Skip to main content

Biological basis of bone formation, remodeling, and repair-part I: biochemical signaling molecules.

Publication ,  Journal Article
Allori, AC; Sailon, AM; Warren, SM
Published in: Tissue Eng Part B Rev
September 2008

The bony biochemical environment is an active and dynamic system that permits and promotes cellular functions that lead to matrix production and ossification. Each component is capable of conveying important regulatory cues to nearby cells, thus effecting gene expression and changes at the cytostructural level. Here, we review the various signaling molecules that contribute to the active and dynamic nature of the biochemical system. These components include hormones, cytokines, and growth factors. We describe their role in regulating bone metabolism. Certain growth factors (i.e., TGF-beta, IGF-1, and VEGF) are described in greater detail because of their potential importance in developing successful tissue-engineering strategies.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Tissue Eng Part B Rev

DOI

EISSN

1937-3376

Publication Date

September 2008

Volume

14

Issue

3

Start / End Page

259 / 273

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Transforming Growth Factor beta
  • Signal Transduction
  • Insulin-Like Growth Factor I
  • Humans
  • Hormones
  • Growth Substances
  • Cytokines
  • Cell Division
  • Cell Differentiation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Allori, A. C., Sailon, A. M., & Warren, S. M. (2008). Biological basis of bone formation, remodeling, and repair-part I: biochemical signaling molecules. Tissue Eng Part B Rev, 14(3), 259–273. https://doi.org/10.1089/ten.teb.2008.0082
Allori, Alexander C., Alexander M. Sailon, and Stephen M. Warren. “Biological basis of bone formation, remodeling, and repair-part I: biochemical signaling molecules.Tissue Eng Part B Rev 14, no. 3 (September 2008): 259–73. https://doi.org/10.1089/ten.teb.2008.0082.
Allori AC, Sailon AM, Warren SM. Biological basis of bone formation, remodeling, and repair-part I: biochemical signaling molecules. Tissue Eng Part B Rev. 2008 Sep;14(3):259–73.
Allori, Alexander C., et al. “Biological basis of bone formation, remodeling, and repair-part I: biochemical signaling molecules.Tissue Eng Part B Rev, vol. 14, no. 3, Sept. 2008, pp. 259–73. Pubmed, doi:10.1089/ten.teb.2008.0082.
Allori AC, Sailon AM, Warren SM. Biological basis of bone formation, remodeling, and repair-part I: biochemical signaling molecules. Tissue Eng Part B Rev. 2008 Sep;14(3):259–273.

Published In

Tissue Eng Part B Rev

DOI

EISSN

1937-3376

Publication Date

September 2008

Volume

14

Issue

3

Start / End Page

259 / 273

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Transforming Growth Factor beta
  • Signal Transduction
  • Insulin-Like Growth Factor I
  • Humans
  • Hormones
  • Growth Substances
  • Cytokines
  • Cell Division
  • Cell Differentiation