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Recent advances in the regulation of pancreatic secretion.

Publication ,  Journal Article
Chandra, R; Liddle, RA
Published in: Curr Opin Gastroenterol
September 2014

PURPOSE OF REVIEW: This review highlights recent progress made in the field of pancreatic secretion. RECENT FINDINGS: This review summarizes a number of recent studies demonstrating the intracellular pathways by which hormones and neural inputs regulate pancreatic exocrine and endocrine secretion. In particular, the effects of vasoactive intestinal peptide and secretin on intra-acinar cell adenosine 3',5'-cyclic monophosphate are explored. Considerable attention is paid to regulation of β-cell function and includes studies detailing the mechanisms of regulation of insulin by somatostatin, serotonin, and melanocortins. These studies emphasize the critical role that hormonal, paracrine, and neural factors play in glucose homeostasis. SUMMARY: Exocrine and endocrine pancreatic secretions are regulated by hormonal and neural mechanisms, and understanding these pathways will enable the discovery and design of new and improved therapies for prevention and control of diabetes and perhaps exocrine insufficiency.

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Published In

Curr Opin Gastroenterol

DOI

EISSN

1531-7056

Publication Date

September 2014

Volume

30

Issue

5

Start / End Page

490 / 494

Location

United States

Related Subject Headings

  • Pancreas, Exocrine
  • Insulin Secretion
  • Insulin
  • Humans
  • Hormones
  • Gastroenterology & Hepatology
  • Diabetes Mellitus
  • Blood Glucose
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Chandra, R., & Liddle, R. A. (2014). Recent advances in the regulation of pancreatic secretion. Curr Opin Gastroenterol, 30(5), 490–494. https://doi.org/10.1097/MOG.0000000000000099
Chandra, Rashmi, and Rodger A. Liddle. “Recent advances in the regulation of pancreatic secretion.Curr Opin Gastroenterol 30, no. 5 (September 2014): 490–94. https://doi.org/10.1097/MOG.0000000000000099.
Chandra R, Liddle RA. Recent advances in the regulation of pancreatic secretion. Curr Opin Gastroenterol. 2014 Sep;30(5):490–4.
Chandra, Rashmi, and Rodger A. Liddle. “Recent advances in the regulation of pancreatic secretion.Curr Opin Gastroenterol, vol. 30, no. 5, Sept. 2014, pp. 490–94. Pubmed, doi:10.1097/MOG.0000000000000099.
Chandra R, Liddle RA. Recent advances in the regulation of pancreatic secretion. Curr Opin Gastroenterol. 2014 Sep;30(5):490–494.

Published In

Curr Opin Gastroenterol

DOI

EISSN

1531-7056

Publication Date

September 2014

Volume

30

Issue

5

Start / End Page

490 / 494

Location

United States

Related Subject Headings

  • Pancreas, Exocrine
  • Insulin Secretion
  • Insulin
  • Humans
  • Hormones
  • Gastroenterology & Hepatology
  • Diabetes Mellitus
  • Blood Glucose
  • 3202 Clinical sciences
  • 1103 Clinical Sciences