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Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations.

Publication ,  Journal Article
de Bruin, MA; Kwong, A; Goldstein, BA; Lipson, JA; Ikeda, DM; McPherson, L; Sharma, B; Kardashian, A; Schackmann, E; Kingham, KE; Mills, MA ...
Published in: Fam Cancer
September 2012

The prevalence and penetrance of BRCA1 and BRCA2 (BRCA1/2) mutations may differ between Asians and whites. We investigated BRCA1/2 mutations and cancer risk factors in a clinic-based sample. BRCA1/2 mutation carriers were enrolled from cancer genetics clinics in Hong Kong and California according to standardized entry criteria. We compared BRCA mutation position, cancer history, hormonal and reproductive exposures. We analyzed DNA samples for single-nucleotide polymorphisms reported to modify breast cancer risk. We performed logistic regression to identify independent predictors of breast cancer. Fifty Asian women and forty-nine white American women were enrolled. BRCA1 mutations were more common among whites (67 vs. 42 %, p = 0.02), and BRCA2 mutations among Asians (58 vs. 37 %, p = 0.04). More Asians had breast cancer (76 vs. 53 %, p = 0.03); more whites had relatives with breast cancer (86 vs. 50 %, p = 0.0003). More whites than Asians had breastfed (71 vs. 42 %, p = 0.005), had high BMI (median 24.3 vs. 21.2, p = 0.04), consumed alcohol (2 drinks/week vs. 0, p < 0.001), and had oophorectomy (61 vs. 34 %, p = 0.01). Asians had a higher frequency of risk-associated alleles in MAP3K1 (88 vs. 59 %, p = 0.005) and TOX3/TNRC9 (88 vs. 55 %, p = 0.0002). On logistic regression, MAP3K1 was associated with increased breast cancer risk for BRCA2, but not BRCA1 mutation carriers; breast density was associated with increased risk among Asians but not whites. We found significant differences in breast cancer risk factors between Asian and white BRCA1/2 mutation carriers. Further investigation of racial differences in BRCA1/2 mutation epidemiology could inform targeted cancer risk-reduction strategies.

Duke Scholars

Published In

Fam Cancer

DOI

EISSN

1573-7292

Publication Date

September 2012

Volume

11

Issue

3

Start / End Page

429 / 439

Location

Netherlands

Related Subject Headings

  • White People
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Ovariectomy
  • Oncology & Carcinogenesis
  • Mutation
  • Middle Aged
  • MAP Kinase Kinase Kinase 1
  • Logistic Models
  • Life Style
 

Citation

APA
Chicago
ICMJE
MLA
NLM
de Bruin, M. A., Kwong, A., Goldstein, B. A., Lipson, J. A., Ikeda, D. M., McPherson, L., … Kurian, A. W. (2012). Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations. Fam Cancer, 11(3), 429–439. https://doi.org/10.1007/s10689-012-9531-9
Bruin, Monique A. de, Ava Kwong, Benjamin A. Goldstein, Jafi A. Lipson, Debra M. Ikeda, Lisa McPherson, Bhavna Sharma, et al. “Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations.Fam Cancer 11, no. 3 (September 2012): 429–39. https://doi.org/10.1007/s10689-012-9531-9.
de Bruin MA, Kwong A, Goldstein BA, Lipson JA, Ikeda DM, McPherson L, et al. Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations. Fam Cancer. 2012 Sep;11(3):429–39.
de Bruin, Monique A., et al. “Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations.Fam Cancer, vol. 11, no. 3, Sept. 2012, pp. 429–39. Pubmed, doi:10.1007/s10689-012-9531-9.
de Bruin MA, Kwong A, Goldstein BA, Lipson JA, Ikeda DM, McPherson L, Sharma B, Kardashian A, Schackmann E, Kingham KE, Mills MA, West DW, Ford JM, Kurian AW. Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations. Fam Cancer. 2012 Sep;11(3):429–439.
Journal cover image

Published In

Fam Cancer

DOI

EISSN

1573-7292

Publication Date

September 2012

Volume

11

Issue

3

Start / End Page

429 / 439

Location

Netherlands

Related Subject Headings

  • White People
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Ovariectomy
  • Oncology & Carcinogenesis
  • Mutation
  • Middle Aged
  • MAP Kinase Kinase Kinase 1
  • Logistic Models
  • Life Style