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Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research.

Publication ,  Journal Article
Arai, S; Arora, M; Wang, T; Spellman, SR; He, W; Couriel, DR; Urbano-Ispizua, A; Cutler, CS; Bacigalupo, AA; Battiwalla, M; Flowers, ME ...
Published in: Biol Blood Marrow Transplant
February 2015

Although transplant practices have changed over the last decades, no information is available on trends in incidence and outcome of chronic graft-versus-host disease (cGVHD) over time. This study used the central database of the Center for International Blood and Marrow Transplant Research (CIBMTR) to describe time trends for cGVHD incidence, nonrelapse mortality, and risk factors for cGVHD. The 12-year period was divided into 3 intervals, 1995 to 1999, 2000 to 2003, and 2004 to 2007, and included 26,563 patients with acute leukemia, chronic myeloid leukemia, and myelodysplastic syndrome. Multivariate analysis showed an increased incidence of cGVHD in more recent years (odds ratio = 1.19, P < .0001), and this trend was still seen when adjusting for donor type, graft type, or conditioning intensity. In patients with cGVHD, nonrelapse mortality has decreased over time, but at 5 years there were no significant differences among different time periods. Risk factors for cGVHD were in line with previous studies. This is the first comprehensive characterization of the trends in cGVHD incidence and underscores the mounting need for addressing this major late complication of transplantation in future research.

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Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

February 2015

Volume

21

Issue

2

Start / End Page

266 / 274

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Survival Analysis
  • Odds Ratio
  • Myelodysplastic Syndromes
  • Myeloablative Agonists
  • Middle Aged
  • Male
  • Leukemia, Myeloid, Acute
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • International Cooperation
 

Citation

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Arai, S., Arora, M., Wang, T., Spellman, S. R., He, W., Couriel, D. R., … Graft-vs-Host Disease Working Committee of the CIBMTR. (2015). Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research. Biol Blood Marrow Transplant, 21(2), 266–274. https://doi.org/10.1016/j.bbmt.2014.10.021
Arai, Sally, Mukta Arora, Tao Wang, Stephen R. Spellman, Wensheng He, Daniel R. Couriel, Alvaro Urbano-Ispizua, et al. “Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research.Biol Blood Marrow Transplant 21, no. 2 (February 2015): 266–74. https://doi.org/10.1016/j.bbmt.2014.10.021.
Arai S, Arora M, Wang T, Spellman SR, He W, Couriel DR, et al. Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research. Biol Blood Marrow Transplant. 2015 Feb;21(2):266–74.
Arai, Sally, et al. “Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research.Biol Blood Marrow Transplant, vol. 21, no. 2, Feb. 2015, pp. 266–74. Pubmed, doi:10.1016/j.bbmt.2014.10.021.
Arai S, Arora M, Wang T, Spellman SR, He W, Couriel DR, Urbano-Ispizua A, Cutler CS, Bacigalupo AA, Battiwalla M, Flowers ME, Juckett MB, Lee SJ, Loren AW, Klumpp TR, Prockup SE, Ringdén OTH, Savani BN, Socié G, Schultz KR, Spitzer T, Teshima T, Bredeson CN, Jacobsohn DA, Hayashi RJ, Drobyski WR, Frangoul HA, Akpek G, Ho VT, Lewis VA, Gale RP, Koreth J, Chao NJ, Aljurf MD, Cooper BW, Laughlin MJ, Hsu JW, Hematti P, Verdonck LF, Solh MM, Norkin M, Reddy V, Martino R, Gadalla S, Goldberg JD, McCarthy PL, Pérez-Simón JA, Khera N, Lewis ID, Atsuta Y, Olsson RF, Saber W, Waller EK, Blaise D, Pidala JA, Martin PJ, Satwani P, Bornhäuser M, Inamoto Y, Weisdorf DJ, Horowitz MM, Pavletic SZ, Graft-vs-Host Disease Working Committee of the CIBMTR. Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research. Biol Blood Marrow Transplant. 2015 Feb;21(2):266–274.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

February 2015

Volume

21

Issue

2

Start / End Page

266 / 274

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Survival Analysis
  • Odds Ratio
  • Myelodysplastic Syndromes
  • Myeloablative Agonists
  • Middle Aged
  • Male
  • Leukemia, Myeloid, Acute
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • International Cooperation