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White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities.

Publication ,  Journal Article
Sullivan, S; Eucker, SA; Gabrieli, D; Bradfield, C; Coats, B; Maltese, MR; Lee, J; Smith, C; Margulies, SS
Published in: Biomech Model Mechanobiol
August 2015

A systematic correlation between finite element models (FEMs) and histopathology is needed to define deformation thresholds associated with traumatic brain injury (TBI). In this study, a FEM of a transected piglet brain was used to reverse engineer the range of optimal shear moduli for infant (5 days old, 553-658 Pa) and 4-week-old toddler piglet brain (692-811 Pa) from comparisons with measured in situ tissue strains. The more mature brain modulus was found to have significant strain and strain rate dependencies not observed with the infant brain. Age-appropriate FEMs were then used to simulate experimental TBI in infant (n=36) and preadolescent (n=17) piglets undergoing a range of rotational head loads. The experimental animals were evaluated for the presence of clinically significant traumatic axonal injury (TAI), which was then correlated with FEM-calculated measures of overall and white matter tract-oriented tissue deformations, and used to identify the metric with the highest sensitivity and specificity for detecting TAI. The best predictors of TAI were the tract-oriented strain (6-7%), strain rate (38-40 s(-1), and strain times strain rate (1.3-1.8 s(-1) values exceeded by 90% of the brain. These tract-oriented strain and strain rate thresholds for TAI were comparable to those found in isolated axonal stretch studies. Furthermore, we proposed that the higher degree of agreement between tissue distortion aligned with white matter tracts and TAI may be the underlying mechanism responsible for more severe TAI after horizontal and sagittal head rotations in our porcine model of nonimpact TAI than coronal plane rotations.

Duke Scholars

Published In

Biomech Model Mechanobiol

DOI

EISSN

1617-7940

Publication Date

August 2015

Volume

14

Issue

4

Start / End Page

877 / 896

Location

Germany

Related Subject Headings

  • White Matter
  • Sus scrofa
  • Rotation
  • ROC Curve
  • Finite Element Analysis
  • Female
  • Disease Models, Animal
  • Diffuse Axonal Injury
  • Computer Simulation
  • Brain Injuries
 

Citation

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ICMJE
MLA
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Sullivan, S., Eucker, S. A., Gabrieli, D., Bradfield, C., Coats, B., Maltese, M. R., … Margulies, S. S. (2015). White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities. Biomech Model Mechanobiol, 14(4), 877–896. https://doi.org/10.1007/s10237-014-0643-z
Sullivan, Sarah, Stephanie A. Eucker, David Gabrieli, Connor Bradfield, Brittany Coats, Matthew R. Maltese, Jongho Lee, Colin Smith, and Susan S. Margulies. “White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities.Biomech Model Mechanobiol 14, no. 4 (August 2015): 877–96. https://doi.org/10.1007/s10237-014-0643-z.
Sullivan S, Eucker SA, Gabrieli D, Bradfield C, Coats B, Maltese MR, et al. White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities. Biomech Model Mechanobiol. 2015 Aug;14(4):877–96.
Sullivan, Sarah, et al. “White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities.Biomech Model Mechanobiol, vol. 14, no. 4, Aug. 2015, pp. 877–96. Pubmed, doi:10.1007/s10237-014-0643-z.
Sullivan S, Eucker SA, Gabrieli D, Bradfield C, Coats B, Maltese MR, Lee J, Smith C, Margulies SS. White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities. Biomech Model Mechanobiol. 2015 Aug;14(4):877–896.
Journal cover image

Published In

Biomech Model Mechanobiol

DOI

EISSN

1617-7940

Publication Date

August 2015

Volume

14

Issue

4

Start / End Page

877 / 896

Location

Germany

Related Subject Headings

  • White Matter
  • Sus scrofa
  • Rotation
  • ROC Curve
  • Finite Element Analysis
  • Female
  • Disease Models, Animal
  • Diffuse Axonal Injury
  • Computer Simulation
  • Brain Injuries