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Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations.

Publication ,  Journal Article
Hurria, A; Dale, W; Mooney, M; Rowland, JH; Ballman, KV; Cohen, HJ; Muss, HB; Schilsky, RL; Ferrell, B; Extermann, M; Schmader, KE; Mohile, SG ...
Published in: J Clin Oncol
August 20, 2014

A majority of cancer diagnoses and deaths occur in patients age ≥ 65 years. With the aging of the US population, the number of older adults with cancer will grow. Although the coming wave of older patients with cancer was anticipated in the early 1980s, when the need for more research on the cancer-aging interface was recognized, many knowledge gaps remain when it comes to treating older and/or frailer patients with cancer. Relatively little is known about the best way to balance the risks and benefits of existing cancer therapies in older patients; however, these patients continue to be underrepresented in clinical trials. Furthermore, the available clinical trials often do not include end points pertinent to the older adult population, such as preservation of function, cognition, and independence. As part of its ongoing effort to advance research in the field of geriatric oncology, the Cancer and Aging Research Group held a conference in November 2012 in collaboration with the National Cancer Institute, the National Institute on Aging, and the Alliance for Clinical Trials in Oncology. The goal was to develop recommendations and establish research guidelines for the design and implementation of therapeutic clinical trials for older and/or frail adults. The conference sought to identify knowledge gaps in cancer clinical trials for older adults and propose clinical trial designs to fill these gaps. The ultimate goal of this conference series is to develop research that will lead to evidence-based care for older and/or frail adults with cancer.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

August 20, 2014

Volume

32

Issue

24

Start / End Page

2587 / 2594

Location

United States

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Oncology & Carcinogenesis
  • Neoplasms
  • Medical Oncology
  • Humans
  • Geriatrics
  • Frail Elderly
  • Clinical Trials, Phase III as Topic
  • Clinical Trials, Phase II as Topic
  • Clinical Trials as Topic
 

Citation

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Hurria, A., Dale, W., Mooney, M., Rowland, J. H., Ballman, K. V., Cohen, H. J., … Cancer and Aging Research Group. (2014). Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations. J Clin Oncol, 32(24), 2587–2594. https://doi.org/10.1200/JCO.2013.55.0418
Hurria, Arti, William Dale, Margaret Mooney, Julia H. Rowland, Karla V. Ballman, Harvey J. Cohen, Hyman B. Muss, et al. “Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations.J Clin Oncol 32, no. 24 (August 20, 2014): 2587–94. https://doi.org/10.1200/JCO.2013.55.0418.
Hurria A, Dale W, Mooney M, Rowland JH, Ballman KV, Cohen HJ, et al. Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations. J Clin Oncol. 2014 Aug 20;32(24):2587–94.
Hurria, Arti, et al. “Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations.J Clin Oncol, vol. 32, no. 24, Aug. 2014, pp. 2587–94. Pubmed, doi:10.1200/JCO.2013.55.0418.
Hurria A, Dale W, Mooney M, Rowland JH, Ballman KV, Cohen HJ, Muss HB, Schilsky RL, Ferrell B, Extermann M, Schmader KE, Mohile SG, Cancer and Aging Research Group. Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations. J Clin Oncol. 2014 Aug 20;32(24):2587–2594.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

August 20, 2014

Volume

32

Issue

24

Start / End Page

2587 / 2594

Location

United States

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Oncology & Carcinogenesis
  • Neoplasms
  • Medical Oncology
  • Humans
  • Geriatrics
  • Frail Elderly
  • Clinical Trials, Phase III as Topic
  • Clinical Trials, Phase II as Topic
  • Clinical Trials as Topic