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How I use fibrinogen replacement therapy in acquired bleeding.

Publication ,  Other
Levy, JH; Goodnough, LT
Published in: Blood
February 26, 2015

Fibrinogen is a critical protein for hemostasis and clot formation. However, transfusion guidelines have variable recommendations for maintaining fibrinogen levels in bleeding patients. An increasing number of studies support the practice of fibrinogen replacement therapy for acquired coagulopathies, and additional studies are underway. Fibrinogen therapy can be administered with cryoprecipitate or fibrinogen concentrates, and clinical practice varies according to their availability and licensing status. Fibrinogen concentrate therapy has been studied in animal models and clinical trials and supports the critical role of fibrinogen repletion in bleeding patients. Point-of-care testing will have an important role in guiding fibrinogen replacement for hemostatic therapy in clinical settings such as cardiovascular surgery, postpartum hemorrhage, and trauma. Fibrinogen therapy is an important component of a multimodal strategy for the treatment of coagulopathic bleeding.

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Published In

Blood

DOI

EISSN

1528-0020

Publication Date

February 26, 2015

Volume

125

Issue

9

Start / End Page

1387 / 1393

Location

United States

Related Subject Headings

  • Prognosis
  • Practice Patterns, Physicians'
  • Middle Aged
  • Male
  • Immunology
  • Humans
  • Hemorrhage
  • Fibrinogen
  • Blood Transfusion
  • Blood Loss, Surgical
 

Citation

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Levy, J. H., & Goodnough, L. T. (2015). How I use fibrinogen replacement therapy in acquired bleeding. Blood. United States. https://doi.org/10.1182/blood-2014-08-552000
Levy, Jerrold H., and Lawrence T. Goodnough. “How I use fibrinogen replacement therapy in acquired bleeding.Blood, February 26, 2015. https://doi.org/10.1182/blood-2014-08-552000.
Levy JH, Goodnough LT. How I use fibrinogen replacement therapy in acquired bleeding. Vol. 125, Blood. 2015. p. 1387–93.
Levy, Jerrold H., and Lawrence T. Goodnough. “How I use fibrinogen replacement therapy in acquired bleeding.Blood, vol. 125, no. 9, 26 Feb. 2015, pp. 1387–93. Pubmed, doi:10.1182/blood-2014-08-552000.
Levy JH, Goodnough LT. How I use fibrinogen replacement therapy in acquired bleeding. Blood. 2015. p. 1387–1393.

Published In

Blood

DOI

EISSN

1528-0020

Publication Date

February 26, 2015

Volume

125

Issue

9

Start / End Page

1387 / 1393

Location

United States

Related Subject Headings

  • Prognosis
  • Practice Patterns, Physicians'
  • Middle Aged
  • Male
  • Immunology
  • Humans
  • Hemorrhage
  • Fibrinogen
  • Blood Transfusion
  • Blood Loss, Surgical