Skip to main content
Journal cover image

Evaluation of dynamic parameters of thrombus formation measured on whole blood using rotational thromboelastometry in children undergoing cardiac surgery: a descriptive study.

Publication ,  Journal Article
Faraoni, D; Fenger-Eriksen, C; Gillard, S; Willems, A; Levy, JH; Van der Linden, P
Published in: Paediatr Anaesth
June 2015

BACKGROUND: Total thrombus formation velocity calculated using amplitude parameters obtained at different times could be used to estimate the amplification and the propagation phases observed during coagulation processes, and therefore might be useful to predict postoperative hemostatic products administration in pediatric patients. METHODS: We retrospectively analyzed data from 49 children <3 months of age who underwent cardiac surgery. Children ≤1 month of age routinely received fresh frozen plasma during bypass while children >1 month of age did not. The EXTEM parameters were used to calculate velocity curves using amplitudes obtained at different times, the area under the curve called total thrombus formation and the maximum rate of thrombus formation. These parameters were compared between children who received fresh frozen plasma and those who did not. Receiver operating characteristics curves were used to define variables that could be used to predict postoperative fresh frozen plasma transfusion. RESULTS: Total thrombus formation and maximum rate of thrombus formation significantly increased in children who received fresh frozen plasma compared to those who did not. Both total thrombus formation and maximum rate of thrombus formation have a better specificity to predict postoperative fresh frozen plasma transfusion compared to clotting time or maximal clot firmness. CONCLUSION: Based on this descriptive study, dynamic ROTEM(®) parameters of total thrombus formation could be used to estimate the amplification and the propagation phases of coagulation in children. These parameters might be used in further well-designed study to predict the need for hemostatic products in children undergoing cardiac surgery with cardiopulmonary bypass.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Paediatr Anaesth

DOI

EISSN

1460-9592

Publication Date

June 2015

Volume

25

Issue

6

Start / End Page

573 / 579

Location

France

Related Subject Headings

  • Thrombosis
  • Thrombelastography
  • Retrospective Studies
  • ROC Curve
  • Plasma
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Faraoni, D., Fenger-Eriksen, C., Gillard, S., Willems, A., Levy, J. H., & Van der Linden, P. (2015). Evaluation of dynamic parameters of thrombus formation measured on whole blood using rotational thromboelastometry in children undergoing cardiac surgery: a descriptive study. Paediatr Anaesth, 25(6), 573–579. https://doi.org/10.1111/pan.12570
Faraoni, David, Christian Fenger-Eriksen, Stephanie Gillard, Ariane Willems, Jerrold H. Levy, and Philippe Van der Linden. “Evaluation of dynamic parameters of thrombus formation measured on whole blood using rotational thromboelastometry in children undergoing cardiac surgery: a descriptive study.Paediatr Anaesth 25, no. 6 (June 2015): 573–79. https://doi.org/10.1111/pan.12570.
Faraoni D, Fenger-Eriksen C, Gillard S, Willems A, Levy JH, Van der Linden P. Evaluation of dynamic parameters of thrombus formation measured on whole blood using rotational thromboelastometry in children undergoing cardiac surgery: a descriptive study. Paediatr Anaesth. 2015 Jun;25(6):573–9.
Faraoni, David, et al. “Evaluation of dynamic parameters of thrombus formation measured on whole blood using rotational thromboelastometry in children undergoing cardiac surgery: a descriptive study.Paediatr Anaesth, vol. 25, no. 6, June 2015, pp. 573–79. Pubmed, doi:10.1111/pan.12570.
Faraoni D, Fenger-Eriksen C, Gillard S, Willems A, Levy JH, Van der Linden P. Evaluation of dynamic parameters of thrombus formation measured on whole blood using rotational thromboelastometry in children undergoing cardiac surgery: a descriptive study. Paediatr Anaesth. 2015 Jun;25(6):573–579.
Journal cover image

Published In

Paediatr Anaesth

DOI

EISSN

1460-9592

Publication Date

June 2015

Volume

25

Issue

6

Start / End Page

573 / 579

Location

France

Related Subject Headings

  • Thrombosis
  • Thrombelastography
  • Retrospective Studies
  • ROC Curve
  • Plasma
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Female