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Controllable pulse parameter transcranial magnetic stimulator with enhanced circuit topology and pulse shaping.

Publication ,  Journal Article
Peterchev, AV; DʼOstilio, K; Rothwell, JC; Murphy, DL
Published in: J Neural Eng
October 2014

OBJECTIVE: This work aims at flexible and practical pulse parameter control in transcranial magnetic stimulation (TMS), which is currently very limited in commercial devices. APPROACH: We present a third generation controllable pulse parameter device (cTMS3) that uses a novel circuit topology with two energy-storage capacitors. It incorporates several implementation and functionality advantages over conventional TMS devices and other devices with advanced pulse shape control. cTMS3 generates lower internal voltage differences and is implemented with transistors with a lower voltage rating than prior cTMS devices. MAIN RESULTS: cTMS3 provides more flexible pulse shaping since the circuit topology allows four coil-voltage levels during a pulse, including approximately zero voltage. The near-zero coil voltage enables snubbing of the ringing at the end of the pulse without the need for a separate active snubber circuit. cTMS3 can generate powerful rapid pulse sequences (< 10 ms inter pulse interval) by increasing the width of each subsequent pulse and utilizing the large capacitor energy storage, allowing the implementation of paradigms such as paired-pulse and quadripulse TMS with a single pulse generation circuit. cTMS3 can also generate theta (50 Hz) burst stimulation with predominantly unidirectional electric field pulses. The cTMS3 device functionality and output strength are illustrated with electrical output measurements as well as a study of the effect of pulse width and polarity on the active motor threshold in ten healthy volunteers. SIGNIFICANCE: The cTMS3 features could extend the utility of TMS as a research, diagnostic, and therapeutic tool.

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Published In

J Neural Eng

DOI

EISSN

1741-2552

Publication Date

October 2014

Volume

11

Issue

5

Start / End Page

056023

Location

England

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Therapy, Computer-Assisted
  • Signal Processing, Computer-Assisted
  • Muscle, Skeletal
  • Motor Cortex
  • Male
  • Humans
  • Female
  • Evoked Potentials, Motor
  • Equipment Failure Analysis
 

Citation

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Peterchev, A. V., DʼOstilio, K., Rothwell, J. C., & Murphy, D. L. (2014). Controllable pulse parameter transcranial magnetic stimulator with enhanced circuit topology and pulse shaping. J Neural Eng, 11(5), 056023. https://doi.org/10.1088/1741-2560/11/5/056023
Peterchev, Angel V., Kevin DʼOstilio, John C. Rothwell, and David L. Murphy. “Controllable pulse parameter transcranial magnetic stimulator with enhanced circuit topology and pulse shaping.J Neural Eng 11, no. 5 (October 2014): 056023. https://doi.org/10.1088/1741-2560/11/5/056023.
Peterchev AV, DʼOstilio K, Rothwell JC, Murphy DL. Controllable pulse parameter transcranial magnetic stimulator with enhanced circuit topology and pulse shaping. J Neural Eng. 2014 Oct;11(5):056023.
Peterchev, Angel V., et al. “Controllable pulse parameter transcranial magnetic stimulator with enhanced circuit topology and pulse shaping.J Neural Eng, vol. 11, no. 5, Oct. 2014, p. 056023. Pubmed, doi:10.1088/1741-2560/11/5/056023.
Peterchev AV, DʼOstilio K, Rothwell JC, Murphy DL. Controllable pulse parameter transcranial magnetic stimulator with enhanced circuit topology and pulse shaping. J Neural Eng. 2014 Oct;11(5):056023.
Journal cover image

Published In

J Neural Eng

DOI

EISSN

1741-2552

Publication Date

October 2014

Volume

11

Issue

5

Start / End Page

056023

Location

England

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Therapy, Computer-Assisted
  • Signal Processing, Computer-Assisted
  • Muscle, Skeletal
  • Motor Cortex
  • Male
  • Humans
  • Female
  • Evoked Potentials, Motor
  • Equipment Failure Analysis