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Donor predictors of allograft use and recipient outcomes after heart transplantation.

Publication ,  Journal Article
Khush, KK; Menza, R; Nguyen, J; Zaroff, JG; Goldstein, BA
Published in: Circ Heart Fail
March 2013

BACKGROUND: Despite a national organ-donor shortage and a growing population of patients with end-stage heart disease, the acceptance rate of donor hearts for transplantation is low. We sought to identify donor predictors of allograft nonuse, and to determine whether these predictors are in fact associated with adverse recipient post-transplant outcomes. METHODS AND RESULTS: We studied a cohort of 1872 potential organ donors managed by the California Transplant Donor Network from 2001 to 2008. Forty-five percent of available allografts were accepted for heart transplantation. Donor predictors of allograft nonuse included age >50 years, female sex, death attributable to cerebrovascular accident, hypertension, diabetes mellitus, a positive troponin assay, left-ventricular dysfunction and regional wall motion abnormalities, and left-ventricular hypertrophy. For hearts that were transplanted, only donor cause of death was associated with prolonged recipient hospitalization post-transplant, and only donor diabetes mellitus was predictive of increased recipient mortality. CONCLUSIONS: Whereas there are many donor predictors of allograft discard in the current era, these characteristics seem to have little effect on recipient outcomes when the hearts are transplanted. Our results suggest that more liberal use of cardiac allografts with relative contraindications may be warranted.

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Published In

Circ Heart Fail

DOI

EISSN

1941-3297

Publication Date

March 2013

Volume

6

Issue

2

Start / End Page

300 / 309

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Tissue Donors
  • Risk Factors
  • Risk Assessment
  • Postoperative Complications
  • Odds Ratio
  • Middle Aged
  • Male
  • Logistic Models
 

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Khush, K. K., Menza, R., Nguyen, J., Zaroff, J. G., & Goldstein, B. A. (2013). Donor predictors of allograft use and recipient outcomes after heart transplantation. Circ Heart Fail, 6(2), 300–309. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000165
Khush, Kiran K., Rebecca Menza, John Nguyen, Jonathan G. Zaroff, and Benjamin A. Goldstein. “Donor predictors of allograft use and recipient outcomes after heart transplantation.Circ Heart Fail 6, no. 2 (March 2013): 300–309. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000165.
Khush KK, Menza R, Nguyen J, Zaroff JG, Goldstein BA. Donor predictors of allograft use and recipient outcomes after heart transplantation. Circ Heart Fail. 2013 Mar;6(2):300–9.
Khush, Kiran K., et al. “Donor predictors of allograft use and recipient outcomes after heart transplantation.Circ Heart Fail, vol. 6, no. 2, Mar. 2013, pp. 300–09. Pubmed, doi:10.1161/CIRCHEARTFAILURE.112.000165.
Khush KK, Menza R, Nguyen J, Zaroff JG, Goldstein BA. Donor predictors of allograft use and recipient outcomes after heart transplantation. Circ Heart Fail. 2013 Mar;6(2):300–309.

Published In

Circ Heart Fail

DOI

EISSN

1941-3297

Publication Date

March 2013

Volume

6

Issue

2

Start / End Page

300 / 309

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Tissue Donors
  • Risk Factors
  • Risk Assessment
  • Postoperative Complications
  • Odds Ratio
  • Middle Aged
  • Male
  • Logistic Models