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Role of the Autophagy Gene Atg5 in T Lymphocyte Survival and Proliferation

Publication ,  Journal Article
He, MX; Wan, Y; He, YW
January 1, 2013

Macroautophagy (referred to as autophagy) is a highly conserved intracellular process that involves sequestration of cytoplasmic contents by intracellular double-membrane vacuoles. In the adaptive immune system, autophagy is essential for antigen presentation, survival, and activation-induced proliferation of T lymphocytes. Autophagy-related proteins, such as Atg5, Atg7, and LC3, are expressed in T lymphocytes. The basal level of autophagy occurs in resting T lymphocytes, and is enhanced in activated T cells. Both our own and other groups' data show that the autophagy-related gene Atg5 is critical for T cell development, survival, and function. The mitochondrial content of Atg5-deficient naïve T lymphocytes is abnormally high, which leads to defective survival. These findings suggest that autophagy is critical for promoting T lymphocyte survival by regulating intracellular organelle homeostasis. © 2014 Elsevier Inc. All rights reserved.

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Publication Date

January 1, 2013

Start / End Page

239 / 244
 

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He, M. X., Wan, Y., & He, Y. W. (2013). Role of the Autophagy Gene Atg5 in T Lymphocyte Survival and Proliferation, 239–244. https://doi.org/10.1016/B978-0-12-405877-4.00016-0
He, M. X., Y. Wan, and Y. W. He. “Role of the Autophagy Gene Atg5 in T Lymphocyte Survival and Proliferation,” January 1, 2013, 239–44. https://doi.org/10.1016/B978-0-12-405877-4.00016-0.
He, M. X., et al. Role of the Autophagy Gene Atg5 in T Lymphocyte Survival and Proliferation. Jan. 2013, pp. 239–44. Scopus, doi:10.1016/B978-0-12-405877-4.00016-0.

DOI

Publication Date

January 1, 2013

Start / End Page

239 / 244