, Montgomery DW, Ribbeck P, Scheurer ME, Moore IMK. The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment. Oncology nursing forum. 2014 Jul;41(4):E238–E247.

Published In

Oncology nursing forum

DOI

EISSN

1538-0688

ISSN

0190-535X

Publication Date

July 2014

Volume

41

Issue

4

Start / End Page

E238 / E247

Related Subject Headings

  • Vomiting
  • Severity of Illness Index
  • Prospective Studies
  • Pain
  • Oxidative Stress
  • Oncology Nursing
  • Nursing
  • Nausea
  • Mood Disorders
  • Male