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Pharmacology and safety of new oral anticoagulants: the challenge of bleeding persists.

Publication ,  Other
Levy, JH
Published in: Clin Lab Med
September 2014

New oral anticoagulants (NOACs) are increasingly replacing vitamin K antagonists and older parenteral agents in clinical practice. NOACs offer several advantages compared with standard agents, including rapid onset of action, fixed dosing, and no requirement for routine coagulation monitoring. However, like all anticoagulants, NOACs carry a risk of bleeding. Here, we discuss the pharmacology and safety of NOACs, with particular emphasis on the risks of bleeding associated with NOACs versus standard anticoagulants, and we provide an overview of current bleeding management strategies.

Duke Scholars

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Published In

Clin Lab Med

DOI

EISSN

1557-9832

Publication Date

September 2014

Volume

34

Issue

3

Start / End Page

443 / 452

Location

United States

Related Subject Headings

  • beta-Alanine
  • Thiophenes
  • Rivaroxaban
  • Pyridones
  • Pyrazoles
  • Pathology
  • Morpholines
  • Humans
  • Hemorrhage
  • Evidence-Based Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Levy, J. H. (2014). Pharmacology and safety of new oral anticoagulants: the challenge of bleeding persists. Clin Lab Med. United States. https://doi.org/10.1016/j.cll.2014.06.003
Levy, Jerrold H. “Pharmacology and safety of new oral anticoagulants: the challenge of bleeding persists.Clin Lab Med, September 2014. https://doi.org/10.1016/j.cll.2014.06.003.
Levy, Jerrold H. “Pharmacology and safety of new oral anticoagulants: the challenge of bleeding persists.Clin Lab Med, vol. 34, no. 3, Sept. 2014, pp. 443–52. Pubmed, doi:10.1016/j.cll.2014.06.003.
Journal cover image

Published In

Clin Lab Med

DOI

EISSN

1557-9832

Publication Date

September 2014

Volume

34

Issue

3

Start / End Page

443 / 452

Location

United States

Related Subject Headings

  • beta-Alanine
  • Thiophenes
  • Rivaroxaban
  • Pyridones
  • Pyrazoles
  • Pathology
  • Morpholines
  • Humans
  • Hemorrhage
  • Evidence-Based Medicine