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Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.

Publication ,  Journal Article
Chen, K; Ma, H; Li, L; Zang, R; Wang, C; Song, F; Shi, T; Yu, D; Yang, M; Xue, W; Dai, J; Li, S; Zheng, H; Wu, C; Zhang, Y; Wu, X; Li, D ...
Published in: Nature communications
August 2014

Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls in stage I, and replicate 41 SNPs (P(meta)<10(-4)) in 960 EOC cases and 1,799 controls (stage II), and an additional 492 EOC cases and 1,004 controls (stage III). Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages). These results may advance our understanding of genetic susceptibility to EOC.

Duke Scholars

Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

August 2014

Volume

5

Start / End Page

4682

Related Subject Headings

  • Risk Factors
  • Protein Serine-Threonine Kinases
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Nuclear Proteins
  • Neoplasms, Glandular and Epithelial
  • Middle Aged
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
 

Citation

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Chen, K., Ma, H., Li, L., Zang, R., Wang, C., Song, F., … Wei, Q. (2014). Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women. Nature Communications, 5, 4682. https://doi.org/10.1038/ncomms5682
Chen, Kexin, Hongxia Ma, Lian Li, Rongyu Zang, Cheng Wang, Fengju Song, Tingyan Shi, et al. “Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.Nature Communications 5 (August 2014): 4682. https://doi.org/10.1038/ncomms5682.
Chen K, Ma H, Li L, Zang R, Wang C, Song F, et al. Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women. Nature communications. 2014 Aug;5:4682.
Chen, Kexin, et al. “Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.Nature Communications, vol. 5, Aug. 2014, p. 4682. Epmc, doi:10.1038/ncomms5682.
Chen K, Ma H, Li L, Zang R, Wang C, Song F, Shi T, Yu D, Yang M, Xue W, Dai J, Li S, Zheng H, Wu C, Zhang Y, Wu X, Li D, Xue F, Li H, Jiang Z, Liu J, Liu Y, Li P, Tan W, Han J, Jie J, Hao Q, Hu Z, Lin D, Ma D, Jia W, Shen H, Wei Q. Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women. Nature communications. 2014 Aug;5:4682.

Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

August 2014

Volume

5

Start / End Page

4682

Related Subject Headings

  • Risk Factors
  • Protein Serine-Threonine Kinases
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Nuclear Proteins
  • Neoplasms, Glandular and Epithelial
  • Middle Aged
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease