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Meniscal allograft transplantation. Part 1: systematic review of graft biology, graft shrinkage, graft extrusion, graft sizing, and graft fixation.

Publication ,  Journal Article
Samitier, G; Alentorn-Geli, E; Taylor, DC; Rill, B; Lock, T; Moutzouros, V; Kolowich, P
Published in: Knee Surg Sports Traumatol Arthrosc
January 2015

PURPOSE: To provide a systematic review of the literature regarding five topics in meniscal allograft transplantation: graft biology, shrinkage, extrusion, sizing, and fixation. METHODS: A systematic literature search was conducted using the PubMed (MEDLINE), ScienceDirect, and EBSCO-CINAHL databases. Articles were classified only in one topic, but information contained could be reported into other topics. Information was classified according to type of study (animal, in vitro human, and in vivo human) and level of evidence (for in vivo human studies). RESULTS: Sixty-two studies were finally included: 30 biology, 3 graft shrinkage, 11 graft extrusion, 17 graft size, and 6 graft fixation (some studies were categorized in more than one topic). These studies corresponded to 22 animal studies, 22 in vitro human studies, and 23 in vivo human studies (7 level II, 10 level III, and 6 level IV). CONCLUSIONS: The principal conclusions were as follows: (a) Donor cells decrease after MAT and grafts are repopulated with host cells form synovium; (b) graft preservation alters collagen network (deep freezing) and causes cell apoptosis with loss of viable cells (cryopreservation); (c) graft shrinkage occurs mainly in lyophilized and gamma-irradiated grafts (less with cryopreservation); (d) graft extrusion is common but has no clinical/functional implications; (e) overall, MRI is not superior to plain radiograph for graft sizing; (f) graft width size matching is more important than length size matching; (g) height appears to be the most important factor influencing meniscal size; (h) bone fixation better restores contact mechanics than suture fixation, but there are no differences for pullout strength or functional results; and (i) suture fixation has more risk of graft extrusion compared to bone fixation. LEVEL OF EVIDENCE: Systematic review of level II-IV studies, Level IV.

Duke Scholars

Published In

Knee Surg Sports Traumatol Arthrosc

DOI

EISSN

1433-7347

Publication Date

January 2015

Volume

23

Issue

1

Start / End Page

310 / 322

Location

Germany

Related Subject Headings

  • Wound Healing
  • Transplantation, Homologous
  • Tibial Meniscus Injuries
  • Prosthesis Failure
  • Orthopedics
  • Menisci, Tibial
  • Magnetic Resonance Imaging
  • Knee Injuries
  • Humans
  • Graft Survival
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Samitier, G., Alentorn-Geli, E., Taylor, D. C., Rill, B., Lock, T., Moutzouros, V., & Kolowich, P. (2015). Meniscal allograft transplantation. Part 1: systematic review of graft biology, graft shrinkage, graft extrusion, graft sizing, and graft fixation. Knee Surg Sports Traumatol Arthrosc, 23(1), 310–322. https://doi.org/10.1007/s00167-014-3334-5
Samitier, Gonzalo, Eduard Alentorn-Geli, Dean C. Taylor, Brian Rill, Terrence Lock, Vasilius Moutzouros, and Patricia Kolowich. “Meniscal allograft transplantation. Part 1: systematic review of graft biology, graft shrinkage, graft extrusion, graft sizing, and graft fixation.Knee Surg Sports Traumatol Arthrosc 23, no. 1 (January 2015): 310–22. https://doi.org/10.1007/s00167-014-3334-5.
Samitier G, Alentorn-Geli E, Taylor DC, Rill B, Lock T, Moutzouros V, et al. Meniscal allograft transplantation. Part 1: systematic review of graft biology, graft shrinkage, graft extrusion, graft sizing, and graft fixation. Knee Surg Sports Traumatol Arthrosc. 2015 Jan;23(1):310–22.
Samitier, Gonzalo, et al. “Meniscal allograft transplantation. Part 1: systematic review of graft biology, graft shrinkage, graft extrusion, graft sizing, and graft fixation.Knee Surg Sports Traumatol Arthrosc, vol. 23, no. 1, Jan. 2015, pp. 310–22. Pubmed, doi:10.1007/s00167-014-3334-5.
Samitier G, Alentorn-Geli E, Taylor DC, Rill B, Lock T, Moutzouros V, Kolowich P. Meniscal allograft transplantation. Part 1: systematic review of graft biology, graft shrinkage, graft extrusion, graft sizing, and graft fixation. Knee Surg Sports Traumatol Arthrosc. 2015 Jan;23(1):310–322.
Journal cover image

Published In

Knee Surg Sports Traumatol Arthrosc

DOI

EISSN

1433-7347

Publication Date

January 2015

Volume

23

Issue

1

Start / End Page

310 / 322

Location

Germany

Related Subject Headings

  • Wound Healing
  • Transplantation, Homologous
  • Tibial Meniscus Injuries
  • Prosthesis Failure
  • Orthopedics
  • Menisci, Tibial
  • Magnetic Resonance Imaging
  • Knee Injuries
  • Humans
  • Graft Survival