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Characterization of porous, dexamethasone-releasing polyurethane coatings for glucose sensors.

Publication ,  Journal Article
Vallejo-Heligon, SG; Klitzman, B; Reichert, WM
Published in: Acta Biomater
November 2014

Commercially available implantable needle-type glucose sensors for diabetes management are robust analytically but can be unreliable clinically primarily due to tissue-sensor interactions. Here, we present the physical, drug release and bioactivity characterization of tubular, porous dexamethasone (Dex)-releasing polyurethane coatings designed to attenuate local inflammation at the tissue-sensor interface. Porous polyurethane coatings were produced by the salt-leaching/gas-foaming method. Scanning electron microscopy and micro-computed tomography (micro-CT) showed controlled porosity and coating thickness. In vitro drug release from coatings monitored over 2 weeks presented an initial fast release followed by a slower release. Total release from coatings was highly dependent on initial drug loading amount. Functional in vitro testing of glucose sensors deployed with porous coatings against glucose standards demonstrated that highly porous coatings minimally affected signal strength and response rate. Bioactivity of the released drug was determined by monitoring Dex-mediated, dose-dependent apoptosis of human peripheral blood derived monocytes in culture. Acute animal studies were used to determine the appropriate Dex payload for the implanted porous coatings. Pilot short-term animal studies showed that Dex released from porous coatings implanted in rat subcutis attenuated the initial inflammatory response to sensor implantation. These results suggest that deploying sensors with the porous, Dex-releasing coatings is a promising strategy to improve glucose sensor performance.

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Published In

Acta Biomater

DOI

EISSN

1878-7568

Publication Date

November 2014

Volume

10

Issue

11

Start / End Page

4629 / 4638

Location

England

Related Subject Headings

  • X-Ray Microtomography
  • Time Factors
  • Rats, Sprague-Dawley
  • Prosthesis Implantation
  • Porosity
  • Polyurethanes
  • Pilot Projects
  • Humans
  • Glucose
  • Dexamethasone
 

Citation

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Vallejo-Heligon, S. G., Klitzman, B., & Reichert, W. M. (2014). Characterization of porous, dexamethasone-releasing polyurethane coatings for glucose sensors. Acta Biomater, 10(11), 4629–4638. https://doi.org/10.1016/j.actbio.2014.07.019
Vallejo-Heligon, Suzana G., Bruce Klitzman, and William M. Reichert. “Characterization of porous, dexamethasone-releasing polyurethane coatings for glucose sensors.Acta Biomater 10, no. 11 (November 2014): 4629–38. https://doi.org/10.1016/j.actbio.2014.07.019.
Vallejo-Heligon SG, Klitzman B, Reichert WM. Characterization of porous, dexamethasone-releasing polyurethane coatings for glucose sensors. Acta Biomater. 2014 Nov;10(11):4629–38.
Vallejo-Heligon, Suzana G., et al. “Characterization of porous, dexamethasone-releasing polyurethane coatings for glucose sensors.Acta Biomater, vol. 10, no. 11, Nov. 2014, pp. 4629–38. Pubmed, doi:10.1016/j.actbio.2014.07.019.
Vallejo-Heligon SG, Klitzman B, Reichert WM. Characterization of porous, dexamethasone-releasing polyurethane coatings for glucose sensors. Acta Biomater. 2014 Nov;10(11):4629–4638.
Journal cover image

Published In

Acta Biomater

DOI

EISSN

1878-7568

Publication Date

November 2014

Volume

10

Issue

11

Start / End Page

4629 / 4638

Location

England

Related Subject Headings

  • X-Ray Microtomography
  • Time Factors
  • Rats, Sprague-Dawley
  • Prosthesis Implantation
  • Porosity
  • Polyurethanes
  • Pilot Projects
  • Humans
  • Glucose
  • Dexamethasone