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Prenatal alcohol exposure reduces magnetic susceptibility contrast and anisotropy in the white matter of mouse brains.

Publication ,  Journal Article
Cao, W; Li, W; Han, H; O'Leary-Moore, SK; Sulik, KK; Allan Johnson, G; Liu, C
Published in: Neuroimage
November 15, 2014

Prenatal alcohol exposure can result in long-term cognitive and behavioral deficits. Fetal alcohol spectrum disorder (FASD) refers to a range of permanent birth defects caused by prenatal alcohol exposure, and is the most common neurodevelopmental disorder in the US. Studies by autopsy and conventional structural MRI indicate that the midline structures of the brain are particularly vulnerable to prenatal alcohol exposure. Diffusion tensor imaging (DTI) has shown that abnormalities in brain white matter especially the corpus callosum are very common in FASD. Quantitative susceptibility mapping (QSM) is a novel technique that measures tissue's magnetic property. Such magnetic property is affected by tissue microstructure and molecular composition including that of myelin in the white matter. In this work, we studied three major white matter fiber bundles of a mouse model of FASD and compared it to control mice using both QSM and DTI. QSM revealed clear and significant abnormalities in anterior commissure, corpus callosum, and hippocampal commissure, which were likely due to reduced myelination. Our data also suggested that QSM may be even more sensitive than DTI for examining changes due to prenatal alcohol exposure. Although this is a preclinical study, the technique of QSM is readily translatable to human brain.

Duke Scholars

Published In

Neuroimage

DOI

EISSN

1095-9572

Publication Date

November 15, 2014

Volume

102 Pt 2

Issue

0 2

Start / End Page

748 / 755

Location

United States

Related Subject Headings

  • White Matter
  • Sensitivity and Specificity
  • Neurology & Neurosurgery
  • Mice, Inbred C57BL
  • Mice
  • Fetal Alcohol Spectrum Disorders
  • Female
  • Diffusion Tensor Imaging
  • Brain
  • Anisotropy
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cao, W., Li, W., Han, H., O’Leary-Moore, S. K., Sulik, K. K., Allan Johnson, G., & Liu, C. (2014). Prenatal alcohol exposure reduces magnetic susceptibility contrast and anisotropy in the white matter of mouse brains. Neuroimage, 102 Pt 2(0 2), 748–755. https://doi.org/10.1016/j.neuroimage.2014.08.035
Cao, Wei, Wei Li, Hui Han, Shonagh K. O’Leary-Moore, Kathleen K. Sulik, G. Allan Johnson, and Chunlei Liu. “Prenatal alcohol exposure reduces magnetic susceptibility contrast and anisotropy in the white matter of mouse brains.Neuroimage 102 Pt 2, no. 0 2 (November 15, 2014): 748–55. https://doi.org/10.1016/j.neuroimage.2014.08.035.
Cao W, Li W, Han H, O’Leary-Moore SK, Sulik KK, Allan Johnson G, et al. Prenatal alcohol exposure reduces magnetic susceptibility contrast and anisotropy in the white matter of mouse brains. Neuroimage. 2014 Nov 15;102 Pt 2(0 2):748–55.
Cao, Wei, et al. “Prenatal alcohol exposure reduces magnetic susceptibility contrast and anisotropy in the white matter of mouse brains.Neuroimage, vol. 102 Pt 2, no. 0 2, Nov. 2014, pp. 748–55. Pubmed, doi:10.1016/j.neuroimage.2014.08.035.
Cao W, Li W, Han H, O’Leary-Moore SK, Sulik KK, Allan Johnson G, Liu C. Prenatal alcohol exposure reduces magnetic susceptibility contrast and anisotropy in the white matter of mouse brains. Neuroimage. 2014 Nov 15;102 Pt 2(0 2):748–755.
Journal cover image

Published In

Neuroimage

DOI

EISSN

1095-9572

Publication Date

November 15, 2014

Volume

102 Pt 2

Issue

0 2

Start / End Page

748 / 755

Location

United States

Related Subject Headings

  • White Matter
  • Sensitivity and Specificity
  • Neurology & Neurosurgery
  • Mice, Inbred C57BL
  • Mice
  • Fetal Alcohol Spectrum Disorders
  • Female
  • Diffusion Tensor Imaging
  • Brain
  • Anisotropy